6637752

N-(4-chlorophenyl)-2-methoxyacetamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2245
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 681890
SMILES COCC(=O)NC1=CC=C(C=C1)Cl
Standardized SMILES COCC(=O)Nc1ccc(Cl)cc1
Molecular weight 199.6342
ALogP 1.35
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.05
% growth inhibition (Hom. pool) 6.15


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 681890
Download HIP data (tab-delimited text)  (excel)
Gene:CFT1(YDR301W)|FD-Score:4.09|P-value:2.16E-5|Clearance:0.05||SGD DESC:RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF Gene:COG4(YPR105C)|FD-Score:4.04|P-value:2.65E-5|Clearance:0.59||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:FAP7(YDL166C)|FD-Score:4.61|P-value:2.04E-6|Clearance:0.17||SGD DESC:Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D Gene:GNA1(YFL017C)|FD-Score:3.42|P-value:3.18E-4|Clearance:0.1||SGD DESC:Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA Gene:NAF1(YNL124W)|FD-Score:4.29|P-value:8.85E-6|Clearance:0.2||SGD DESC:RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p Gene:NOC4(YPR144C)|FD-Score:4.44|P-value:4.53E-6|Clearance:0.15||SGD DESC:Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Gene:ORC2(YBR060C)|FD-Score:3.45|P-value:2.81E-4|Clearance:0.03||SGD DESC:Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p Gene:PCM1(YEL058W)|FD-Score:-3.11|P-value:9.49E-4|Clearance:0||SGD DESC:Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors Gene:SEC10(YLR166C)|FD-Score:-3.26|P-value:5.55E-4|Clearance:0||SGD DESC:Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion Gene:SNP1(YIL061C)|FD-Score:-3.41|P-value:3.26E-4|Clearance:0||SGD DESC:Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress Gene:TIF11(YMR260C)|FD-Score:3.31|P-value:4.63E-4|Clearance:0.32||SGD DESC:Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 Gene:TYS1(YGR185C)|FD-Score:8.48|P-value:1.15E-17|Clearance:3.87||SGD DESC:Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress Gene:CFT1(YDR301W)|FD-Score:4.09|P-value:2.16E-5|Clearance:0.05||SGD DESC:RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF Gene:COG4(YPR105C)|FD-Score:4.04|P-value:2.65E-5|Clearance:0.59||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:FAP7(YDL166C)|FD-Score:4.61|P-value:2.04E-6|Clearance:0.17||SGD DESC:Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D Gene:GNA1(YFL017C)|FD-Score:3.42|P-value:3.18E-4|Clearance:0.1||SGD DESC:Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA Gene:NAF1(YNL124W)|FD-Score:4.29|P-value:8.85E-6|Clearance:0.2||SGD DESC:RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p Gene:NOC4(YPR144C)|FD-Score:4.44|P-value:4.53E-6|Clearance:0.15||SGD DESC:Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Gene:ORC2(YBR060C)|FD-Score:3.45|P-value:2.81E-4|Clearance:0.03||SGD DESC:Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p Gene:PCM1(YEL058W)|FD-Score:-3.11|P-value:9.49E-4|Clearance:0||SGD DESC:Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors Gene:SEC10(YLR166C)|FD-Score:-3.26|P-value:5.55E-4|Clearance:0||SGD DESC:Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion Gene:SNP1(YIL061C)|FD-Score:-3.41|P-value:3.26E-4|Clearance:0||SGD DESC:Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress Gene:TIF11(YMR260C)|FD-Score:3.31|P-value:4.63E-4|Clearance:0.32||SGD DESC:Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 Gene:TYS1(YGR185C)|FD-Score:8.48|P-value:1.15E-17|Clearance:3.87||SGD DESC:Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 681890
Download HOP data (tab-delimited text)  (excel)
Gene:ADE4(YMR300C)|FD-Score:3.28|P-value:5.22E-4||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ADE5,7(YGL234W)|FD-Score:7.42|P-value:5.98E-14||SGD DESC:Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities Gene:ADO1(YJR105W)|FD-Score:7.55|P-value:2.17E-14||SGD DESC:Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle Gene:AIM26(YKL037W)|FD-Score:-5.4|P-value:3.34E-8||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT Gene:ALF1(YNL148C)|FD-Score:-3.48|P-value:2.51E-4||SGD DESC:Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance Gene:BNA7(YDR428C)|FD-Score:7.16|P-value:4.14E-13||SGD DESC:Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine Gene:CIN2(YPL241C)|FD-Score:-4.17|P-value:1.56E-5||SGD DESC:GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 Gene:CTI6(YPL181W)|FD-Score:-3.56|P-value:1.88E-4||SGD DESC:Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain Gene:CTP1(YBR291C)|FD-Score:-3.18|P-value:7.39E-4||SGD DESC:Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family Gene:DSK2(YMR276W)|FD-Score:-4.65|P-value:1.64E-6||SGD DESC:Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress Gene:ECM15(YBL001C)|FD-Score:4.88|P-value:5.26E-7||SGD DESC:Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis Gene:ERV2(YPR037C)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER Gene:HLJ1(YMR161W)|FD-Score:3.91|P-value:4.69E-5||SGD DESC:Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ Gene:IMP2'(YIL154C)|FD-Score:5.75|P-value:4.51E-9||SGD DESC:Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat Gene:INP1(YMR204C)|FD-Score:-3.3|P-value:4.91E-4||SGD DESC:Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane Gene:ITT1(YML068W)|FD-Score:3.21|P-value:6.68E-4||SGD DESC:Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins Gene:IZH2(YOL002C)|FD-Score:-3.12|P-value:8.94E-4||SGD DESC:Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc Gene:KAP123(YER110C)|FD-Score:-3.76|P-value:8.43E-5||SGD DESC:Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 Gene:MAM3(YOL060C)|FD-Score:4.13|P-value:1.80E-5||SGD DESC:Protein required for normal mitochondrial morphology, has similarity to hemolysins Gene:MDY2(YOL111C)|FD-Score:3.82|P-value:6.55E-5||SGD DESC:Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes Gene:NAB6(YML117W)|FD-Score:3.51|P-value:2.20E-4||SGD DESC:Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP Gene:OCT1(YKL134C)|FD-Score:-3.9|P-value:4.79E-5||SGD DESC:Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis Gene:OMS1(YDR316W)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations Gene:PGC1(YPL206C)|FD-Score:-3.51|P-value:2.21E-4||SGD DESC:Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs Gene:PIN4(YBL051C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage Gene:PMS1(YNL082W)|FD-Score:-3.61|P-value:1.52E-4||SGD DESC:ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL Gene:POP2(YNR052C)|FD-Score:-3.12|P-value:9.14E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:PRM8(YGL053W)|FD-Score:3.97|P-value:3.54E-5||SGD DESC:Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family Gene:PTK2(YJR059W)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake Gene:PUS7(YOR243C)|FD-Score:6.78|P-value:6.19E-12||SGD DESC:Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria Gene:QDR2(YIL121W)|FD-Score:-3.23|P-value:6.17E-4||SGD DESC:Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper Gene:RPL19B(YBL027W)|FD-Score:-3.71|P-value:1.02E-4||SGD DESC:Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication Gene:RPL36B(YPL249C-A)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication Gene:SAT4(YCR008W)|FD-Score:8.92|P-value:2.26E-19||SGD DESC:Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p Gene:SGE1(YPR198W)|FD-Score:7.56|P-value:2.03E-14||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:SKG1(YKR100C)|FD-Score:4.7|P-value:1.31E-6||SGD DESC:Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell Gene:SNX3(YOR357C)|FD-Score:-6.48|P-value:4.63E-11||SGD DESC:Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p Gene:TCM62(YBR044C)|FD-Score:-3.52|P-value:2.19E-4||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone Gene:TIP1(YBR067C)|FD-Score:3.96|P-value:3.68E-5||SGD DESC:Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins Gene:TPN1(YGL186C)|FD-Score:3.16|P-value:7.92E-4||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:TRM7(YBR061C)|FD-Score:5.54|P-value:1.53E-8||SGD DESC:2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively Gene:UBP13(YBL067C)|FD-Score:3.26|P-value:5.58E-4||SGD DESC:Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication Gene:VPS55(YJR044C)|FD-Score:-3.82|P-value:6.56E-5||SGD DESC:Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) Gene:YCL012C(YCL012C)|FD-Score:3.19|P-value:7.02E-4||SGD DESC:Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene Gene:YCR085W(YCR085W_d)|FD-Score:-3.22|P-value:6.50E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL086W(YDL086W_p)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene Gene:YDR109C(YDR109C_p)|FD-Score:4.59|P-value:2.24E-6||SGD DESC:Putative kinase Gene:YDR445C(YDR445C_d)|FD-Score:6.21|P-value:2.69E-10||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR080C(YHR080C)|FD-Score:-3.71|P-value:1.04E-4||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication Gene:YJL119C(YJL119C_d)|FD-Score:3.2|P-value:6.80E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJL144W(YJL144W)|FD-Score:-3.41|P-value:3.22E-4||SGD DESC:Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress Gene:YJR038C(YJR038C_d)|FD-Score:3.3|P-value:4.90E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR129C(YJR129C_p)|FD-Score:4.32|P-value:7.70E-6||SGD DESC:Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YML083C(YML083C_p)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions Gene:YNL050C(YNL050C_p)|FD-Score:3.58|P-value:1.72E-4||SGD DESC:Putative protein of unknown function; YNL050c is not an essential gene Gene:YNL205C(YNL205C_d)|FD-Score:-3.37|P-value:3.72E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YSP1(YHR155W)|FD-Score:5.66|P-value:7.59E-9||SGD DESC:Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication Gene:ADE4(YMR300C)|FD-Score:3.28|P-value:5.22E-4||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ADE5,7(YGL234W)|FD-Score:7.42|P-value:5.98E-14||SGD DESC:Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities Gene:ADO1(YJR105W)|FD-Score:7.55|P-value:2.17E-14||SGD DESC:Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle Gene:AIM26(YKL037W)|FD-Score:-5.4|P-value:3.34E-8||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT Gene:ALF1(YNL148C)|FD-Score:-3.48|P-value:2.51E-4||SGD DESC:Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance Gene:BNA7(YDR428C)|FD-Score:7.16|P-value:4.14E-13||SGD DESC:Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine Gene:CIN2(YPL241C)|FD-Score:-4.17|P-value:1.56E-5||SGD DESC:GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 Gene:CTI6(YPL181W)|FD-Score:-3.56|P-value:1.88E-4||SGD DESC:Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain Gene:CTP1(YBR291C)|FD-Score:-3.18|P-value:7.39E-4||SGD DESC:Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family Gene:DSK2(YMR276W)|FD-Score:-4.65|P-value:1.64E-6||SGD DESC:Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress Gene:ECM15(YBL001C)|FD-Score:4.88|P-value:5.26E-7||SGD DESC:Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis Gene:ERV2(YPR037C)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER Gene:HLJ1(YMR161W)|FD-Score:3.91|P-value:4.69E-5||SGD DESC:Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ Gene:IMP2'(YIL154C)|FD-Score:5.75|P-value:4.51E-9||SGD DESC:Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat Gene:INP1(YMR204C)|FD-Score:-3.3|P-value:4.91E-4||SGD DESC:Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane Gene:ITT1(YML068W)|FD-Score:3.21|P-value:6.68E-4||SGD DESC:Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins Gene:IZH2(YOL002C)|FD-Score:-3.12|P-value:8.94E-4||SGD DESC:Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc Gene:KAP123(YER110C)|FD-Score:-3.76|P-value:8.43E-5||SGD DESC:Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 Gene:MAM3(YOL060C)|FD-Score:4.13|P-value:1.80E-5||SGD DESC:Protein required for normal mitochondrial morphology, has similarity to hemolysins Gene:MDY2(YOL111C)|FD-Score:3.82|P-value:6.55E-5||SGD DESC:Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes Gene:NAB6(YML117W)|FD-Score:3.51|P-value:2.20E-4||SGD DESC:Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP Gene:OCT1(YKL134C)|FD-Score:-3.9|P-value:4.79E-5||SGD DESC:Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis Gene:OMS1(YDR316W)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations Gene:PGC1(YPL206C)|FD-Score:-3.51|P-value:2.21E-4||SGD DESC:Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs Gene:PIN4(YBL051C)|FD-Score:3.5|P-value:2.33E-4||SGD DESC:Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage Gene:PMS1(YNL082W)|FD-Score:-3.61|P-value:1.52E-4||SGD DESC:ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL Gene:POP2(YNR052C)|FD-Score:-3.12|P-value:9.14E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:PRM8(YGL053W)|FD-Score:3.97|P-value:3.54E-5||SGD DESC:Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family Gene:PTK2(YJR059W)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake Gene:PUS7(YOR243C)|FD-Score:6.78|P-value:6.19E-12||SGD DESC:Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria Gene:QDR2(YIL121W)|FD-Score:-3.23|P-value:6.17E-4||SGD DESC:Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper Gene:RPL19B(YBL027W)|FD-Score:-3.71|P-value:1.02E-4||SGD DESC:Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication Gene:RPL36B(YPL249C-A)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication Gene:SAT4(YCR008W)|FD-Score:8.92|P-value:2.26E-19||SGD DESC:Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p Gene:SGE1(YPR198W)|FD-Score:7.56|P-value:2.03E-14||SGD DESC:Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations Gene:SKG1(YKR100C)|FD-Score:4.7|P-value:1.31E-6||SGD DESC:Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell Gene:SNX3(YOR357C)|FD-Score:-6.48|P-value:4.63E-11||SGD DESC:Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p Gene:TCM62(YBR044C)|FD-Score:-3.52|P-value:2.19E-4||SGD DESC:Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone Gene:TIP1(YBR067C)|FD-Score:3.96|P-value:3.68E-5||SGD DESC:Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins Gene:TPN1(YGL186C)|FD-Score:3.16|P-value:7.92E-4||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:TRM7(YBR061C)|FD-Score:5.54|P-value:1.53E-8||SGD DESC:2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively Gene:UBP13(YBL067C)|FD-Score:3.26|P-value:5.58E-4||SGD DESC:Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication Gene:VPS55(YJR044C)|FD-Score:-3.82|P-value:6.56E-5||SGD DESC:Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) Gene:YCL012C(YCL012C)|FD-Score:3.19|P-value:7.02E-4||SGD DESC:Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene Gene:YCR085W(YCR085W_d)|FD-Score:-3.22|P-value:6.50E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL086W(YDL086W_p)|FD-Score:3.68|P-value:1.17E-4||SGD DESC:Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene Gene:YDR109C(YDR109C_p)|FD-Score:4.59|P-value:2.24E-6||SGD DESC:Putative kinase Gene:YDR445C(YDR445C_d)|FD-Score:6.21|P-value:2.69E-10||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR080C(YHR080C)|FD-Score:-3.71|P-value:1.04E-4||SGD DESC:Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication Gene:YJL119C(YJL119C_d)|FD-Score:3.2|P-value:6.80E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJL144W(YJL144W)|FD-Score:-3.41|P-value:3.22E-4||SGD DESC:Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress Gene:YJR038C(YJR038C_d)|FD-Score:3.3|P-value:4.90E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR129C(YJR129C_p)|FD-Score:4.32|P-value:7.70E-6||SGD DESC:Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YML083C(YML083C_p)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions Gene:YNL050C(YNL050C_p)|FD-Score:3.58|P-value:1.72E-4||SGD DESC:Putative protein of unknown function; YNL050c is not an essential gene Gene:YNL205C(YNL205C_d)|FD-Score:-3.37|P-value:3.72E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YSP1(YHR155W)|FD-Score:5.66|P-value:7.59E-9||SGD DESC:Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGR185C8.481.15E-173.87TYS1Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
YDL166C4.612.04E-60.17FAP7Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D
YPR144C4.444.53E-60.15NOC4Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
YNL124W4.298.85E-60.20NAF1RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
YDR301W4.092.16E-50.05CFT1RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF
YPR105C4.042.65E-50.59COG4Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YBR060C3.452.81E-40.03ORC2Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p
YFL017C3.423.18E-40.10GNA1Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
YMR260C3.314.63E-40.32TIF11Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
YOL127W2.990.001390.03RPL25Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23
YCL043C2.960.001520.04PDI1Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication
YGL137W2.920.001750.05SEC27Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
YPR112C2.870.002040.04MRD1Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region
YKL018W2.840.002287.22E-4SWD2Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination
YIR022W2.840.002280.06SEC1118kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YCR008W8.922.26E-19SAT4Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
YPR198W7.562.03E-14SGE1Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
YJR105W7.552.17E-14ADO1Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YGL234W7.425.98E-14ADE5,7Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
YDR428C7.164.14E-13BNA7Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine
YOR243C6.786.19E-12PUS7Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria
YDR445C_d6.212.69E-10YDR445C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL154C5.754.51E-9IMP2'Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
YHR155W5.667.59E-9YSP1Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
YBR061C5.541.53E-8TRM72'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively
YBL001C4.885.26E-7ECM15Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
YKR100C4.701.31E-6SKG1Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
YDR109C_p4.592.24E-6YDR109C_pPutative kinase
YJR129C_p4.327.70E-6YJR129C_pPutative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOL060C4.131.80E-5MAM3Protein required for normal mitochondrial morphology, has similarity to hemolysins

GO enrichment analysis for SGTC_2245
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1321.76E-24SGTC_22436634756 200.0 μMChembridge (Fragment library)8856760.611111
0.1023.22E-15SGTC_22396685329 187.6 μMChembridge (Fragment library)8056800.0784314
0.0961.57E-13SGTC_1210557-0495 61.3 μMChemDiv (Drug-like library)31044270.230769calcium & mitochondrial duress
0.0913.14E-12SGTC_7014424-0219 185.0 μMChemDiv (Drug-like library)29117790.186667calcium & mitochondrial duress
0.0881.19E-11SGTC_502l-744,832 89.3 μMICCB bioactive library66103540.120482calcium & mitochondrial duress
0.0863.22E-11SGTC_400oxethazaine 37.5 μMMiscellaneous46210.145455calcium & mitochondrial duress
0.0849.56E-11SGTC_22446635614 200.0 μMChembridge (Fragment library)8364990.526316
0.0815.55E-10SGTC_1690st023502 41.2 μMTimTec (Natural product derivative library)242074820.0533333calcium & mitochondrial duress
0.0791.15E-9SGTC_13451488-0192 31.4 μMChemDiv (Drug-like library)6583480.166667
0.0772.56E-9SGTC_14504112-4260 37.6 μMChemDiv (Drug-like library)16331750.123077calcium & mitochondrial duress
0.0773.49E-9SGTC_960929-0093 37.3 μMChemDiv (Drug-like library)69915790.0967742calcium & mitochondrial duress
0.0765.35E-9SGTC_9943910-0338 138.0 μMChemDiv (Drug-like library)34794810.084507calcium & mitochondrial duress
0.0714.41E-8SGTC_6090986-0026 86.3 μMChemDiv (Drug-like library)28486100.127273calcium & mitochondrial duress
0.0707.36E-8SGTC_330986-0033 35.8 μMChemDiv (Drug-like library)28480820.172414calcium & mitochondrial duress
0.0681.81E-7SGTC_2523spermine 47.7 μMMicrosource (Natural product library)11030.0526316calcium & mitochondrial duress

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_22436634756200 μM0.611111885676Chembridge (Fragment library)234.079262.01512
SGTC_7950685-026578 μM0.578947302754ChemDiv (Drug-like library)340.599643.86212excess fatty acid
SGTC_20945332512191.67 μM0.567568755774Chembridge (Fragment library)215.247821.59512
SGTC_22446635614200 μM0.526316836499Chembridge (Fragment library)234.079262.01512
SGTC_2826799254119.48 μM0.4878052985066Chembridge (Drug-like library)297.6845063.52514
SGTC_7003453-2283142 μM0.47619565664ChemDiv (Drug-like library)263.719462.88912amide catabolism
SGTC_7924534-1957155 μM0.4565221717904ChemDiv (Drug-like library)282.337022.73412
SGTC_1300136-0219337.66 μM0.428571234244ChemDiv (Drug-like library)296.148643.77812
SGTC_13431487-0095224 μM0.4222224560101ChemDiv (Drug-like library)327.827864.5812
SGTC_5681193-00977.48 μM0.4146343646150ChemDiv (Drug-like library)242.658941.98724ERAD & cell cycle