Deletion Strain | FD score | P-value | Gene | Gene Description |
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YMR190C | 10.90 | 6.39E-28 | SGS1 | Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; forms nuclear foci upon DNA replication stress |
YOR352W | 10.40 | 1.22E-25 | TFB6 | Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus |
YPR101W | 6.54 | 3.05E-11 | SNT309 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p |
YOR309C_d | 5.56 | 1.37E-8 | YOR309C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58 |
YOL007C | 4.93 | 4.19E-7 | CSI2 | Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene |
YDR372C | 4.88 | 5.22E-7 | VPS74 | Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33 |
YEL061C | 4.78 | 8.70E-7 | CIN8 | Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation |
YJR010C-A | 4.70 | 1.33E-6 | SPC1 | Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress |
YDL151C_d | 4.65 | 1.63E-6 | BUD30_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay |
YER107C | 4.59 | 2.22E-6 | GLE2 | RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 |
YLR295C | 4.57 | 2.42E-6 | ATP14 | Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress |
YGR118W | 4.43 | 4.78E-6 | RPS23A | Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal |
YMR021C | 4.03 | 2.81E-5 | MAC1 | Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport |
YGR050C_p | 4.02 | 2.95E-5 | YGR050C_p | Protein of unknown function; mRNA identified as translated by ribosome profiling data |
YML102W | 4.01 | 3.10E-5 | CAC2 | Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription |