Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YBR252W | 4.33 | 7.48E-6 | 0.52 | DUT1 | deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate |
YBL084C | 3.81 | 7.04E-5 | 0.21 | CDC27 | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition |
YBR002C | 3.60 | 1.61E-4 | 0.23 | RER2 | Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting |
YPR086W | 3.37 | 3.75E-4 | 0.01 | SUA7 | Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II |
YGR145W | 3.36 | 3.96E-4 | 0.18 | ENP2 | Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p |
YER013W | 3.17 | 7.54E-4 | 0.20 | PRP22 | DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes |
YGR090W | 2.97 | 0.00147 | 0.16 | UTP22 | Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals |
YLR229C | 2.82 | 0.00242 | 0.08 | CDC42 | Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins |
YOR261C | 2.74 | 0.00311 | 0.02 | RPN8 | Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p |
YMR079W | 2.72 | 0.00327 | 0.05 | SEC14 | Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs |
YGL201C | 2.67 | 0.00381 | 0.08 | MCM6 | Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p |
YDR302W | 2.59 | 0.00481 | 0.04 | GPI11 | ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog |
YJL143W | 2.55 | 0.00535 | 0.01 | TIM17 | Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex |
YER021W | 2.54 | 0.00554 | 7.87E-4 | RPN3 | Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control |
YGR265W_d | 2.54 | 0.00555 | 0.01 | YGR265W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase |