| Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
|---|
| YDL111C | 3.42 | 3.15E-4 | 0.28 | RRP42 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7) |
| YDR280W | 3.35 | 4.09E-4 | 0.28 | RRP45 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress |
| YGL075C | 3.16 | 7.89E-4 | 0.28 | MPS2 | Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p |
| YGR013W | 2.95 | 0.00158 | 0.28 | SNU71 | Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart |
| YGR274C | 2.68 | 0.00373 | 0.01 | TAF1 | TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression |
| YFL008W | 2.67 | 0.00384 | 0.14 | SMC1 | Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure |
| YBL014C | 2.53 | 0.00574 | 0.03 | RRN6 | Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p |
| YNR017W | 2.50 | 0.00629 | 0.01 | TIM23 | Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel |
| YNR016C | 2.48 | 0.00656 | 0.01 | ACC1 | Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; |
| YMR208W | 2.47 | 0.00669 | 0.00 | ERG12 | Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate |
| YOL005C | 2.47 | 0.00671 | 0.06 | RPB11 | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit |
| YAL034C-B_d | 2.41 | 0.00789 | 0.01 | YAL034C-B_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| YKL180W | 2.41 | 0.00802 | 0.01 | RPL17A | Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
| YPL175W | 2.40 | 0.00829 | 0.01 | SPT14 | UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins |
| YJL085W | 2.39 | 0.00851 | 0.08 | EXO70 | Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress |
