6807166

[4-(2-fluorophenyl)piperazin-1-yl]-(furan-2-yl)methanone

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2221
Screen concentration 181.1 μM
Source Chembridge (Fragment library)
PubChem CID 674925
SMILES C1CN(CCN1C2=CC=CC=C2F)C(=O)C3=CC=CO3
Standardized SMILES Fc1ccccc1N2CCN(CC2)C(=O)c3occc3
Molecular weight 274.2902
ALogP 2.47
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 8.52
% growth inhibition (Hom. pool) 7.86


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 674925
Download HIP data (tab-delimited text)  (excel)
Gene:ABF1(YKL112W)|FD-Score:4.17|P-value:1.49E-5|Clearance:0.82||SGD DESC:DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair Gene:CCT6(YDR188W)|FD-Score:-3.65|P-value:1.30E-4|Clearance:0||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif Gene:YBL077W(YBL077W_d)|FD-Score:3.88|P-value:5.25E-5|Clearance:0.82||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C Gene:ABF1(YKL112W)|FD-Score:4.17|P-value:1.49E-5|Clearance:0.82||SGD DESC:DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair Gene:CCT6(YDR188W)|FD-Score:-3.65|P-value:1.30E-4|Clearance:0||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif Gene:YBL077W(YBL077W_d)|FD-Score:3.88|P-value:5.25E-5|Clearance:0.82||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 674925
Download HOP data (tab-delimited text)  (excel)
Gene:ATG11(YPR049C)|FD-Score:-3.68|P-value:1.15E-4||SGD DESC:Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) Gene:CDC73(YLR418C)|FD-Score:4.52|P-value:3.17E-6||SGD DESC:Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress Gene:CDH1(YGL003C)|FD-Score:3.81|P-value:6.82E-5||SGD DESC:Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p Gene:CUR1(YPR158W)|FD-Score:4.01|P-value:3.03E-5||SGD DESC:Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication Gene:DOT6(YER088C)|FD-Score:4.54|P-value:2.81E-6||SGD DESC:Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:ERS1(YCR075C)|FD-Score:3.19|P-value:7.17E-4||SGD DESC:Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains Gene:RCY1(YJL204C)|FD-Score:-4.06|P-value:2.43E-5||SGD DESC:F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth Gene:RIM8(YGL045W)|FD-Score:3.45|P-value:2.83E-4||SGD DESC:Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family Gene:RPL34B(YIL052C)|FD-Score:4.09|P-value:2.13E-5||SGD DESC:Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:-5.04|P-value:2.33E-7||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:SAP30(YMR263W)|FD-Score:4.09|P-value:2.16E-5||SGD DESC:Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance Gene:YDR008C(YDR008C_d)|FD-Score:3.17|P-value:7.71E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR093W(YGR093W_p)|FD-Score:3.24|P-value:5.88E-4||SGD DESC:Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:YIR016W(YIR016W_p)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication Gene:YOR015W(YOR015W_d)|FD-Score:3.31|P-value:4.70E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR172W(YPR172W_p)|FD-Score:3.86|P-value:5.74E-5||SGD DESC:Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication Gene:ATG11(YPR049C)|FD-Score:-3.68|P-value:1.15E-4||SGD DESC:Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) Gene:CDC73(YLR418C)|FD-Score:4.52|P-value:3.17E-6||SGD DESC:Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress Gene:CDH1(YGL003C)|FD-Score:3.81|P-value:6.82E-5||SGD DESC:Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p Gene:CUR1(YPR158W)|FD-Score:4.01|P-value:3.03E-5||SGD DESC:Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication Gene:DOT6(YER088C)|FD-Score:4.54|P-value:2.81E-6||SGD DESC:Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:ERS1(YCR075C)|FD-Score:3.19|P-value:7.17E-4||SGD DESC:Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains Gene:RCY1(YJL204C)|FD-Score:-4.06|P-value:2.43E-5||SGD DESC:F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth Gene:RIM8(YGL045W)|FD-Score:3.45|P-value:2.83E-4||SGD DESC:Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family Gene:RPL34B(YIL052C)|FD-Score:4.09|P-value:2.13E-5||SGD DESC:Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:-5.04|P-value:2.33E-7||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:SAP30(YMR263W)|FD-Score:4.09|P-value:2.16E-5||SGD DESC:Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance Gene:YDR008C(YDR008C_d)|FD-Score:3.17|P-value:7.71E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR093W(YGR093W_p)|FD-Score:3.24|P-value:5.88E-4||SGD DESC:Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:YIR016W(YIR016W_p)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication Gene:YOR015W(YOR015W_d)|FD-Score:3.31|P-value:4.70E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR172W(YPR172W_p)|FD-Score:3.86|P-value:5.74E-5||SGD DESC:Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKL112W4.171.49E-50.82ABF1DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair
YBL077W_d3.885.25E-50.82YBL077W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YFL024C3.060.001100.31EPL1Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
YPL094C2.750.002940.12SEC62Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YHR072W2.640.004200.04ERG7Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
YLR002C2.600.004670.10NOC3Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing
YDR381W2.490.006300.00YRA1RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
YLR132C2.490.006380.10USB1Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants
YOR148C2.390.008460.05SPP2Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
YHR065C2.340.009650.00RRP3Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
YNL222W2.340.009690.00SSU72Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo
YGR113W2.340.009760.01DAM1Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments
YCL031C2.330.009930.02RRP7Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress
YPR161C2.310.010400.04SGV1Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins
YFL017W-A2.270.011500.01SMX2Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YER088C4.542.81E-6DOT6Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
YLR418C4.523.17E-6CDC73Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress
YIL052C4.092.13E-5RPL34BRibosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
YMR263W4.092.16E-5SAP30Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
YPR158W4.013.03E-5CUR1Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication
YPR172W_p3.865.74E-5YPR172W_pPutative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication
YGL003C3.816.82E-5CDH1Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p
YIR016W_p3.551.92E-4YIR016W_pPutative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication
YGL045W3.452.83E-4RIM8Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
YOR015W_d3.314.70E-4YOR015W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR093W_p3.245.88E-4YGR093W_pPutative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YCR075C3.197.17E-4ERS1Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
YDR008C_d3.177.71E-4YDR008C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR108W3.020.00126GGA2Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
YCL001W2.940.00164RER1Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER

GO enrichment analysis for SGTC_2221
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1157.98E-19SGTC_8910929-0073 133.0 μMChemDiv (Drug-like library)56036320.0923077
0.1133.48E-18SGTC_22016605497 169.9 μMChembridge (Fragment library)6707410.346939ergosterol biosynthesis
0.1126.40E-18SGTC_32549136651 49.5 μMChembridge (Drug-like library)164540300.05DNA damage response
0.1016.92E-15SGTC_420mitomycin C 81.9 mMMiscellaneous57460.0740741
0.0992.03E-14SGTC_9231900-2434 73.3 μMChemDiv (Drug-like library)59105700.0789474RNA processing & uracil transport
0.0912.63E-12SGTC_5423381-0244 89.3 μMChemDiv (Drug-like library)11128430.234375
0.0912.67E-12SGTC_9031134-0042 114.0 μMChemDiv (Drug-like library)7010090.105263
0.0904.73E-12SGTC_2551apiole 73.9 μMMicrosource (Natural product library)106590.0615385
0.0871.91E-11SGTC_23779073351 62.6 μMChembridge (Fragment library)73379460.263158ergosterol biosynthesis
0.0872.16E-11SGTC_415dibenzyl ketone 100.0 μMMiscellaneous75930.177778
0.0864.01E-11SGTC_1562morin hydrate 59.1 μMTimTec (Pure natural product library)185421360.078125
0.0856.68E-11SGTC_398bronopol 33.3 μMMiscellaneous24500.0192308RNA processing & uracil transport
0.0841.09E-10SGTC_1135dihydrocapsaicin 536.7 nMTimTec (Natural product library)1079820.0821918
0.0841.10E-10SGTC_2741miltefosine 3.0 μMMiscellaneous35990.015873
0.0814.26E-10SGTC_22236903751 107.6 μMChembridge (Fragment library)55988630.222222superoxide

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_21645685496200 μM0.586957759046Chembridge (Fragment library)257.28781.65704
SGTC_2045510665278.05 μM0.5673349Chembridge (Fragment library)213.231942.2902
SGTC_3046909221249.47 μM0.425236637Chembridge (Drug-like library)328.3806433.404
SGTC_10174239-0030168 μM0.3859651149593ChemDiv (Drug-like library)406.2919433.78814
SGTC_3143908665849.47 μM0.38461525236626Chembridge (Drug-like library)300.41853.45803
SGTC_3036909018149.47 μM0.3703725236586Chembridge (Drug-like library)314.445083.65303
SGTC_3149909785549.47 μM0.3703725236625Chembridge (Drug-like library)365.287983.88103Golgi
SGTC_22887946289167.31 μM0.3636361246052Chembridge (Fragment library)271.314381.80204
SGTC_22016605497169.86 μM0.346939670741Chembridge (Fragment library)232.32142.18102ergosterol biosynthesis
SGTC_3056909490049.47 μM0.34482825236784Chembridge (Drug-like library)342.4072233.88404