5259487

3-acetyl-4-(butylamino)-6-methylpyran-2-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2123
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 2173474
SMILES CCCCNC1=C(C(=O)OC(=C1)C)C(=O)C
Standardized SMILES CCCCN=C1C=C(C)OC(=C1C(=O)C)O
Molecular weight 223.2683
ALogP 1.09
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 4.58
% growth inhibition (Hom. pool) 6.54


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2173474
Download HIP data (tab-delimited text)  (excel)
Gene:FOL2(YGR267C)|FD-Score:4.01|P-value:2.98E-5|Clearance:0.26||SGD DESC:GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway Gene:GPI2(YPL076W)|FD-Score:-3.72|P-value:9.85E-5|Clearance:0||SGD DESC:Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein Gene:JAC1(YGL018C)|FD-Score:3.84|P-value:6.03E-5|Clearance:0.26||SGD DESC:Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix Gene:MCM3(YEL032W)|FD-Score:3.12|P-value:8.93E-4|Clearance:0.07||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex Gene:MOB2(YFL034C-B)|FD-Score:3.59|P-value:1.68E-4|Clearance:0.01||SGD DESC:Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p Gene:PTI1(YGR156W)|FD-Score:-3.12|P-value:9.14E-4|Clearance:0||SGD DESC:Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 Gene:RRP9(YPR137W)|FD-Score:-3.53|P-value:2.06E-4|Clearance:0||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:RTP1(YMR185W_p)|FD-Score:3.57|P-value:1.78E-4|Clearance:0.24||SGD DESC:Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene Gene:SDS22(YKL193C)|FD-Score:3.17|P-value:7.61E-4|Clearance:0.05||SGD DESC:Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function Gene:YLR198C(YLR198C_d)|FD-Score:3.33|P-value:4.38E-4|Clearance:0.16||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W Gene:FOL2(YGR267C)|FD-Score:4.01|P-value:2.98E-5|Clearance:0.26||SGD DESC:GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway Gene:GPI2(YPL076W)|FD-Score:-3.72|P-value:9.85E-5|Clearance:0||SGD DESC:Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein Gene:JAC1(YGL018C)|FD-Score:3.84|P-value:6.03E-5|Clearance:0.26||SGD DESC:Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix Gene:MCM3(YEL032W)|FD-Score:3.12|P-value:8.93E-4|Clearance:0.07||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex Gene:MOB2(YFL034C-B)|FD-Score:3.59|P-value:1.68E-4|Clearance:0.01||SGD DESC:Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p Gene:PTI1(YGR156W)|FD-Score:-3.12|P-value:9.14E-4|Clearance:0||SGD DESC:Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 Gene:RRP9(YPR137W)|FD-Score:-3.53|P-value:2.06E-4|Clearance:0||SGD DESC:Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein Gene:RTP1(YMR185W_p)|FD-Score:3.57|P-value:1.78E-4|Clearance:0.24||SGD DESC:Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene Gene:SDS22(YKL193C)|FD-Score:3.17|P-value:7.61E-4|Clearance:0.05||SGD DESC:Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function Gene:YLR198C(YLR198C_d)|FD-Score:3.33|P-value:4.38E-4|Clearance:0.16||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2173474
Download HOP data (tab-delimited text)  (excel)
Gene:ACB1(YGR037C)|FD-Score:5.22|P-value:9.08E-8||SGD DESC:Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress Gene:AIM26(YKL037W)|FD-Score:5.69|P-value:6.40E-9||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT Gene:ALK1(YGL021W)|FD-Score:3.39|P-value:3.49E-4||SGD DESC:Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins Gene:ASF1(YJL115W)|FD-Score:4.69|P-value:1.36E-6||SGD DESC:Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition Gene:ASG7(YJL170C)|FD-Score:3.82|P-value:6.58E-5||SGD DESC:Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor Gene:COQ8(YGL119W)|FD-Score:-3.14|P-value:8.40E-4||SGD DESC:Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication Gene:COX18(YGR062C)|FD-Score:5.81|P-value:3.20E-9||SGD DESC:Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC Gene:CRH1(YGR189C)|FD-Score:-3.46|P-value:2.68E-4||SGD DESC:Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress Gene:CYB5(YNL111C)|FD-Score:3.91|P-value:4.53E-5||SGD DESC:Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation Gene:DET1(YDR051C)|FD-Score:3.34|P-value:4.15E-4||SGD DESC:Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel Gene:EAF5(YEL018W)|FD-Score:4.4|P-value:5.52E-6||SGD DESC:Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex Gene:ECM34(YHL043W)|FD-Score:-3.47|P-value:2.56E-4||SGD DESC:Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:GAL11(YOL051W)|FD-Score:-3.39|P-value:3.45E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator Gene:GND2(YGR256W)|FD-Score:4.85|P-value:6.12E-7||SGD DESC:6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication Gene:GPM3(YOL056W)|FD-Score:5.7|P-value:5.94E-9||SGD DESC:Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Gene:HIS1(YER055C)|FD-Score:-3.63|P-value:1.43E-4||SGD DESC:ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control Gene:HMO1(YDR174W)|FD-Score:4.67|P-value:1.48E-6||SGD DESC:Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase Gene:IOC3(YFR013W)|FD-Score:5.95|P-value:1.36E-9||SGD DESC:Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication Gene:JHD2(YJR119C)|FD-Score:-3.12|P-value:9.06E-4||SGD DESC:JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation Gene:LEM3(YNL323W)|FD-Score:4.29|P-value:8.85E-6||SGD DESC:Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane Gene:MNN1(YER001W)|FD-Score:3.93|P-value:4.34E-5||SGD DESC:Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family Gene:MPT5(YGL178W)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity Gene:MSE1(YOL033W)|FD-Score:3.13|P-value:8.66E-4||SGD DESC:Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated Gene:MUD2(YKL074C)|FD-Score:3.13|P-value:8.85E-4||SGD DESC:Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65 Gene:NGG1(YDR176W)|FD-Score:3.13|P-value:8.80E-4||SGD DESC:Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex Gene:NUM1(YDR150W)|FD-Score:3.32|P-value:4.52E-4||SGD DESC:Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex Gene:OXR1(YPL196W)|FD-Score:-4.82|P-value:7.35E-7||SGD DESC:Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes Gene:PCL8(YPL219W)|FD-Score:-3.49|P-value:2.39E-4||SGD DESC:Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation Gene:PDX1(YGR193C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core Gene:PRY1(YJL079C)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication Gene:RCK2(YLR248W)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication Gene:RNH1(YMR234W)|FD-Score:5.04|P-value:2.30E-7||SGD DESC:Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) Gene:RPL6B(YLR448W)|FD-Score:4.09|P-value:2.18E-5||SGD DESC:Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication Gene:RPP2A(YOL039W)|FD-Score:3.85|P-value:5.81E-5||SGD DESC:Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm Gene:RTC3(YHR087W)|FD-Score:-3.11|P-value:9.35E-4||SGD DESC:Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress Gene:SAK1(YER129W)|FD-Score:-3.78|P-value:7.81E-5||SGD DESC:Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome Gene:SAM2(YDR502C)|FD-Score:3.1|P-value:9.54E-4||SGD DESC:S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication Gene:SAS5(YOR213C)|FD-Score:4.31|P-value:8.30E-6||SGD DESC:Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity Gene:SKM1(YOL113W)|FD-Score:-3.1|P-value:9.75E-4||SGD DESC:Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth Gene:SLI1(YGR212W)|FD-Score:-3.61|P-value:1.53E-4||SGD DESC:N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin Gene:SLX5(YDL013W)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers Gene:SOL4(YGR248W)|FD-Score:3.79|P-value:7.38E-5||SGD DESC:6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication Gene:STE20(YHL007C)|FD-Score:3.34|P-value:4.26E-4||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p Gene:TAZ1(YPR140W)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome Gene:TGL1(YKL140W)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes Gene:UPF3(YGR072W)|FD-Score:3.46|P-value:2.69E-4||SGD DESC:Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance Gene:VMA16(YHR026W)|FD-Score:-3.74|P-value:9.31E-5||SGD DESC:Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain Gene:WTM2(YOR229W)|FD-Score:4.42|P-value:4.86E-6||SGD DESC:Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats Gene:YBL059W(YBL059W_p)|FD-Score:3.42|P-value:3.11E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication Gene:YDL027C(YDL027C_p)|FD-Score:3.13|P-value:8.74E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene Gene:YDR169C-A(YDR169C-A_p)|FD-Score:3.17|P-value:7.59E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR338C(YDR338C_p)|FD-Score:5.61|P-value:1.03E-8||SGD DESC:Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily Gene:YGL015C(YGL015C_p)|FD-Score:3.35|P-value:4.05E-4||SGD DESC:Putative protein of unknown function; null mutants accumulate cargo in the Golgi Gene:YGL117W(YGL117W_p)|FD-Score:3.15|P-value:8.16E-4||SGD DESC:Putative protein of unknown function Gene:YGR176W(YGR176W_d)|FD-Score:3.4|P-value:3.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHL037C(YHL037C_d)|FD-Score:-3.7|P-value:1.07E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR003C(YHR003C)|FD-Score:3.18|P-value:7.25E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YJL045W(YJL045W)|FD-Score:3.12|P-value:8.89E-4||SGD DESC:Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner Gene:YJR015W(YJR015W_p)|FD-Score:3.1|P-value:9.80E-4||SGD DESC:Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene Gene:YKL123W(YKL123W_d)|FD-Score:-3.44|P-value:2.89E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4 Gene:YLR031W(YLR031W_p)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Putative protein of unknown function Gene:YNL200C(YNL200C)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YNL235C(YNL235C_d)|FD-Score:4.84|P-value:6.51E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex Gene:YNL296W(YNL296W_d)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog Gene:YNR073C(YNR073C_p)|FD-Score:-4.32|P-value:7.78E-6||SGD DESC:Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p Gene:YOR105W(YOR105W_p)|FD-Score:4.12|P-value:1.91E-5||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YOR365C(YOR365C_p)|FD-Score:-3.55|P-value:1.92E-4||SGD DESC:Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication Gene:ACB1(YGR037C)|FD-Score:5.22|P-value:9.08E-8||SGD DESC:Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress Gene:AIM26(YKL037W)|FD-Score:5.69|P-value:6.40E-9||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT Gene:ALK1(YGL021W)|FD-Score:3.39|P-value:3.49E-4||SGD DESC:Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins Gene:ASF1(YJL115W)|FD-Score:4.69|P-value:1.36E-6||SGD DESC:Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition Gene:ASG7(YJL170C)|FD-Score:3.82|P-value:6.58E-5||SGD DESC:Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor Gene:COQ8(YGL119W)|FD-Score:-3.14|P-value:8.40E-4||SGD DESC:Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication Gene:COX18(YGR062C)|FD-Score:5.81|P-value:3.20E-9||SGD DESC:Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC Gene:CRH1(YGR189C)|FD-Score:-3.46|P-value:2.68E-4||SGD DESC:Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress Gene:CYB5(YNL111C)|FD-Score:3.91|P-value:4.53E-5||SGD DESC:Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation Gene:DET1(YDR051C)|FD-Score:3.34|P-value:4.15E-4||SGD DESC:Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel Gene:EAF5(YEL018W)|FD-Score:4.4|P-value:5.52E-6||SGD DESC:Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex Gene:ECM34(YHL043W)|FD-Score:-3.47|P-value:2.56E-4||SGD DESC:Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:GAL11(YOL051W)|FD-Score:-3.39|P-value:3.45E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator Gene:GND2(YGR256W)|FD-Score:4.85|P-value:6.12E-7||SGD DESC:6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication Gene:GPM3(YOL056W)|FD-Score:5.7|P-value:5.94E-9||SGD DESC:Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Gene:HIS1(YER055C)|FD-Score:-3.63|P-value:1.43E-4||SGD DESC:ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control Gene:HMO1(YDR174W)|FD-Score:4.67|P-value:1.48E-6||SGD DESC:Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase Gene:IOC3(YFR013W)|FD-Score:5.95|P-value:1.36E-9||SGD DESC:Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication Gene:JHD2(YJR119C)|FD-Score:-3.12|P-value:9.06E-4||SGD DESC:JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation Gene:LEM3(YNL323W)|FD-Score:4.29|P-value:8.85E-6||SGD DESC:Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane Gene:MNN1(YER001W)|FD-Score:3.93|P-value:4.34E-5||SGD DESC:Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family Gene:MPT5(YGL178W)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity Gene:MSE1(YOL033W)|FD-Score:3.13|P-value:8.66E-4||SGD DESC:Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated Gene:MUD2(YKL074C)|FD-Score:3.13|P-value:8.85E-4||SGD DESC:Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65 Gene:NGG1(YDR176W)|FD-Score:3.13|P-value:8.80E-4||SGD DESC:Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex Gene:NUM1(YDR150W)|FD-Score:3.32|P-value:4.52E-4||SGD DESC:Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex Gene:OXR1(YPL196W)|FD-Score:-4.82|P-value:7.35E-7||SGD DESC:Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes Gene:PCL8(YPL219W)|FD-Score:-3.49|P-value:2.39E-4||SGD DESC:Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation Gene:PDX1(YGR193C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core Gene:PRY1(YJL079C)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication Gene:RCK2(YLR248W)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication Gene:RNH1(YMR234W)|FD-Score:5.04|P-value:2.30E-7||SGD DESC:Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) Gene:RPL6B(YLR448W)|FD-Score:4.09|P-value:2.18E-5||SGD DESC:Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication Gene:RPP2A(YOL039W)|FD-Score:3.85|P-value:5.81E-5||SGD DESC:Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm Gene:RTC3(YHR087W)|FD-Score:-3.11|P-value:9.35E-4||SGD DESC:Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress Gene:SAK1(YER129W)|FD-Score:-3.78|P-value:7.81E-5||SGD DESC:Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome Gene:SAM2(YDR502C)|FD-Score:3.1|P-value:9.54E-4||SGD DESC:S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication Gene:SAS5(YOR213C)|FD-Score:4.31|P-value:8.30E-6||SGD DESC:Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity Gene:SKM1(YOL113W)|FD-Score:-3.1|P-value:9.75E-4||SGD DESC:Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth Gene:SLI1(YGR212W)|FD-Score:-3.61|P-value:1.53E-4||SGD DESC:N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin Gene:SLX5(YDL013W)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers Gene:SOL4(YGR248W)|FD-Score:3.79|P-value:7.38E-5||SGD DESC:6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication Gene:STE20(YHL007C)|FD-Score:3.34|P-value:4.26E-4||SGD DESC:Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p Gene:TAZ1(YPR140W)|FD-Score:-3.62|P-value:1.45E-4||SGD DESC:Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome Gene:TGL1(YKL140W)|FD-Score:3.7|P-value:1.07E-4||SGD DESC:Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes Gene:UPF3(YGR072W)|FD-Score:3.46|P-value:2.69E-4||SGD DESC:Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance Gene:VMA16(YHR026W)|FD-Score:-3.74|P-value:9.31E-5||SGD DESC:Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain Gene:WTM2(YOR229W)|FD-Score:4.42|P-value:4.86E-6||SGD DESC:Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats Gene:YBL059W(YBL059W_p)|FD-Score:3.42|P-value:3.11E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication Gene:YDL027C(YDL027C_p)|FD-Score:3.13|P-value:8.74E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene Gene:YDR169C-A(YDR169C-A_p)|FD-Score:3.17|P-value:7.59E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YDR338C(YDR338C_p)|FD-Score:5.61|P-value:1.03E-8||SGD DESC:Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily Gene:YGL015C(YGL015C_p)|FD-Score:3.35|P-value:4.05E-4||SGD DESC:Putative protein of unknown function; null mutants accumulate cargo in the Golgi Gene:YGL117W(YGL117W_p)|FD-Score:3.15|P-value:8.16E-4||SGD DESC:Putative protein of unknown function Gene:YGR176W(YGR176W_d)|FD-Score:3.4|P-value:3.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHL037C(YHL037C_d)|FD-Score:-3.7|P-value:1.07E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR003C(YHR003C)|FD-Score:3.18|P-value:7.25E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YJL045W(YJL045W)|FD-Score:3.12|P-value:8.89E-4||SGD DESC:Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner Gene:YJR015W(YJR015W_p)|FD-Score:3.1|P-value:9.80E-4||SGD DESC:Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene Gene:YKL123W(YKL123W_d)|FD-Score:-3.44|P-value:2.89E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4 Gene:YLR031W(YLR031W_p)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Putative protein of unknown function Gene:YNL200C(YNL200C)|FD-Score:3.56|P-value:1.86E-4||SGD DESC:NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YNL235C(YNL235C_d)|FD-Score:4.84|P-value:6.51E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex Gene:YNL296W(YNL296W_d)|FD-Score:3.36|P-value:3.88E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog Gene:YNR073C(YNR073C_p)|FD-Score:-4.32|P-value:7.78E-6||SGD DESC:Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p Gene:YOR105W(YOR105W_p)|FD-Score:4.12|P-value:1.91E-5||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YOR365C(YOR365C_p)|FD-Score:-3.55|P-value:1.92E-4||SGD DESC:Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGR267C4.012.98E-50.26FOL2GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
YGL018C3.846.03E-50.26JAC1Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
YFL034C-B3.591.68E-40.01MOB2Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
YMR185W_p3.571.78E-40.24RTP1_pProtein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene
YLR198C_d3.334.38E-40.16YLR198C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
YKL193C3.177.61E-40.05SDS22Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
YEL032W3.128.93E-40.07MCM3Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YGR278W3.050.001130.06CWC22Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein
YML092C3.000.001370.01PRE8Alpha 2 subunit of the 20S proteasome
YKL012W2.990.001390.16PRP40U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
YPR107C2.830.002300.08YTH1Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
YBL050W2.750.002970.02SEC17Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP
YDR526C_d2.730.003180.04YDR526C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL018W2.680.003630.01SWD2Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination
YFL038C2.670.003760.06YPT1Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YFR013W5.951.36E-9IOC3Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication
YGR062C5.813.20E-9COX18Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC
YOL056W5.705.94E-9GPM3Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
YKL037W5.696.40E-9AIM26Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT
YDR338C_p5.611.03E-8YDR338C_pPutative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily
YGR037C5.229.08E-8ACB1Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
YMR234W5.042.30E-7RNH1Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)
YGR256W4.856.12E-7GND26-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication
YNL235C_d4.846.51E-7YNL235C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
YJL115W4.691.36E-6ASF1Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YDR174W4.671.48E-6HMO1Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
YOR229W4.424.86E-6WTM2Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats
YEL018W4.405.52E-6EAF5Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex
YOR213C4.318.30E-6SAS5Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
YNL323W4.298.85E-6LEM3Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane

GO enrichment analysis for SGTC_2123
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0681.51E-7SGTC_31409094243 49.5 μMChembridge (Drug-like library)192911120.111111
0.0672.30E-7SGTC_2779methotrexate 400.0 μMMiscellaneous1269410.0930233
0.0631.26E-6SGTC_662k832-1615 104.0 μMChemDiv (Drug-like library)58784780.0555556
0.0595.65E-6SGTC_32019113999 49.5 μMChembridge (Drug-like library)166492240.114286
0.0596.30E-6SGTC_5294076-0302 30.3 μMChemDiv (Drug-like library)58165220.037037mitochondrial processes
0.0587.80E-6SGTC_21165511452 16.9 μMChembridge (Fragment library)8707440.0350877
0.0561.93E-5SGTC_15382',3',6-trimethoxyflavanone 63.6 μMTimTec (Pure natural product library)42137740.0833333
0.0552.37E-5SGTC_10995-nonyloxytryptamine 2.9 μMNIH Clinical Collection235818250.119403
0.0534.79E-5SGTC_9511171-0579 82.7 μMChemDiv (Drug-like library)16160500.119403cell wall
0.0526.45E-5SGTC_1973st070275 50.2 μMTimTec (Natural product derivative library)171183340.0422535
0.0519.83E-5SGTC_14183966-3099 2.4 μMChemDiv (Drug-like library)7403350.0847458
0.0511.02E-4SGTC_22176934799 96.1 μMChembridge (Fragment library)6756060.175439TSC3-RPN4
0.0501.09E-4SGTC_1794st048918 76.9 μMTimTec (Natural product derivative library)6723030.134328
0.0501.15E-4SGTC_31229126309 49.5 μMChembridge (Drug-like library)175912060.0394737cell wall signaling
0.0491.45E-4SGTC_2692st077426 47.7 μMTimTec (Natural product derivative library)252385710.1375

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_21225258151111.69 μM0.6279072173356Chembridge (Fragment library)237.294861.75814
SGTC_21375261020140 μM0.479167763655Chembridge (Fragment library)237.294861.61214
SGTC_21715739187198.08 μM0.279072262761Chembridge (Fragment library)222.283520.90324copper-dependent oxidative stress
SGTC_3252913587149.47 μM0.25423717682838Chembridge (Drug-like library)245.27711.51122
SGTC_1782st03942380.64 μM0.2456142068169TimTec (Natural product derivative library)246.301624.10403
SGTC_1220236-0016402.4 μM0.2394376808838ChemDiv (Drug-like library)361.458523.09835RNA processing & uracil transport
SGTC_1074carmofur3.8 μM0.2372882577NIH Clinical Collection257.2614431.12524exosome
SGTC_12273909-801046.6 μM0.23636415982272ChemDiv (Drug-like library)249.375063.37614
SGTC_2961222-003974.9 μM0.2222225984176ChemDiv (Drug-like library)218.291524.22812
SGTC_9591222-0044107 μM0.2181826083612ChemDiv (Drug-like library)232.31814.68512