7960471

4-(4-ethylpiperazin-1-yl)-6-methylthieno[2,3-d]pyrimidine hydrochloride

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2258
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 2974708
SMILES CCN1CCN(CC1)C2=C3C=C(SC3=NC=N2)C.Cl
Standardized SMILES CCN1CCN(CC1)c2ncnc3sc(C)cc23
Molecular weight 298.8348
ALogP 2.65
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.05
% growth inhibition (Hom. pool) 5.17


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2974708
Download HIP data (tab-delimited text)  (excel)
Gene:ARP7(YPR034W)|FD-Score:3.32|P-value:4.54E-4|Clearance:0.05||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CDC3(YLR314C)|FD-Score:3.78|P-value:7.83E-5|Clearance:0.03||SGD DESC:Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells Gene:DPM1(YPR183W)|FD-Score:3.1|P-value:9.82E-4|Clearance:0.14||SGD DESC:Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation Gene:ECM16(YMR128W)|FD-Score:3.27|P-value:5.45E-4|Clearance:0.05||SGD DESC:Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis Gene:MEC1(YBR136W)|FD-Score:3.34|P-value:4.13E-4|Clearance:0.03||SGD DESC:Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres Gene:PRP2(YNR011C)|FD-Score:3.45|P-value:2.83E-4|Clearance:0.09||SGD DESC:RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 Gene:PRP6(YBR055C)|FD-Score:3.21|P-value:6.52E-4|Clearance:0.09||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RPF1(YHR088W)|FD-Score:-3.51|P-value:2.25E-4|Clearance:0||SGD DESC:Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA Gene:RPL17A(YKL180W)|FD-Score:3.13|P-value:8.77E-4|Clearance:0.02||SGD DESC:Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RPP0(YLR340W)|FD-Score:4.87|P-value:5.58E-7|Clearance:0.64||SGD DESC:Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10 Gene:RPT5(YOR117W)|FD-Score:4.42|P-value:4.93E-6|Clearance:0.64||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 Gene:RSC6(YCR052W)|FD-Score:4.47|P-value:3.82E-6|Clearance:0.64||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SEC20(YDR498C)|FD-Score:3.75|P-value:8.86E-5|Clearance:0.3||SGD DESC:Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p Gene:SNU56(YDR240C)|FD-Score:3.11|P-value:9.46E-4|Clearance:0.01||SGD DESC:Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex Gene:YTH1(YPR107C)|FD-Score:3.35|P-value:4.00E-4|Clearance:0.01||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation Gene:ARP7(YPR034W)|FD-Score:3.32|P-value:4.54E-4|Clearance:0.05||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Gene:CDC3(YLR314C)|FD-Score:3.78|P-value:7.83E-5|Clearance:0.03||SGD DESC:Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells Gene:DPM1(YPR183W)|FD-Score:3.1|P-value:9.82E-4|Clearance:0.14||SGD DESC:Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation Gene:ECM16(YMR128W)|FD-Score:3.27|P-value:5.45E-4|Clearance:0.05||SGD DESC:Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis Gene:MEC1(YBR136W)|FD-Score:3.34|P-value:4.13E-4|Clearance:0.03||SGD DESC:Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres Gene:PRP2(YNR011C)|FD-Score:3.45|P-value:2.83E-4|Clearance:0.09||SGD DESC:RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 Gene:PRP6(YBR055C)|FD-Score:3.21|P-value:6.52E-4|Clearance:0.09||SGD DESC:Splicing factor, component of the U4/U6-U5 snRNP complex Gene:RPF1(YHR088W)|FD-Score:-3.51|P-value:2.25E-4|Clearance:0||SGD DESC:Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA Gene:RPL17A(YKL180W)|FD-Score:3.13|P-value:8.77E-4|Clearance:0.02||SGD DESC:Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RPP0(YLR340W)|FD-Score:4.87|P-value:5.58E-7|Clearance:0.64||SGD DESC:Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10 Gene:RPT5(YOR117W)|FD-Score:4.42|P-value:4.93E-6|Clearance:0.64||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 Gene:RSC6(YCR052W)|FD-Score:4.47|P-value:3.82E-6|Clearance:0.64||SGD DESC:Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p Gene:SEC20(YDR498C)|FD-Score:3.75|P-value:8.86E-5|Clearance:0.3||SGD DESC:Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p Gene:SNU56(YDR240C)|FD-Score:3.11|P-value:9.46E-4|Clearance:0.01||SGD DESC:Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex Gene:YTH1(YPR107C)|FD-Score:3.35|P-value:4.00E-4|Clearance:0.01||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2974708
Download HOP data (tab-delimited text)  (excel)
Gene:ADY4(YLR227C)|FD-Score:3.94|P-value:4.01E-5||SGD DESC:Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane Gene:AIM18(YHR198C)|FD-Score:3.95|P-value:3.98E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:ATG34(YOL083W)|FD-Score:-4.2|P-value:1.31E-5||SGD DESC:Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog Gene:BAP2(YBR068C)|FD-Score:3.17|P-value:7.65E-4||SGD DESC:High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication Gene:BIK1(YCL029C)|FD-Score:3.29|P-value:4.97E-4||SGD DESC:Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 Gene:BNI1(YNL271C)|FD-Score:-3.1|P-value:9.66E-4||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:CHL4(YDR254W)|FD-Score:-3.32|P-value:4.53E-4||SGD DESC:Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15 Gene:COX23(YHR116W)|FD-Score:-5.57|P-value:1.24E-8||SGD DESC:Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs Gene:CTF8(YHR191C)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion Gene:CTP1(YBR291C)|FD-Score:3.17|P-value:7.71E-4||SGD DESC:Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family Gene:DAN1(YJR150C)|FD-Score:-3.53|P-value:2.11E-4||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:DCC1(YCL016C)|FD-Score:4.99|P-value:3.02E-7||SGD DESC:Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance Gene:ERV14(YGL054C)|FD-Score:3.14|P-value:8.31E-4||SGD DESC:COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication Gene:FMC1(YIL098C)|FD-Score:-4.28|P-value:9.37E-6||SGD DESC:Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p Gene:GLE2(YER107C)|FD-Score:-3.11|P-value:9.46E-4||SGD DESC:RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 Gene:IME2(YJL106W)|FD-Score:-3.62|P-value:1.48E-4||SGD DESC:Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p Gene:KES1(YPL145C)|FD-Score:-3.52|P-value:2.15E-4||SGD DESC:One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication Gene:LSB5(YCL034W)|FD-Score:3.25|P-value:5.78E-4||SGD DESC:Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat Gene:MDJ1(YFL016C)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones Gene:MRC1(YCL061C)|FD-Score:4.51|P-value:3.26E-6||SGD DESC:S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres Gene:NMD4(YLR363C)|FD-Score:3.25|P-value:5.73E-4||SGD DESC:Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:OXA1(YER154W)|FD-Score:3.53|P-value:2.07E-4||SGD DESC:Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals Gene:PAU11(YGL261C_p)|FD-Score:7.1|P-value:6.15E-13||SGD DESC:Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2 Gene:PEX10(YDR265W)|FD-Score:-6.13|P-value:4.37E-10||SGD DESC:Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders Gene:PEX2(YJL210W)|FD-Score:-3.71|P-value:1.05E-4||SGD DESC:RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import Gene:PSR1(YLL010C)|FD-Score:3.78|P-value:7.81E-5||SGD DESC:Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:RCO1(YMR075W)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Gene:RNH1(YMR234W)|FD-Score:3.89|P-value:4.96E-5||SGD DESC:Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) Gene:RRT5(YFR032C_p)|FD-Score:4.14|P-value:1.73E-5||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation Gene:RSM23(YGL129C)|FD-Score:3.78|P-value:7.80E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p Gene:RTF1(YGL244W)|FD-Score:-4.3|P-value:8.50E-6||SGD DESC:Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:SEE1(YIL064W)|FD-Score:4.7|P-value:1.30E-6||SGD DESC:Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport Gene:SER2(YGR208W)|FD-Score:-3.67|P-value:1.23E-4||SGD DESC:Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source Gene:SLY41(YOR307C)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Protein involved in ER-to-Golgi transport Gene:SPO77(YLR341W)|FD-Score:3.58|P-value:1.73E-4||SGD DESC:Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis Gene:SPT7(YBR081C)|FD-Score:3.27|P-value:5.32E-4||SGD DESC:Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex Gene:SRO7(YPR032W)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication Gene:SUT2(YPR009W)|FD-Score:3.89|P-value:5.08E-5||SGD DESC:Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p Gene:TDA1(YMR291W)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:TIP41(YPR040W)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress Gene:TRM11(YOL124C)|FD-Score:-3.32|P-value:4.47E-4||SGD DESC:Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain Gene:VNX1(YNL321W)|FD-Score:3.8|P-value:7.36E-5||SGD DESC:Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate Gene:WSC2(YNL283C)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response Gene:YBR056W-A(YBR056W-A_p)|FD-Score:3.35|P-value:4.11E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B Gene:YBR220C(YBR220C_p)|FD-Score:3.19|P-value:7.03E-4||SGD DESC:Putative protein of unknown function; YBR220C is not an essential gene Gene:YBR232C(YBR232C_d)|FD-Score:-3.54|P-value:2.00E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCL001W-B(YCL001W-B_p)|FD-Score:3.79|P-value:7.67E-5||SGD DESC:Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication Gene:YCR016W(YCR016W_p)|FD-Score:3.11|P-value:9.27E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis Gene:YCR100C(YCR100C_p)|FD-Score:3.28|P-value:5.15E-4||SGD DESC:Putative protein of unknown function Gene:YEH1(YLL012W)|FD-Score:-3.16|P-value:7.88E-4||SGD DESC:Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes Gene:YGL188C-A(YGL188C-A_p)|FD-Score:4.5|P-value:3.38E-6||SGD DESC:Putative protein of unknown function Gene:YHR007C-A(YHR007C-A_p)|FD-Score:-3.43|P-value:2.96E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YLR326W(YLR326W_p)|FD-Score:6.58|P-value:2.33E-11||SGD DESC:Putative protein of unknown function, predicted to be palmitoylated Gene:YMR158W-B(YMR158W-B_d)|FD-Score:-4.65|P-value:1.64E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Gene:YOL159C(YOL159C)|FD-Score:-3.29|P-value:4.95E-4||SGD DESC:Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA Gene:YRO2(YBR054W)|FD-Score:3.19|P-value:7.11E-4||SGD DESC:Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication Gene:YVH1(YIR026C)|FD-Score:-3.23|P-value:6.11E-4||SGD DESC:Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases Gene:ADY4(YLR227C)|FD-Score:3.94|P-value:4.01E-5||SGD DESC:Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane Gene:AIM18(YHR198C)|FD-Score:3.95|P-value:3.98E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:ATG34(YOL083W)|FD-Score:-4.2|P-value:1.31E-5||SGD DESC:Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog Gene:BAP2(YBR068C)|FD-Score:3.17|P-value:7.65E-4||SGD DESC:High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication Gene:BIK1(YCL029C)|FD-Score:3.29|P-value:4.97E-4||SGD DESC:Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 Gene:BNI1(YNL271C)|FD-Score:-3.1|P-value:9.66E-4||SGD DESC:Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Gene:CHL4(YDR254W)|FD-Score:-3.32|P-value:4.53E-4||SGD DESC:Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15 Gene:COX23(YHR116W)|FD-Score:-5.57|P-value:1.24E-8||SGD DESC:Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs Gene:CTF8(YHR191C)|FD-Score:3.52|P-value:2.13E-4||SGD DESC:Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion Gene:CTP1(YBR291C)|FD-Score:3.17|P-value:7.71E-4||SGD DESC:Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family Gene:DAN1(YJR150C)|FD-Score:-3.53|P-value:2.11E-4||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:DCC1(YCL016C)|FD-Score:4.99|P-value:3.02E-7||SGD DESC:Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance Gene:ERV14(YGL054C)|FD-Score:3.14|P-value:8.31E-4||SGD DESC:COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication Gene:FMC1(YIL098C)|FD-Score:-4.28|P-value:9.37E-6||SGD DESC:Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p Gene:GLE2(YER107C)|FD-Score:-3.11|P-value:9.46E-4||SGD DESC:RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 Gene:IME2(YJL106W)|FD-Score:-3.62|P-value:1.48E-4||SGD DESC:Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p Gene:KES1(YPL145C)|FD-Score:-3.52|P-value:2.15E-4||SGD DESC:One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication Gene:LSB5(YCL034W)|FD-Score:3.25|P-value:5.78E-4||SGD DESC:Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat Gene:MDJ1(YFL016C)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones Gene:MRC1(YCL061C)|FD-Score:4.51|P-value:3.26E-6||SGD DESC:S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres Gene:NMD4(YLR363C)|FD-Score:3.25|P-value:5.73E-4||SGD DESC:Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:OXA1(YER154W)|FD-Score:3.53|P-value:2.07E-4||SGD DESC:Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals Gene:PAU11(YGL261C_p)|FD-Score:7.1|P-value:6.15E-13||SGD DESC:Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2 Gene:PEX10(YDR265W)|FD-Score:-6.13|P-value:4.37E-10||SGD DESC:Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders Gene:PEX2(YJL210W)|FD-Score:-3.71|P-value:1.05E-4||SGD DESC:RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import Gene:PSR1(YLL010C)|FD-Score:3.78|P-value:7.81E-5||SGD DESC:Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:RCO1(YMR075W)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p Gene:RNH1(YMR234W)|FD-Score:3.89|P-value:4.96E-5||SGD DESC:Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) Gene:RRT5(YFR032C_p)|FD-Score:4.14|P-value:1.73E-5||SGD DESC:Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation Gene:RSM23(YGL129C)|FD-Score:3.78|P-value:7.80E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p Gene:RTF1(YGL244W)|FD-Score:-4.3|P-value:8.50E-6||SGD DESC:Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:SEE1(YIL064W)|FD-Score:4.7|P-value:1.30E-6||SGD DESC:Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport Gene:SER2(YGR208W)|FD-Score:-3.67|P-value:1.23E-4||SGD DESC:Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source Gene:SLY41(YOR307C)|FD-Score:3.58|P-value:1.74E-4||SGD DESC:Protein involved in ER-to-Golgi transport Gene:SPO77(YLR341W)|FD-Score:3.58|P-value:1.73E-4||SGD DESC:Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis Gene:SPT7(YBR081C)|FD-Score:3.27|P-value:5.32E-4||SGD DESC:Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex Gene:SRO7(YPR032W)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication Gene:SUT2(YPR009W)|FD-Score:3.89|P-value:5.08E-5||SGD DESC:Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p Gene:TDA1(YMR291W)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:TIP41(YPR040W)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress Gene:TRM11(YOL124C)|FD-Score:-3.32|P-value:4.47E-4||SGD DESC:Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain Gene:VNX1(YNL321W)|FD-Score:3.8|P-value:7.36E-5||SGD DESC:Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate Gene:WSC2(YNL283C)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response Gene:YBR056W-A(YBR056W-A_p)|FD-Score:3.35|P-value:4.11E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B Gene:YBR220C(YBR220C_p)|FD-Score:3.19|P-value:7.03E-4||SGD DESC:Putative protein of unknown function; YBR220C is not an essential gene Gene:YBR232C(YBR232C_d)|FD-Score:-3.54|P-value:2.00E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YCL001W-B(YCL001W-B_p)|FD-Score:3.79|P-value:7.67E-5||SGD DESC:Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication Gene:YCR016W(YCR016W_p)|FD-Score:3.11|P-value:9.27E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis Gene:YCR100C(YCR100C_p)|FD-Score:3.28|P-value:5.15E-4||SGD DESC:Putative protein of unknown function Gene:YEH1(YLL012W)|FD-Score:-3.16|P-value:7.88E-4||SGD DESC:Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes Gene:YGL188C-A(YGL188C-A_p)|FD-Score:4.5|P-value:3.38E-6||SGD DESC:Putative protein of unknown function Gene:YHR007C-A(YHR007C-A_p)|FD-Score:-3.43|P-value:2.96E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YLR326W(YLR326W_p)|FD-Score:6.58|P-value:2.33E-11||SGD DESC:Putative protein of unknown function, predicted to be palmitoylated Gene:YMR158W-B(YMR158W-B_d)|FD-Score:-4.65|P-value:1.64E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Gene:YOL159C(YOL159C)|FD-Score:-3.29|P-value:4.95E-4||SGD DESC:Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA Gene:YRO2(YBR054W)|FD-Score:3.19|P-value:7.11E-4||SGD DESC:Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication Gene:YVH1(YIR026C)|FD-Score:-3.23|P-value:6.11E-4||SGD DESC:Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR340W4.875.58E-70.64RPP0Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10
YCR052W4.473.82E-60.64RSC6Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YOR117W4.424.93E-60.64RPT5One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
YLR314C3.787.83E-50.03CDC3Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells
YDR498C3.758.86E-50.30SEC20Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p
YNR011C3.452.83E-40.09PRP2RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16
YPR107C3.354.00E-40.01YTH1Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
YBR136W3.344.13E-40.03MEC1Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres
YPR034W3.324.54E-40.05ARP7Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YMR128W3.275.45E-40.05ECM16Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
YBR055C3.216.52E-40.09PRP6Splicing factor, component of the U4/U6-U5 snRNP complex
YKL180W3.138.77E-40.02RPL17ARibosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
YDR240C3.119.46E-40.01SNU56Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YPR183W3.109.82E-40.14DPM1Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
YBR152W2.950.001570.07SPP381mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGL261C_p7.106.15E-13PAU11_pPutative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2
YLR326W_p6.582.33E-11YLR326W_pPutative protein of unknown function, predicted to be palmitoylated
YCL016C4.993.02E-7DCC1Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance
YIL064W4.701.30E-6SEE1Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport
YCL061C4.513.26E-6MRC1S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres
YGL188C-A_p4.503.38E-6YGL188C-A_pPutative protein of unknown function
YFR032C_p4.141.73E-5RRT5_pPutative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation
YHR198C3.953.98E-5AIM18Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
YLR227C3.944.01E-5ADY4Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
YMR234W3.894.96E-5RNH1Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)
YPR009W3.895.08E-5SUT2Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
YNL321W3.807.36E-5VNX1Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate
YCL001W-B_p3.797.67E-5YCL001W-B_pPutative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication
YGL129C3.787.80E-5RSM23Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p
YLL010C3.787.81E-5PSR1Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p

GO enrichment analysis for SGTC_2258
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0953.39E-13SGTC_22287354201 200.0 μMChembridge (Fragment library)7534510.111111endomembrane recycling
0.0944.54E-13SGTC_20014023502 57.7 μMChembridge (Fragment library)1089410.0877193mitochondrial processes
0.0863.97E-11SGTC_22567954252 200.0 μMChembridge (Fragment library)29729200.0625mitochondrial processes
0.0672.69E-7SGTC_22607964312 200.0 μMChembridge (Fragment library)2319510.0819672
0.0655.96E-7SGTC_10523253-3998 198.0 μMChemDiv (Drug-like library)54503170.0609756
0.0648.28E-7SGTC_30641327-0027 10.0 μMChemDiv (Drug-like library)160004550.0533333
0.0622.09E-6SGTC_246cycloheximide 667.0 μMICCB bioactive library167600400.0597015
0.0603.46E-6SGTC_5660958-0068 16.5 μMChemDiv (Drug-like library)68153650.0365854RSC & ERG11
0.0594.90E-6SGTC_21245246320 200.0 μMChembridge (Fragment library)5793420.0483871heme biosynthesis & mitochondrial translocase
0.0595.55E-6SGTC_23207373003 200.0 μMChembridge (Fragment library)54158280.0675676
0.0561.69E-5SGTC_31309127414 49.5 μMChembridge (Drug-like library)14946460.157895
0.0552.04E-5SGTC_2747doxorubicin 7.6 μMMiscellaneous317030.0485437anthracycline transcription coupled DNA repair
0.0543.19E-5SGTC_30601327-0027 12.5 μMChemDiv (Drug-like library)160004550.0533333
0.0534.20E-5SGTC_1898st060199 18.6 μMTimTec (Natural product derivative library)6888660.078125
0.0525.65E-5SGTC_10084106-0037 6.0 μMChemDiv (Drug-like library)29053940.15493PDR1

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_9923909-8734162 μM0.3653854288319ChemDiv (Drug-like library)275.75664.01114
SGTC_11513909-831615.3 μM0.357143800431ChemDiv (Drug-like library)332.442064.50104
SGTC_9933909-875762.7 μM0.3518524288324ChemDiv (Drug-like library)275.75664.01114
SGTC_5953909-800373.7 μM0.326923699517ChemDiv (Drug-like library)259.369883.65704
SGTC_3330914142471.43 μM0.32258127261020Chembridge (Drug-like library)308.400743.80324amide catabolism
SGTC_11483909-766327.7 μM0.3035714084526ChemDiv (Drug-like library)320.38833.70205
SGTC_970535-070119.13 μM0.2786892832013ChemDiv (Drug-like library)311.381543.2440660S ribosome export
SGTC_23017769476200 μM0.275862977820Chembridge (Fragment library)253.343841.85915
SGTC_3145908551649.47 μM0.27586225236195Chembridge (Drug-like library)306.466143.79903fatty acid desaturase (OLE1)
SGTC_3320913700535.14 μM0.2698414908713Chembridge (Drug-like library)335.4463.39704endomembrane recycling