| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YER181C_d | 5.62 | 9.79E-9 | YER181C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies |
| YML034C-A_d | 4.86 | 5.89E-7 | YML034C-A_d | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YOR025W | 4.16 | 1.61E-5 | HST3 | Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism |
| YCR023C | 3.93 | 4.20E-5 | YCR023C | Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene |
| YBR227C | 3.70 | 1.08E-4 | MCX1 | Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins |
| YCR064C_d | 3.63 | 1.44E-4 | YCR064C_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 |
| YDR432W | 3.40 | 3.38E-4 | NPL3 | RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress |
| YDR500C | 3.14 | 8.45E-4 | RPL37B | Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication |
| YCL011C | 3.13 | 8.61E-4 | GBP2 | Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication |
| YBR008C | 3.10 | 9.78E-4 | FLR1 | Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress |
| YCR077C | 3.05 | 0.00116 | PAT1 | Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress |
| YOR293W | 3.02 | 0.00128 | RPS10A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication |
| YKR094C | 3.01 | 0.00132 | RPL40B | Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication |
| YLL044W_d | 3.00 | 0.00133 | YLL044W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant |
| YNL307C | 2.99 | 0.00137 | MCK1 | Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family |
