Deletion Strain | FD score | P-value | Gene | Gene Description |
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YKR026C | 7.62 | 1.27E-14 | GCN3 | Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression |
YGL026C | 5.78 | 3.64E-9 | TRP5 | Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis |
YLR201C | 5.10 | 1.74E-7 | COQ9 | Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes |
YDR283C | 4.98 | 3.11E-7 | GCN2 | Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control |
YEL009C | 4.69 | 1.40E-6 | GCN4 | Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels |
YER090W | 4.45 | 4.26E-6 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
YNL237W | 4.38 | 6.00E-6 | YTP1 | Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins |
YGL118C_d | 4.38 | 6.06E-6 | YGL118C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YLR110C | 4.36 | 6.63E-6 | CCW12 | Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication |
YGR266W | 4.30 | 8.62E-6 | YGR266W | Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress |
YGR023W | 4.29 | 8.81E-6 | MTL1 | Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p |
YOR183W_p | 4.24 | 1.09E-5 | FYV12_p | Protein of unknown function, required for survival upon exposure to K1 killer toxin |
YML129C | 4.11 | 2.00E-5 | COX14 | Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes |
YKL090W | 4.09 | 2.11E-5 | CUE2 | Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination |
YGL095C | 4.03 | 2.82E-5 | VPS45 | Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment |