Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YBR124W_d | 5.46 | 2.37E-8 | 1.05 | YBR124W_d | Putative protein of unknown function |
YBR196C | 4.41 | 5.18E-6 | 0.70 | PGI1 | Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation |
YPR136C_d | 3.71 | 1.05E-4 | 0.47 | YPR136C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9 |
YBR029C | 3.24 | 5.95E-4 | 0.12 | CDS1 | Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids |
YGL047W | 3.13 | 8.86E-4 | 0.05 | ALG13 | Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress |
YLR147C | 3.07 | 0.00106 | 0.27 | SMD3 | Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 |
YOL040C | 2.81 | 0.00251 | 0.04 | RPS15 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 |
YBR190W_d | 2.77 | 0.00280 | 0.02 | YBR190W_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W |
YLR075W | 2.75 | 0.00296 | 0.05 | RPL10 | Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects |
YIL118W | 2.70 | 0.00343 | 0.10 | RHO3 | Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p |
YLR167W | 2.60 | 0.00463 | 0.05 | RPS31 | Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog |
YDL196W_d | 2.56 | 0.00528 | 0.04 | YDL196W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |
YGL169W | 2.51 | 0.00595 | 0.01 | SUA5 | Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family |
YLR198C_d | 2.51 | 0.00605 | 0.01 | YLR198C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W |
YIL021W | 2.50 | 0.00625 | 0.05 | RPB3 | RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit |