5809774

4-(3,4-dimethylphenyl)-1,3-thiazol-2-amine hydrochloride

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2176
Screen concentration 34.0 μM
Source Chembridge (Fragment library)
PubChem CID 2870539
SMILES CC1=C(C=C(C=C1)C2=CSC(=N2)N)C.Cl
Standardized SMILES Cc1ccc(cc1C)c2csc(N)n2
Molecular weight 240.7523
ALogP 3.38
H-bond donor count 2
H-bond acceptor count 3
Response signature mitochondrial processes

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.59
% growth inhibition (Hom. pool) 10.47


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2870539
Download HIP data (tab-delimited text)  (excel)
Gene:GPI11(YDR302W)|FD-Score:-3.49|P-value:2.44E-4|Clearance:0||SGD DESC:ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog Gene:RFA1(YAR007C)|FD-Score:-4.87|P-value:5.61E-7|Clearance:0||SGD DESC:Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination Gene:RPB2(YOR151C)|FD-Score:-3.15|P-value:8.04E-4|Clearance:0||SGD DESC:RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit Gene:RPL18A(YOL120C)|FD-Score:3.14|P-value:8.44E-4|Clearance:0.38||SGD DESC:Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication Gene:RSC8(YFR037C)|FD-Score:-3.29|P-value:4.97E-4|Clearance:0||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SHR3(YDL212W)|FD-Score:-3.36|P-value:3.91E-4|Clearance:0||SGD DESC:Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface Gene:TOM40(YMR203W)|FD-Score:3.23|P-value:6.15E-4|Clearance:0.38||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:GPI11(YDR302W)|FD-Score:-3.49|P-value:2.44E-4|Clearance:0||SGD DESC:ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog Gene:RFA1(YAR007C)|FD-Score:-4.87|P-value:5.61E-7|Clearance:0||SGD DESC:Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination Gene:RPB2(YOR151C)|FD-Score:-3.15|P-value:8.04E-4|Clearance:0||SGD DESC:RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit Gene:RPL18A(YOL120C)|FD-Score:3.14|P-value:8.44E-4|Clearance:0.38||SGD DESC:Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication Gene:RSC8(YFR037C)|FD-Score:-3.29|P-value:4.97E-4|Clearance:0||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SHR3(YDL212W)|FD-Score:-3.36|P-value:3.91E-4|Clearance:0||SGD DESC:Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface Gene:TOM40(YMR203W)|FD-Score:3.23|P-value:6.15E-4|Clearance:0.38||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2870539
Download HOP data (tab-delimited text)  (excel)
Gene:AKR2(YOR034C)|FD-Score:3.79|P-value:7.66E-5||SGD DESC:Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication Gene:AMS1(YGL156W)|FD-Score:-3.45|P-value:2.79E-4||SGD DESC:Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway Gene:ARG82(YDR173C)|FD-Score:3.72|P-value:9.99E-5||SGD DESC:Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes Gene:ARP6(YLR085C)|FD-Score:3.77|P-value:8.28E-5||SGD DESC:Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:ARR1(YPR199C)|FD-Score:-3.33|P-value:4.28E-4||SGD DESC:Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds Gene:ATG22(YCL038C)|FD-Score:4.27|P-value:1.00E-5||SGD DESC:Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation Gene:ATP11(YNL315C)|FD-Score:5.22|P-value:8.88E-8||SGD DESC:Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Gene:ATP2(YJR121W)|FD-Score:7.51|P-value:2.89E-14||SGD DESC:Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Gene:BNS1(YGR230W)|FD-Score:3.55|P-value:1.93E-4||SGD DESC:Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis Gene:CNE1(YAL058W)|FD-Score:4.33|P-value:7.31E-6||SGD DESC:Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast Gene:COX5B(YIL111W)|FD-Score:3.97|P-value:3.59E-5||SGD DESC:Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication Gene:ECM18(YDR125C)|FD-Score:3.33|P-value:4.28E-4||SGD DESC:Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication Gene:EMP65(YER140W_p)|FD-Score:3.14|P-value:8.49E-4||SGD DESC:ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FMP52(YER004W)|FD-Score:-3.42|P-value:3.13E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:HMI1(YOL095C)|FD-Score:3.18|P-value:7.29E-4||SGD DESC:Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD Gene:HTZ1(YOL012C)|FD-Score:5|P-value:2.81E-7||SGD DESC:Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin Gene:ICY1(YMR195W)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation Gene:IPK1(YDR315C)|FD-Score:-4.27|P-value:9.80E-6||SGD DESC:Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable Gene:ISW2(YOR304W)|FD-Score:3.83|P-value:6.40E-5||SGD DESC:ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth Gene:MDL2(YPL270W)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis Gene:MET14(YKL001C)|FD-Score:3.26|P-value:5.61E-4||SGD DESC:Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism Gene:MTC1(YJL123C)|FD-Score:3.85|P-value:5.80E-5||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 Gene:MTG1(YMR097C)|FD-Score:-3.21|P-value:6.56E-4||SGD DESC:Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals Gene:NAM7(YMR080C)|FD-Score:-3.37|P-value:3.70E-4||SGD DESC:ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress Gene:NHA1(YLR138W)|FD-Score:3.19|P-value:7.03E-4||SGD DESC:Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH Gene:OPI3(YJR073C)|FD-Score:3.8|P-value:7.28E-5||SGD DESC:Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis Gene:PEX32(YBR168W)|FD-Score:3.74|P-value:9.34E-5||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p Gene:POR1(YNL055C)|FD-Score:6.41|P-value:7.46E-11||SGD DESC:Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication Gene:PPE1(YHR075C)|FD-Score:3.94|P-value:4.05E-5||SGD DESC:Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein Gene:PPN1(YDR452W)|FD-Score:-3.48|P-value:2.47E-4||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:PRM1(YNL279W)|FD-Score:3.17|P-value:7.69E-4||SGD DESC:Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p Gene:RIF2(YLR453C)|FD-Score:3.48|P-value:2.55E-4||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:RMD6(YEL072W)|FD-Score:-3.43|P-value:3.00E-4||SGD DESC:Protein required for sporulation Gene:ROM2(YLR371W)|FD-Score:3.5|P-value:2.28E-4||SGD DESC:GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p Gene:RPL29(YFR032C-A)|FD-Score:5.25|P-value:7.81E-8||SGD DESC:Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog Gene:RPS21B(YJL136C)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication Gene:RPS4B(YHR203C)|FD-Score:3.14|P-value:8.45E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication Gene:RRM3(YHR031C)|FD-Score:3.35|P-value:4.11E-4||SGD DESC:DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Gene:RTC5(YOR118W)|FD-Score:-3.34|P-value:4.15E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Gene:SLT2(YHR030C)|FD-Score:-3.44|P-value:2.94E-4||SGD DESC:Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway Gene:SWC3(YAL011W)|FD-Score:3.53|P-value:2.07E-4||SGD DESC:Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae Gene:TRM82(YDR165W)|FD-Score:-5.69|P-value:6.17E-9||SGD DESC:Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p Gene:TSR3(YOR006C)|FD-Score:3.54|P-value:2.01E-4||SGD DESC:Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:TUB3(YML124C)|FD-Score:6.22|P-value:2.48E-10||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication Gene:UAF30(YOR295W)|FD-Score:3.37|P-value:3.80E-4||SGD DESC:Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication Gene:VPS5(YOR069W)|FD-Score:3.71|P-value:1.04E-4||SGD DESC:Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes Gene:VPS52(YDR484W)|FD-Score:-3.13|P-value:8.74E-4||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YAL066W(YAL066W_d)|FD-Score:-7.06|P-value:8.38E-13||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBL039W-B(YBL039W-B_p)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Putative protein of unknown function Gene:YDR179W-A(YDR179W-A_p)|FD-Score:-3.27|P-value:5.43E-4||SGD DESC:Putative protein of unknown function Gene:YEA6(YEL006W)|FD-Score:-3.36|P-value:3.92E-4||SGD DESC:Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog Gene:YGL152C(YGL152C_d)|FD-Score:-5.42|P-value:3.02E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Gene:YGR146C-A(YGR146C-A_p)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Putative protein of unknown function Gene:YJL118W(YJL118W)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein Gene:YLR296W(YLR296W_d)|FD-Score:-4.14|P-value:1.71E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR406C-A(YLR406C-A_p)|FD-Score:-4.29|P-value:8.89E-6||SGD DESC:Putative protein of unknown function Gene:YME1(YPR024W)|FD-Score:4.57|P-value:2.39E-6||SGD DESC:Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover Gene:YMR084W(YMR084W_p)|FD-Score:-3.57|P-value:1.76E-4||SGD DESC:Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 Gene:YOR082C(YOR082C_d)|FD-Score:3.72|P-value:9.94E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W Gene:YPR109W(YPR109W_p)|FD-Score:-3.39|P-value:3.47E-4||SGD DESC:Predicted membrane protein; dipoid deletion strain has high budding index Gene:AKR2(YOR034C)|FD-Score:3.79|P-value:7.66E-5||SGD DESC:Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication Gene:AMS1(YGL156W)|FD-Score:-3.45|P-value:2.79E-4||SGD DESC:Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway Gene:ARG82(YDR173C)|FD-Score:3.72|P-value:9.99E-5||SGD DESC:Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes Gene:ARP6(YLR085C)|FD-Score:3.77|P-value:8.28E-5||SGD DESC:Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:ARR1(YPR199C)|FD-Score:-3.33|P-value:4.28E-4||SGD DESC:Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds Gene:ATG22(YCL038C)|FD-Score:4.27|P-value:1.00E-5||SGD DESC:Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation Gene:ATP11(YNL315C)|FD-Score:5.22|P-value:8.88E-8||SGD DESC:Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Gene:ATP2(YJR121W)|FD-Score:7.51|P-value:2.89E-14||SGD DESC:Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Gene:BNS1(YGR230W)|FD-Score:3.55|P-value:1.93E-4||SGD DESC:Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis Gene:CNE1(YAL058W)|FD-Score:4.33|P-value:7.31E-6||SGD DESC:Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast Gene:COX5B(YIL111W)|FD-Score:3.97|P-value:3.59E-5||SGD DESC:Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication Gene:ECM18(YDR125C)|FD-Score:3.33|P-value:4.28E-4||SGD DESC:Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication Gene:EMP65(YER140W_p)|FD-Score:3.14|P-value:8.49E-4||SGD DESC:ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FMP52(YER004W)|FD-Score:-3.42|P-value:3.13E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:HMI1(YOL095C)|FD-Score:3.18|P-value:7.29E-4||SGD DESC:Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD Gene:HTZ1(YOL012C)|FD-Score:5|P-value:2.81E-7||SGD DESC:Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin Gene:ICY1(YMR195W)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation Gene:IPK1(YDR315C)|FD-Score:-4.27|P-value:9.80E-6||SGD DESC:Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable Gene:ISW2(YOR304W)|FD-Score:3.83|P-value:6.40E-5||SGD DESC:ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth Gene:MDL2(YPL270W)|FD-Score:3.61|P-value:1.51E-4||SGD DESC:Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis Gene:MET14(YKL001C)|FD-Score:3.26|P-value:5.61E-4||SGD DESC:Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism Gene:MTC1(YJL123C)|FD-Score:3.85|P-value:5.80E-5||SGD DESC:Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 Gene:MTG1(YMR097C)|FD-Score:-3.21|P-value:6.56E-4||SGD DESC:Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals Gene:NAM7(YMR080C)|FD-Score:-3.37|P-value:3.70E-4||SGD DESC:ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress Gene:NHA1(YLR138W)|FD-Score:3.19|P-value:7.03E-4||SGD DESC:Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH Gene:OPI3(YJR073C)|FD-Score:3.8|P-value:7.28E-5||SGD DESC:Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis Gene:PEX32(YBR168W)|FD-Score:3.74|P-value:9.34E-5||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p Gene:POR1(YNL055C)|FD-Score:6.41|P-value:7.46E-11||SGD DESC:Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication Gene:PPE1(YHR075C)|FD-Score:3.94|P-value:4.05E-5||SGD DESC:Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein Gene:PPN1(YDR452W)|FD-Score:-3.48|P-value:2.47E-4||SGD DESC:Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:PRM1(YNL279W)|FD-Score:3.17|P-value:7.69E-4||SGD DESC:Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p Gene:RIF2(YLR453C)|FD-Score:3.48|P-value:2.55E-4||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:RMD6(YEL072W)|FD-Score:-3.43|P-value:3.00E-4||SGD DESC:Protein required for sporulation Gene:ROM2(YLR371W)|FD-Score:3.5|P-value:2.28E-4||SGD DESC:GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p Gene:RPL29(YFR032C-A)|FD-Score:5.25|P-value:7.81E-8||SGD DESC:Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog Gene:RPS21B(YJL136C)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication Gene:RPS4B(YHR203C)|FD-Score:3.14|P-value:8.45E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication Gene:RRM3(YHR031C)|FD-Score:3.35|P-value:4.11E-4||SGD DESC:DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Gene:RTC5(YOR118W)|FD-Score:-3.34|P-value:4.15E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity Gene:SLT2(YHR030C)|FD-Score:-3.44|P-value:2.94E-4||SGD DESC:Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway Gene:SWC3(YAL011W)|FD-Score:3.53|P-value:2.07E-4||SGD DESC:Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae Gene:TRM82(YDR165W)|FD-Score:-5.69|P-value:6.17E-9||SGD DESC:Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p Gene:TSR3(YOR006C)|FD-Score:3.54|P-value:2.01E-4||SGD DESC:Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:TUB3(YML124C)|FD-Score:6.22|P-value:2.48E-10||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication Gene:UAF30(YOR295W)|FD-Score:3.37|P-value:3.80E-4||SGD DESC:Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication Gene:VPS5(YOR069W)|FD-Score:3.71|P-value:1.04E-4||SGD DESC:Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes Gene:VPS52(YDR484W)|FD-Score:-3.13|P-value:8.74E-4||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YAL066W(YAL066W_d)|FD-Score:-7.06|P-value:8.38E-13||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBL039W-B(YBL039W-B_p)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Putative protein of unknown function Gene:YDR179W-A(YDR179W-A_p)|FD-Score:-3.27|P-value:5.43E-4||SGD DESC:Putative protein of unknown function Gene:YEA6(YEL006W)|FD-Score:-3.36|P-value:3.92E-4||SGD DESC:Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog Gene:YGL152C(YGL152C_d)|FD-Score:-5.42|P-value:3.02E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Gene:YGR146C-A(YGR146C-A_p)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Putative protein of unknown function Gene:YJL118W(YJL118W)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein Gene:YLR296W(YLR296W_d)|FD-Score:-4.14|P-value:1.71E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR406C-A(YLR406C-A_p)|FD-Score:-4.29|P-value:8.89E-6||SGD DESC:Putative protein of unknown function Gene:YME1(YPR024W)|FD-Score:4.57|P-value:2.39E-6||SGD DESC:Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover Gene:YMR084W(YMR084W_p)|FD-Score:-3.57|P-value:1.76E-4||SGD DESC:Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 Gene:YOR082C(YOR082C_d)|FD-Score:3.72|P-value:9.94E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W Gene:YPR109W(YPR109W_p)|FD-Score:-3.39|P-value:3.47E-4||SGD DESC:Predicted membrane protein; dipoid deletion strain has high budding index

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YMR203W3.236.15E-40.38TOM40Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
YOL120C3.148.44E-40.38RPL18ARibosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
YML010W2.760.002900.24SPT5Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair
YDR437W2.520.005920.02GPI19Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P
YCR012W2.500.006210.10PGK13-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YHR072W2.400.008170.00ERG7Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
YDL147W2.400.008280.01RPN5Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein
YBR192W2.390.008480.02RIM2Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
YNR046W2.360.009040.02TRM112Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress
YDR527W2.340.009580.06RBA50Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
YDR398W2.290.011100.02UTP5Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
YLR208W2.260.011800.01SEC13Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress
YFR050C2.250.012100.01PRE4Beta 7 subunit of the 20S proteasome
YOR157C2.240.012400.05PUP1Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
YFL039C2.190.014100.01ACT1Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YJR121W7.512.89E-14ATP2Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YNL055C6.417.46E-11POR1Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication
YML124C6.222.48E-10TUB3Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication
YFR032C-A5.257.81E-8RPL29Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog
YNL315C5.228.88E-8ATP11Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
YOL012C5.002.81E-7HTZ1Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YPR024W4.572.39E-6YME1Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
YAL058W4.337.31E-6CNE1Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast
YCL038C4.271.00E-5ATG22Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
YIL111W3.973.59E-5COX5BSubunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
YHR075C3.944.05E-5PPE1Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
YJL123C3.855.80E-5MTC1Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1
YOR304W3.836.40E-5ISW2ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
YJR073C3.807.28E-5OPI3Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis
YOR034C3.797.66E-5AKR2Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication

GO enrichment analysis for SGTC_2176
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1261.82E-22SGTC_2630antimycin a 100.0 μMMicrosource (Natural product library)57021990.0434783mitochondrial processes
0.1241.00E-21SGTC_21755807670 165.3 μMChembridge (Fragment library)2411860.0727273
0.1211.34E-20SGTC_8800833-0487 87.2 μMChemDiv (Drug-like library)760750.558824mitochondrial processes
0.1125.40E-18SGTC_286k060-0067 22.9 μMChemDiv (Drug-like library)59850510.123077tubulin folding & SWR complex
0.1071.58E-16SGTC_229benomyl 22.9 μMMiscellaneous287800.0909091tubulin folding & SWR complex
0.1071.78E-16SGTC_11453546-0597 10.2 μMChemDiv (Drug-like library)8753340.133333mitochondrial processes
0.1032.10E-15SGTC_1641st009299 47.1 μMTimTec (Natural product derivative library)40460540.0806452mitochondrial processes
0.1032.77E-15SGTC_20615245884 81.0 μMChembridge (Fragment library)5738630.115385tubulin folding & SWR complex
0.1016.44E-15SGTC_21775811945 192.0 μMChembridge (Fragment library)53434750.0701754
0.1001.57E-14SGTC_23196033012 152.6 μMChembridge (Fragment library)8472460.150943tubulin folding & SWR complex
0.0943.66E-13SGTC_20114012611 177.0 μMChembridge (Fragment library)20498870.204545mitochondrial processes
0.0944.51E-13SGTC_13261431-2094 10.8 μMChemDiv (Drug-like library)6162780.1875tubulin folding & SWR complex
0.0945.73E-13SGTC_22006600604 21.9 μMChembridge (Fragment library)29047770.117647tubulin folding & SWR complex
0.0937.11E-13SGTC_32949122953 26.3 μMChembridge (Drug-like library)164598260.0547945tubulin folding & SWR complex
0.0939.75E-13SGTC_21415621638 7.7 μMChembridge (Fragment library)28562380.0625tubulin folding & SWR complex

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_2166593306131.5 μM0.5833332877375Chembridge (Fragment library)240.752323.38123tubulin folding & SWR complex
SGTC_8800833-048787.2 μM0.55882476075ChemDiv (Drug-like library)252.334183.54513mitochondrial processes
SGTC_20084012253172 μM0.292683603940Chembridge (Fragment library)185.225142.05513
SGTC_270485-000132.62 μM0.2888892054479ChemDiv (Drug-like library)266.360764.32313RPP1 & pyrimidine depletion
SGTC_10124112-352218 μM0.2884623112398ChemDiv (Drug-like library)322.836243.81326
SGTC_15110906-310928.5 μM0.2884622882180ChemDiv (Drug-like library)324.482964.64313excess fatty acid
SGTC_8024112-3352742 μM0.283019704594ChemDiv (Drug-like library)267.348823.65914
SGTC_6360kpi-0074126 μM0.27907616434ChemDiv (Drug-like library)234.360422.91813
SGTC_3252810-4341181 μM0.269231774970ChemDiv (Drug-like library)252.311043.96213amide catabolism
SGTC_3025908789549.47 μM0.26229517173641Chembridge (Drug-like library)365.448762.88924PDR1