| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YPR129W | 5.78 | 3.66E-9 | SCD6 | Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress |
| YOR226C | 5.34 | 4.60E-8 | ISU2 | Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved |
| YKL212W | 5.09 | 1.83E-7 | SAC1 | Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism |
| YLR358C_p | 5.05 | 2.21E-7 | YLR358C_p | Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W |
| YCR020C-A | 4.08 | 2.21E-5 | MAK31 | Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family |
| YMR057C_d | 3.93 | 4.17E-5 | YMR057C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1 |
| YJL062W | 3.90 | 4.76E-5 | LAS21 | Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity |
| YGR240C | 3.78 | 7.70E-5 | PFK1 | Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes |
| YLR262C | 3.55 | 1.93E-4 | YPT6 | Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 |
| YJL133W | 3.54 | 1.96E-4 | MRS3 | Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication |
| YCR020W-B | 3.48 | 2.54E-4 | HTL1 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
| YBR292C_d | 3.41 | 3.23E-4 | YBR292C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene |
| YML115C | 3.30 | 4.78E-4 | VAN1 | Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant |
| YPR189W | 3.24 | 5.92E-4 | SKI3 | Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay |
| YBR056W_p | 3.21 | 6.66E-4 | YBR056W_p | Putative glycoside hydrolase of the mitochondrial intermembrane space |
