Deletion Strain | FD score | P-value | Gene | Gene Description |
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YOR191W | 10.70 | 4.17E-27 | ULS1 | Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress |
YOL006C | 7.17 | 3.67E-13 | TOP1 | Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination |
YML002W_p | 6.40 | 7.89E-11 | YML002W_p | Putative protein of unknown function; expression induced by heat and by calcium shortage |
YER032W | 6.03 | 7.99E-10 | FIR1 | Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate |
YER130C_p | 5.84 | 2.66E-9 | YER130C_p | Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress |
YDR435C | 5.53 | 1.58E-8 | PPM1 | Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits |
YOR055W_d | 5.40 | 3.40E-8 | YOR055W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YLR131C | 5.20 | 9.94E-8 | ACE2 | Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication |
YMR279C | 5.19 | 1.07E-7 | YMR279C | Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication |
YDR218C | 5.08 | 1.89E-7 | SPR28 | Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation |
YJR048W | 4.98 | 3.23E-7 | CYC1 | Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication |
YGR167W | 4.97 | 3.32E-7 | CLC1 | Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W |
YNL296W_d | 4.95 | 3.64E-7 | YNL296W_d | Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog |
YKL139W | 4.90 | 4.70E-7 | CTK1 | Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13 |
YOR139C_d | 4.79 | 8.24E-7 | YOR139C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W |