morpholine

[3-(dimethylamino)phenyl]-morpholin-4-ylmethanone

Reacts with secondary amines.

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2170
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 121171
SMILES CN(C)C1=CC=CC(=C1)C(=O)N2CCOCC2
Standardized SMILES CN(C)c1cccc(c1)C(=O)N2CCOCC2
Molecular weight 234.2942
ALogP 1.09
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.05
% growth inhibition (Hom. pool) 3.13


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 121171
Download HIP data (tab-delimited text)  (excel)
Gene:ACS2(YLR153C)|FD-Score:3.49|P-value:2.43E-4|Clearance:0.2||SGD DESC:Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions Gene:CDC12(YHR107C)|FD-Score:5.41|P-value:3.10E-8|Clearance:0.85||SGD DESC:Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells Gene:CLP1(YOR250C)|FD-Score:4.23|P-value:1.18E-5|Clearance:0.32||SGD DESC:Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation Gene:ERG29(YMR134W_p)|FD-Score:4.25|P-value:1.08E-5|Clearance:0.02||SGD DESC:Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes Gene:POL3(YDL102W)|FD-Score:-3.22|P-value:6.49E-4|Clearance:0||SGD DESC:Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) Gene:RPL10(YLR075W)|FD-Score:3.91|P-value:4.69E-5|Clearance:0.42||SGD DESC:Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects Gene:SWC4(YGR002C)|FD-Score:-3.95|P-value:3.89E-5|Clearance:0||SGD DESC:Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex Gene:YJR012C(YJR012C_p)|FD-Score:3.29|P-value:5.09E-4|Clearance:0.16||SGD DESC:Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W Gene:YLR140W(YLR140W_d)|FD-Score:3.13|P-value:8.75E-4|Clearance:0.08||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Gene:YPL142C(YPL142C_d)|FD-Score:4.56|P-value:2.52E-6|Clearance:0.32||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit Gene:ACS2(YLR153C)|FD-Score:3.49|P-value:2.43E-4|Clearance:0.2||SGD DESC:Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions Gene:CDC12(YHR107C)|FD-Score:5.41|P-value:3.10E-8|Clearance:0.85||SGD DESC:Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells Gene:CLP1(YOR250C)|FD-Score:4.23|P-value:1.18E-5|Clearance:0.32||SGD DESC:Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation Gene:ERG29(YMR134W_p)|FD-Score:4.25|P-value:1.08E-5|Clearance:0.02||SGD DESC:Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes Gene:POL3(YDL102W)|FD-Score:-3.22|P-value:6.49E-4|Clearance:0||SGD DESC:Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) Gene:RPL10(YLR075W)|FD-Score:3.91|P-value:4.69E-5|Clearance:0.42||SGD DESC:Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects Gene:SWC4(YGR002C)|FD-Score:-3.95|P-value:3.89E-5|Clearance:0||SGD DESC:Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex Gene:YJR012C(YJR012C_p)|FD-Score:3.29|P-value:5.09E-4|Clearance:0.16||SGD DESC:Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W Gene:YLR140W(YLR140W_d)|FD-Score:3.13|P-value:8.75E-4|Clearance:0.08||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Gene:YPL142C(YPL142C_d)|FD-Score:4.56|P-value:2.52E-6|Clearance:0.32||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 121171
Download HOP data (tab-delimited text)  (excel)
Gene:AVT3(YKL146W)|FD-Score:3.84|P-value:6.10E-5||SGD DESC:Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:CHO2(YGR157W)|FD-Score:3.38|P-value:3.60E-4||SGD DESC:Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis Gene:DIG1(YPL049C)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p Gene:DOA4(YDR069C)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole Gene:EDC3(YEL015W)|FD-Score:-3.98|P-value:3.50E-5||SGD DESC:Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress Gene:ERG3(YLR056W)|FD-Score:-3.93|P-value:4.19E-5||SGD DESC:C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase Gene:EXO1(YOR033C)|FD-Score:-3.17|P-value:7.64E-4||SGD DESC:5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress Gene:HES1(YOR237W)|FD-Score:4.53|P-value:2.88E-6||SGD DESC:Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication Gene:HHF1(YBR009C)|FD-Score:4.5|P-value:3.42E-6||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:HMF1(YER057C)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro Gene:JHD1(YER051W)|FD-Score:-3.11|P-value:9.35E-4||SGD DESC:JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe Gene:LEA1(YPL213W)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein Gene:MAG2(YLR427W)|FD-Score:3.98|P-value:3.46E-5||SGD DESC:Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1 Gene:MIR1(YJR077C)|FD-Score:3.2|P-value:6.75E-4||SGD DESC:Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated Gene:MNN2(YBR015C)|FD-Score:3.38|P-value:3.68E-4||SGD DESC:Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment Gene:MRPL31(YKL138C)|FD-Score:4.68|P-value:1.45E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS8(YMR158W)|FD-Score:-4.39|P-value:5.65E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSC2(YDR205W)|FD-Score:3.63|P-value:1.41E-4||SGD DESC:Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids Gene:NCR1(YPL006W)|FD-Score:3.46|P-value:2.65E-4||SGD DESC:Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein Gene:NUP42(YDR192C)|FD-Score:3.41|P-value:3.23E-4||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p Gene:PCL1(YNL289W)|FD-Score:-3.24|P-value:5.89E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth Gene:POR2(YIL114C)|FD-Score:-3.56|P-value:1.88E-4||SGD DESC:Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication Gene:PRM6(YML047C)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family Gene:PUT4(YOR348C)|FD-Score:-3.89|P-value:4.96E-5||SGD DESC:Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells Gene:RCO1(YMR075W)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Gene:RIM13(YMR154C)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB Gene:RPL1B(YGL135W)|FD-Score:4.86|P-value:5.79E-7||SGD DESC:Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal Gene:RRT8(YOL048C_p)|FD-Score:-3.4|P-value:3.34E-4||SGD DESC:Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress Gene:SCS22(YBL091C-A)|FD-Score:3.75|P-value:8.82E-5||SGD DESC:Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication Gene:SRB5(YGR104C)|FD-Score:3.75|P-value:8.95E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance Gene:SUE1(YPR151C)|FD-Score:3.09|P-value:9.99E-4||SGD DESC:Mitochondrial protein required for degradation of unstable forms of cytochrome c Gene:SWI3(YJL176C)|FD-Score:3.15|P-value:8.08E-4||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions Gene:SWM2(YNR004W_p)|FD-Score:5.65|P-value:7.90E-9||SGD DESC:Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds Gene:URM1(YIL008W)|FD-Score:-3.9|P-value:4.78E-5||SGD DESC:Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response Gene:VPS27(YNR006W)|FD-Score:4.04|P-value:2.67E-5||SGD DESC:Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) Gene:YAL067W-A(YAL067W-A_p)|FD-Score:-3.71|P-value:1.05E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YBL055C(YBL055C)|FD-Score:4.66|P-value:1.55E-6||SGD DESC:3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases Gene:YCR001W(YCR001W_d)|FD-Score:4.07|P-value:2.34E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene Gene:YCR085W(YCR085W_d)|FD-Score:3.85|P-value:6.03E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YER130C(YER130C_p)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress Gene:YGR066C(YGR066C_p)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Putative protein of unknown function Gene:YKL096C-B(YKL096C-B_p)|FD-Score:-3.77|P-value:8.17E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YKR015C(YKR015C_p)|FD-Score:3.41|P-value:3.30E-4||SGD DESC:Putative protein of unknown function Gene:YMR084W(YMR084W_p)|FD-Score:10.7|P-value:4.90E-27||SGD DESC:Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 Gene:YPR109W(YPR109W_p)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Predicted membrane protein; dipoid deletion strain has high budding index Gene:AVT3(YKL146W)|FD-Score:3.84|P-value:6.10E-5||SGD DESC:Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters Gene:CHO2(YGR157W)|FD-Score:3.38|P-value:3.60E-4||SGD DESC:Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis Gene:DIG1(YPL049C)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p Gene:DOA4(YDR069C)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole Gene:EDC3(YEL015W)|FD-Score:-3.98|P-value:3.50E-5||SGD DESC:Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress Gene:ERG3(YLR056W)|FD-Score:-3.93|P-value:4.19E-5||SGD DESC:C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase Gene:EXO1(YOR033C)|FD-Score:-3.17|P-value:7.64E-4||SGD DESC:5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress Gene:HES1(YOR237W)|FD-Score:4.53|P-value:2.88E-6||SGD DESC:Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication Gene:HHF1(YBR009C)|FD-Score:4.5|P-value:3.42E-6||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:HMF1(YER057C)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro Gene:JHD1(YER051W)|FD-Score:-3.11|P-value:9.35E-4||SGD DESC:JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe Gene:LEA1(YPL213W)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein Gene:MAG2(YLR427W)|FD-Score:3.98|P-value:3.46E-5||SGD DESC:Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1 Gene:MIR1(YJR077C)|FD-Score:3.2|P-value:6.75E-4||SGD DESC:Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated Gene:MNN2(YBR015C)|FD-Score:3.38|P-value:3.68E-4||SGD DESC:Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment Gene:MRPL31(YKL138C)|FD-Score:4.68|P-value:1.45E-6||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS8(YMR158W)|FD-Score:-4.39|P-value:5.65E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSC2(YDR205W)|FD-Score:3.63|P-value:1.41E-4||SGD DESC:Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids Gene:NCR1(YPL006W)|FD-Score:3.46|P-value:2.65E-4||SGD DESC:Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein Gene:NUP42(YDR192C)|FD-Score:3.41|P-value:3.23E-4||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p Gene:PCL1(YNL289W)|FD-Score:-3.24|P-value:5.89E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth Gene:POR2(YIL114C)|FD-Score:-3.56|P-value:1.88E-4||SGD DESC:Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication Gene:PRM6(YML047C)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family Gene:PUT4(YOR348C)|FD-Score:-3.89|P-value:4.96E-5||SGD DESC:Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells Gene:RCO1(YMR075W)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Gene:RIM13(YMR154C)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB Gene:RPL1B(YGL135W)|FD-Score:4.86|P-value:5.79E-7||SGD DESC:Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal Gene:RRT8(YOL048C_p)|FD-Score:-3.4|P-value:3.34E-4||SGD DESC:Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress Gene:SCS22(YBL091C-A)|FD-Score:3.75|P-value:8.82E-5||SGD DESC:Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication Gene:SRB5(YGR104C)|FD-Score:3.75|P-value:8.95E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance Gene:SUE1(YPR151C)|FD-Score:3.09|P-value:9.99E-4||SGD DESC:Mitochondrial protein required for degradation of unstable forms of cytochrome c Gene:SWI3(YJL176C)|FD-Score:3.15|P-value:8.08E-4||SGD DESC:Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions Gene:SWM2(YNR004W_p)|FD-Score:5.65|P-value:7.90E-9||SGD DESC:Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds Gene:URM1(YIL008W)|FD-Score:-3.9|P-value:4.78E-5||SGD DESC:Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response Gene:VPS27(YNR006W)|FD-Score:4.04|P-value:2.67E-5||SGD DESC:Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) Gene:YAL067W-A(YAL067W-A_p)|FD-Score:-3.71|P-value:1.05E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YBL055C(YBL055C)|FD-Score:4.66|P-value:1.55E-6||SGD DESC:3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases Gene:YCR001W(YCR001W_d)|FD-Score:4.07|P-value:2.34E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene Gene:YCR085W(YCR085W_d)|FD-Score:3.85|P-value:6.03E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YER130C(YER130C_p)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress Gene:YGR066C(YGR066C_p)|FD-Score:3.48|P-value:2.48E-4||SGD DESC:Putative protein of unknown function Gene:YKL096C-B(YKL096C-B_p)|FD-Score:-3.77|P-value:8.17E-5||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YKR015C(YKR015C_p)|FD-Score:3.41|P-value:3.30E-4||SGD DESC:Putative protein of unknown function Gene:YMR084W(YMR084W_p)|FD-Score:10.7|P-value:4.90E-27||SGD DESC:Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 Gene:YPR109W(YPR109W_p)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Predicted membrane protein; dipoid deletion strain has high budding index

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR107C5.413.10E-80.85CDC12Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells
YPL142C_d4.562.52E-60.32YPL142C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
YMR134W_p4.251.08E-50.02ERG29_pProtein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
YOR250C4.231.18E-50.32CLP1Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation
YLR075W3.914.69E-50.42RPL10Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects
YLR153C3.492.43E-40.20ACS2Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
YJR012C_p3.295.09E-40.16YJR012C_pEssential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
YLR140W_d3.138.75E-40.08YLR140W_dDubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
YGL102C_d3.050.001160.00YGL102C_dDubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YMR131C3.040.001170.15RRB1Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YBR252W2.890.001920.02DUT1deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate
YDR060W2.870.002070.05MAK21Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YDR302W2.820.002420.05GPI11ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
YJR093C2.760.002860.08FIP1Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
YDR238C2.690.003620.09SEC26Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YMR084W_p10.704.90E-27YMR084W_pPutative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
YNR004W_p5.657.90E-9SWM2_pPutative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds
YGL135W4.865.79E-7RPL1BRibosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
YKL138C4.681.45E-6MRPL31Mitochondrial ribosomal protein of the large subunit
YBL055C4.661.55E-6YBL055C3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
YOR237W4.532.88E-6HES1Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication
YBR009C4.503.42E-6HHF1Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YCR001W_d4.072.34E-5YCR001W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
YNR006W4.042.67E-5VPS27Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
YLR427W3.983.46E-5MAG2Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1
YCR085W_d3.856.03E-5YCR085W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL146W3.846.10E-5AVT3Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YBL091C-A3.758.82E-5SCS22Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication
YGR104C3.758.95E-5SRB5Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance
YER057C3.651.29E-4HMF1Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro

GO enrichment analysis for SGTC_2170
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0977.74E-14SGTC_162k030-0015 37.8 μMChemDiv (Drug-like library)18099200.0740741iron homeostasis
0.0841.11E-10SGTC_22199098279 200.0 μMChembridge (Fragment library)9023490.122807
0.0808.40E-10SGTC_2774tamoxifen 10.9 μMMiscellaneous27335260.169492
0.0764.89E-9SGTC_12951013-0063 9.8 μMChemDiv (Drug-like library)68260380.112903
0.0731.72E-8SGTC_9443370-0224 231.0 μMChemDiv (Drug-like library)45805140.152542
0.0723.57E-8SGTC_30299088683 49.5 μMChembridge (Drug-like library)252366150.196721
0.0715.44E-8SGTC_26323-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 100.0 μMMicrosource (Natural product library)68577840.102941
0.0681.97E-7SGTC_14264048-4480 71.7 μMChemDiv (Drug-like library)142243430.10769260S ribosome export
0.0649.27E-7SGTC_14801070-0044 41.2 μMChemDiv (Drug-like library)31249870.222222
0.0631.11E-6SGTC_577r071-0003 38.6 μMChemDiv (Drug-like library)45685170.113208fatty acid desaturase (OLE1)
0.0612.54E-6SGTC_1575cyproterone acetate 48.0 μMMiscellaneous98800.0886076
0.0603.87E-6SGTC_33339141820 12.1 μMChembridge (Drug-like library)19394330.128571
0.0571.13E-5SGTC_437s-farnesyl-l-cysteine methyl ester 6.7 μMICCB bioactive library64392250.0597015
0.0561.54E-5SGTC_14843473-2379 286.0 μMChemDiv (Drug-like library)6719170.136364
0.0561.84E-5SGTC_9491165-0505 146.0 μMChemDiv (Drug-like library)62442670.0793651

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_2868903560832.47 μM0.4629636462614Chembridge (Drug-like library)366.238483.82703
SGTC_3158910000749.47 μM0.3703719297233Chembridge (Drug-like library)373.286844.01902
SGTC_3049909222349.47 μM0.3636368623917Chembridge (Drug-like library)328.835843.93502
SGTC_2992907459171.43 μM0.33898317741321Chembridge (Drug-like library)374.453981.91215
SGTC_11564092-03674.88 μM0.3333331357585ChemDiv (Drug-like library)382.926285.00702
SGTC_13752910-0797186 μM0.321429742508ChemDiv (Drug-like library)340.416162.75204
SGTC_3054909439749.47 μM0.3207552598354Chembridge (Drug-like library)330.422883.69302fatty acid desaturase (OLE1)
SGTC_2042p-Dimethylaminoacetophenone200 μM0.31707375037Chembridge (Fragment library)163.216321.73202
SGTC_7294092-058594.1 μM0.3166672169061ChemDiv (Drug-like library)390.4500234.5504
SGTC_2350902389538.85 μM0.3137262997209Chembridge (Fragment library)266.337622.29402ergosterol biosynthesis