dapsone FDA approved compound

4-(4-aminophenyl)sulfonylaniline

A bacterial DFR inhibitor. An anti-cancer agent.

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PubChem MeSH terms: Anti-Infective Agents;Antimalarials;Folic Acid Antagonists;Leprostatic Agents



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2236
Screen concentration 200.0 μM
Source Miscellaneous
PubChem CID 2955
SMILES C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N
Standardized SMILES Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2
Molecular weight 248.3009
ALogP 1.44
H-bond donor count 2
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 2.59
% growth inhibition (Hom. pool) -1.33


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2955
Download HIP data (tab-delimited text)  (excel)
Gene:CWC23(YGL128C)|FD-Score:3.29|P-value:5.04E-4|Clearance:0.03||SGD DESC:Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p Gene:DBP6(YNR038W)|FD-Score:3.21|P-value:6.72E-4|Clearance:0.03||SGD DESC:Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family Gene:MRD1(YPR112C)|FD-Score:-3.25|P-value:5.67E-4|Clearance:0||SGD DESC:Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region Gene:MSL5(YLR116W)|FD-Score:3.18|P-value:7.33E-4|Clearance:0.04||SGD DESC:Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA Gene:NET1(YJL076W)|FD-Score:3.26|P-value:5.55E-4|Clearance:0.05||SGD DESC:Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication Gene:NOP19(YGR251W)|FD-Score:-3.22|P-value:6.42E-4|Clearance:0||SGD DESC:Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes Gene:NOP7(YGR103W)|FD-Score:3.14|P-value:8.44E-4|Clearance:0.24||SGD DESC:Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation Gene:RPL18A(YOL120C)|FD-Score:3.55|P-value:1.90E-4|Clearance:0.27||SGD DESC:Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication Gene:YBL073W(YBL073W_d)|FD-Score:-3.34|P-value:4.21E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C Gene:CWC23(YGL128C)|FD-Score:3.29|P-value:5.04E-4|Clearance:0.03||SGD DESC:Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p Gene:DBP6(YNR038W)|FD-Score:3.21|P-value:6.72E-4|Clearance:0.03||SGD DESC:Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family Gene:MRD1(YPR112C)|FD-Score:-3.25|P-value:5.67E-4|Clearance:0||SGD DESC:Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region Gene:MSL5(YLR116W)|FD-Score:3.18|P-value:7.33E-4|Clearance:0.04||SGD DESC:Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA Gene:NET1(YJL076W)|FD-Score:3.26|P-value:5.55E-4|Clearance:0.05||SGD DESC:Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication Gene:NOP19(YGR251W)|FD-Score:-3.22|P-value:6.42E-4|Clearance:0||SGD DESC:Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes Gene:NOP7(YGR103W)|FD-Score:3.14|P-value:8.44E-4|Clearance:0.24||SGD DESC:Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation Gene:RPL18A(YOL120C)|FD-Score:3.55|P-value:1.90E-4|Clearance:0.27||SGD DESC:Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication Gene:YBL073W(YBL073W_d)|FD-Score:-3.34|P-value:4.21E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2955
Download HOP data (tab-delimited text)  (excel)
Gene:ACO1(YLR304C)|FD-Score:3.11|P-value:9.20E-4||SGD DESC:Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy Gene:ALG5(YPL227C)|FD-Score:3.9|P-value:4.79E-5||SGD DESC:UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum Gene:ANT1(YPR128C)|FD-Score:5.81|P-value:3.09E-9||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:ASC1(YMR116C)|FD-Score:3.21|P-value:6.69E-4||SGD DESC:G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation Gene:CNM67(YNL225C)|FD-Score:3.89|P-value:4.98E-5||SGD DESC:Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication Gene:DCI1(YOR180C)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed Gene:GTR2(YGR163W)|FD-Score:3.86|P-value:5.64E-5||SGD DESC:Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD Gene:HHT2(YNL031C)|FD-Score:4.32|P-value:7.95E-6||SGD DESC:Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation Gene:HXK1(YFR053C)|FD-Score:-3.85|P-value:5.91E-5||SGD DESC:Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication Gene:IMP2'(YIL154C)|FD-Score:4.54|P-value:2.85E-6||SGD DESC:Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat Gene:ISC10(YER180C)|FD-Score:3.79|P-value:7.60E-5||SGD DESC:Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells Gene:ITC1(YGL133W)|FD-Score:3.1|P-value:9.71E-4||SGD DESC:Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex Gene:MAG1(YER142C)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress Gene:NUR1(YDL089W)|FD-Score:3.36|P-value:3.94E-4||SGD DESC:Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate Gene:PHO80(YOL001W)|FD-Score:3.12|P-value:9.11E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling Gene:REV3(YPL167C)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair Gene:SAC1(YKL212W)|FD-Score:4.54|P-value:2.87E-6||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SFL1(YOR140W)|FD-Score:3.21|P-value:6.69E-4||SGD DESC:Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p Gene:SHE4(YOR035C)|FD-Score:4.03|P-value:2.74E-5||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SOL2(YCR073W-A)|FD-Score:3.38|P-value:3.63E-4||SGD DESC:Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication Gene:THI2(YBR240C)|FD-Score:3.84|P-value:6.10E-5||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:THP1(YOL072W)|FD-Score:4|P-value:3.17E-5||SGD DESC:Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding Gene:UPS3(YDR185C)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations Gene:VID27(YNL212W)|FD-Score:3.21|P-value:6.70E-4||SGD DESC:Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth Gene:YAT2(YER024W)|FD-Score:-3.43|P-value:3.03E-4||SGD DESC:Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane Gene:YBR027C(YBR027C_d)|FD-Score:-3.3|P-value:4.76E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YFR012W-A(YFR012W-A_p)|FD-Score:4.32|P-value:7.84E-6||SGD DESC:Putative protein of unknown function; identified by homology Gene:YJL160C(YJL160C_p)|FD-Score:3.3|P-value:4.84E-4||SGD DESC:Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication Gene:YML082W(YML082W_p)|FD-Score:4.12|P-value:1.88E-5||SGD DESC:Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene Gene:YMR244W(YMR244W_p)|FD-Score:4.11|P-value:2.00E-5||SGD DESC:Putative protein of unknown function Gene:YOR152C(YOR152C_p)|FD-Score:-3.3|P-value:4.79E-4||SGD DESC:Putative protein of unknown function; YOR152C is not an essential gene Gene:YPL272C(YPL272C_p)|FD-Score:4.13|P-value:1.80E-5||SGD DESC:Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene Gene:YPR117W(YPR117W_p)|FD-Score:-3.26|P-value:5.56E-4||SGD DESC:Putative protein of unknown function Gene:ACO1(YLR304C)|FD-Score:3.11|P-value:9.20E-4||SGD DESC:Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy Gene:ALG5(YPL227C)|FD-Score:3.9|P-value:4.79E-5||SGD DESC:UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum Gene:ANT1(YPR128C)|FD-Score:5.81|P-value:3.09E-9||SGD DESC:Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Gene:ASC1(YMR116C)|FD-Score:3.21|P-value:6.69E-4||SGD DESC:G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation Gene:CNM67(YNL225C)|FD-Score:3.89|P-value:4.98E-5||SGD DESC:Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication Gene:DCI1(YOR180C)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed Gene:GTR2(YGR163W)|FD-Score:3.86|P-value:5.64E-5||SGD DESC:Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD Gene:HHT2(YNL031C)|FD-Score:4.32|P-value:7.95E-6||SGD DESC:Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation Gene:HXK1(YFR053C)|FD-Score:-3.85|P-value:5.91E-5||SGD DESC:Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication Gene:IMP2'(YIL154C)|FD-Score:4.54|P-value:2.85E-6||SGD DESC:Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat Gene:ISC10(YER180C)|FD-Score:3.79|P-value:7.60E-5||SGD DESC:Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells Gene:ITC1(YGL133W)|FD-Score:3.1|P-value:9.71E-4||SGD DESC:Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex Gene:MAG1(YER142C)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress Gene:NUR1(YDL089W)|FD-Score:3.36|P-value:3.94E-4||SGD DESC:Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate Gene:PHO80(YOL001W)|FD-Score:3.12|P-value:9.11E-4||SGD DESC:Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling Gene:REV3(YPL167C)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair Gene:SAC1(YKL212W)|FD-Score:4.54|P-value:2.87E-6||SGD DESC:Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism Gene:SFL1(YOR140W)|FD-Score:3.21|P-value:6.69E-4||SGD DESC:Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p Gene:SHE4(YOR035C)|FD-Score:4.03|P-value:2.74E-5||SGD DESC:Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization Gene:SOL2(YCR073W-A)|FD-Score:3.38|P-value:3.63E-4||SGD DESC:Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication Gene:THI2(YBR240C)|FD-Score:3.84|P-value:6.10E-5||SGD DESC:Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type Gene:THP1(YOL072W)|FD-Score:4|P-value:3.17E-5||SGD DESC:Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding Gene:UPS3(YDR185C)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations Gene:VID27(YNL212W)|FD-Score:3.21|P-value:6.70E-4||SGD DESC:Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth Gene:YAT2(YER024W)|FD-Score:-3.43|P-value:3.03E-4||SGD DESC:Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane Gene:YBR027C(YBR027C_d)|FD-Score:-3.3|P-value:4.76E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YFR012W-A(YFR012W-A_p)|FD-Score:4.32|P-value:7.84E-6||SGD DESC:Putative protein of unknown function; identified by homology Gene:YJL160C(YJL160C_p)|FD-Score:3.3|P-value:4.84E-4||SGD DESC:Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication Gene:YML082W(YML082W_p)|FD-Score:4.12|P-value:1.88E-5||SGD DESC:Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene Gene:YMR244W(YMR244W_p)|FD-Score:4.11|P-value:2.00E-5||SGD DESC:Putative protein of unknown function Gene:YOR152C(YOR152C_p)|FD-Score:-3.3|P-value:4.79E-4||SGD DESC:Putative protein of unknown function; YOR152C is not an essential gene Gene:YPL272C(YPL272C_p)|FD-Score:4.13|P-value:1.80E-5||SGD DESC:Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene Gene:YPR117W(YPR117W_p)|FD-Score:-3.26|P-value:5.56E-4||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOL120C3.551.90E-40.27RPL18ARibosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
YGL128C3.295.04E-40.03CWC23Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p
YJL076W3.265.55E-40.05NET1Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication
YNR038W3.216.72E-40.03DBP6Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
YLR116W3.187.33E-40.04MSL5Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA
YGR103W3.148.44E-40.24NOP7Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation
YOR048C2.900.001880.08RAT1Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination
YPL237W2.820.002410.08SUI3Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
YHR083W2.740.003110.02SAM35Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
YDR045C2.720.003290.21RPC11RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
YNL131W2.510.006100.01TOM22Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
YDL004W2.490.006310.00ATP16Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YDR180W2.490.006350.07SCC2Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin
YDR240C2.430.007640.02SNU56Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YLR088W2.410.008000.07GAA1Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPR128C5.813.09E-9ANT1Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation
YIL154C4.542.85E-6IMP2'Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
YKL212W4.542.87E-6SAC1Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism
YFR012W-A_p4.327.84E-6YFR012W-A_pPutative protein of unknown function; identified by homology
YNL031C4.327.95E-6HHT2Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation
YPL272C_p4.131.80E-5YPL272C_pPutative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
YML082W_p4.121.88E-5YML082W_pPutative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene
YMR244W_p4.112.00E-5YMR244W_pPutative protein of unknown function
YOR035C4.032.74E-5SHE4Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
YOL072W4.003.17E-5THP1Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
YPL227C3.904.79E-5ALG5UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
YNL225C3.894.98E-5CNM67Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication
YGR163W3.865.64E-5GTR2Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
YBR240C3.846.10E-5THI2Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type
YER180C3.797.60E-5ISC10Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells

GO enrichment analysis for SGTC_2236
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1339.53E-25SGTC_400oxethazaine 37.5 μMMiscellaneous46210.0833333calcium & mitochondrial duress
0.1331.27E-24SGTC_1666st014829 29.0 μMTimTec (Natural product derivative library)38582300.0461538calcium & mitochondrial duress
0.1262.14E-22SGTC_330986-0033 35.8 μMChemDiv (Drug-like library)28480820.0754717calcium & mitochondrial duress
0.1218.23E-21SGTC_14504112-4260 37.6 μMChemDiv (Drug-like library)16331750.0508475calcium & mitochondrial duress
0.1171.48E-19SGTC_7014424-0219 185.0 μMChemDiv (Drug-like library)29117790.0540541calcium & mitochondrial duress
0.1062.82E-16SGTC_9943910-0338 138.0 μMChemDiv (Drug-like library)34794810.047619calcium & mitochondrial duress
0.1057.09E-16SGTC_6090986-0026 86.3 μMChemDiv (Drug-like library)28486100.0851064calcium & mitochondrial duress
0.0978.65E-14SGTC_6583253-0951 102.0 μMChemDiv (Drug-like library)11848780.0588235calcium & mitochondrial duress
0.0961.68E-13SGTC_2523spermine 47.7 μMMicrosource (Natural product library)11030.0357143calcium & mitochondrial duress
0.0903.75E-12SGTC_540159-0055 9.0 μMChemDiv (Drug-like library)33190990.0555556ERG2
0.0863.89E-11SGTC_12600700-1617 7.8 μMChemDiv (Drug-like library)28530780.0952381calcium & mitochondrial duress
0.0864.91E-11SGTC_10573448-5381 134.0 μMChemDiv (Drug-like library)54979110.0625calcium & mitochondrial duress
0.0849.20E-11SGTC_1690st023502 41.2 μMTimTec (Natural product derivative library)242074820.0793651calcium & mitochondrial duress
0.0822.30E-10SGTC_397arbidol 50.0 μMMiscellaneous1314100.057971cell wall
0.0822.55E-10SGTC_5820987-0078 156.0 μMChemDiv (Drug-like library)16257650.0727273calcium & mitochondrial duress

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_13131220-0047237 μM0.3214293528706ChemDiv (Drug-like library)231.67763.15212
SGTC_1169aniline yellow25.8 μM0.3076926051ChemDiv (Drug-like library)197.235843.45213
SGTC_8370091-026512.5 μM0.296296759367ChemDiv (Drug-like library)264.11793.39212ubiquinone biosynthesis & proteasome
SGTC_12330325-040814.2 μM0.29629612874ChemDiv (Drug-like library)211.262423.93813
SGTC_7791360-0071233 μM0.2903237566ChemDiv (Drug-like library)246.2853.09614fatty acid desaturase (OLE1)
SGTC_6690108-002126.2 μM0.28571417201ChemDiv (Drug-like library)292.331843.45724fatty acid desaturase (OLE1)
SGTC_1841494-039324.71 μM0.2758623090647ChemDiv (Drug-like library)523.044226.66704
SGTC_3851494-039312.4 μM0.2758623090647ChemDiv (Drug-like library)523.044226.66704
SGTC_493zm226600134 μM0.2682935240098ICCB bioactive library373.346872.83527mitochondrial processes
SGTC_21605660466132.93 μM0.2666672859134Chembridge (Fragment library)209.672082.5242260S ribosome export
SGTC_23859074692200 μM0.26666717046906Chembridge (Fragment library)201.693142.6422