Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YJL195C_d | 41.20 | 0 | 10.50 | YJL195C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6 |
YOR174W | 32.30 | 8.46E-230 | 10.50 | MED4 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation |
YER133W | 30.20 | 5.06E-200 | 10.50 | GLC7 | Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest |
YCR093W | 28.70 | 6.48E-182 | 10.50 | CDC39 | Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor |
YHR036W | 18.20 | 3.05E-74 | 2.26 | BRL1 | Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export |
YJL054W | 15.90 | 1.87E-57 | 0.40 | TIM54 | Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane |
YFR037C | 15.50 | 9.54E-55 | 2.44 | RSC8 | Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters |
YML127W | 13.10 | 1.68E-39 | 0.24 | RSC9 | Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway |
YHR007C | 12.90 | 4.07E-38 | 0.24 | ERG11 | Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p |
YMR211W | 12.60 | 9.19E-37 | 1.84 | DML1 | Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family |
YOL127W | 10.80 | 2.25E-27 | 0.23 | RPL25 | Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23 |
YDR145W | 10.50 | 2.66E-26 | 1.10 | TAF12 | Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A |
YPR034W | 9.45 | 1.71E-21 | 0.43 | ARP7 | Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation |
YML085C | 9.02 | 9.68E-20 | 0.09 | TUB1 | Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication |
YDL205C | 8.93 | 2.19E-19 | 0.23 | HEM3 | Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme |