| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YIL074C | 3.38 | 3.59E-4 | SER33 | 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication |
| YLL052C | 3.16 | 7.82E-4 | AQY2 | Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains |
| YML034C-A_d | 3.08 | 0.00103 | YML034C-A_d | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YIR027C | 3.00 | 0.00133 | DAL1 | Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression |
| YOL015W | 2.97 | 0.00146 | IRC10 | Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci |
| YKL033W-A_p | 2.78 | 0.00274 | YKL033W-A_p | Putative protein of unknown function; similar to uncharacterized proteins from other fungi |
| YGR027C | 2.77 | 0.00277 | RPS25A | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication |
| YLR386W | 2.76 | 0.00288 | VAC14 | Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p |
| YDL085W | 2.76 | 0.00292 | NDE2 | Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain |
| YOR002W | 2.74 | 0.00303 | ALG6 | Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease |
| YKL126W | 2.72 | 0.00331 | YPK1 | Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication |
| YMR122C_d | 2.67 | 0.00381 | YMR122C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YGL027C | 2.65 | 0.00408 | CWH41 | Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress |
| YKR090W | 2.63 | 0.00424 | PXL1 | Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| YHR048W_p | 2.62 | 0.00435 | YHK8_p | Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles |
