1287-0124

(E)-3-(3-bromophenyl)-N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]prop-2-en-1-imine

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_215
Screen concentration 461.5 μM
Source ChemDiv (Drug-like library)
PubChem CID 5560863
SMILES CC1=CC2=C(C=C1)N=C(S2)C3=CC=C(C=C3)N=CC=CC4=CC(=CC=C4)Br
Standardized SMILES Cc1ccc2nc(sc2c1)c3ccc(cc3)N=CC=Cc4cccc(Br)c4
Molecular weight 433.3635
ALogP 7.03
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.27
% growth inhibition (Hom. pool) 3.8


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5560863
Download HIP data (tab-delimited text)  (excel)
Gene:COG3(YER157W)|FD-Score:-3.3|P-value:4.84E-4|Clearance:0||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:MPS2(YGL075C)|FD-Score:3.16|P-value:7.89E-4|Clearance:0.28||SGD DESC:Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p Gene:RRP42(YDL111C)|FD-Score:3.42|P-value:3.15E-4|Clearance:0.28||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7) Gene:RRP45(YDR280W)|FD-Score:3.35|P-value:4.09E-4|Clearance:0.28||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress Gene:COG3(YER157W)|FD-Score:-3.3|P-value:4.84E-4|Clearance:0||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:MPS2(YGL075C)|FD-Score:3.16|P-value:7.89E-4|Clearance:0.28||SGD DESC:Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p Gene:RRP42(YDL111C)|FD-Score:3.42|P-value:3.15E-4|Clearance:0.28||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7) Gene:RRP45(YDR280W)|FD-Score:3.35|P-value:4.09E-4|Clearance:0.28||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5560863
Download HOP data (tab-delimited text)  (excel)
Gene:AIR1(YIL079C)|FD-Score:3.79|P-value:7.42E-5||SGD DESC:Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication Gene:IDP1(YDL066W)|FD-Score:3.11|P-value:9.28E-4||SGD DESC:Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes Gene:MSS18(YPR134W)|FD-Score:3.13|P-value:8.61E-4||SGD DESC:Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Gene:PMC1(YGL006W)|FD-Score:3.23|P-value:6.20E-4||SGD DESC:Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a Gene:RNH203(YLR154C)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome Gene:TRM2(YKR056W)|FD-Score:3.52|P-value:2.14E-4||SGD DESC:tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair Gene:YDR306C(YDR306C_p)|FD-Score:3.14|P-value:8.54E-4||SGD DESC:F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain Gene:YGR259C(YGR259C_d)|FD-Score:3.8|P-value:7.24E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W Gene:YGR266W(YGR266W)|FD-Score:-3.38|P-value:3.62E-4||SGD DESC:Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress Gene:YLR252W(YLR252W_d)|FD-Score:3.1|P-value:9.83E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism Gene:YOL131W(YOL131W_p)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Putative protein of unknown function Gene:YOR008C-A(YOR008C-A_p)|FD-Score:3.4|P-value:3.32E-4||SGD DESC:Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres Gene:YPR098C(YPR098C)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YSC83(YHR017W)|FD-Score:3.31|P-value:4.71E-4||SGD DESC:Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 Gene:AIR1(YIL079C)|FD-Score:3.79|P-value:7.42E-5||SGD DESC:Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication Gene:IDP1(YDL066W)|FD-Score:3.11|P-value:9.28E-4||SGD DESC:Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes Gene:MSS18(YPR134W)|FD-Score:3.13|P-value:8.61E-4||SGD DESC:Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Gene:PMC1(YGL006W)|FD-Score:3.23|P-value:6.20E-4||SGD DESC:Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a Gene:RNH203(YLR154C)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome Gene:TRM2(YKR056W)|FD-Score:3.52|P-value:2.14E-4||SGD DESC:tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair Gene:YDR306C(YDR306C_p)|FD-Score:3.14|P-value:8.54E-4||SGD DESC:F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain Gene:YGR259C(YGR259C_d)|FD-Score:3.8|P-value:7.24E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W Gene:YGR266W(YGR266W)|FD-Score:-3.38|P-value:3.62E-4||SGD DESC:Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress Gene:YLR252W(YLR252W_d)|FD-Score:3.1|P-value:9.83E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism Gene:YOL131W(YOL131W_p)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Putative protein of unknown function Gene:YOR008C-A(YOR008C-A_p)|FD-Score:3.4|P-value:3.32E-4||SGD DESC:Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres Gene:YPR098C(YPR098C)|FD-Score:3.7|P-value:1.06E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane Gene:YSC83(YHR017W)|FD-Score:3.31|P-value:4.71E-4||SGD DESC:Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDL111C3.423.15E-40.28RRP42Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
YDR280W3.354.09E-40.28RRP45Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
YGL075C3.167.89E-40.28MPS2Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
YGR013W2.950.001580.28SNU71Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
YGR274C2.680.003730.01TAF1TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
YFL008W2.670.003840.14SMC1Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
YBL014C2.530.005740.03RRN6Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
YNR017W2.500.006290.01TIM23Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel
YNR016C2.480.006560.01ACC1Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
YMR208W2.470.006690.00ERG12Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YOL005C2.470.006710.06RPB11RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YAL034C-B_d2.410.007890.01YAL034C-B_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL180W2.410.008020.01RPL17ARibosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
YPL175W2.400.008290.01SPT14UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
YJL085W2.390.008510.08EXO70Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR259C_d3.807.24E-5YGR259C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YIL079C3.797.42E-5AIR1Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication
YPR098C3.701.06E-4YPR098CProtein of unknown function, localized to the mitochondrial outer membrane
YKR056W3.522.14E-4TRM2tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
YOL131W_p3.452.84E-4YOL131W_pPutative protein of unknown function
YOR008C-A_p3.403.32E-4YOR008C-A_pPutative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YHR017W3.314.71E-4YSC83Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83
YLR154C3.304.77E-4RNH203Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
YGL006W3.236.20E-4PMC1Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a
YDR306C_p3.148.54E-4YDR306C_pF-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
YPR134W3.138.61E-4MSS18Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions
YDL066W3.119.28E-4IDP1Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
YLR252W_d3.109.83E-4YLR252W_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism
YPL041C_p3.060.00112YPL041C_pProtein of unknown function involved in maintenance of proper telomere length
YPL015C3.020.00125HST2Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export

GO enrichment analysis for SGTC_215
biological processes

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1352.91E-25SGTC_16985-fluorocytosine 1.1 μMTimTec (Natural product derivative library)33660.0434783exosome
0.1231.86E-21SGTC_10775-fluorocytosine 377.0 nMNIH Clinical Collection33660.0434783exosome
0.1111.62E-17SGTC_2615-fluorouridine 15.4 μMMiscellaneous18210.0235294exosome
0.1057.51E-16SGTC_6104215-0184 155.0 μMChemDiv (Drug-like library)56050150.134831exosome
0.1031.92E-15SGTC_1074carmofur 3.8 μMNIH Clinical Collection25770.0352941exosome
0.0823.17E-10SGTC_2425hr heat shock (37°C) + 5-fluorouracil 4.6 μMMiscellaneous33850.0298507heat shock/prefoldin
0.0807.85E-10SGTC_13001094-0077 113.0 μMChemDiv (Drug-like library)55326360.113636
0.0791.14E-9SGTC_4235-fluorouracil 457.0 μMMiscellaneous33850.0298507exosome
0.0764.77E-9SGTC_33539151644 39.3 μMChembridge (Drug-like library)49091580.107143
0.0715.11E-8SGTC_32869117135 37.2 μMChembridge (Drug-like library)34381500.107143
0.0699.30E-8SGTC_6173770-0098 35.0 μMChemDiv (Drug-like library)59626390.0666667exosome
0.0699.47E-8SGTC_32219128209 49.5 μMChembridge (Drug-like library)164607230.13253
0.0691.24E-7SGTC_28007887935 81.8 μMChembridge (Drug-like library)29610020.0581395RPP1 & pyrimidine depletion
0.0654.87E-7SGTC_2745rifampicin 24.3 μMMiscellaneous251414280.0431655
0.0655.39E-7SGTC_30239089636 49.5 μMChembridge (Drug-like library)172492410.0666667

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_6970508-1955564 μM0.7924536243113ChemDiv (Drug-like library)354.467426.28103
SGTC_3371315-0038354 μM0.6129031626437ChemDiv (Drug-like library)423.357547.6103amide catabolism
SGTC_9641287-010719.4 μM0.57812551516812ChemDiv (Drug-like library)435.33635.47814cell wall
SGTC_9871497-1013404 μM0.551676435ChemDiv (Drug-like library)362.87526.58603
SGTC_7360958-025492.6 μM0.4927546812352ChemDiv (Drug-like library)453.351584.73515Golgi
SGTC_8830850-024524.6 μM0.4264716823229ChemDiv (Drug-like library)409.299025.11814cell wall
SGTC_1100850-0284111.64 μM0.3857143906265ChemDiv (Drug-like library)391.26066.11103
SGTC_6320781-23534.65 μM0.3802826811515ChemDiv (Drug-like library)443.744084.92914Golgi
SGTC_910417-175158.38 μM0.3661976795624ChemDiv (Drug-like library)409.299024.56114Golgi
SGTC_1380850-025940.92 μM0.3648656813004ChemDiv (Drug-like library)407.265.04614cell wall