7123476

2-propan-2-yl-1H-quinazoline-4-thione

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2212
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 1085715
SMILES CC(C)C1=NC(=S)C2=CC=CC=C2N1
Standardized SMILES CC(C)c1nc(S)c2ccccc2n1
Molecular weight 204.2914
ALogP 2.86
H-bond donor count 1
H-bond acceptor count 1
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 8.97
% growth inhibition (Hom. pool) 7.85


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 1085715
Download HIP data (tab-delimited text)  (excel)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 1085715
Download HOP data (tab-delimited text)  (excel)
Gene:FLR1(YBR008C)|FD-Score:3.1|P-value:9.78E-4||SGD DESC:Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:GBP2(YCL011C)|FD-Score:3.13|P-value:8.61E-4||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication Gene:GTO3(YMR251W)|FD-Score:-3.36|P-value:3.93E-4||SGD DESC:Omega class glutathione transferase; putative cytosolic localization Gene:HST3(YOR025W)|FD-Score:4.16|P-value:1.61E-5||SGD DESC:Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism Gene:MCX1(YBR227C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins Gene:NPL3(YDR432W)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress Gene:RPL37B(YDR500C)|FD-Score:3.14|P-value:8.45E-4||SGD DESC:Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication Gene:YCR023C(YCR023C)|FD-Score:3.93|P-value:4.20E-5||SGD DESC:Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene Gene:YCR064C(YCR064C_d)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 Gene:YER181C(YER181C_d)|FD-Score:5.62|P-value:9.79E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies Gene:YIL166C(YIL166C_p)|FD-Score:-3.37|P-value:3.73E-4||SGD DESC:Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene Gene:YML034C-A(YML034C-A_d)|FD-Score:4.86|P-value:5.89E-7||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:FLR1(YBR008C)|FD-Score:3.1|P-value:9.78E-4||SGD DESC:Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:GBP2(YCL011C)|FD-Score:3.13|P-value:8.61E-4||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication Gene:GTO3(YMR251W)|FD-Score:-3.36|P-value:3.93E-4||SGD DESC:Omega class glutathione transferase; putative cytosolic localization Gene:HST3(YOR025W)|FD-Score:4.16|P-value:1.61E-5||SGD DESC:Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism Gene:MCX1(YBR227C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins Gene:NPL3(YDR432W)|FD-Score:3.4|P-value:3.38E-4||SGD DESC:RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress Gene:RPL37B(YDR500C)|FD-Score:3.14|P-value:8.45E-4||SGD DESC:Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication Gene:YCR023C(YCR023C)|FD-Score:3.93|P-value:4.20E-5||SGD DESC:Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene Gene:YCR064C(YCR064C_d)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 Gene:YER181C(YER181C_d)|FD-Score:5.62|P-value:9.79E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies Gene:YIL166C(YIL166C_p)|FD-Score:-3.37|P-value:3.73E-4||SGD DESC:Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene Gene:YML034C-A(YML034C-A_d)|FD-Score:4.86|P-value:5.89E-7||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR347C3.492.44E-40.46KAP95Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p
YOR341W3.070.001070.46RPA190RNA polymerase I largest subunit A190
YMR001C2.610.004550.16CDC5Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate
YJR141W_p2.440.007250.13YJR141W_pEssential protein of unknown function
YJL085W2.310.010300.04EXO70Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
YJL061W2.280.011300.03NUP82Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)
YDR141C2.250.012300.03DOP1Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies
YOL127W2.220.013300.02RPL25Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
YPL237W2.200.013900.00SUI3Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
YDL017W2.200.014000.01CDC7DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p
YPR178W2.190.014200.03PRP4Splicing factor, component of the U4/U6-U5 snRNP complex
YER126C2.160.015300.01NSA2Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
YMR227C2.150.015803.68E-4TAF7TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YNL222W2.150.015800.06SSU72Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo
YOR336W2.090.018300.00KRE5Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YER181C_d5.629.79E-9YER181C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies
YML034C-A_d4.865.89E-7YML034C-A_dDubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR025W4.161.61E-5HST3Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YCR023C3.934.20E-5YCR023CVacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
YBR227C3.701.08E-4MCX1Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins
YCR064C_d3.631.44E-4YCR064C_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
YDR432W3.403.38E-4NPL3RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress
YDR500C3.148.45E-4RPL37BRibosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
YCL011C3.138.61E-4GBP2Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication
YBR008C3.109.78E-4FLR1Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress
YCR077C3.050.00116PAT1Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
YOR293W3.020.00128RPS10AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
YKR094C3.010.00132RPL40BUbiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication
YLL044W_d3.000.00133YLL044W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant
YNL307C2.990.00137MCK1Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family

GO enrichment analysis for SGTC_2212
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1133.39E-18SGTC_165k038-0023 64.4 μMChemDiv (Drug-like library)463685430.0615385ubiquinone biosynthesis & proteasome
0.1024.38E-15SGTC_15024534-4282 27.7 μMChemDiv (Drug-like library)32789490.09375
0.0858.16E-11SGTC_21925915882 198.5 μMChembridge (Fragment library)28761490.0909091RNA processing & uracil transport
0.0841.17E-10SGTC_13792144-0755 36.5 μMChemDiv (Drug-like library)53923270.0757576
0.0815.07E-10SGTC_9403232-1287 54.8 μMChemDiv (Drug-like library)15854930.0833333NEO1
0.0758.86E-9SGTC_30559094636 49.5 μMChembridge (Drug-like library)252361760.0923077
0.0664.48E-7SGTC_30039075612 71.4 μMChembridge (Drug-like library)65019930.0895522
0.0656.86E-7SGTC_3773970-0964 33.1 μMChemDiv (Drug-like library)164812350.0810811
0.0649.44E-7SGTC_33379144342 33.5 μMChembridge (Drug-like library)176829490.0909091
0.0621.83E-6SGTC_28639028737 58.4 μMChembridge (Drug-like library)64609170.0895522
0.0622.19E-6SGTC_2670beta-carotene 100.0 μMMicrosource (Natural product library)52804890.0338983
0.0604.86E-6SGTC_2676harmalol 100.0 μMMicrosource (Natural product library)54591870.0877193mitochondrial processes
0.0595.22E-6SGTC_29077721985 69.9 μMChembridge (Drug-like library)32678810.0945946
0.0595.44E-6SGTC_20765212012 200.0 μMChembridge (Fragment library)6048020.0909091
0.0571.22E-5SGTC_8460335-0850 148.0 μMChemDiv (Drug-like library)68195980.0847458ubiquinone biosynthesis & proteasome

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_22297354935190 μM0.311111318112Chembridge (Fragment library)237.256641.74722RSC complex & mRNA processing
SGTC_21685727979200 μM0.295455695210Chembridge (Fragment library)206.26422.23603
SGTC_3252913587149.47 μM0.28846217682838Chembridge (Drug-like library)245.27711.51122
SGTC_21775811945192 μM0.2708335343475Chembridge (Fragment library)201.224540.91212
SGTC_21785812956200 μM0.2653065403383Chembridge (Fragment library)215.251121.49212
SGTC_1678st01926580.2 μM0.2553195367020TimTec (Natural product derivative library)249.264043.6080360S ribosome export
SGTC_13853091-483414.1 μM0.2549024072814ChemDiv (Drug-like library)252.267982.99213RPP1 & pyrimidine depletion
SGTC_1037k284-109178.7 μM0.253334711ChemDiv (Drug-like library)285.3392833.98522
SGTC_1505k297-003720.6 μM0.254089396ChemDiv (Drug-like library)301.793884.44421
SGTC_1467k284-1082293 μM0.2452833334705ChemDiv (Drug-like library)273.376543.5222