Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YJL015C_d | 4.31 | 8.06E-6 | 0.33 | YJL015C_d | Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W |
YHR074W | 3.99 | 3.35E-5 | 0.17 | QNS1 | Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide |
YDL015C | 3.82 | 6.76E-5 | 0.18 | TSC13 | Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress |
YLR212C | 3.64 | 1.38E-4 | 0.02 | TUB4 | Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress |
YHR023W | 3.62 | 1.48E-4 | 0.14 | MYO1 | Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively |
YPR108W | 3.48 | 2.49E-4 | 0.30 | RPN7 | Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits |
YDR062W | 3.18 | 7.28E-4 | 0.18 | LCB2 | Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine |
YDR240C | 3.00 | 0.00133 | 0.08 | SNU56 | Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex |
YDR224C | 2.93 | 0.00171 | 0.07 | HTB1 | Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation |
YGR147C | 2.86 | 0.00214 | 0.05 | NAT2 | Protein with an apparent role in acetylation of N-terminal methionine residues |
YBR234C | 2.80 | 0.00252 | 0.00 | ARC40 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches |
YLR355C | 2.80 | 0.00255 | 0.00 | ILV5 | Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids |
YML114C | 2.80 | 0.00258 | 0.07 | TAF8 | TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation |
YOR250C | 2.72 | 0.00323 | 0.04 | CLP1 | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation |
YGR190C_d | 2.69 | 0.00361 | 0.00 | YGR190C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W |