6885208

5,5-dimethylspiro[1,3-dioxane-2,3'-1H-indole]-2'-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2222
Screen concentration 172.1 μM
Source Chembridge (Fragment library)
PubChem CID 609514
SMILES CC1(COC2(C3=CC=CC=C3NC2=O)OC1)C
Standardized SMILES CC1(C)COC2(OC1)C(=O)Nc3ccccc23
Molecular weight 233.2631
ALogP 1.43
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.84
% growth inhibition (Hom. pool) 7.86


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 609514
Download HIP data (tab-delimited text)  (excel)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 609514
Download HOP data (tab-delimited text)  (excel)
Gene:FMP23(YBR047W_p)|FD-Score:4.26|P-value:1.02E-5||SGD DESC:Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MAC1(YMR021C)|FD-Score:3.82|P-value:6.77E-5||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MF(ALPHA)1(YPL187W)|FD-Score:-3.26|P-value:5.57E-4||SGD DESC:Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor Gene:MSC6(YOR354C)|FD-Score:3.18|P-value:7.48E-4||SGD DESC:Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:NDJ1(YOL104C)|FD-Score:-3.43|P-value:3.05E-4||SGD DESC:Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement Gene:NDT80(YHR124W)|FD-Score:-3.12|P-value:9.02E-4||SGD DESC:Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) Gene:PPT2(YPL148C)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:SIS2(YKR072C)|FD-Score:-3.37|P-value:3.77E-4||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:YMR265C(YMR265C_p)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Putative protein of unknown function Gene:FMP23(YBR047W_p)|FD-Score:4.26|P-value:1.02E-5||SGD DESC:Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MAC1(YMR021C)|FD-Score:3.82|P-value:6.77E-5||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MF(ALPHA)1(YPL187W)|FD-Score:-3.26|P-value:5.57E-4||SGD DESC:Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor Gene:MSC6(YOR354C)|FD-Score:3.18|P-value:7.48E-4||SGD DESC:Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:NDJ1(YOL104C)|FD-Score:-3.43|P-value:3.05E-4||SGD DESC:Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement Gene:NDT80(YHR124W)|FD-Score:-3.12|P-value:9.02E-4||SGD DESC:Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) Gene:PPT2(YPL148C)|FD-Score:3.46|P-value:2.72E-4||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:SIS2(YKR072C)|FD-Score:-3.37|P-value:3.77E-4||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:YMR265C(YMR265C_p)|FD-Score:3.62|P-value:1.45E-4||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKL021C4.347.02E-61.65MAK11Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
YMR131C2.690.003560.02RRB1Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YGR099W2.670.003780.02TEL2Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
YJR093C2.650.003970.20FIP1Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
YOR232W2.460.006960.02MGE1Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE
YGR029W2.440.007410.06ERV1Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
YGL137W2.370.008820.02SEC27Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
YGR274C2.350.009330.07TAF1TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
YKL182W2.290.011100.07FAS1Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YDR311W2.220.013200.01TFB1Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators
YOL097C2.210.013608.24E-4WRS1Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
YFL045C2.210.013600.09SEC53Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
YDR190C2.120.016900.01RVB1ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly
YPR104C2.110.017300.06FHL1Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
YPR113W2.050.020003.13E-5PIS1Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YBR047W_p4.261.02E-5FMP23_pPutative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR021C3.826.77E-5MAC1Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YMR265C_p3.621.45E-4YMR265C_pPutative protein of unknown function
YPL148C3.462.72E-4PPT2Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation
YOR354C3.187.48E-4MSC6Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR077C_d3.070.00106YPR077C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1
YLR287C-A3.040.00120RPS30AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication
YPL080C_d3.030.00123YPL080C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR021W_p3.030.00124YGR021W_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR151C3.010.00133PCD1Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member
YPR167C2.980.00145MET163'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
YPR047W2.970.00148MSF1Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase
YAL024C2.970.00148LTE1Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
YNR073C_p2.930.00171YNR073C_pPutative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p
YGL157W2.910.00183ARI1NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily

GO enrichment analysis for SGTC_2222
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1286.11E-23SGTC_1569carminic acid 40.6 μMTimTec (Pure natural product library)147490.0779221
0.0993.21E-14SGTC_8570438-0306 1.4 μMChemDiv (Drug-like library)46861360.0869565copper-dependent oxidative stress
0.0985.67E-14SGTC_1657st012939 43.4 μMTimTec (Natural product derivative library)242072570.0188679
0.0978.21E-14SGTC_31159123671 49.5 μMChembridge (Drug-like library)32869880.12069
0.0921.32E-12SGTC_21045389443 200.0 μMChembridge (Fragment library)22445360.148148
0.0912.51E-12SGTC_1109tnp00067 928.3 nMTimTec (Natural product library)6762950.142857
0.0904.30E-12SGTC_220paclitaxel 373.4 μMMiscellaneous46660.12381
0.0881.23E-11SGTC_22287354201 200.0 μMChembridge (Fragment library)7534510.203704endomembrane recycling
0.0864.03E-11SGTC_9041141-0088 396.0 μMChemDiv (Drug-like library)13781190.132353
0.0849.02E-11SGTC_1000086-0128 49.6 μMChemDiv (Drug-like library)932970.101695copper-dependent oxidative stress
0.0831.49E-10SGTC_1763st044482 94.5 μMTimTec (Natural product derivative library)885050.0740741copper-dependent oxidative stress
0.0822.31E-10SGTC_13923455-1037 33.9 μMChemDiv (Drug-like library)9811320.109589
0.0807.31E-10SGTC_25483',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 19.9 μMMicrosource (Natural product library)40002430.0967742redox potentiating
0.0807.70E-10SGTC_21625663267 200.0 μMChembridge (Fragment library)64564930.112903
0.0773.24E-9SGTC_1390099-0334 718.6 μMChemDiv (Drug-like library)976900.142857

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_23609040895200 μM0.4222224914414Chembridge (Fragment library)239.6551.24613RPP1 & pyrimidine depletion
SGTC_23579067248200 μM0.4090919150235Chembridge (Fragment library)225.628421.18413
SGTC_23799035213200 μM0.313726646551Chembridge (Fragment library)240.300342.32213
SGTC_1635st00703542.4 μM0.3114753716403TimTec (Natural product derivative library)351.31622-0.25226
SGTC_1520flindersine88 μM0.368230TimTec (Pure natural product library)227.258521.70412
SGTC_2270792457590.91 μM0.2916671262135Chembridge (Fragment library)241.3050232.21414RPP1 & pyrimidine depletion
SGTC_10613448-9325110 μM0.254545723482ChemDiv (Drug-like library)277.360263.65812
SGTC_1567st06930368.4 μM0.255581319TimTec (Pure natural product library)292.37492.25213mitochondrial processes
SGTC_1752st04481983.04 μM0.25441209TimTec (Natural product derivative library)204.178821.45304
SGTC_235890371574 μM0.252388925Chembridge (Fragment library)231.250520.20513