5925765

N-[2-(hydroxymethyl)phenyl]-3-methylbenzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2193
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 877370
SMILES CC1=CC=CC(=C1)C(=O)NC2=CC=CC=C2CO
Standardized SMILES Cc1cccc(c1)C(=O)Nc2ccccc2CO
Molecular weight 241.2851
ALogP 2.5
H-bond donor count 2
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.54
% growth inhibition (Hom. pool) 6.6


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 877370
Download HIP data (tab-delimited text)  (excel)
Gene:CSL4(YNL232W)|FD-Score:-3.19|P-value:7.23E-4|Clearance:0||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) Gene:ERB1(YMR049C)|FD-Score:3.11|P-value:9.25E-4|Clearance:0.21||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 Gene:MCM10(YIL150C)|FD-Score:-3.45|P-value:2.76E-4|Clearance:0||SGD DESC:Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins Gene:RRP7(YCL031C)|FD-Score:3.15|P-value:8.19E-4|Clearance:0.04||SGD DESC:Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress Gene:SDS22(YKL193C)|FD-Score:-4.04|P-value:2.67E-5|Clearance:0||SGD DESC:Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function Gene:TSR1(YDL060W)|FD-Score:-3.12|P-value:9.03E-4|Clearance:0||SGD DESC:Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:YDR526C(YDR526C_d)|FD-Score:5.33|P-value:4.93E-8|Clearance:2.18||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR458W(YLR458W_d)|FD-Score:-3.52|P-value:2.13E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis Gene:CSL4(YNL232W)|FD-Score:-3.19|P-value:7.23E-4|Clearance:0||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) Gene:ERB1(YMR049C)|FD-Score:3.11|P-value:9.25E-4|Clearance:0.21||SGD DESC:Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 Gene:MCM10(YIL150C)|FD-Score:-3.45|P-value:2.76E-4|Clearance:0||SGD DESC:Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins Gene:RRP7(YCL031C)|FD-Score:3.15|P-value:8.19E-4|Clearance:0.04||SGD DESC:Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress Gene:SDS22(YKL193C)|FD-Score:-4.04|P-value:2.67E-5|Clearance:0||SGD DESC:Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function Gene:TSR1(YDL060W)|FD-Score:-3.12|P-value:9.03E-4|Clearance:0||SGD DESC:Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:YDR526C(YDR526C_d)|FD-Score:5.33|P-value:4.93E-8|Clearance:2.18||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR458W(YLR458W_d)|FD-Score:-3.52|P-value:2.13E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 877370
Download HOP data (tab-delimited text)  (excel)
Gene:ANT1(YPR128C)|FD-Score:-3.21|P-value:6.67E-4||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:GBP2(YCL011C)|FD-Score:3.16|P-value:7.94E-4||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication Gene:HTL1(YCR020W-B)|FD-Score:3.48|P-value:2.54E-4||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:IRC24(YIR036C_p)|FD-Score:3.15|P-value:8.17E-4||SGD DESC:Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci Gene:ISU2(YOR226C)|FD-Score:5.34|P-value:4.60E-8||SGD DESC:Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved Gene:LAS21(YJL062W)|FD-Score:3.9|P-value:4.76E-5||SGD DESC:Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity Gene:MAK31(YCR020C-A)|FD-Score:4.08|P-value:2.21E-5||SGD DESC:Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family Gene:MRS3(YJL133W)|FD-Score:3.54|P-value:1.96E-4||SGD DESC:Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication Gene:MSB4(YOL112W)|FD-Score:-3.25|P-value:5.83E-4||SGD DESC:GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization Gene:PAN5(YHR063C)|FD-Score:-3.2|P-value:6.91E-4||SGD DESC:2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE Gene:PFK1(YGR240C)|FD-Score:3.78|P-value:7.70E-5||SGD DESC:Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:RXT2(YBR095C)|FD-Score:3.11|P-value:9.29E-4||SGD DESC:Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth Gene:SAC1(YKL212W)|FD-Score:5.09|P-value:1.83E-7||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SCD6(YPR129W)|FD-Score:5.78|P-value:3.66E-9||SGD DESC:Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress Gene:SKI3(YPR189W)|FD-Score:3.24|P-value:5.92E-4||SGD DESC:Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay Gene:TUB3(YML124C)|FD-Score:-3.39|P-value:3.50E-4||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication Gene:VAN1(YML115C)|FD-Score:3.3|P-value:4.78E-4||SGD DESC:Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant Gene:VMR1(YHL035C)|FD-Score:-4.5|P-value:3.36E-6||SGD DESC:Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions Gene:YBR056W(YBR056W_p)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Putative glycoside hydrolase of the mitochondrial intermembrane space Gene:YBR292C(YBR292C_d)|FD-Score:3.41|P-value:3.23E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Gene:YLR358C(YLR358C_p)|FD-Score:5.05|P-value:2.21E-7||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W Gene:YMR057C(YMR057C_d)|FD-Score:3.93|P-value:4.17E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1 Gene:YPR039W(YPR039W_d)|FD-Score:-4.64|P-value:1.75E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Gene:YPT6(YLR262C)|FD-Score:3.55|P-value:1.93E-4||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 Gene:ANT1(YPR128C)|FD-Score:-3.21|P-value:6.67E-4||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:GBP2(YCL011C)|FD-Score:3.16|P-value:7.94E-4||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication Gene:HTL1(YCR020W-B)|FD-Score:3.48|P-value:2.54E-4||SGD DESC:Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance Gene:IRC24(YIR036C_p)|FD-Score:3.15|P-value:8.17E-4||SGD DESC:Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci Gene:ISU2(YOR226C)|FD-Score:5.34|P-value:4.60E-8||SGD DESC:Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved Gene:LAS21(YJL062W)|FD-Score:3.9|P-value:4.76E-5||SGD DESC:Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity Gene:MAK31(YCR020C-A)|FD-Score:4.08|P-value:2.21E-5||SGD DESC:Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family Gene:MRS3(YJL133W)|FD-Score:3.54|P-value:1.96E-4||SGD DESC:Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication Gene:MSB4(YOL112W)|FD-Score:-3.25|P-value:5.83E-4||SGD DESC:GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization Gene:PAN5(YHR063C)|FD-Score:-3.2|P-value:6.91E-4||SGD DESC:2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE Gene:PFK1(YGR240C)|FD-Score:3.78|P-value:7.70E-5||SGD DESC:Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:RXT2(YBR095C)|FD-Score:3.11|P-value:9.29E-4||SGD DESC:Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth Gene:SAC1(YKL212W)|FD-Score:5.09|P-value:1.83E-7||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SCD6(YPR129W)|FD-Score:5.78|P-value:3.66E-9||SGD DESC:Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress Gene:SKI3(YPR189W)|FD-Score:3.24|P-value:5.92E-4||SGD DESC:Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay Gene:TUB3(YML124C)|FD-Score:-3.39|P-value:3.50E-4||SGD DESC:Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication Gene:VAN1(YML115C)|FD-Score:3.3|P-value:4.78E-4||SGD DESC:Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant Gene:VMR1(YHL035C)|FD-Score:-4.5|P-value:3.36E-6||SGD DESC:Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions Gene:YBR056W(YBR056W_p)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Putative glycoside hydrolase of the mitochondrial intermembrane space Gene:YBR292C(YBR292C_d)|FD-Score:3.41|P-value:3.23E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Gene:YLR358C(YLR358C_p)|FD-Score:5.05|P-value:2.21E-7||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W Gene:YMR057C(YMR057C_d)|FD-Score:3.93|P-value:4.17E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1 Gene:YPR039W(YPR039W_d)|FD-Score:-4.64|P-value:1.75E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Gene:YPT6(YLR262C)|FD-Score:3.55|P-value:1.93E-4||SGD DESC:Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR526C_d5.334.93E-82.18YDR526C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL031C3.158.19E-40.04RRP7Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress
YMR049C3.119.25E-40.21ERB1Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1
YHR118C2.900.001870.04ORC6Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
YPR186C2.860.002120.04PZF1Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA
YDL084W2.820.002430.09SUB2Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress
YFR029W2.720.003250.20PTR3Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YGR175C2.530.005770.02ERG1Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
YLL018C2.500.006180.06DPS1Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
YHR065C2.440.007400.03RRP3Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
YJR057W2.400.008090.01CDC8Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
YDR301W2.390.008390.02CFT1RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF
YPR143W2.370.008840.04RRP15Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
YOR063W2.330.009780.01RPL3Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus
YER127W2.320.010100.03LCP5Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPR129W5.783.66E-9SCD6Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress
YOR226C5.344.60E-8ISU2Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved
YKL212W5.091.83E-7SAC1Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism
YLR358C_p5.052.21E-7YLR358C_pProtein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W
YCR020C-A4.082.21E-5MAK31Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family
YMR057C_d3.934.17E-5YMR057C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
YJL062W3.904.76E-5LAS21Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity
YGR240C3.787.70E-5PFK1Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YLR262C3.551.93E-4YPT6Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
YJL133W3.541.96E-4MRS3Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication
YCR020W-B3.482.54E-4HTL1Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YBR292C_d3.413.23E-4YBR292C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YML115C3.304.78E-4VAN1Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
YPR189W3.245.92E-4SKI3Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay
YBR056W_p3.216.66E-4YBR056W_pPutative glycoside hydrolase of the mitochondrial intermembrane space

GO enrichment analysis for SGTC_2193
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0773.76E-9SGTC_31889110789 49.5 μMChembridge (Drug-like library)8492170.327273iron homeostasis
0.0764.89E-9SGTC_21996590217 200.0 μMChembridge (Fragment library)7031090.145161mitochondrial processes
0.0765.77E-9SGTC_1167k781-0610 148.0 μMChemDiv (Drug-like library)45251690.174603RNA processing & uracil transport
0.0732.39E-8SGTC_1625st003711 30.1 μMTimTec (Natural product derivative library)242070340.116279calcium & mitochondrial duress
0.0691.01E-7SGTC_22267298446 200.0 μMChembridge (Fragment library)32830100.153846
0.0691.42E-7SGTC_28859057732 52.0 μMChembridge (Drug-like library)64714140.339286
0.0681.72E-7SGTC_1974544-0043 41.6 μMChemDiv (Drug-like library)8965230.101449endomembrane recycling
0.0655.64E-7SGTC_7323970-1727 52.7 μMChemDiv (Drug-like library)12756990.1
0.0649.69E-7SGTC_1873rapamycin 2.0 nMMiscellaneous52846160.0538462
0.0621.62E-6SGTC_32459134821 49.5 μMChembridge (Drug-like library)170149010.327586
0.0596.54E-6SGTC_1968st069590 43.6 μMTimTec (Natural product derivative library)63840660.177419
0.0588.74E-6SGTC_487nimodipine 119.0 μMMiscellaneous44970.157895
0.0589.14E-6SGTC_491tetrandrine 80.3 μMICCB bioactive library730780.0574713
0.0561.84E-5SGTC_6583253-0951 102.0 μMChemDiv (Drug-like library)11848780.123077calcium & mitochondrial duress
0.0543.09E-5SGTC_11513909-8316 15.3 μMChemDiv (Drug-like library)8004310.136364

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_21826325192200 μM0.5736248Chembridge (Fragment library)226.273762.35422Golgi
SGTC_20134024628200 μM0.4888895230760Chembridge (Fragment library)226.273762.35422
SGTC_2824799840451.95 μM0.468085837851Chembridge (Drug-like library)257.35073.64212
SGTC_8261683-5028118 μM0.428571722377ChemDiv (Drug-like library)261.703583.26212
SGTC_1759st04305970 μM0.411765669426TimTec (Natural product derivative library)285.29462.45314amide catabolism
SGTC_8034488-1585147 μM0.410714747204ChemDiv (Drug-like library)315.386783.924
SGTC_3108912178549.47 μM0.39285717140271Chembridge (Drug-like library)312.3632.79223
SGTC_3090911769649.47 μM0.3921577923821Chembridge (Drug-like library)297.2475534.37915
SGTC_3232913287449.47 μM0.3753784940Chembridge (Drug-like library)255.268622.4713RPP1 & pyrimidine depletion
SGTC_21545570129200 μM0.365385673366Chembridge (Fragment library)227.261821.68413