| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YBL042C | 5.80 | 3.23E-9 | FUI1 | High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress |
| YGR228W_d | 5.58 | 1.20E-8 | YGR228W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C |
| YBR069C | 5.54 | 1.48E-8 | TAT1 | Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress |
| YNL314W | 4.87 | 5.66E-7 | DAL82 | Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain |
| YBR015C | 4.82 | 7.30E-7 | MNN2 | Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment |
| YPL046C | 4.73 | 1.12E-6 | ELC1 | Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair |
| YBR232C_d | 4.48 | 3.76E-6 | YBR232C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| YFR034C | 4.44 | 4.40E-6 | PHO4 | Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability |
| YJR113C | 4.39 | 5.60E-6 | RSM7 | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein |
| YNL334C | 4.19 | 1.41E-5 | SNO2 | Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin |
| YFR033C | 4.12 | 1.92E-5 | QCR6 | Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space |
| YBR077C | 4.11 | 1.96E-5 | SLM4 | Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 |
| YEL033W_p | 4.10 | 2.03E-5 | MTC7_p | Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant |
| YGL060W | 4.06 | 2.42E-5 | YBP2 | Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication |
| YPR197C_d | 4.06 | 2.47E-5 | YPR197C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
