9014885

4-(2,3-dihydroindol-1-yl)-1,3,5-triazin-2-amine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2262
Screen concentration 67.5 μM
Source Chembridge (Fragment library)
PubChem CID 6457424
SMILES C1CN(C2=CC=CC=C21)C3=NC(=NC=N3)N
Standardized SMILES Nc1ncnc(n1)N2CCc3ccccc23
Molecular weight 213.2385
ALogP 2.07
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.21
% growth inhibition (Hom. pool) 7.27


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6457424
Download HIP data (tab-delimited text)  (excel)
Gene:HYM1(YKL189W)|FD-Score:3.4|P-value:3.35E-4|Clearance:0.43||SGD DESC:Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response Gene:SGT1(YOR057W)|FD-Score:3.11|P-value:9.40E-4|Clearance:0.43||SGD DESC:Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress Gene:HYM1(YKL189W)|FD-Score:3.4|P-value:3.35E-4|Clearance:0.43||SGD DESC:Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response Gene:SGT1(YOR057W)|FD-Score:3.11|P-value:9.40E-4|Clearance:0.43||SGD DESC:Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6457424
Download HOP data (tab-delimited text)  (excel)
Gene:AIM17(YHL021C)|FD-Score:-4.52|P-value:3.15E-6||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss Gene:ARF1(YDL192W)|FD-Score:-4.07|P-value:2.32E-5||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication Gene:CSI1(YMR025W)|FD-Score:4.45|P-value:4.25E-6||SGD DESC:Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome Gene:DNF2(YDR093W)|FD-Score:-3.23|P-value:6.27E-4||SGD DESC:Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase Gene:EFM2(YBR271W)|FD-Score:-3.49|P-value:2.38E-4||SGD DESC:S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis Gene:ERV2(YPR037C)|FD-Score:-5.95|P-value:1.37E-9||SGD DESC:Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER Gene:KSP1(YHR082C)|FD-Score:3.1|P-value:9.69E-4||SGD DESC:Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress Gene:LDB19(YOR322C)|FD-Score:5.8|P-value:3.23E-9||SGD DESC:Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye Gene:LRE1(YCL051W)|FD-Score:3.23|P-value:6.29E-4||SGD DESC:Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication Gene:MNN4(YKL201C)|FD-Score:-3.32|P-value:4.49E-4||SGD DESC:Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication Gene:NPP2(YEL016C)|FD-Score:-3.59|P-value:1.67E-4||SGD DESC:Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication Gene:OPI7(YDR360W_d)|FD-Score:3.15|P-value:8.20E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C. Gene:PDR18(YNR070W_p)|FD-Score:3.66|P-value:1.26E-4||SGD DESC:Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:PUT1(YLR142W)|FD-Score:-4.18|P-value:1.45E-5||SGD DESC:Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source Gene:RIP1(YEL024W)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly Gene:RTT10(YPL183C)|FD-Score:3.76|P-value:8.54E-5||SGD DESC:WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6 Gene:SEF1(YBL066C)|FD-Score:3.8|P-value:7.27E-5||SGD DESC:Putative transcription factor, has homolog in Kluyveromyces lactis Gene:SLK19(YOR195W)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate Gene:UBP15(YMR304W)|FD-Score:-3.16|P-value:7.83E-4||SGD DESC:Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p Gene:ULS1(YOR191W)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:YDR445C(YDR445C_d)|FD-Score:-8.14|P-value:2.02E-16||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YEL010W(YEL010W_d)|FD-Score:4.52|P-value:3.06E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR037W(YJR037W_d)|FD-Score:-3.12|P-value:9.12E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces Gene:YML094C-A(YML094C-A_d)|FD-Score:-3.32|P-value:4.57E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO Gene:YPL039W(YPL039W_p)|FD-Score:-3.88|P-value:5.21E-5||SGD DESC:Putative protein of unknown function; YPL039W is not an essential gene Gene:YPR196W(YPR196W_p)|FD-Score:3.65|P-value:1.30E-4||SGD DESC:Putative maltose-responsive transcription factor Gene:AIM17(YHL021C)|FD-Score:-4.52|P-value:3.15E-6||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss Gene:ARF1(YDL192W)|FD-Score:-4.07|P-value:2.32E-5||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication Gene:CSI1(YMR025W)|FD-Score:4.45|P-value:4.25E-6||SGD DESC:Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome Gene:DNF2(YDR093W)|FD-Score:-3.23|P-value:6.27E-4||SGD DESC:Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase Gene:EFM2(YBR271W)|FD-Score:-3.49|P-value:2.38E-4||SGD DESC:S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis Gene:ERV2(YPR037C)|FD-Score:-5.95|P-value:1.37E-9||SGD DESC:Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER Gene:KSP1(YHR082C)|FD-Score:3.1|P-value:9.69E-4||SGD DESC:Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress Gene:LDB19(YOR322C)|FD-Score:5.8|P-value:3.23E-9||SGD DESC:Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye Gene:LRE1(YCL051W)|FD-Score:3.23|P-value:6.29E-4||SGD DESC:Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; <br>LRE1 has a paralog, HLR1, that arose from the whole genome duplication Gene:MNN4(YKL201C)|FD-Score:-3.32|P-value:4.49E-4||SGD DESC:Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication Gene:NPP2(YEL016C)|FD-Score:-3.59|P-value:1.67E-4||SGD DESC:Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication Gene:OPI7(YDR360W_d)|FD-Score:3.15|P-value:8.20E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C. Gene:PDR18(YNR070W_p)|FD-Score:3.66|P-value:1.26E-4||SGD DESC:Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:PUT1(YLR142W)|FD-Score:-4.18|P-value:1.45E-5||SGD DESC:Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source Gene:RIP1(YEL024W)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly Gene:RTT10(YPL183C)|FD-Score:3.76|P-value:8.54E-5||SGD DESC:WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6 Gene:SEF1(YBL066C)|FD-Score:3.8|P-value:7.27E-5||SGD DESC:Putative transcription factor, has homolog in Kluyveromyces lactis Gene:SLK19(YOR195W)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate Gene:UBP15(YMR304W)|FD-Score:-3.16|P-value:7.83E-4||SGD DESC:Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p Gene:ULS1(YOR191W)|FD-Score:3.65|P-value:1.29E-4||SGD DESC:Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:YDR445C(YDR445C_d)|FD-Score:-8.14|P-value:2.02E-16||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YEL010W(YEL010W_d)|FD-Score:4.52|P-value:3.06E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR037W(YJR037W_d)|FD-Score:-3.12|P-value:9.12E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces Gene:YML094C-A(YML094C-A_d)|FD-Score:-3.32|P-value:4.57E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO Gene:YPL039W(YPL039W_p)|FD-Score:-3.88|P-value:5.21E-5||SGD DESC:Putative protein of unknown function; YPL039W is not an essential gene Gene:YPR196W(YPR196W_p)|FD-Score:3.65|P-value:1.30E-4||SGD DESC:Putative maltose-responsive transcription factor

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKL189W3.403.35E-40.43HYM1Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
YOR057W3.119.40E-40.43SGT1Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
YMR213W3.090.001000.43CEF1Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
YPR165W2.990.001410.43RHO1GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)
YIL019W2.970.001470.43FAF1Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
YDR041W2.870.002060.43RSM10Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YNL247W2.440.007370.03YNL247WCysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments
YER104W2.410.008040.01RTT105Protein with a role in regulation of Ty1 transposition
YOR060C2.400.008260.08SLD7Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria
YLR276C2.320.010200.10DBP9DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
YGL098W2.220.013400.07USE1Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
YOR169C_d2.150.016000.00YOR169C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W
YDR232W2.140.016100.08HEM15-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YCR054C2.060.019600.00CTR86Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
YLR223C2.060.019800.01IFH1Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOR322C5.803.23E-9LDB19Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye
YEL010W_d4.523.06E-6YEL010W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR025W4.454.25E-6CSI1Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome
YBL066C3.807.27E-5SEF1Putative transcription factor, has homolog in Kluyveromyces lactis
YPL183C3.768.54E-5RTT10WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6
YNR070W_p3.661.26E-4PDR18_pPutative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR191W3.651.29E-4ULS1Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
YPR196W_p3.651.30E-4YPR196W_pPutative maltose-responsive transcription factor
YEL024W3.492.45E-4RIP1Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly
YCL051W3.236.29E-4LRE1Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication
YDR360W_d3.158.20E-4OPI7_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.
YOR195W3.128.94E-4SLK19Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
YHR082C3.109.69E-4KSP1Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress
YAL044C3.040.00119GCV3H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF
YPR198W3.010.00130SGE1Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations

GO enrichment analysis for SGTC_2262
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0808.19E-10SGTC_608k048-0125 159.0 μMChemDiv (Drug-like library)68176520.0547945
0.0781.92E-9SGTC_22557941087 197.4 μMChembridge (Fragment library)9355610.126984
0.0706.12E-8SGTC_712r015-0009 80.6 μMChemDiv (Drug-like library)68138720.0666667
0.0621.77E-6SGTC_28989056270 58.4 μMChembridge (Drug-like library)191546990.106667
0.0622.07E-6SGTC_730327-0325 16.2 μMChemDiv (Drug-like library)532980.125DNA damage response
0.0595.75E-6SGTC_9973996-0078 137.0 μMChemDiv (Drug-like library)7356870.0547945
0.0589.20E-6SGTC_32979117502 71.4 μMChembridge (Drug-like library)74537200.0724638
0.0571.15E-5SGTC_28479005661 71.4 μMChembridge (Drug-like library)29914490.0757576
0.0543.72E-5SGTC_2532xanthone 78.9 μMMicrosource (Natural product library)70200.108696
0.0543.96E-5SGTC_1823448-4371 550.5 μMChemDiv (Drug-like library)34914030.130435
0.0525.97E-5SGTC_22376667747 47.2 μMChembridge (Fragment library)7299400.0645161
0.0527.37E-5SGTC_2518prenyletin 46.3 μMMicrosource (Natural product library)38734590.0285714
0.0517.55E-5SGTC_2693st077581 40.7 μMTimTec (Natural product derivative library)252387610.0736842
0.0491.74E-4SGTC_13983558-0053 112.0 μMChemDiv (Drug-like library)45323690.0952381
0.0491.83E-4SGTC_32479135149 49.5 μMChembridge (Drug-like library)89344360.137255DNA damage response

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2045510665278.05 μM0.294118673349Chembridge (Fragment library)213.231942.2902
SGTC_22837944793200 μM0.2909092970533Chembridge (Fragment library)228.246581.92303
SGTC_23117694451200 μM0.2884622163142Chembridge (Fragment library)205.2531.31602
SGTC_23097664088163.95 μM0.270833704922Chembridge (Fragment library)205.1917231.99626
SGTC_10204335-096193.3 μM0.267857669075ChemDiv (Drug-like library)267.322382.91302
SGTC_2730imipramine71.33 μM0.2653063696Miscellaneous280.407264.38702
SGTC_20165121758140 μM0.2558142795203Chembridge (Fragment library)168.623461.22821redox potentiating
SGTC_1783st03945987.52 μM0.254902729761TimTec (Natural product derivative library)185.221841.97901Golgi
SGTC_11483909-766327.7 μM0.254084526ChemDiv (Drug-like library)320.38833.70205
SGTC_2902043-672248.1 μM0.241379773758ChemDiv (Drug-like library)281.3241434.02402