| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YDR173C | 4.50 | 3.42E-6 | ARG82 | Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes |
| YDR017C | 4.44 | 4.60E-6 | KCS1 | Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance |
| YHR143W | 3.94 | 4.03E-5 | DSE2 | Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP |
| YIL074C | 3.79 | 7.49E-5 | SER33 | 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication |
| YJL122W | 3.49 | 2.40E-4 | ALB1 | Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p |
| YKR104W | 3.43 | 3.01E-4 | YKR104W | Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds |
| YLR280C_d | 3.42 | 3.16E-4 | YLR280C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YDR525W-A | 3.31 | 4.69E-4 | SNA2 | Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
| YKL164C | 3.28 | 5.13E-4 | PIR1 | O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication |
| YDR100W | 3.28 | 5.20E-4 | TVP15 | Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p |
| YBR018C | 3.22 | 6.33E-4 | GAL7 | Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism |
| YBL047C | 3.10 | 9.58E-4 | EDE1 | Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death |
| YLR335W | 3.10 | 9.80E-4 | NUP2 | Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization |
| YGR235C | 3.05 | 0.00113 | MOS2 | Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture |
| YPR067W | 3.04 | 0.00117 | ISA2 | Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations |
