5658611

5-amino-3-methyl-2-N-(2-methylphenyl)thiophene-2,4-dicarboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2159
Screen concentration 73.8 μM
Source Chembridge (Fragment library)
PubChem CID 793844
SMILES CC1=CC=CC=C1NC(=O)C2=C(C(=C(S2)N)C(=O)N)C
Standardized SMILES Cc1ccccc1NC(=O)c2sc(N)c(C(=O)N)c2C
Molecular weight 289.3528
ALogP 1.92
H-bond donor count 3
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.44
% growth inhibition (Hom. pool) 1.06


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 793844
Download HIP data (tab-delimited text)  (excel)
Gene:CCT7(YJL111W)|FD-Score:-3.24|P-value:5.92E-4|Clearance:0||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance Gene:CDC39(YCR093W)|FD-Score:4.2|P-value:1.32E-5|Clearance:0.03||SGD DESC:Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor Gene:CDC8(YJR057W)|FD-Score:-3.4|P-value:3.41E-4|Clearance:0||SGD DESC:Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p Gene:CTR86(YCR054C)|FD-Score:-3.41|P-value:3.26E-4|Clearance:0||SGD DESC:Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress Gene:DHR2(YKL078W)|FD-Score:5.15|P-value:1.28E-7|Clearance:0.06||SGD DESC:Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis Gene:ERV1(YGR029W)|FD-Score:5.09|P-value:1.80E-7|Clearance:0.89||SGD DESC:Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR) Gene:GPI19(YDR437W)|FD-Score:-3.76|P-value:8.47E-5|Clearance:0||SGD DESC:Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P Gene:HYP2(YEL034W)|FD-Score:3.27|P-value:5.46E-4|Clearance:0.03||SGD DESC:Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication Gene:MAS2(YHR024C)|FD-Score:3.19|P-value:7.22E-4|Clearance:0.09||SGD DESC:Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:MCM10(YIL150C)|FD-Score:3.58|P-value:1.75E-4|Clearance:0.23||SGD DESC:Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins Gene:PAM16(YJL104W)|FD-Score:3.78|P-value:7.83E-5|Clearance:0.02||SGD DESC:Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain Gene:POL5(YEL055C)|FD-Score:-3.37|P-value:3.70E-4|Clearance:0||SGD DESC:DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA Gene:PWP2(YCR057C)|FD-Score:-3.17|P-value:7.68E-4|Clearance:0||SGD DESC:Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis Gene:RMP1(YLR145W)|FD-Score:3.23|P-value:6.13E-4|Clearance:0.05||SGD DESC:Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P Gene:ROK1(YGL171W)|FD-Score:6.33|P-value:1.25E-10|Clearance:1.17||SGD DESC:RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation Gene:RPC37(YKR025W)|FD-Score:3.76|P-value:8.62E-5|Clearance:0.01||SGD DESC:RNA polymerase III subunit C37 Gene:RPS13(YDR064W)|FD-Score:3.09|P-value:9.90E-4|Clearance:0.01||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15 Gene:RPS31(YLR167W)|FD-Score:4.17|P-value:1.53E-5|Clearance:0.28||SGD DESC:Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog Gene:RPT2(YDL007W)|FD-Score:3.34|P-value:4.14E-4|Clearance:0.08||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle Gene:RRP3(YHR065C)|FD-Score:3.75|P-value:8.86E-5|Clearance:0.17||SGD DESC:Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity Gene:SEC24(YIL109C)|FD-Score:3.89|P-value:4.95E-5|Clearance:0.11||SGD DESC:Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p Gene:SPC97(YHR172W)|FD-Score:-3.17|P-value:7.62E-4|Clearance:0||SGD DESC:Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque Gene:CCT7(YJL111W)|FD-Score:-3.24|P-value:5.92E-4|Clearance:0||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance Gene:CDC39(YCR093W)|FD-Score:4.2|P-value:1.32E-5|Clearance:0.03||SGD DESC:Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor Gene:CDC8(YJR057W)|FD-Score:-3.4|P-value:3.41E-4|Clearance:0||SGD DESC:Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p Gene:CTR86(YCR054C)|FD-Score:-3.41|P-value:3.26E-4|Clearance:0||SGD DESC:Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress Gene:DHR2(YKL078W)|FD-Score:5.15|P-value:1.28E-7|Clearance:0.06||SGD DESC:Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis Gene:ERV1(YGR029W)|FD-Score:5.09|P-value:1.80E-7|Clearance:0.89||SGD DESC:Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR) Gene:GPI19(YDR437W)|FD-Score:-3.76|P-value:8.47E-5|Clearance:0||SGD DESC:Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P Gene:HYP2(YEL034W)|FD-Score:3.27|P-value:5.46E-4|Clearance:0.03||SGD DESC:Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication Gene:MAS2(YHR024C)|FD-Score:3.19|P-value:7.22E-4|Clearance:0.09||SGD DESC:Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins Gene:MCM10(YIL150C)|FD-Score:3.58|P-value:1.75E-4|Clearance:0.23||SGD DESC:Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins Gene:PAM16(YJL104W)|FD-Score:3.78|P-value:7.83E-5|Clearance:0.02||SGD DESC:Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain Gene:POL5(YEL055C)|FD-Score:-3.37|P-value:3.70E-4|Clearance:0||SGD DESC:DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA Gene:PWP2(YCR057C)|FD-Score:-3.17|P-value:7.68E-4|Clearance:0||SGD DESC:Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis Gene:RMP1(YLR145W)|FD-Score:3.23|P-value:6.13E-4|Clearance:0.05||SGD DESC:Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P Gene:ROK1(YGL171W)|FD-Score:6.33|P-value:1.25E-10|Clearance:1.17||SGD DESC:RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation Gene:RPC37(YKR025W)|FD-Score:3.76|P-value:8.62E-5|Clearance:0.01||SGD DESC:RNA polymerase III subunit C37 Gene:RPS13(YDR064W)|FD-Score:3.09|P-value:9.90E-4|Clearance:0.01||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15 Gene:RPS31(YLR167W)|FD-Score:4.17|P-value:1.53E-5|Clearance:0.28||SGD DESC:Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog Gene:RPT2(YDL007W)|FD-Score:3.34|P-value:4.14E-4|Clearance:0.08||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle Gene:RRP3(YHR065C)|FD-Score:3.75|P-value:8.86E-5|Clearance:0.17||SGD DESC:Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity Gene:SEC24(YIL109C)|FD-Score:3.89|P-value:4.95E-5|Clearance:0.11||SGD DESC:Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p Gene:SPC97(YHR172W)|FD-Score:-3.17|P-value:7.62E-4|Clearance:0||SGD DESC:Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 793844
Download HOP data (tab-delimited text)  (excel)
Gene:ACF2(YLR144C)|FD-Score:3.21|P-value:6.54E-4||SGD DESC:Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress Gene:AGE2(YIL044C)|FD-Score:3.11|P-value:9.27E-4||SGD DESC:ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif Gene:AIM11(YER093C-A)|FD-Score:3.14|P-value:8.40E-4||SGD DESC:Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication Gene:AVT2(YEL064C)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BPH1(YCR032W)|FD-Score:-3.13|P-value:8.84E-4||SGD DESC:Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting Gene:COQ6(YGR255C)|FD-Score:-3.46|P-value:2.66E-4||SGD DESC:Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS) Gene:CTK1(YKL139W)|FD-Score:-3.83|P-value:6.54E-5||SGD DESC:Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13 Gene:CYC7(YEL039C)|FD-Score:-3.42|P-value:3.19E-4||SGD DESC:Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication Gene:DAS1(YJL149W)|FD-Score:-3.64|P-value:1.37E-4||SGD DESC:Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C Gene:DEF1(YKL054C)|FD-Score:3.79|P-value:7.47E-5||SGD DESC:RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis Gene:GPR1(YDL035C)|FD-Score:-4.25|P-value:1.09E-5||SGD DESC:Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis Gene:HOP2(YGL033W)|FD-Score:4.7|P-value:1.31E-6||SGD DESC:Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair Gene:ISA2(YPR067W)|FD-Score:3.56|P-value:1.89E-4||SGD DESC:Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations Gene:LAA1(YJL207C)|FD-Score:3.35|P-value:4.03E-4||SGD DESC:AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene Gene:LSM1(YJL124C)|FD-Score:-6.63|P-value:1.73E-11||SGD DESC:Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress Gene:MAF1(YDR005C)|FD-Score:4.63|P-value:1.80E-6||SGD DESC:Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions Gene:MTC4(YBR255W)|FD-Score:-3.46|P-value:2.69E-4||SGD DESC:Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 Gene:PFA3(YNL326C)|FD-Score:5.6|P-value:1.05E-8||SGD DESC:Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions Gene:PRM1(YNL279W)|FD-Score:4.1|P-value:2.03E-5||SGD DESC:Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p Gene:PUT2(YHR037W)|FD-Score:3.94|P-value:4.04E-5||SGD DESC:Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism Gene:RPS4B(YHR203C)|FD-Score:-3.49|P-value:2.41E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication Gene:RPS6A(YPL090C)|FD-Score:-3.44|P-value:2.92E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication Gene:RSM25(YIL093C)|FD-Score:-3.26|P-value:5.54E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:SEC66(YBR171W)|FD-Score:3.84|P-value:6.26E-5||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SPS18(YNL204C)|FD-Score:4.14|P-value:1.77E-5||SGD DESC:Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation Gene:SWM2(YNR004W_p)|FD-Score:4.24|P-value:1.10E-5||SGD DESC:Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds Gene:TEA1(YOR337W)|FD-Score:-3.22|P-value:6.52E-4||SGD DESC:Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein Gene:TOM70(YNL121C)|FD-Score:4.72|P-value:1.15E-6||SGD DESC:Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication Gene:TYW1(YPL207W)|FD-Score:3.9|P-value:4.74E-5||SGD DESC:Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron Gene:UGA1(YGR019W)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress Gene:YBL055C(YBL055C)|FD-Score:3.32|P-value:4.54E-4||SGD DESC:3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases Gene:YBR074W(YBR074W_p)|FD-Score:4.16|P-value:1.62E-5||SGD DESC:Putative metalloprotease Gene:YBR219C(YBR219C_p)|FD-Score:3.14|P-value:8.44E-4||SGD DESC:Putative protein of unknown function; YBR219C is not an essential gene Gene:YDR524C-B(YDR524C-B_p)|FD-Score:-3.2|P-value:6.93E-4||SGD DESC:Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication Gene:YGL159W(YGL159W_p)|FD-Score:3.32|P-value:4.43E-4||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YIL077C(YIL077C_p)|FD-Score:4.58|P-value:2.27E-6||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:YJL213W(YJL213W)|FD-Score:-3.56|P-value:1.87E-4||SGD DESC:Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p Gene:YOR342C(YOR342C_p)|FD-Score:-3.32|P-value:4.58E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication Gene:YPL257W(YPL257W_p)|FD-Score:-3.97|P-value:3.60E-5||SGD DESC:Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene Gene:YPR078C(YPR078C_p)|FD-Score:3.87|P-value:5.36E-5||SGD DESC:Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible Gene:ACF2(YLR144C)|FD-Score:3.21|P-value:6.54E-4||SGD DESC:Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress Gene:AGE2(YIL044C)|FD-Score:3.11|P-value:9.27E-4||SGD DESC:ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif Gene:AIM11(YER093C-A)|FD-Score:3.14|P-value:8.40E-4||SGD DESC:Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication Gene:AVT2(YEL064C)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:BPH1(YCR032W)|FD-Score:-3.13|P-value:8.84E-4||SGD DESC:Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting Gene:COQ6(YGR255C)|FD-Score:-3.46|P-value:2.66E-4||SGD DESC:Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS) Gene:CTK1(YKL139W)|FD-Score:-3.83|P-value:6.54E-5||SGD DESC:Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13 Gene:CYC7(YEL039C)|FD-Score:-3.42|P-value:3.19E-4||SGD DESC:Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication Gene:DAS1(YJL149W)|FD-Score:-3.64|P-value:1.37E-4||SGD DESC:Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C Gene:DEF1(YKL054C)|FD-Score:3.79|P-value:7.47E-5||SGD DESC:RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis Gene:GPR1(YDL035C)|FD-Score:-4.25|P-value:1.09E-5||SGD DESC:Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis Gene:HOP2(YGL033W)|FD-Score:4.7|P-value:1.31E-6||SGD DESC:Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair Gene:ISA2(YPR067W)|FD-Score:3.56|P-value:1.89E-4||SGD DESC:Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations Gene:LAA1(YJL207C)|FD-Score:3.35|P-value:4.03E-4||SGD DESC:AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene Gene:LSM1(YJL124C)|FD-Score:-6.63|P-value:1.73E-11||SGD DESC:Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress Gene:MAF1(YDR005C)|FD-Score:4.63|P-value:1.80E-6||SGD DESC:Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions Gene:MTC4(YBR255W)|FD-Score:-3.46|P-value:2.69E-4||SGD DESC:Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 Gene:PFA3(YNL326C)|FD-Score:5.6|P-value:1.05E-8||SGD DESC:Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions Gene:PRM1(YNL279W)|FD-Score:4.1|P-value:2.03E-5||SGD DESC:Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p Gene:PUT2(YHR037W)|FD-Score:3.94|P-value:4.04E-5||SGD DESC:Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism Gene:RPS4B(YHR203C)|FD-Score:-3.49|P-value:2.41E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication Gene:RPS6A(YPL090C)|FD-Score:-3.44|P-value:2.92E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication Gene:RSM25(YIL093C)|FD-Score:-3.26|P-value:5.54E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:SEC66(YBR171W)|FD-Score:3.84|P-value:6.26E-5||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SPS18(YNL204C)|FD-Score:4.14|P-value:1.77E-5||SGD DESC:Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation Gene:SWM2(YNR004W_p)|FD-Score:4.24|P-value:1.10E-5||SGD DESC:Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds Gene:TEA1(YOR337W)|FD-Score:-3.22|P-value:6.52E-4||SGD DESC:Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein Gene:TOM70(YNL121C)|FD-Score:4.72|P-value:1.15E-6||SGD DESC:Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication Gene:TYW1(YPL207W)|FD-Score:3.9|P-value:4.74E-5||SGD DESC:Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron Gene:UGA1(YGR019W)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress Gene:YBL055C(YBL055C)|FD-Score:3.32|P-value:4.54E-4||SGD DESC:3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases Gene:YBR074W(YBR074W_p)|FD-Score:4.16|P-value:1.62E-5||SGD DESC:Putative metalloprotease Gene:YBR219C(YBR219C_p)|FD-Score:3.14|P-value:8.44E-4||SGD DESC:Putative protein of unknown function; YBR219C is not an essential gene Gene:YDR524C-B(YDR524C-B_p)|FD-Score:-3.2|P-value:6.93E-4||SGD DESC:Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication Gene:YGL159W(YGL159W_p)|FD-Score:3.32|P-value:4.43E-4||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YIL077C(YIL077C_p)|FD-Score:4.58|P-value:2.27E-6||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Gene:YJL213W(YJL213W)|FD-Score:-3.56|P-value:1.87E-4||SGD DESC:Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p Gene:YOR342C(YOR342C_p)|FD-Score:-3.32|P-value:4.58E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication Gene:YPL257W(YPL257W_p)|FD-Score:-3.97|P-value:3.60E-5||SGD DESC:Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene Gene:YPR078C(YPR078C_p)|FD-Score:3.87|P-value:5.36E-5||SGD DESC:Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL171W6.331.25E-101.17ROK1RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation
YKL078W5.151.28E-70.06DHR2Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
YGR029W5.091.80E-70.89ERV1Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
YCR093W4.201.32E-50.03CDC39Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
YLR167W4.171.53E-50.28RPS31Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog
YIL109C3.894.95E-50.11SEC24Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p
YJL104W3.787.83E-50.02PAM16Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain
YKR025W3.768.62E-50.01RPC37RNA polymerase III subunit C37
YHR065C3.758.86E-50.17RRP3Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
YIL150C3.581.75E-40.23MCM10Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins
YDL007W3.344.14E-40.08RPT2One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YEL034W3.275.46E-40.03HYP2Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
YLR145W3.236.13E-40.05RMP1Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
YHR024C3.197.22E-40.09MAS2Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YDR064W3.099.90E-40.01RPS13Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNL326C5.601.05E-8PFA3Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions
YNL121C4.721.15E-6TOM70Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication
YGL033W4.701.31E-6HOP2Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YDR005C4.631.80E-6MAF1Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions
YIL077C_p4.582.27E-6YIL077C_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YNR004W_p4.241.10E-5SWM2_pPutative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds
YBR074W_p4.161.62E-5YBR074W_pPutative metalloprotease
YNL204C4.141.77E-5SPS18Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation
YNL279W4.102.03E-5PRM1Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
YHR037W3.944.04E-5PUT2Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
YPL207W3.904.74E-5TYW1Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron
YPR078C_p3.875.36E-5YPR078C_pPutative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YBR171W3.846.26E-5SEC66Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YKL054C3.797.47E-5DEF1RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis
YPR067W3.561.89E-4ISA2Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations

GO enrichment analysis for SGTC_2159
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0741.30E-8SGTC_22256654152 15.4 μMChembridge (Fragment library)975820.113208
0.0612.47E-6SGTC_23447990960 77.0 μMChembridge (Fragment library)1408130.113208
0.0594.77E-6SGTC_10613448-9325 110.0 μMChemDiv (Drug-like library)7234820.102941
0.0552.23E-5SGTC_13101188-0297 994.0 nMChemDiv (Drug-like library)15883520.115385azole & statin
0.0527.39E-5SGTC_28509015429 58.4 μMChembridge (Drug-like library)64575700.111111
0.0501.13E-4SGTC_2039Aminomethylbenzodioxan 200.0 μMChembridge (Fragment library)150530.107143
0.0491.56E-4SGTC_1967st070177 51.4 μMTimTec (Natural product derivative library)57292140.113924
0.0472.84E-4SGTC_23437990716 14.8 μMChembridge (Fragment library)64568620.0923077
0.0473.26E-4SGTC_21585657123 3.6 μMChembridge (Fragment library)28588270.114754
0.0463.67E-4SGTC_33309141424 71.4 μMChembridge (Drug-like library)272610200.136986amide catabolism
0.0463.96E-4SGTC_21525568786 200.0 μMChembridge (Fragment library)53998830.0793651
0.0454.78E-4SGTC_7450469-0705 296.0 μMChemDiv (Drug-like library)34867360.102941mitochondrial processes
0.0448.22E-4SGTC_1811447-1644 8.1 μMChemDiv (Drug-like library)5346000.0361446endomembrane recycling
0.0438.44E-4SGTC_29919074669 71.4 μMChembridge (Drug-like library)173331090.08azole & statin
0.0438.46E-4SGTC_11750741-0056 27.6 μMChemDiv (Drug-like library)7659270.0958904

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3274913829849.47 μM0.40740717015756Chembridge (Drug-like library)293.32322.66624
SGTC_8500388-014375.9 μM0.467273ChemDiv (Drug-like library)277.31723.76722
SGTC_22957971645200 μM0.3752978226Chembridge (Fragment library)204.268242.09911
SGTC_3228913179949.47 μM0.37288117015818Chembridge (Drug-like library)307.349783.15224amide catabolism
SGTC_22067254556146.97 μM0.3518524398905Chembridge (Fragment library)275.326220.8842460S ribosome export
SGTC_9272425-1185123 μM0.333333730375ChemDiv (Drug-like library)316.353243.13522
SGTC_530973-002339.98 μM0.327273674768ChemDiv (Drug-like library)261.33943.3714RNA processing & uracil transport
SGTC_3233913234049.47 μM0.32258117682950Chembridge (Drug-like library)329.803983.08314
SGTC_2196657353742.67 μM0.3137262903087Chembridge (Fragment library)278.305262.13624copper-dependent oxidative stress
SGTC_3215912994249.47 μM0.312517682944Chembridge (Drug-like library)323.412083.36114