omeprazole FDA approved compound

6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole

A proton pump inhibitor.

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 

PubChem MeSH terms: Anti-Ulcer Agents;Enzyme Inhibitors



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2252
Screen concentration 400.0 μM
Source Miscellaneous
PubChem CID 4594
SMILES CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC
Standardized SMILES COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C
Molecular weight 345.4161
ALogP 2.9
H-bond donor count 1
H-bond acceptor count 6
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.67
% growth inhibition (Hom. pool) 1.11


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4594
Download HIP data (tab-delimited text)  (excel)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4594
Download HOP data (tab-delimited text)  (excel)
Gene:AIR2(YDL175C)|FD-Score:5.76|P-value:4.11E-9||SGD DESC:RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication Gene:APD1(YBR151W)|FD-Score:-3.96|P-value:3.71E-5||SGD DESC:Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus Gene:ATG33(YLR356W)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes Gene:CRP1(YHR146W)|FD-Score:4|P-value:3.20E-5||SGD DESC:Protein that binds to cruciform DNA structures Gene:DSE4(YNR067C)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother Gene:FAA4(YMR246W)|FD-Score:3.71|P-value:1.03E-4||SGD DESC:Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication Gene:FZO1(YBR179C)|FD-Score:3.95|P-value:3.88E-5||SGD DESC:Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system Gene:HEL2(YDR266C)|FD-Score:-3.73|P-value:9.39E-5||SGD DESC:RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor Gene:HTB2(YBL002W)|FD-Score:-4.28|P-value:9.51E-6||SGD DESC:Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation Gene:MRT4(YKL009W)|FD-Score:3.46|P-value:2.66E-4||SGD DESC:Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus Gene:MXR1(YER042W)|FD-Score:-3.92|P-value:4.50E-5||SGD DESC:Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan Gene:NST1(YNL091W)|FD-Score:3.2|P-value:6.99E-4||SGD DESC:Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 Gene:OSH3(YHR073W)|FD-Score:3.12|P-value:8.99E-4||SGD DESC:Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability Gene:PAR32(YDL173W)|FD-Score:3.17|P-value:7.72E-4||SGD DESC:Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene Gene:PDH1(YPR002W)|FD-Score:3.14|P-value:8.32E-4||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PEX34(YCL056C)|FD-Score:-3.82|P-value:6.76E-5||SGD DESC:Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation Gene:PSR2(YLR019W)|FD-Score:-3.33|P-value:4.33E-4||SGD DESC:Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:RPS0B(YLR048W)|FD-Score:3.15|P-value:8.04E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2 Gene:RRD2(YPL152W)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress Gene:RTT106(YNL206C)|FD-Score:3.86|P-value:5.72E-5||SGD DESC:Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition Gene:SLY41(YOR307C)|FD-Score:4.52|P-value:3.15E-6||SGD DESC:Protein involved in ER-to-Golgi transport Gene:SPC2(YML055W)|FD-Score:3.84|P-value:6.08E-5||SGD DESC:Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 Gene:STF1(YDL130W-A)|FD-Score:-3.39|P-value:3.47E-4||SGD DESC:Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress Gene:SVS1(YPL163C)|FD-Score:3.4|P-value:3.32E-4||SGD DESC:Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication Gene:TMA10(YLR327C)|FD-Score:4.19|P-value:1.38E-5||SGD DESC:Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress Gene:TOM1(YDR457W)|FD-Score:4.44|P-value:4.45E-6||SGD DESC:E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase Gene:TRX1(YLR043C)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress Gene:YCR085W(YCR085W_d)|FD-Score:4.11|P-value:1.96E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YHL017W(YHL017W_p)|FD-Score:3.26|P-value:5.62E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication Gene:YIL163C(YIL163C_p)|FD-Score:4.9|P-value:4.69E-7||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YMR178W(YMR178W_p)|FD-Score:3.84|P-value:6.05E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YMR306C-A(YMR306C-A_d)|FD-Score:3.17|P-value:7.69E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL195C(YNL195C_p)|FD-Score:5.04|P-value:2.34E-7||SGD DESC:Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:AIR2(YDL175C)|FD-Score:5.76|P-value:4.11E-9||SGD DESC:RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication Gene:APD1(YBR151W)|FD-Score:-3.96|P-value:3.71E-5||SGD DESC:Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus Gene:ATG33(YLR356W)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes Gene:CRP1(YHR146W)|FD-Score:4|P-value:3.20E-5||SGD DESC:Protein that binds to cruciform DNA structures Gene:DSE4(YNR067C)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother Gene:FAA4(YMR246W)|FD-Score:3.71|P-value:1.03E-4||SGD DESC:Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication Gene:FZO1(YBR179C)|FD-Score:3.95|P-value:3.88E-5||SGD DESC:Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system Gene:HEL2(YDR266C)|FD-Score:-3.73|P-value:9.39E-5||SGD DESC:RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor Gene:HTB2(YBL002W)|FD-Score:-4.28|P-value:9.51E-6||SGD DESC:Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation Gene:MRT4(YKL009W)|FD-Score:3.46|P-value:2.66E-4||SGD DESC:Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus Gene:MXR1(YER042W)|FD-Score:-3.92|P-value:4.50E-5||SGD DESC:Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan Gene:NST1(YNL091W)|FD-Score:3.2|P-value:6.99E-4||SGD DESC:Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 Gene:OSH3(YHR073W)|FD-Score:3.12|P-value:8.99E-4||SGD DESC:Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability Gene:PAR32(YDL173W)|FD-Score:3.17|P-value:7.72E-4||SGD DESC:Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene Gene:PDH1(YPR002W)|FD-Score:3.14|P-value:8.32E-4||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PEX34(YCL056C)|FD-Score:-3.82|P-value:6.76E-5||SGD DESC:Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation Gene:PSR2(YLR019W)|FD-Score:-3.33|P-value:4.33E-4||SGD DESC:Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:RPS0B(YLR048W)|FD-Score:3.15|P-value:8.04E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2 Gene:RRD2(YPL152W)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress Gene:RTT106(YNL206C)|FD-Score:3.86|P-value:5.72E-5||SGD DESC:Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition Gene:SLY41(YOR307C)|FD-Score:4.52|P-value:3.15E-6||SGD DESC:Protein involved in ER-to-Golgi transport Gene:SPC2(YML055W)|FD-Score:3.84|P-value:6.08E-5||SGD DESC:Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 Gene:STF1(YDL130W-A)|FD-Score:-3.39|P-value:3.47E-4||SGD DESC:Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress Gene:SVS1(YPL163C)|FD-Score:3.4|P-value:3.32E-4||SGD DESC:Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication Gene:TMA10(YLR327C)|FD-Score:4.19|P-value:1.38E-5||SGD DESC:Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress Gene:TOM1(YDR457W)|FD-Score:4.44|P-value:4.45E-6||SGD DESC:E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase Gene:TRX1(YLR043C)|FD-Score:3.2|P-value:6.93E-4||SGD DESC:Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress Gene:YCR085W(YCR085W_d)|FD-Score:4.11|P-value:1.96E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YHL017W(YHL017W_p)|FD-Score:3.26|P-value:5.62E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication Gene:YIL163C(YIL163C_p)|FD-Score:4.9|P-value:4.69E-7||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YMR178W(YMR178W_p)|FD-Score:3.84|P-value:6.05E-5||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YMR306C-A(YMR306C-A_d)|FD-Score:3.17|P-value:7.69E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL195C(YNL195C_p)|FD-Score:5.04|P-value:2.34E-7||SGD DESC:Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YCR054C3.363.88E-40.36CTR86Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
YDR041W3.000.001340.08RSM10Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YHR062C2.920.001750.06RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YBR192W2.860.002100.03RIM2Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
YMR197C2.830.002300.08VTI1Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways
YLR066W2.750.002940.05SPC3Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
YKL189W2.710.003380.13HYM1Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
YIL129C2.580.005000.04TAO3Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
YIL019W2.530.005660.02FAF1Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
YER025W2.510.005990.02GCD11Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
YJL011C2.490.006400.02RPC17RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress
YKL210W2.470.006730.01UBA1Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress
YNL118C2.460.006970.00DCP2Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress
YJR022W2.460.007030.04LSM8Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
YLR272C2.410.007900.03YCS4Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDL175C5.764.11E-9AIR2RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication
YNL195C_p5.042.34E-7YNL195C_pPutative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL163C_p4.904.69E-7YIL163C_pProtein of unknown function; mRNA identified as translated by ribosome profiling data
YOR307C4.523.15E-6SLY41Protein involved in ER-to-Golgi transport
YDR457W4.444.45E-6TOM1E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
YLR327C4.191.38E-5TMA10Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress
YCR085W_d4.111.96E-5YCR085W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR146W4.003.20E-5CRP1Protein that binds to cruciform DNA structures
YBR179C3.953.88E-5FZO1Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
YNL206C3.865.72E-5RTT106Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition
YMR178W_p3.846.05E-5YMR178W_pProtein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress
YML055W3.846.08E-5SPC2Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25
YMR246W3.711.03E-4FAA4Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication
YPL152W3.591.66E-4RRD2Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress
YKL009W3.462.66E-4MRT4Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus

GO enrichment analysis for SGTC_2252
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0706.05E-8SGTC_24805767542 37.2 μMMiscellaneous28673580.0444444
0.0681.58E-7SGTC_12610712-0010 12.7 μMChemDiv (Drug-like library)28401230.111111RNA processing & uracil transport
0.0613.16E-6SGTC_22087283366 200.0 μMChembridge (Fragment library)8986630.0540541
0.0596.63E-6SGTC_28307992007 71.4 μMChembridge (Drug-like library)19520750.0941176
0.0587.00E-6SGTC_6414092-0595 30.0 μMChemDiv (Drug-like library)7862600.0810811
0.0571.21E-5SGTC_7800109-0199 192.0 μMChemDiv (Drug-like library)6104140.169231
0.0561.49E-5SGTC_1568digitonin 820.0 nMTimTec (Pure natural product library)27350100.0229008sphingolipid biosynthesis & PDR1
0.0552.11E-5SGTC_14294049-0205 9.5 μMChemDiv (Drug-like library)227744780.109589
0.0482.27E-4SGTC_22697935389 174.4 μMChembridge (Fragment library)976050.0533333tubulin folding & SWR complex
0.0482.28E-4SGTC_29319014674 55.7 μMChembridge (Drug-like library)29968100.113924
0.0473.12E-4SGTC_2248tofa 1.1 μMMiscellaneous1151750.0945946sphingolipid biosynthesis & PDR1
0.0463.54E-4SGTC_29849022109 39.0 μMChembridge (Drug-like library)64592070.194444
0.0463.78E-4SGTC_1950st077106 7.2 μMTimTec (Natural product derivative library)138318640.0714286RNA processing & uracil transport
0.0464.00E-4SGTC_15773(2'-chlorophenyl)-7-ethoxycoumarin 66.5 μMTimTec (Pure natural product library)6890070.125
0.0464.11E-4SGTC_20965468907 200.0 μMChembridge (Fragment library)7597850.0921053

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2251lansoprazole556 μM0.420293883NIH Clinical Collection369.361473.44218
SGTC_1547harmine94.2 μM0.2857145280953Miscellaneous212.247182.43812ergosterol biosynthesis
SGTC_2525harmine47.85 μM0.2857145280953Miscellaneous212.247182.43812ergosterol biosynthesis
SGTC_917harmaline728.09 nM0.2537315280951TimTec (Natural product library)214.263060.6613ergosterol biosynthesis
SGTC_8380109-020371.4 μM0.241935759422ChemDiv (Drug-like library)208.258483.75611
SGTC_7734358-145744.6 μM0.241186886ChemDiv (Drug-like library)352.38383.73716
SGTC_1793st04825672.23 μM0.236842672022TimTec (Natural product derivative library)274.315022.51113
SGTC_1615st00265686.5 μM0.2318841584458TimTec (Natural product derivative library)231.253821.1424redox potentiating
SGTC_9721319-0219195 μM0.22988523903702ChemDiv (Drug-like library)410.424724.12325
SGTC_11861319-021626 μM0.2289164565136ChemDiv (Drug-like library)385.3904435.32615
SGTC_20185133068143 μM0.227273785362Chembridge (Fragment library)186.20992.0212