| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YOL088C | 5.22 | 9.12E-8 | MPD2 | Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p |
| YPL159C | 4.91 | 4.54E-7 | PET20 | Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome |
| YNL055C | 4.63 | 1.79E-6 | POR1 | Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication |
| YML071C | 4.55 | 2.64E-6 | COG8 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
| YOR114W_p | 4.40 | 5.32E-6 | YOR114W_p | Putative protein of unknown function; null mutant is viable |
| YER183C | 4.31 | 7.98E-6 | FAU1 | 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis |
| YGL005C | 4.29 | 9.06E-6 | COG7 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
| YMR067C | 3.83 | 6.45E-5 | UBX4 | UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress |
| YHR158C | 3.64 | 1.34E-4 | KEL1 | Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate |
| YHL014C | 3.64 | 1.39E-4 | YLF2 | Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| YMR020W | 3.63 | 1.42E-4 | FMS1 | Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis |
| YNL138W | 3.49 | 2.43E-4 | SRV2 | CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis |
| YBR061C | 3.43 | 2.98E-4 | TRM7 | 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively |
| YHR155W | 3.42 | 3.14E-4 | YSP1 | Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication |
| YDL137W | 3.38 | 3.61E-4 | ARF2 | ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication |
