Deletion Strain | FD score | P-value | Gene | Gene Description |
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YPR074C | 13.30 | 1.84E-40 | TKL1 | Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication |
YJL120W_d | 11.60 | 2.48E-31 | YJL120W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO |
YJR049C | 11.20 | 3.17E-29 | UTR1 | ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication |
YHR132W-A | 5.86 | 2.29E-9 | IGO2 | Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p |
YGR210C_p | 5.64 | 8.66E-9 | YGR210C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm |
YDL040C | 5.29 | 6.28E-8 | NAT1 | Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing |
YPL144W | 5.19 | 1.03E-7 | POC4 | Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions |
YMR098C | 5.16 | 1.24E-7 | ATP25 | Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene |
YHR011W | 5.14 | 1.40E-7 | DIA4 | Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth |
YEL037C | 4.82 | 7.05E-7 | RAD23 | Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover |
YPR156C | 4.57 | 2.43E-6 | TPO3 | Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication |
YMR282C | 4.21 | 1.28E-5 | AEP2 | Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader |
YBR221W-A_p | 4.18 | 1.46E-5 | YBR221W-A_p | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
YHR100C | 4.15 | 1.69E-5 | GEP4 | Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT |
YOL023W | 4.04 | 2.67E-5 | IFM1 | Mitochondrial translation initiation factor 2 |