7298446

(3-methylthiophen-2-yl)-(4-pyridin-2-ylpiperazin-1-yl)methanone

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2226
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 3283010
SMILES CC1=C(SC=C1)C(=O)N2CCN(CC2)C3=CC=CC=N3
Standardized SMILES Cc1ccsc1C(=O)N2CCN(CC2)c3ccccn3
Molecular weight 287.38
ALogP 2.7
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.57
% growth inhibition (Hom. pool) 7.15


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3283010
Download HIP data (tab-delimited text)  (excel)
Gene:ARP4(YJL081C)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.03||SGD DESC:Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes Gene:DPB11(YJL090C)|FD-Score:-3.25|P-value:5.77E-4|Clearance:0||SGD DESC:DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress Gene:FMN1(YDR236C)|FD-Score:3.57|P-value:1.75E-4|Clearance:0.12||SGD DESC:Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane Gene:LSM4(YER112W)|FD-Score:5.34|P-value:4.60E-8|Clearance:0.87||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress Gene:NSL1(YPL233W)|FD-Score:4.5|P-value:3.46E-6|Clearance:0.87||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation Gene:NUP192(YJL039C)|FD-Score:-3.18|P-value:7.36E-4|Clearance:0||SGD DESC:Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205 Gene:RDS3(YPR094W)|FD-Score:3.59|P-value:1.63E-4|Clearance:0.02||SGD DESC:Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance Gene:RET1(YOR207C)|FD-Score:3.4|P-value:3.42E-4|Clearance:0.16||SGD DESC:Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs Gene:SSS1(YDR086C)|FD-Score:3.46|P-value:2.75E-4|Clearance:0.06||SGD DESC:Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p Gene:SUI3(YPL237W)|FD-Score:3.23|P-value:6.09E-4|Clearance:0.14||SGD DESC:Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding Gene:TFA1(YKL028W)|FD-Score:3.09|P-value:9.84E-4|Clearance:0.02||SGD DESC:TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening Gene:TIF34(YMR146C)|FD-Score:-3.39|P-value:3.53E-4|Clearance:0||SGD DESC:eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation Gene:ARP4(YJL081C)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.03||SGD DESC:Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes Gene:DPB11(YJL090C)|FD-Score:-3.25|P-value:5.77E-4|Clearance:0||SGD DESC:DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress Gene:FMN1(YDR236C)|FD-Score:3.57|P-value:1.75E-4|Clearance:0.12||SGD DESC:Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane Gene:LSM4(YER112W)|FD-Score:5.34|P-value:4.60E-8|Clearance:0.87||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress Gene:NSL1(YPL233W)|FD-Score:4.5|P-value:3.46E-6|Clearance:0.87||SGD DESC:Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation Gene:NUP192(YJL039C)|FD-Score:-3.18|P-value:7.36E-4|Clearance:0||SGD DESC:Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205 Gene:RDS3(YPR094W)|FD-Score:3.59|P-value:1.63E-4|Clearance:0.02||SGD DESC:Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance Gene:RET1(YOR207C)|FD-Score:3.4|P-value:3.42E-4|Clearance:0.16||SGD DESC:Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs Gene:SSS1(YDR086C)|FD-Score:3.46|P-value:2.75E-4|Clearance:0.06||SGD DESC:Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p Gene:SUI3(YPL237W)|FD-Score:3.23|P-value:6.09E-4|Clearance:0.14||SGD DESC:Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding Gene:TFA1(YKL028W)|FD-Score:3.09|P-value:9.84E-4|Clearance:0.02||SGD DESC:TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening Gene:TIF34(YMR146C)|FD-Score:-3.39|P-value:3.53E-4|Clearance:0||SGD DESC:eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3283010
Download HOP data (tab-delimited text)  (excel)
Gene:APM4(YOL062C)|FD-Score:3.59|P-value:1.64E-4||SGD DESC:Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport Gene:COQ9(YLR201C)|FD-Score:3.91|P-value:4.53E-5||SGD DESC:Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes Gene:GAT3(YLR013W)|FD-Score:3.36|P-value:3.97E-4||SGD DESC:Protein containing GATA family zinc finger motifs Gene:GET1(YGL020C)|FD-Score:3.2|P-value:6.83E-4||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance Gene:HUA1(YGR268C)|FD-Score:5.67|P-value:7.15E-9||SGD DESC:Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly Gene:LHP1(YDL051W)|FD-Score:4.39|P-value:5.73E-6||SGD DESC:RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen Gene:MSB4(YOL112W)|FD-Score:-3.39|P-value:3.45E-4||SGD DESC:GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization Gene:PFK1(YGR240C)|FD-Score:5.02|P-value:2.60E-7||SGD DESC:Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:PLP1(YDR183W)|FD-Score:3.29|P-value:4.93E-4||SGD DESC:Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators Gene:REG1(YDR028C)|FD-Score:-3.27|P-value:5.38E-4||SGD DESC:Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p Gene:RPS1A(YLR441C)|FD-Score:-3.29|P-value:4.95E-4||SGD DESC:Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication Gene:TRP2(YER090W)|FD-Score:-3.28|P-value:5.26E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:VAM10(YOR068C)|FD-Score:3.15|P-value:8.11E-4||SGD DESC:Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering Gene:YMR187C(YMR187C_p)|FD-Score:3.41|P-value:3.31E-4||SGD DESC:Putative protein of unknown function; YMR187C is not an essential gene Gene:YNL058C(YNL058C_p)|FD-Score:4|P-value:3.14E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene Gene:APM4(YOL062C)|FD-Score:3.59|P-value:1.64E-4||SGD DESC:Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport Gene:COQ9(YLR201C)|FD-Score:3.91|P-value:4.53E-5||SGD DESC:Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes Gene:GAT3(YLR013W)|FD-Score:3.36|P-value:3.97E-4||SGD DESC:Protein containing GATA family zinc finger motifs Gene:GET1(YGL020C)|FD-Score:3.2|P-value:6.83E-4||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance Gene:HUA1(YGR268C)|FD-Score:5.67|P-value:7.15E-9||SGD DESC:Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly Gene:LHP1(YDL051W)|FD-Score:4.39|P-value:5.73E-6||SGD DESC:RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen Gene:MSB4(YOL112W)|FD-Score:-3.39|P-value:3.45E-4||SGD DESC:GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization Gene:PFK1(YGR240C)|FD-Score:5.02|P-value:2.60E-7||SGD DESC:Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes Gene:PLP1(YDR183W)|FD-Score:3.29|P-value:4.93E-4||SGD DESC:Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators Gene:REG1(YDR028C)|FD-Score:-3.27|P-value:5.38E-4||SGD DESC:Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p Gene:RPS1A(YLR441C)|FD-Score:-3.29|P-value:4.95E-4||SGD DESC:Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication Gene:TRP2(YER090W)|FD-Score:-3.28|P-value:5.26E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:VAM10(YOR068C)|FD-Score:3.15|P-value:8.11E-4||SGD DESC:Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering Gene:YMR187C(YMR187C_p)|FD-Score:3.41|P-value:3.31E-4||SGD DESC:Putative protein of unknown function; YMR187C is not an essential gene Gene:YNL058C(YNL058C_p)|FD-Score:4|P-value:3.14E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YER112W5.344.60E-80.87LSM4Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress
YPL233W4.503.46E-60.87NSL1Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YJL081C3.621.45E-40.03ARP4Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YPR094W3.591.63E-40.02RDS3Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance
YDR236C3.571.75E-40.12FMN1Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
YDR086C3.462.75E-40.06SSS1Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YOR207C3.403.42E-40.16RET1Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
YPL237W3.236.09E-40.14SUI3Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
YKL028W3.099.84E-40.02TFA1TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YML114C3.070.001060.03TAF8TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YBR236C3.040.001170.01ABD1Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
YGR005C3.030.001220.05TFG2TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
YOR048C2.980.001430.14RAT1Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination
YML127W2.840.002250.07RSC9Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YGR113W2.770.002780.02DAM1Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR268C5.677.15E-9HUA1Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YGR240C5.022.60E-7PFK1Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YDL051W4.395.73E-6LHP1RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
YNL058C_p4.003.14E-5YNL058C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene
YLR201C3.914.53E-5COQ9Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
YOL062C3.591.64E-4APM4Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport
YMR187C_p3.413.31E-4YMR187C_pPutative protein of unknown function; YMR187C is not an essential gene
YLR013W3.363.97E-4GAT3Protein containing GATA family zinc finger motifs
YDR183W3.294.93E-4PLP1Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators
YGL020C3.206.83E-4GET1Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance
YOR068C3.158.11E-4VAM10Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
YMR103C_d3.090.00100YMR103C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR086C3.050.00115PIL1Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
YMR053C3.020.00127STB2Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p
YLR110C2.990.00138CCW12Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication

GO enrichment analysis for SGTC_2226
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0831.69E-10SGTC_1880MG-132 525.0 μMMiscellaneous4623820.121622
0.0823.10E-10SGTC_11791021-1431 9.3 μMChemDiv (Drug-like library)28409580.119403
0.0807.60E-10SGTC_1915st067105 30.6 μMTimTec (Natural product derivative library)697510.153846RNA pol III & RNase P/MRP
0.0751.04E-8SGTC_1652st011932 78.0 μMTimTec (Natural product derivative library)15510760.109589RSC complex & mRNA processing
0.0723.23E-8SGTC_21695-(ethoxymethyl)quinolin-8-ol 49.5 μMChembridge (Fragment library)2796210.140625
0.0723.53E-8SGTC_31399095020 49.5 μMChembridge (Drug-like library)252362920.265625
0.0723.70E-8SGTC_2522biochanin a 4.9 μMMicrosource (Natural product library)52803730.0684932RNA pol III & RNase P/MRP
0.0709.26E-8SGTC_503tyrphostin 8 294.0 μMICCB bioactive library929700.0689655TSC3-RPN4
0.0691.01E-7SGTC_21935925765 200.0 μMChembridge (Fragment library)8773700.153846
0.0672.73E-7SGTC_30399090270 49.5 μMChembridge (Drug-like library)171737500.1RPP1 & pyrimidine depletion
0.0664.48E-7SGTC_8960964-0007 44.5 μMChemDiv (Drug-like library)67567580.0714286
0.0654.94E-7SGTC_8010866-0028 10.1 μMChemDiv (Drug-like library)68497710.108434
0.0656.42E-7SGTC_2544sphondin 68.5 μMMicrosource (Natural product library)1081040.0714286RNA pol III & RNase P/MRP
0.0649.84E-7SGTC_2103551-0445 56.8 μMChemDiv (Drug-like library)28651800.141026
0.0603.67E-6SGTC_1643st009866 20.2 μMTimTec (Natural product derivative library)31562730.101266

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_22867945697125 μM0.621245733Chembridge (Fragment library)287.379982.06904
SGTC_22887946289167.31 μM0.581246052Chembridge (Fragment library)271.314381.80204
SGTC_21645685496200 μM0.54759046Chembridge (Fragment library)257.28781.65704
SGTC_2970909093841.86 μM0.47457617217104Chembridge (Drug-like library)339.43143.55304RNA processing & uracil transport
SGTC_3136909567249.47 μM0.47457617217380Chembridge (Drug-like library)373.876464.21804
SGTC_3214534-389065.3 μM0.466667699746ChemDiv (Drug-like library)345.82333.24704RPP1 & pyrimidine depletion
SGTC_3028908777849.47 μM0.45901617217395Chembridge (Drug-like library)373.876464.04304
SGTC_3157909927449.47 μM0.44067817217662Chembridge (Drug-like library)339.43143.29104
SGTC_3058909386149.47 μM0.437517217477Chembridge (Drug-like library)373.876464.25504
SGTC_3160910021649.47 μM0.43548417191039Chembridge (Drug-like library)359.849883.73204