7258803

N-(4-bromo-2-methoxyphenyl)acetamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2207
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 3666799
SMILES CC(=O)NC1=C(C=C(C=C1)Br)OC
Standardized SMILES COc1cc(Br)ccc1NC(=O)C
Molecular weight 244.0852
ALogP 1.68
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.2
% growth inhibition (Hom. pool) 4.56


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3666799
Download HIP data (tab-delimited text)  (excel)
Gene:BPL1(YDL141W)|FD-Score:3.34|P-value:4.15E-4|Clearance:0.16||SGD DESC:Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation Gene:IPI3(YNL182C)|FD-Score:3.12|P-value:8.90E-4|Clearance:0.19||SGD DESC:Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene Gene:NUP49(YGL172W)|FD-Score:3.18|P-value:7.42E-4|Clearance:0.05||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) Gene:NUP57(YGR119C)|FD-Score:5.15|P-value:1.27E-7|Clearance:1.81||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) Gene:BPL1(YDL141W)|FD-Score:3.34|P-value:4.15E-4|Clearance:0.16||SGD DESC:Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation Gene:IPI3(YNL182C)|FD-Score:3.12|P-value:8.90E-4|Clearance:0.19||SGD DESC:Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene Gene:NUP49(YGL172W)|FD-Score:3.18|P-value:7.42E-4|Clearance:0.05||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) Gene:NUP57(YGR119C)|FD-Score:5.15|P-value:1.27E-7|Clearance:1.81||SGD DESC:FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3666799
Download HOP data (tab-delimited text)  (excel)
Gene:ARF2(YDL137W)|FD-Score:3.38|P-value:3.61E-4||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication Gene:CCS1(YMR038C)|FD-Score:-3.4|P-value:3.36E-4||SGD DESC:Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress Gene:COG7(YGL005C)|FD-Score:4.29|P-value:9.06E-6||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:4.55|P-value:2.64E-6||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COX14(YML129C)|FD-Score:3.26|P-value:5.60E-4||SGD DESC:Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes Gene:FAU1(YER183C)|FD-Score:4.31|P-value:7.98E-6||SGD DESC:5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis Gene:FMS1(YMR020W)|FD-Score:3.63|P-value:1.42E-4||SGD DESC:Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis Gene:KEL1(YHR158C)|FD-Score:3.64|P-value:1.34E-4||SGD DESC:Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate Gene:LEO1(YOR123C)|FD-Score:3.32|P-value:4.54E-4||SGD DESC:Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:MHR1(YDR296W)|FD-Score:3.12|P-value:8.96E-4||SGD DESC:Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress Gene:MPD2(YOL088C)|FD-Score:5.22|P-value:9.12E-8||SGD DESC:Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p Gene:MTD1(YKR080W)|FD-Score:-3.92|P-value:4.42E-5||SGD DESC:NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline Gene:OPT1(YJL212C)|FD-Score:3.23|P-value:6.15E-4||SGD DESC:Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family Gene:PET20(YPL159C)|FD-Score:4.91|P-value:4.54E-7||SGD DESC:Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome Gene:POR1(YNL055C)|FD-Score:4.63|P-value:1.79E-6||SGD DESC:Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication Gene:QCR6(YFR033C)|FD-Score:3.35|P-value:4.05E-4||SGD DESC:Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space Gene:RPS8A(YBL072C)|FD-Score:3.21|P-value:6.52E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication Gene:RTT10(YPL183C)|FD-Score:3.24|P-value:5.89E-4||SGD DESC:WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6 Gene:SER33(YIL074C)|FD-Score:3.25|P-value:5.73E-4||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication Gene:SMA1(YPL027W)|FD-Score:3.11|P-value:9.31E-4||SGD DESC:Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p Gene:SOV1(YMR066W)|FD-Score:3.32|P-value:4.44E-4||SGD DESC:Mitochondrial protein of unknown function Gene:SRV2(YNL138W)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis Gene:TRM7(YBR061C)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively Gene:UBX4(YMR067C)|FD-Score:3.83|P-value:6.45E-5||SGD DESC:UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress Gene:YBL071C(YBL071C_d)|FD-Score:-3.23|P-value:6.23E-4||SGD DESC:Dubious open reading frame, predicted protein contains a peroxisomal targeting signal Gene:YBR292C(YBR292C_d)|FD-Score:3.14|P-value:8.38E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Gene:YIL002W-A(YIL002W-A_p)|FD-Score:3.36|P-value:3.84E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YLF2(YHL014C)|FD-Score:3.64|P-value:1.39E-4||SGD DESC:Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOR114W(YOR114W_p)|FD-Score:4.4|P-value:5.32E-6||SGD DESC:Putative protein of unknown function; null mutant is viable Gene:YPL191C(YPL191C_p)|FD-Score:-3.64|P-value:1.37E-4||SGD DESC:Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YSP1(YHR155W)|FD-Score:3.42|P-value:3.14E-4||SGD DESC:Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication Gene:ARF2(YDL137W)|FD-Score:3.38|P-value:3.61E-4||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication Gene:CCS1(YMR038C)|FD-Score:-3.4|P-value:3.36E-4||SGD DESC:Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress Gene:COG7(YGL005C)|FD-Score:4.29|P-value:9.06E-6||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:4.55|P-value:2.64E-6||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COX14(YML129C)|FD-Score:3.26|P-value:5.60E-4||SGD DESC:Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes Gene:FAU1(YER183C)|FD-Score:4.31|P-value:7.98E-6||SGD DESC:5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis Gene:FMS1(YMR020W)|FD-Score:3.63|P-value:1.42E-4||SGD DESC:Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis Gene:KEL1(YHR158C)|FD-Score:3.64|P-value:1.34E-4||SGD DESC:Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate Gene:LEO1(YOR123C)|FD-Score:3.32|P-value:4.54E-4||SGD DESC:Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:MHR1(YDR296W)|FD-Score:3.12|P-value:8.96E-4||SGD DESC:Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress Gene:MPD2(YOL088C)|FD-Score:5.22|P-value:9.12E-8||SGD DESC:Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p Gene:MTD1(YKR080W)|FD-Score:-3.92|P-value:4.42E-5||SGD DESC:NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline Gene:OPT1(YJL212C)|FD-Score:3.23|P-value:6.15E-4||SGD DESC:Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family Gene:PET20(YPL159C)|FD-Score:4.91|P-value:4.54E-7||SGD DESC:Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome Gene:POR1(YNL055C)|FD-Score:4.63|P-value:1.79E-6||SGD DESC:Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication Gene:QCR6(YFR033C)|FD-Score:3.35|P-value:4.05E-4||SGD DESC:Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space Gene:RPS8A(YBL072C)|FD-Score:3.21|P-value:6.52E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication Gene:RTT10(YPL183C)|FD-Score:3.24|P-value:5.89E-4||SGD DESC:WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6 Gene:SER33(YIL074C)|FD-Score:3.25|P-value:5.73E-4||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication Gene:SMA1(YPL027W)|FD-Score:3.11|P-value:9.31E-4||SGD DESC:Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p Gene:SOV1(YMR066W)|FD-Score:3.32|P-value:4.44E-4||SGD DESC:Mitochondrial protein of unknown function Gene:SRV2(YNL138W)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis Gene:TRM7(YBR061C)|FD-Score:3.43|P-value:2.98E-4||SGD DESC:2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively Gene:UBX4(YMR067C)|FD-Score:3.83|P-value:6.45E-5||SGD DESC:UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress Gene:YBL071C(YBL071C_d)|FD-Score:-3.23|P-value:6.23E-4||SGD DESC:Dubious open reading frame, predicted protein contains a peroxisomal targeting signal Gene:YBR292C(YBR292C_d)|FD-Score:3.14|P-value:8.38E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Gene:YIL002W-A(YIL002W-A_p)|FD-Score:3.36|P-value:3.84E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YLF2(YHL014C)|FD-Score:3.64|P-value:1.39E-4||SGD DESC:Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YOR114W(YOR114W_p)|FD-Score:4.4|P-value:5.32E-6||SGD DESC:Putative protein of unknown function; null mutant is viable Gene:YPL191C(YPL191C_p)|FD-Score:-3.64|P-value:1.37E-4||SGD DESC:Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YSP1(YHR155W)|FD-Score:3.42|P-value:3.14E-4||SGD DESC:Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGR119C5.151.27E-71.81NUP57FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)
YDL141W3.344.15E-40.17BPL1Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation
YGL172W3.187.42E-40.05NUP49FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)
YNL182C3.128.90E-40.19IPI3Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene
YPR144C2.940.001650.12NOC4Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
YOR116C2.820.002410.02RPO31RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
YLR163C2.800.002580.10MAS1Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YDL164C2.700.003450.01CDC9DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
YDL150W2.690.003560.03RPC53RNA polymerase III subunit C53
YBR167C2.660.003860.04POP7Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YJL091C2.630.004300.06GWT1Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
YLL004W2.560.005180.06ORC3Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
YJR002W2.510.006090.01MPP10Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
YKL152C2.500.006290.05GPM1Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YPR178W2.450.007160.01PRP4Splicing factor, component of the U4/U6-U5 snRNP complex

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOL088C5.229.12E-8MPD2Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p
YPL159C4.914.54E-7PET20Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome
YNL055C4.631.79E-6POR1Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication
YML071C4.552.64E-6COG8Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YOR114W_p4.405.32E-6YOR114W_pPutative protein of unknown function; null mutant is viable
YER183C4.317.98E-6FAU15,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
YGL005C4.299.06E-6COG7Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YMR067C3.836.45E-5UBX4UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
YHR158C3.641.34E-4KEL1Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate
YHL014C3.641.39E-4YLF2Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR020W3.631.42E-4FMS1Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
YNL138W3.492.43E-4SRV2CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis
YBR061C3.432.98E-4TRM72'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively
YHR155W3.423.14E-4YSP1Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
YDL137W3.383.61E-4ARF2ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication

GO enrichment analysis for SGTC_2207
No biological processes are significantly enriched (FDR < 0.1).

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1353.72E-25SGTC_608k048-0125 159.0 μMChemDiv (Drug-like library)68176520.327273
0.1234.06E-21SGTC_624k048-0052 28.0 μMChemDiv (Drug-like library)68355310.183333Golgi
0.1164.23E-19SGTC_712r015-0009 80.6 μMChemDiv (Drug-like library)68138720.176471
0.1165.46E-19SGTC_3660181-0206 4.3 μMChemDiv (Drug-like library)2748740.236842Golgi
0.1156.53E-19SGTC_6320781-2353 4.7 μMChemDiv (Drug-like library)68115150.084507Golgi
0.1111.36E-17SGTC_1783st039459 87.5 μMTimTec (Natural product derivative library)7297610.0909091Golgi
0.1071.65E-16SGTC_13061185-0270 9.0 μMChemDiv (Drug-like library)15480760.0517241Golgi
0.1071.85E-16SGTC_1162k048-0130 20.1 μMChemDiv (Drug-like library)67974060.125Golgi
0.1072.13E-16SGTC_2234tolnaftate 200.0 μMMiscellaneous55100.118644
0.1025.60E-15SGTC_1039k821-0043 94.0 μMChemDiv (Drug-like library)159927680.142857Golgi
0.0961.36E-13SGTC_1139k015-0024 46.9 μMChemDiv (Drug-like library)27666520.0819672PDR1
0.0961.68E-13SGTC_31539100258 49.5 μMChembridge (Drug-like library)252368480.131148
0.0962.01E-13SGTC_2770toltrazuril 17.5 μMMiscellaneous685910.115942
0.0952.84E-13SGTC_2766oltipraz 83.9 μMMiscellaneous473180.0555556heme requiring
0.0953.01E-13SGTC_1689st020265 53.5 μMTimTec (Natural product derivative library)57583200.0588235

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2905779906520.05 μM0.5348841296806Chembridge (Drug-like library)420.085324.56723
SGTC_12520493-087534.8 μM0.3695653960963ChemDiv (Drug-like library)501.374544.55424
SGTC_8261683-5028118 μM0.361702722377ChemDiv (Drug-like library)261.703583.26212
SGTC_2845900302442.97 μM0.362990173Chembridge (Drug-like library)348.191263.13713amide catabolism
SGTC_8971000-013931.4 μM0.3555566151020ChemDiv (Drug-like library)220.224580.54923
SGTC_2246729350791.56 μM0.355556887656Chembridge (Fragment library)244.245980.99413
SGTC_1090132-003633.7 μM0.35416767274ChemDiv (Drug-like library)293.31663.26423
SGTC_12201838-0075193 μM0.3518525529645ChemDiv (Drug-like library)379.20533.15625
SGTC_20535265679138 μM0.347826764595Chembridge (Fragment library)233.286242.55113
SGTC_1035k081-004155.2 μM0.346154731709ChemDiv (Drug-like library)341.58772.8613Golgi