salicylic acid

2-hydroxybenzoic acid

A COX inhibitor and kinase inhibitor.

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PubChem MeSH terms: Anti-Infective Agents;Antifungal Agents;Keratolytic Agents



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2235
Screen concentration 500.0 μM
Source Miscellaneous
PubChem CID 338
SMILES C1=CC=C(C(=C1)C(=O)O)O
Standardized SMILES OC(=O)c1ccccc1O
Molecular weight 138.1207
ALogP 1.22
H-bond donor count 2
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 0.07
% growth inhibition (Hom. pool) -2.66


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 338
Download HIP data (tab-delimited text)  (excel)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 338
Download HOP data (tab-delimited text)  (excel)
Gene:ADE4(YMR300C)|FD-Score:5.43|P-value:2.81E-8||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ARC18(YLR370C)|FD-Score:5.04|P-value:2.35E-7||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:DAL81(YIR023W)|FD-Score:-4.18|P-value:1.48E-5||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:GUT1(YHL032C)|FD-Score:3.99|P-value:3.27E-5||SGD DESC:Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p Gene:LDB7(YBL006C)|FD-Score:-3.44|P-value:2.86E-4||SGD DESC:Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions Gene:MNN11(YJL183W)|FD-Score:3.12|P-value:8.95E-4||SGD DESC:Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p Gene:NDT80(YHR124W)|FD-Score:4.55|P-value:2.68E-6||SGD DESC:Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) Gene:RIF2(YLR453C)|FD-Score:3.99|P-value:3.28E-5||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:SHE4(YOR035C)|FD-Score:3.11|P-value:9.24E-4||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SLP1(YOR154W_p)|FD-Score:3.44|P-value:2.88E-4||SGD DESC:Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p Gene:THI2(YBR240C)|FD-Score:3.26|P-value:5.54E-4||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:UME6(YDR207C)|FD-Score:4.16|P-value:1.56E-5||SGD DESC:Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p Gene:YDR149C(YDR149C_d)|FD-Score:3.78|P-value:7.72E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Gene:YGL010W(YGL010W_p)|FD-Score:-3.22|P-value:6.51E-4||SGD DESC:Putative protein of unknown function; YGL010W is not an essential gene Gene:YGR064W(YGR064W_d)|FD-Score:3.38|P-value:3.56E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C Gene:YIL141W(YIL141W_d)|FD-Score:4.69|P-value:1.39E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR297W(YLR297W_p)|FD-Score:-3.12|P-value:9.01E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication Gene:ADE4(YMR300C)|FD-Score:5.43|P-value:2.81E-8||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ARC18(YLR370C)|FD-Score:5.04|P-value:2.35E-7||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:DAL81(YIR023W)|FD-Score:-4.18|P-value:1.48E-5||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:GUT1(YHL032C)|FD-Score:3.99|P-value:3.27E-5||SGD DESC:Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p Gene:LDB7(YBL006C)|FD-Score:-3.44|P-value:2.86E-4||SGD DESC:Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions Gene:MNN11(YJL183W)|FD-Score:3.12|P-value:8.95E-4||SGD DESC:Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p Gene:NDT80(YHR124W)|FD-Score:4.55|P-value:2.68E-6||SGD DESC:Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) Gene:RIF2(YLR453C)|FD-Score:3.99|P-value:3.28E-5||SGD DESC:Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation Gene:SHE4(YOR035C)|FD-Score:3.11|P-value:9.24E-4||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SLP1(YOR154W_p)|FD-Score:3.44|P-value:2.88E-4||SGD DESC:Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p Gene:THI2(YBR240C)|FD-Score:3.26|P-value:5.54E-4||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:UME6(YDR207C)|FD-Score:4.16|P-value:1.56E-5||SGD DESC:Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p Gene:YDR149C(YDR149C_d)|FD-Score:3.78|P-value:7.72E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Gene:YGL010W(YGL010W_p)|FD-Score:-3.22|P-value:6.51E-4||SGD DESC:Putative protein of unknown function; YGL010W is not an essential gene Gene:YGR064W(YGR064W_d)|FD-Score:3.38|P-value:3.56E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C Gene:YIL141W(YIL141W_d)|FD-Score:4.69|P-value:1.39E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR297W(YLR297W_p)|FD-Score:-3.12|P-value:9.01E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YER112W3.304.83E-40.27LSM4Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress
YJL005W3.030.001230.16CYR1Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YMR309C2.870.002050.07NIP1eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection
YER126C2.800.002530.09NSA2Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
YDR177W2.710.003380.00UBC1Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress
YHR005C-A2.710.003390.02TIM10Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
YNL216W2.690.003580.06RAP1Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)
YNL178W2.630.004250.10RPS3Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
YOL040C2.530.005770.04RPS15Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
YPL083C2.490.006370.01SEN54Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
YDL015C2.480.006570.01TSC13Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
YAL025C2.470.006740.02MAK16Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YJR057W2.450.007180.06CDC8Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
YDR091C2.390.008460.05RLI1Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species
YDL017W2.340.009610.02CDC7DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YMR300C5.432.81E-8ADE4Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
YLR370C5.042.35E-7ARC18Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YIL141W_d4.691.39E-6YIL141W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR124W4.552.68E-6NDT80Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
YDR207C4.161.56E-5UME6Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
YHL032C3.993.27E-5GUT1Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
YLR453C3.993.28E-5RIF2Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YDR149C_d3.787.72E-5YDR149C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth
YOR154W_p3.442.88E-4SLP1_pGlycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p
YGR064W_d3.383.56E-4YGR064W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C
YBR240C3.265.54E-4THI2Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type
YJL183W3.128.95E-4MNN11Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p
YOR035C3.119.24E-4SHE4Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
YGR093W_p3.050.00115YGR093W_pPutative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YOR089C3.010.00130VPS21Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication

GO enrichment analysis for SGTC_2235
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1132.67E-18SGTC_14364092-1007 8.3 μMChemDiv (Drug-like library)28811210.0961538
0.1024.24E-15SGTC_12750867-0008 21.1 μMChemDiv (Drug-like library)34228360.0943396
0.0961.93E-13SGTC_30769116187 49.5 μMChembridge (Drug-like library)272412100.134615
0.0921.34E-12SGTC_328k915-0120 63.5 μMChemDiv (Drug-like library)66245430.163636TSC3-RPN4
0.0891.02E-11SGTC_27875284540 71.4 μMChembridge (Drug-like library)7369580.145833
0.0881.11E-11SGTC_30949117742 49.5 μMChembridge (Drug-like library)171496980.12963
0.0863.89E-11SGTC_32429133940 49.5 μMChembridge (Drug-like library)172484440.0833333
0.0855.52E-11SGTC_2230bromochlorosalicylanilide 954.5 nMMiscellaneous772540.268293
0.0855.54E-11SGTC_31379097352 49.5 μMChembridge (Drug-like library)441204350.127273
0.0791.09E-9SGTC_22047233102 200.0 μMChembridge (Fragment library)21724800.16666760S ribosome export
0.0782.07E-9SGTC_23995884133 200.0 μMMiscellaneous7224450.0793651cell wall signaling
0.0765.91E-9SGTC_32449134489 49.5 μMChembridge (Drug-like library)165842710.0806452
0.0758.40E-9SGTC_22416772625 37.8 μMChembridge (Fragment library)22854110.122449
0.0759.39E-9SGTC_22667929956 200.0 μMChembridge (Fragment library)29671530.125
0.0759.86E-9SGTC_3590081-0058 15.9 μMChemDiv (Drug-like library)34941590.11363660S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_18233-hydroxy-2-naphthoic acid106 μM0.5555567104TimTec (Natural product derivative library)188.179422.12623
SGTC_22117117706200 μM0.483871822771Chembridge (Fragment library)177.199841.28522
SGTC_8670518-0118155 μM0.4722226848158ChemDiv (Drug-like library)256.256681.40235DNA intercalators
SGTC_1642st00958277.7 μM0.4722226739311TimTec (Natural product derivative library)257.241441.48735RPP1 & pyrimidine depletion
SGTC_15852',4'-dihydroxychalcone10.4 μM0.4545455357218TimTec (Pure natural product library)240.253983.21823
SGTC_25732',4'-dihydroxychalcone15.04 μM0.4545455357218TimTec (Pure natural product library)240.253983.21823
SGTC_25742',4'-dihydroxychalcone14.64 μM0.4545455357218TimTec (Pure natural product library)240.253983.21823
SGTC_26602',4'-dihydroxychalcone17.14 μM0.4545455357218TimTec (Pure natural product library)240.253983.21823
SGTC_26682',4'-dihydroxychalcone15.08 μM0.4545455357218TimTec (Pure natural product library)240.253983.21823
SGTC_2471546695624.79 μM0.441176724419Miscellaneous274.699043.57713mitochondrial processes
SGTC_8600443-001625.1 μM0.4285715337942ChemDiv (Drug-like library)242.2450433.66513
SGTC_22619010538184.68 μM0.4166676457250Chembridge (Fragment library)233.306162.8612
SGTC_245958111579.22 μM0.4054052870684Miscellaneous258.2444433.11814mitochondrial processes
SGTC_2481547894845.16 μM0.40540577792Miscellaneous270.279962.89614PDR1