7964312

10-methyl-1,2,3,4-tetrahydroacridin-9-one

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2260
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 231951
SMILES CN1C2=C(CCCC2)C(=O)C3=CC=CC=C31
Standardized SMILES CN1C2=C(CCCC2)C(=O)c3ccccc13
Molecular weight 213.275
ALogP 3.14
H-bond donor count 0
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 4.13
% growth inhibition (Hom. pool) 6.23


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 231951
Download HIP data (tab-delimited text)  (excel)
Gene:ALG2(YGL065C)|FD-Score:3.29|P-value:5.10E-4|Clearance:0.09||SGD DESC:Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol Gene:ATM1(YMR301C)|FD-Score:3.33|P-value:4.27E-4|Clearance:0.05||SGD DESC:Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol Gene:HEM2(YGL040C)|FD-Score:3.2|P-value:6.93E-4|Clearance:0.02||SGD DESC:Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus Gene:IRR1(YIL026C)|FD-Score:4.97|P-value:3.28E-7|Clearance:0.47||SGD DESC:Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability Gene:LSG1(YGL099W)|FD-Score:4.51|P-value:3.31E-6|Clearance:0.44||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:LSM3(YLR438C-A)|FD-Score:3.85|P-value:5.82E-5|Clearance:0.09||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:MTR10(YOR160W)|FD-Score:3.18|P-value:7.48E-4|Clearance:0||SGD DESC:Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:NMD3(YHR170W)|FD-Score:5.13|P-value:1.48E-7|Clearance:0.47||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:RDS3(YPR094W)|FD-Score:-3.21|P-value:6.68E-4|Clearance:0||SGD DESC:Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance Gene:ROK1(YGL171W)|FD-Score:3.14|P-value:8.45E-4|Clearance:0.09||SGD DESC:RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation Gene:RPO31(YOR116C)|FD-Score:3.68|P-value:1.15E-4|Clearance:0||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:RPT5(YOR117W)|FD-Score:3.9|P-value:4.80E-5|Clearance:0.05||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 Gene:SMC5(YOL034W)|FD-Score:-4.25|P-value:1.06E-5|Clearance:0||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair Gene:SRP14(YDL092W)|FD-Score:4.07|P-value:2.37E-5|Clearance:0.17||SGD DESC:Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 Gene:THI80(YOR143C)|FD-Score:3.17|P-value:7.58E-4|Clearance:0.03||SGD DESC:Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate) Gene:TIM17(YJL143W)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.05||SGD DESC:Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex Gene:UFE1(YOR075W)|FD-Score:-3.45|P-value:2.78E-4|Clearance:0||SGD DESC:t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER Gene:VRG4(YGL225W)|FD-Score:3.68|P-value:1.17E-4|Clearance:0.06||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:YDR396W(YDR396W_d)|FD-Score:3.57|P-value:1.76E-4|Clearance:0.24||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex Gene:YJR141W(YJR141W_p)|FD-Score:3.76|P-value:8.34E-5|Clearance:0.08||SGD DESC:Essential protein of unknown function Gene:ALG2(YGL065C)|FD-Score:3.29|P-value:5.10E-4|Clearance:0.09||SGD DESC:Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol Gene:ATM1(YMR301C)|FD-Score:3.33|P-value:4.27E-4|Clearance:0.05||SGD DESC:Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol Gene:HEM2(YGL040C)|FD-Score:3.2|P-value:6.93E-4|Clearance:0.02||SGD DESC:Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus Gene:IRR1(YIL026C)|FD-Score:4.97|P-value:3.28E-7|Clearance:0.47||SGD DESC:Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability Gene:LSG1(YGL099W)|FD-Score:4.51|P-value:3.31E-6|Clearance:0.44||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:LSM3(YLR438C-A)|FD-Score:3.85|P-value:5.82E-5|Clearance:0.09||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:MTR10(YOR160W)|FD-Score:3.18|P-value:7.48E-4|Clearance:0||SGD DESC:Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:NMD3(YHR170W)|FD-Score:5.13|P-value:1.48E-7|Clearance:0.47||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:RDS3(YPR094W)|FD-Score:-3.21|P-value:6.68E-4|Clearance:0||SGD DESC:Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance Gene:ROK1(YGL171W)|FD-Score:3.14|P-value:8.45E-4|Clearance:0.09||SGD DESC:RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation Gene:RPO31(YOR116C)|FD-Score:3.68|P-value:1.15E-4|Clearance:0||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:RPT5(YOR117W)|FD-Score:3.9|P-value:4.80E-5|Clearance:0.05||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 Gene:SMC5(YOL034W)|FD-Score:-4.25|P-value:1.06E-5|Clearance:0||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair Gene:SRP14(YDL092W)|FD-Score:4.07|P-value:2.37E-5|Clearance:0.17||SGD DESC:Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 Gene:THI80(YOR143C)|FD-Score:3.17|P-value:7.58E-4|Clearance:0.03||SGD DESC:Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate) Gene:TIM17(YJL143W)|FD-Score:3.62|P-value:1.45E-4|Clearance:0.05||SGD DESC:Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex Gene:UFE1(YOR075W)|FD-Score:-3.45|P-value:2.78E-4|Clearance:0||SGD DESC:t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER Gene:VRG4(YGL225W)|FD-Score:3.68|P-value:1.17E-4|Clearance:0.06||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:YDR396W(YDR396W_d)|FD-Score:3.57|P-value:1.76E-4|Clearance:0.24||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex Gene:YJR141W(YJR141W_p)|FD-Score:3.76|P-value:8.34E-5|Clearance:0.08||SGD DESC:Essential protein of unknown function

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 231951
Download HOP data (tab-delimited text)  (excel)
Gene:AAC1(YMR056C)|FD-Score:4.33|P-value:7.40E-6||SGD DESC:Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress Gene:ADH4(YGL256W)|FD-Score:3.16|P-value:7.92E-4||SGD DESC:Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency Gene:ADY2(YCR010C)|FD-Score:4.85|P-value:6.12E-7||SGD DESC:Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication Gene:AIM3(YBR108W)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:APL5(YPL195W)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function Gene:ARN2(YHL047C)|FD-Score:3.26|P-value:5.51E-4||SGD DESC:Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C Gene:BAR1(YIL015W)|FD-Score:3.12|P-value:8.93E-4||SGD DESC:Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest Gene:BNA7(YDR428C)|FD-Score:3.15|P-value:8.26E-4||SGD DESC:Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine Gene:BTS1(YPL069C)|FD-Score:4.07|P-value:2.30E-5||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:COX17(YLL009C)|FD-Score:-4.37|P-value:6.21E-6||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:COX23(YHR116W)|FD-Score:-4.69|P-value:1.37E-6||SGD DESC:Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs Gene:DBF20(YPR111W)|FD-Score:-3.48|P-value:2.55E-4||SGD DESC:Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs Gene:ECM5(YMR176W)|FD-Score:-3.49|P-value:2.44E-4||SGD DESC:Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress Gene:GFD2(YCL036W)|FD-Score:3.82|P-value:6.67E-5||SGD DESC:Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication Gene:GLO1(YML004C)|FD-Score:3.36|P-value:3.83E-4||SGD DESC:Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress Gene:HRD1(YOL013C)|FD-Score:3.1|P-value:9.66E-4||SGD DESC:Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon Gene:HTA2(YBL003C)|FD-Score:3.17|P-value:7.66E-4||SGD DESC:Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p Gene:HXT2(YMR011W)|FD-Score:3.84|P-value:6.15E-5||SGD DESC:High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose Gene:HXT8(YJL214W)|FD-Score:3.29|P-value:5.04E-4||SGD DESC:Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose Gene:ISM1(YPL040C)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth Gene:IST1(YNL265C)|FD-Score:3.38|P-value:3.60E-4||SGD DESC:Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p Gene:MOH1(YBL049W)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase Gene:MOT3(YMR070W)|FD-Score:3.67|P-value:1.22E-4||SGD DESC:Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion Gene:NCE101(YJL205C)|FD-Score:-3.16|P-value:7.87E-4||SGD DESC:Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences Gene:PET111(YMR257C)|FD-Score:3.85|P-value:5.87E-5||SGD DESC:Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane Gene:PHO84(YML123C)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity Gene:PMT2(YAL023C)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication Gene:PRC1(YMR297W)|FD-Score:3.27|P-value:5.47E-4||SGD DESC:Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family Gene:PUS5(YLR165C)|FD-Score:4.19|P-value:1.38E-5||SGD DESC:Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability Gene:RDL2(YOR286W)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss Gene:RNH201(YNL072W)|FD-Score:4.41|P-value:5.27E-6||SGD DESC:Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome Gene:RPL8A(YHL033C)|FD-Score:-3.1|P-value:9.51E-4||SGD DESC:Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication Gene:SMF1(YOL122C)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins Gene:SUT2(YPR009W)|FD-Score:3.76|P-value:8.52E-5||SGD DESC:Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p Gene:TDA1(YMR291W)|FD-Score:5.1|P-value:1.69E-7||SGD DESC:Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:TOP1(YOL006C)|FD-Score:3.31|P-value:4.66E-4||SGD DESC:Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Gene:TPO5(YKL174C)|FD-Score:4.24|P-value:1.13E-5||SGD DESC:Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles Gene:TRM2(YKR056W)|FD-Score:3.3|P-value:4.92E-4||SGD DESC:tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair Gene:VPH2(YKL119C)|FD-Score:-3.29|P-value:5.00E-4||SGD DESC:Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) Gene:YBL012C(YBL012C_d)|FD-Score:3.26|P-value:5.58E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR196C-A(YBR196C-A_p)|FD-Score:-5.58|P-value:1.17E-8||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YCL002C(YCL002C_p)|FD-Score:5.18|P-value:1.13E-7||SGD DESC:Putative protein of unknown function; YCL002C is not an essential gene Gene:YDR102C(YDR102C_d)|FD-Score:5.58|P-value:1.18E-8||SGD DESC:Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index Gene:YGL039W(YGL039W)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols Gene:YGR012W(YGR012W)|FD-Score:3.24|P-value:6.04E-4||SGD DESC:Putative cysteine synthase, localized to the mitochondrial outer membrane Gene:YGR168C(YGR168C_p)|FD-Score:4.89|P-value:5.05E-7||SGD DESC:Putative protein of unknown function; YGR168C is not an essential gene Gene:YGR228W(YGR228W_d)|FD-Score:3.73|P-value:9.68E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Gene:YHL005C(YHL005C_d)|FD-Score:-4.21|P-value:1.29E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W Gene:YJL070C(YJL070C_p)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication Gene:YLR123C(YLR123C_d)|FD-Score:3.95|P-value:3.93E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif Gene:YMR090W(YMR090W_p)|FD-Score:-3.46|P-value:2.69E-4||SGD DESC:Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability Gene:YPL039W(YPL039W_p)|FD-Score:4.34|P-value:7.27E-6||SGD DESC:Putative protein of unknown function; YPL039W is not an essential gene Gene:YPL107W(YPL107W_p)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene Gene:YPL247C(YPL247C_p)|FD-Score:-3.52|P-value:2.16E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest Gene:YPL277C(YPL277C_p)|FD-Score:4.1|P-value:2.04E-5||SGD DESC:Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels Gene:AAC1(YMR056C)|FD-Score:4.33|P-value:7.40E-6||SGD DESC:Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress Gene:ADH4(YGL256W)|FD-Score:3.16|P-value:7.92E-4||SGD DESC:Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency Gene:ADY2(YCR010C)|FD-Score:4.85|P-value:6.12E-7||SGD DESC:Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication Gene:AIM3(YBR108W)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:APL5(YPL195W)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function Gene:ARN2(YHL047C)|FD-Score:3.26|P-value:5.51E-4||SGD DESC:Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C Gene:BAR1(YIL015W)|FD-Score:3.12|P-value:8.93E-4||SGD DESC:Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest Gene:BNA7(YDR428C)|FD-Score:3.15|P-value:8.26E-4||SGD DESC:Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine Gene:BTS1(YPL069C)|FD-Score:4.07|P-value:2.30E-5||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:COX17(YLL009C)|FD-Score:-4.37|P-value:6.21E-6||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:COX23(YHR116W)|FD-Score:-4.69|P-value:1.37E-6||SGD DESC:Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs Gene:DBF20(YPR111W)|FD-Score:-3.48|P-value:2.55E-4||SGD DESC:Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs Gene:ECM5(YMR176W)|FD-Score:-3.49|P-value:2.44E-4||SGD DESC:Non-essential protein of unknown function; contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress Gene:GFD2(YCL036W)|FD-Score:3.82|P-value:6.67E-5||SGD DESC:Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication Gene:GLO1(YML004C)|FD-Score:3.36|P-value:3.83E-4||SGD DESC:Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress Gene:HRD1(YOL013C)|FD-Score:3.1|P-value:9.66E-4||SGD DESC:Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon Gene:HTA2(YBL003C)|FD-Score:3.17|P-value:7.66E-4||SGD DESC:Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p Gene:HXT2(YMR011W)|FD-Score:3.84|P-value:6.15E-5||SGD DESC:High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose Gene:HXT8(YJL214W)|FD-Score:3.29|P-value:5.04E-4||SGD DESC:Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose Gene:ISM1(YPL040C)|FD-Score:3.67|P-value:1.23E-4||SGD DESC:Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth Gene:IST1(YNL265C)|FD-Score:3.38|P-value:3.60E-4||SGD DESC:Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p Gene:MOH1(YBL049W)|FD-Score:3.57|P-value:1.79E-4||SGD DESC:Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase Gene:MOT3(YMR070W)|FD-Score:3.67|P-value:1.22E-4||SGD DESC:Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion Gene:NCE101(YJL205C)|FD-Score:-3.16|P-value:7.87E-4||SGD DESC:Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences Gene:PET111(YMR257C)|FD-Score:3.85|P-value:5.87E-5||SGD DESC:Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane Gene:PHO84(YML123C)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity Gene:PMT2(YAL023C)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication Gene:PRC1(YMR297W)|FD-Score:3.27|P-value:5.47E-4||SGD DESC:Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family Gene:PUS5(YLR165C)|FD-Score:4.19|P-value:1.38E-5||SGD DESC:Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability Gene:RDL2(YOR286W)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss Gene:RNH201(YNL072W)|FD-Score:4.41|P-value:5.27E-6||SGD DESC:Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome Gene:RPL8A(YHL033C)|FD-Score:-3.1|P-value:9.51E-4||SGD DESC:Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication Gene:SMF1(YOL122C)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins Gene:SUT2(YPR009W)|FD-Score:3.76|P-value:8.52E-5||SGD DESC:Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p Gene:TDA1(YMR291W)|FD-Score:5.1|P-value:1.69E-7||SGD DESC:Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:TOP1(YOL006C)|FD-Score:3.31|P-value:4.66E-4||SGD DESC:Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Gene:TPO5(YKL174C)|FD-Score:4.24|P-value:1.13E-5||SGD DESC:Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles Gene:TRM2(YKR056W)|FD-Score:3.3|P-value:4.92E-4||SGD DESC:tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair Gene:VPH2(YKL119C)|FD-Score:-3.29|P-value:5.00E-4||SGD DESC:Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) Gene:YBL012C(YBL012C_d)|FD-Score:3.26|P-value:5.58E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR196C-A(YBR196C-A_p)|FD-Score:-5.58|P-value:1.17E-8||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YCL002C(YCL002C_p)|FD-Score:5.18|P-value:1.13E-7||SGD DESC:Putative protein of unknown function; YCL002C is not an essential gene Gene:YDR102C(YDR102C_d)|FD-Score:5.58|P-value:1.18E-8||SGD DESC:Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index Gene:YGL039W(YGL039W)|FD-Score:3.15|P-value:8.05E-4||SGD DESC:Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols Gene:YGR012W(YGR012W)|FD-Score:3.24|P-value:6.04E-4||SGD DESC:Putative cysteine synthase, localized to the mitochondrial outer membrane Gene:YGR168C(YGR168C_p)|FD-Score:4.89|P-value:5.05E-7||SGD DESC:Putative protein of unknown function; YGR168C is not an essential gene Gene:YGR228W(YGR228W_d)|FD-Score:3.73|P-value:9.68E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Gene:YHL005C(YHL005C_d)|FD-Score:-4.21|P-value:1.29E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W Gene:YJL070C(YJL070C_p)|FD-Score:3.36|P-value:3.93E-4||SGD DESC:Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication Gene:YLR123C(YLR123C_d)|FD-Score:3.95|P-value:3.93E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif Gene:YMR090W(YMR090W_p)|FD-Score:-3.46|P-value:2.69E-4||SGD DESC:Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability Gene:YPL039W(YPL039W_p)|FD-Score:4.34|P-value:7.27E-6||SGD DESC:Putative protein of unknown function; YPL039W is not an essential gene Gene:YPL107W(YPL107W_p)|FD-Score:3.21|P-value:6.61E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene Gene:YPL247C(YPL247C_p)|FD-Score:-3.52|P-value:2.16E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest Gene:YPL277C(YPL277C_p)|FD-Score:4.1|P-value:2.04E-5||SGD DESC:Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR170W5.131.48E-70.47NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YIL026C4.973.28E-70.47IRR1Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
YGL099W4.513.31E-60.44LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YDL092W4.072.37E-50.17SRP14Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
YOR117W3.904.80E-50.05RPT5One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
YLR438C-A3.855.82E-50.09LSM3Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
YJR141W_p3.768.34E-50.08YJR141W_pEssential protein of unknown function
YOR116C3.681.15E-40.00RPO31RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
YGL225W3.681.17E-40.06VRG4Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YJL143W3.621.45E-40.05TIM17Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
YDR396W_d3.571.76E-40.24YDR396W_dDubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex
YMR301C3.334.27E-40.05ATM1Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
YGL065C3.295.10E-40.09ALG2Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
YGL040C3.206.93E-40.02HEM2Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
YOR160W3.187.48E-40.00MTR10Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR102C_d5.581.18E-8YDR102C_dDubious open reading frame; homozygous diploid deletion strain exhibits high budding index
YCL002C_p5.181.13E-7YCL002C_pPutative protein of unknown function; YCL002C is not an essential gene
YMR291W5.101.69E-7TDA1Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress
YGR168C_p4.895.05E-7YGR168C_pPutative protein of unknown function; YGR168C is not an essential gene
YCR010C4.856.12E-7ADY2Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication
YNL072W4.415.27E-6RNH201Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome
YPL039W_p4.347.27E-6YPL039W_pPutative protein of unknown function; YPL039W is not an essential gene
YMR056C4.337.40E-6AAC1Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
YKL174C4.241.13E-5TPO5Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles
YLR165C4.191.38E-5PUS5Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability
YPL277C_p4.102.04E-5YPL277C_pPutative protein of unknown function; localized to the membranes; gene expression regulated by copper levels
YPL069C4.072.30E-5BTS1Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
YLR123C_d3.953.93E-5YLR123C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YMR257C3.855.87E-5PET111Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
YMR011W3.846.15E-5HXT2High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose

GO enrichment analysis for SGTC_2260
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1253.85E-22SGTC_7651319-0117 244.0 μMChemDiv (Drug-like library)34877460.086419860S ribosome export
0.1189.33E-20SGTC_618k072-0232 33.2 μMChemDiv (Drug-like library)58727560.096774260S ribosome export
0.1171.80E-19SGTC_970535-0701 19.1 μMChemDiv (Drug-like library)28320130.260S ribosome export
0.1071.75E-16SGTC_1913914-0123 66.5 μMChemDiv (Drug-like library)31444120.075757660S ribosome export
0.1055.16E-16SGTC_20785212016 200.0 μMChembridge (Fragment library)18997080.054545560S ribosome export
0.1032.14E-15SGTC_1775st081588 35.2 μMTimTec (Natural product derivative library)14264430.11111160S ribosome export
0.1001.13E-14SGTC_1829berberine 14.4 μMTimTec (Natural product derivative library)23530.10144960S ribosome export
0.0992.60E-14SGTC_29839022671 13.0 μMChembridge (Drug-like library)64051610.075949460S ribosome export
0.0961.09E-13SGTC_1958st076513 41.9 μMTimTec (Natural product derivative library)7321220.11864460S ribosome export
0.0961.12E-13SGTC_490717-0965 32.1 μMChemDiv (Drug-like library)58893490.10769260S ribosome export
0.0961.41E-13SGTC_1070indatraline 8.8 μMNIH Clinical Collection103144720.12560S ribosome export
0.0961.80E-13SGTC_1522st012842 45.6 μMTimTec (Pure natural product library)34910670.1125RNA pol III & RNase P/MRP
0.0953.02E-13SGTC_1971st069429 63.5 μMTimTec (Natural product derivative library)12465220.12560S ribosome export
0.0921.83E-12SGTC_32939120939 62.0 μMChembridge (Drug-like library)9340870.125
0.0905.15E-12SGTC_8103825-7150 143.0 μMChemDiv (Drug-like library)223304110.085714360S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_1915st06710530.6 μM0.562569751TimTec (Natural product derivative library)209.243243.1602RNA pol III & RNase P/MRP
SGTC_1686st019653115.5 μM0.41025697252TimTec (Natural product derivative library)173.211141.90401mitochondrial processes
SGTC_20335192550145 μM0.380952182073Chembridge (Fragment library)189.210541.14602
SGTC_20225136654200 μM0.3488371713771Chembridge (Fragment library)204.225180.99703
SGTC_13111190-0148100 μM0.3269231961333ChemDiv (Drug-like library)344.40643.5903azole & statin
SGTC_20124023501200 μM0.3095243477460Chembridge (Fragment library)175.183961.36202
SGTC_2001402350257.66 μM0.302326108941Chembridge (Fragment library)195.602441.5402mitochondrial processes
SGTC_20665222451176 μM0.32281147Chembridge (Fragment library)242.273161.60503heme biosynthesis & mitochondrial translocase
SGTC_544k015-002052.4 μM0.2978723008304ChemDiv (Drug-like library)316.14943.20802
SGTC_606k015-000838.6 μM0.2978721970475ChemDiv (Drug-like library)306.143463.78802