7189485

5,6-dimethyl-3-(2-oxopropyl)thieno[2,3-d]pyrimidin-4-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2216
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 731273
SMILES CC1=C(SC2=C1C(=O)N(C=N2)CC(=O)C)C
Standardized SMILES CC(=O)CN1C=Nc2sc(C)c(C)c2C1=O
Molecular weight 236.2902
ALogP 0.96
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 8.16
% growth inhibition (Hom. pool) 3.48


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 731273
Download HIP data (tab-delimited text)  (excel)
Gene:ALA1(YOR335C)|FD-Score:4.38|P-value:5.81E-6|Clearance:0.7||SGD DESC:Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog Gene:FAS1(YKL182W)|FD-Score:3.55|P-value:1.90E-4|Clearance:0.51||SGD DESC:Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities Gene:LSM4(YER112W)|FD-Score:-3.51|P-value:2.22E-4|Clearance:0||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress Gene:RPB8(YOR224C)|FD-Score:5.38|P-value:3.74E-8|Clearance:0.99||SGD DESC:RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III Gene:RPN3(YER021W)|FD-Score:-3.43|P-value:2.98E-4|Clearance:0||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control Gene:TRE2(YOR256C)|FD-Score:3.62|P-value:1.46E-4|Clearance:0.07||SGD DESC:Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication Gene:YDR396W(YDR396W_d)|FD-Score:3.69|P-value:1.13E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex Gene:YRA1(YDR381W)|FD-Score:-3.11|P-value:9.43E-4|Clearance:0||SGD DESC:RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member Gene:ALA1(YOR335C)|FD-Score:4.38|P-value:5.81E-6|Clearance:0.7||SGD DESC:Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog Gene:FAS1(YKL182W)|FD-Score:3.55|P-value:1.90E-4|Clearance:0.51||SGD DESC:Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities Gene:LSM4(YER112W)|FD-Score:-3.51|P-value:2.22E-4|Clearance:0||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress Gene:RPB8(YOR224C)|FD-Score:5.38|P-value:3.74E-8|Clearance:0.99||SGD DESC:RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III Gene:RPN3(YER021W)|FD-Score:-3.43|P-value:2.98E-4|Clearance:0||SGD DESC:Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control Gene:TRE2(YOR256C)|FD-Score:3.62|P-value:1.46E-4|Clearance:0.07||SGD DESC:Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication Gene:YDR396W(YDR396W_d)|FD-Score:3.69|P-value:1.13E-4|Clearance:0.07||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex Gene:YRA1(YDR381W)|FD-Score:-3.11|P-value:9.43E-4|Clearance:0||SGD DESC:RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 731273
Download HOP data (tab-delimited text)  (excel)
Gene:ALB1(YJL122W)|FD-Score:3.49|P-value:2.40E-4||SGD DESC:Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p Gene:ARG82(YDR173C)|FD-Score:4.5|P-value:3.42E-6||SGD DESC:Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes Gene:DSE2(YHR143W)|FD-Score:3.94|P-value:4.03E-5||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:EDE1(YBL047C)|FD-Score:3.1|P-value:9.58E-4||SGD DESC:Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death Gene:GAL7(YBR018C)|FD-Score:3.22|P-value:6.33E-4||SGD DESC:Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism Gene:KCS1(YDR017C)|FD-Score:4.44|P-value:4.60E-6||SGD DESC:Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance Gene:NUP2(YLR335W)|FD-Score:3.1|P-value:9.80E-4||SGD DESC:Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization Gene:PIR1(YKL164C)|FD-Score:3.28|P-value:5.13E-4||SGD DESC:O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication Gene:SER33(YIL074C)|FD-Score:3.79|P-value:7.49E-5||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication Gene:SIP5(YMR140W)|FD-Score:-3.2|P-value:6.79E-4||SGD DESC:Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress Gene:SNA2(YDR525W-A)|FD-Score:3.31|P-value:4.69E-4||SGD DESC:Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:TVP15(YDR100W)|FD-Score:3.28|P-value:5.20E-4||SGD DESC:Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p Gene:WSS1(YHR134W)|FD-Score:-3.11|P-value:9.34E-4||SGD DESC:Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response Gene:YKR104W(YKR104W)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YLR280C(YLR280C_d)|FD-Score:3.42|P-value:3.16E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:ALB1(YJL122W)|FD-Score:3.49|P-value:2.40E-4||SGD DESC:Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p Gene:ARG82(YDR173C)|FD-Score:4.5|P-value:3.42E-6||SGD DESC:Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes Gene:DSE2(YHR143W)|FD-Score:3.94|P-value:4.03E-5||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:EDE1(YBL047C)|FD-Score:3.1|P-value:9.58E-4||SGD DESC:Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death Gene:GAL7(YBR018C)|FD-Score:3.22|P-value:6.33E-4||SGD DESC:Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism Gene:KCS1(YDR017C)|FD-Score:4.44|P-value:4.60E-6||SGD DESC:Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance Gene:NUP2(YLR335W)|FD-Score:3.1|P-value:9.80E-4||SGD DESC:Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization Gene:PIR1(YKL164C)|FD-Score:3.28|P-value:5.13E-4||SGD DESC:O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication Gene:SER33(YIL074C)|FD-Score:3.79|P-value:7.49E-5||SGD DESC:3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication Gene:SIP5(YMR140W)|FD-Score:-3.2|P-value:6.79E-4||SGD DESC:Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress Gene:SNA2(YDR525W-A)|FD-Score:3.31|P-value:4.69E-4||SGD DESC:Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:TVP15(YDR100W)|FD-Score:3.28|P-value:5.20E-4||SGD DESC:Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p Gene:WSS1(YHR134W)|FD-Score:-3.11|P-value:9.34E-4||SGD DESC:Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response Gene:YKR104W(YKR104W)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YLR280C(YLR280C_d)|FD-Score:3.42|P-value:3.16E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOR224C5.383.74E-80.99RPB8RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
YOR335C4.385.81E-60.70ALA1Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
YDR396W_d3.691.13E-40.07YDR396W_dDubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex
YOR256C3.621.46E-40.07TRE2Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication
YKL182W3.551.90E-40.51FAS1Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YNL244C3.040.001180.03SUI1Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
YOR272W3.010.001310.10YTM1Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
YML130C2.910.001830.01ERO1Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
YFL039C2.890.001910.04ACT1Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YGR099W2.850.002170.03TEL2Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
YDL163W_d2.820.002380.02YDL163W_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase
YFL022C2.810.002500.07FRS2Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YML126C2.740.003100.04ERG133-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
YFL045C2.700.003500.02SEC53Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
YPR113W2.670.003760.01PIS1Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR173C4.503.42E-6ARG82Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
YDR017C4.444.60E-6KCS1Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
YHR143W3.944.03E-5DSE2Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YIL074C3.797.49E-5SER333-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication
YJL122W3.492.40E-4ALB1Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
YKR104W3.433.01E-4YKR104WPutative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds
YLR280C_d3.423.16E-4YLR280C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR525W-A3.314.69E-4SNA2Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKL164C3.285.13E-4PIR1O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
YDR100W3.285.20E-4TVP15Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
YBR018C3.226.33E-4GAL7Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
YBL047C3.109.58E-4EDE1Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death
YLR335W3.109.80E-4NUP2Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
YGR235C3.050.00113MOS2Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
YPR067W3.040.00117ISA2Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations

GO enrichment analysis for SGTC_2216
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1631.87E-36SGTC_2261,3-diallylurea 8.3 mMMiscellaneous745370.0851064
0.1578.20E-34SGTC_2234tolnaftate 200.0 μMMiscellaneous55100.0746269
0.0773.62E-9SGTC_2606farnesol 9.8 μMMicrosource (Natural product library)4450700.0769231
0.0741.02E-8SGTC_2417cerulenin 830.0 nMICCB bioactive library52820540.0806452
0.0714.59E-8SGTC_1817st052116 64.4 μMTimTec (Natural product derivative library)43613980.119403RNA processing & uracil transport
0.0706.40E-8SGTC_326k292-0812 17.5 μMChemDiv (Drug-like library)35793570.155844
0.0603.92E-6SGTC_597k018-0003 82.8 μMChemDiv (Drug-like library)67862340.197368RNA pol III & RNase P/MRP
0.0603.98E-6SGTC_29969066192 71.4 μMChembridge (Drug-like library)64728540.0857143
0.0588.70E-6SGTC_31239126162 49.5 μMChembridge (Drug-like library)252398840.0921053
0.0571.23E-5SGTC_22067254556 147.0 μMChembridge (Fragment library)43989050.22413860S ribosome export
0.0561.99E-5SGTC_23939031399 185.9 μMChembridge (Fragment library)15266230.116667RNA processing & uracil transport
0.0552.45E-5SGTC_9521185-0122 232.0 μMChemDiv (Drug-like library)6786000.0967742
0.0552.77E-5SGTC_477mead ethanolamide 10.0 μMICCB bioactive library160611850.078125
0.0526.41E-5SGTC_1105epirubicin 18.1 μMNIH Clinical Collection653480.0918367anthracycline transcription coupled DNA repair
0.0527.37E-5SGTC_2525harmine 47.9 μMMiscellaneous52809530.0793651ergosterol biosynthesis

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1039k821-004394 μM0.40983615992768ChemDiv (Drug-like library)347.819263.31814Golgi
SGTC_14123909-8563178 μM0.38571423767530ChemDiv (Drug-like library)449.525422.45416
SGTC_2083530604665.94 μM0.235294539837Chembridge (Fragment library)194.25351.24713
SGTC_5931203-021861.7 μM0.2321433666956ChemDiv (Drug-like library)244.33213.65302
SGTC_22067254556146.97 μM0.2241384398905Chembridge (Fragment library)275.326220.8842460S ribosome export
SGTC_2217693479996.07 μM0.218182675606Chembridge (Fragment library)240.321941.49323TSC3-RPN4
SGTC_13201313-048195.3 μM0.2162166813365ChemDiv (Drug-like library)355.410881.78216
SGTC_10074101-003170 μM0.2131151146276ChemDiv (Drug-like library)424.4249431.55525
SGTC_597k018-000382.8 μM0.1973686786234ChemDiv (Drug-like library)370.382461.83717RNA pol III & RNase P/MRP
SGTC_22186965428192.98 μM0.196429675684Chembridge (Fragment library)238.306061.12823TSC3-RPN4