Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR058C-A | 9.25 | 1.08E-20 | TSC3 | Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis |
YHR093W_d | 4.95 | 3.78E-7 | AHT1_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region |
YER007W | 4.60 | 2.08E-6 | PAC2 | Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl |
YLR085C | 4.14 | 1.70E-5 | ARP6 | Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A |
YPL159C | 4.02 | 2.94E-5 | PET20 | Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome |
YDR007W | 3.95 | 3.98E-5 | TRP1 | Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) |
YMR207C | 3.89 | 4.94E-5 | HFA1 | Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress |
YDR395W | 3.87 | 5.53E-5 | SXM1 | Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1 |
YDR334W | 3.77 | 8.29E-5 | SWR1 | Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A |
YJL084C | 3.73 | 9.74E-5 | ALY2 | Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication |
YHR095W_d | 3.55 | 1.92E-4 | YHR095W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YGL184C | 3.43 | 3.03E-4 | STR3 | Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p |
YGL003C | 3.40 | 3.37E-4 | CDH1 | Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p |
YML041C | 3.27 | 5.36E-4 | VPS71 | Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting |
YNL241C | 3.26 | 5.52E-4 | ZWF1 | Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress |