7254556

N-(3-carbamoyl-4,5-dimethylthiophen-2-yl)pyridine-4-carboxamide

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2206
Screen concentration 147.0 μM
Source Chembridge (Fragment library)
PubChem CID 4398905
SMILES CC1=C(SC(=C1C(=O)N)NC(=O)C2=CC=NC=C2)C
Standardized SMILES Cc1sc(NC(=O)c2ccncc2)c(C(=O)N)c1C
Molecular weight 275.3262
ALogP 0.88
H-bond donor count 2
H-bond acceptor count 4
Response signature 60S ribosome export

Pool Growth Kinetics
% growth inhibition (Het. pool) 11.1
% growth inhibition (Hom. pool) 3.4


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4398905
Download HIP data (tab-delimited text)  (excel)
Gene:ALG14(YBR070C)|FD-Score:3.63|P-value:1.43E-4|Clearance:0.13||SGD DESC:Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases Gene:DPM1(YPR183W)|FD-Score:3.11|P-value:9.47E-4|Clearance:0.26||SGD DESC:Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation Gene:IMP4(YNL075W)|FD-Score:-3.67|P-value:1.23E-4|Clearance:0||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs Gene:LSG1(YGL099W)|FD-Score:10.4|P-value:1.89E-25|Clearance:4.44||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:NAR1(YNL240C)|FD-Score:4.91|P-value:4.57E-7|Clearance:1.24||SGD DESC:Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf Gene:RPB8(YOR224C)|FD-Score:5.92|P-value:1.57E-9|Clearance:1.02||SGD DESC:RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III Gene:RPL32(YBL092W)|FD-Score:-3.35|P-value:4.09E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog Gene:RPO31(YOR116C)|FD-Score:3.5|P-value:2.34E-4|Clearance:0.39||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:TIM22(YDL217C)|FD-Score:3.66|P-value:1.24E-4|Clearance:0.04||SGD DESC:Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported Gene:YOR146W(YOR146W_d)|FD-Score:-3.24|P-value:5.94E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C Gene:ALG14(YBR070C)|FD-Score:3.63|P-value:1.43E-4|Clearance:0.13||SGD DESC:Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases Gene:DPM1(YPR183W)|FD-Score:3.11|P-value:9.47E-4|Clearance:0.26||SGD DESC:Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation Gene:IMP4(YNL075W)|FD-Score:-3.67|P-value:1.23E-4|Clearance:0||SGD DESC:Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs Gene:LSG1(YGL099W)|FD-Score:10.4|P-value:1.89E-25|Clearance:4.44||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:NAR1(YNL240C)|FD-Score:4.91|P-value:4.57E-7|Clearance:1.24||SGD DESC:Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf Gene:RPB8(YOR224C)|FD-Score:5.92|P-value:1.57E-9|Clearance:1.02||SGD DESC:RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III Gene:RPL32(YBL092W)|FD-Score:-3.35|P-value:4.09E-4|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog Gene:RPO31(YOR116C)|FD-Score:3.5|P-value:2.34E-4|Clearance:0.39||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:TIM22(YDL217C)|FD-Score:3.66|P-value:1.24E-4|Clearance:0.04||SGD DESC:Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported Gene:YOR146W(YOR146W_d)|FD-Score:-3.24|P-value:5.94E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4398905
Download HOP data (tab-delimited text)  (excel)
Gene:ARC1(YGL105W)|FD-Score:4.24|P-value:1.12E-5||SGD DESC:Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress Gene:BSC6(YOL137W)|FD-Score:3.13|P-value:8.71E-4||SGD DESC:Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression Gene:DCG1(YIR030C)|FD-Score:3.33|P-value:4.37E-4||SGD DESC:Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain Gene:DCN1(YLR128W)|FD-Score:3.39|P-value:3.55E-4||SGD DESC:Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation Gene:GAS1(YMR307W)|FD-Score:3.59|P-value:1.67E-4||SGD DESC:Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery Gene:KRE2(YDR483W)|FD-Score:4.42|P-value:5.03E-6||SGD DESC:Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication Gene:MTC3(YGL226W)|FD-Score:3.21|P-value:6.53E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 Gene:NOP16(YER002W)|FD-Score:-3.28|P-value:5.21E-4||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis Gene:PPT2(YPL148C)|FD-Score:3.22|P-value:6.49E-4||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:RDH54(YBR073W)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p Gene:SDC25(YLL016W)|FD-Score:4.1|P-value:2.06E-5||SGD DESC:Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Gene:UBP1(YDL122W)|FD-Score:3.15|P-value:8.10E-4||SGD DESC:Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains Gene:WSS1(YHR134W)|FD-Score:3.32|P-value:4.55E-4||SGD DESC:Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response Gene:YGR201C(YGR201C_p)|FD-Score:3.52|P-value:2.14E-4||SGD DESC:Putative protein of unknown function Gene:YMR247W-A(YMR247W-A_p)|FD-Score:3.28|P-value:5.13E-4||SGD DESC:Putative protein of unknown function Gene:ARC1(YGL105W)|FD-Score:4.24|P-value:1.12E-5||SGD DESC:Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress Gene:BSC6(YOL137W)|FD-Score:3.13|P-value:8.71E-4||SGD DESC:Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression Gene:DCG1(YIR030C)|FD-Score:3.33|P-value:4.37E-4||SGD DESC:Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain Gene:DCN1(YLR128W)|FD-Score:3.39|P-value:3.55E-4||SGD DESC:Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation Gene:GAS1(YMR307W)|FD-Score:3.59|P-value:1.67E-4||SGD DESC:Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery Gene:KRE2(YDR483W)|FD-Score:4.42|P-value:5.03E-6||SGD DESC:Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication Gene:MTC3(YGL226W)|FD-Score:3.21|P-value:6.53E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 Gene:NOP16(YER002W)|FD-Score:-3.28|P-value:5.21E-4||SGD DESC:Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis Gene:PPT2(YPL148C)|FD-Score:3.22|P-value:6.49E-4||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:RDH54(YBR073W)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p Gene:SDC25(YLL016W)|FD-Score:4.1|P-value:2.06E-5||SGD DESC:Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Gene:UBP1(YDL122W)|FD-Score:3.15|P-value:8.10E-4||SGD DESC:Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains Gene:WSS1(YHR134W)|FD-Score:3.32|P-value:4.55E-4||SGD DESC:Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response Gene:YGR201C(YGR201C_p)|FD-Score:3.52|P-value:2.14E-4||SGD DESC:Putative protein of unknown function Gene:YMR247W-A(YMR247W-A_p)|FD-Score:3.28|P-value:5.13E-4||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL099W10.401.89E-254.44LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YOR224C5.921.57E-91.02RPB8RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
YNL240C4.914.57E-71.24NAR1Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf
YDL217C3.661.24E-40.04TIM22Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
YBR070C3.631.43E-40.13ALG14Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
YOR116C3.502.34E-40.39RPO31RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
YPR183W3.119.47E-40.26DPM1Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
YDL016C_d2.850.002180.05YDL016C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication
YDL108W2.810.002520.09KIN28Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
YOL120C2.720.003270.10RPL18ARibosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
YER006W2.620.004450.00NUG1GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
YGL137W2.610.004516.23E-5SEC27Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
YDR473C2.610.004510.03PRP3Splicing factor, component of the U4/U6-U5 snRNP complex
YDR188W2.580.004890.16CCT6Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
YGR099W2.420.007730.01TEL2Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR483W4.425.03E-6KRE2Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication
YGL105W4.241.12E-5ARC1Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress
YLL016W4.102.06E-5SDC25Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
YBR073W3.691.12E-4RDH54DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p
YMR307W3.591.67E-4GAS1Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery
YGR201C_p3.522.14E-4YGR201C_pPutative protein of unknown function
YLR128W3.393.55E-4DCN1Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
YIR030C3.334.37E-4DCG1Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain
YHR134W3.324.55E-4WSS1Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response
YMR247W-A_p3.285.13E-4YMR247W-A_pPutative protein of unknown function
YPL148C3.226.49E-4PPT2Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation
YGL226W3.216.53E-4MTC3Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1
YDL122W3.158.10E-4UBP1Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
YOL137W3.138.71E-4BSC6Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YLR257W_p3.070.00106YLR257W_pProtein of unknown function; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_2206
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.3021.55E-124SGTC_618k072-0232 33.2 μMChemDiv (Drug-like library)58727560.10447860S ribosome export
0.2711.06E-99SGTC_7651319-0117 244.0 μMChemDiv (Drug-like library)34877460.14634160S ribosome export
0.2513.34E-85SGTC_1070indatraline 8.8 μMNIH Clinical Collection103144720.07812560S ribosome export
0.2214.92E-66SGTC_8103825-7150 143.0 μMChemDiv (Drug-like library)223304110.093333360S ribosome export
0.2172.05E-63SGTC_1775st081588 35.2 μMTimTec (Natural product derivative library)14264430.061728460S ribosome export
0.2148.97E-62SGTC_1958st076513 41.9 μMTimTec (Natural product derivative library)7321220.074626960S ribosome export
0.2101.26E-59SGTC_970535-0701 19.1 μMChemDiv (Drug-like library)28320130.068493260S ribosome export
0.1984.79E-53SGTC_623k072-0108 16.9 μMChemDiv (Drug-like library)53828030.183333heme biosynthesis & mitochondrial translocase
0.1912.47E-49SGTC_1522st012842 45.6 μMTimTec (Pure natural product library)34910670.0555556RNA pol III & RNase P/MRP
0.1845.06E-46SGTC_490717-0965 32.1 μMChemDiv (Drug-like library)58893490.098591660S ribosome export
0.1823.62E-45SGTC_9761348-1067 47.6 μMChemDiv (Drug-like library)53106710.089552260S ribosome export
0.1791.06E-43SGTC_403arphamenine a 50.0 μMMiscellaneous54871580.12676160S ribosome export
0.1786.99E-43SGTC_1971st069429 63.5 μMTimTec (Natural product derivative library)12465220.18181860S ribosome export
0.1736.22E-41SGTC_32809140961 49.5 μMChembridge (Drug-like library)49012260.0860S ribosome export
0.1694.10E-39SGTC_5794491-1009 110.0 μMChemDiv (Drug-like library)12710410.11111160S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3022908799349.47 μM0.51851917173644Chembridge (Drug-like library)351.422182.40224
SGTC_2217693479996.07 μM0.511111675606Chembridge (Fragment library)240.321941.49323TSC3-RPN4
SGTC_22186965428192.98 μM0.511111675684Chembridge (Fragment library)238.306061.12823TSC3-RPN4
SGTC_3025908789549.47 μM0.49122817173641Chembridge (Drug-like library)365.448762.88924PDR1
SGTC_2421569054390.72 μM0.4423083397993Chembridge (Fragment library)268.332040.70324
SGTC_3151909982149.47 μM0.39344317174189Chembridge (Drug-like library)329.416662.03624
SGTC_11770983-020423.6 μM0.377358766818ChemDiv (Drug-like library)318.369123.99613
SGTC_22857945142200 μM0.3773582970608Chembridge (Fragment library)247.273060.25224
SGTC_9861493-048384 μM0.37254940079ChemDiv (Drug-like library)256.256681.31914
SGTC_10553448-067286 μM0.372549748378ChemDiv (Drug-like library)302.369723.92412