Deletion Strain | FD score | P-value | Gene | Gene Description |
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YML121W | 11.00 | 2.41E-28 | GTR1 | Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB |
YBR077C | 8.59 | 4.43E-18 | SLM4 | Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 |
YPL180W | 7.33 | 1.18E-13 | TCO89 | Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin |
YGR163W | 6.34 | 1.15E-10 | GTR2 | Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD |
YJL077C | 4.97 | 3.43E-7 | ICS3 | Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2 |
YKR007W | 4.86 | 5.84E-7 | MEH1 | Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification |
YIL030C | 4.55 | 2.74E-6 | SSM4 | Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation |
YDR285W | 4.07 | 2.37E-5 | ZIP1 | Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate |
YDR003W-A_p | 3.98 | 3.49E-5 | YDR003W-A_p | Putative protein of unknown function; identified by expression profiling and mass spectrometry |
YNL089C_d | 3.86 | 5.61E-5 | YNL089C_d | Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins |
YDR077W | 3.86 | 5.65E-5 | SED1 | Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites |
YFL012W_p | 3.79 | 7.56E-5 | YFL012W_p | Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin |
YHR100C | 3.73 | 9.62E-5 | GEP4 | Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT |
YLR131C | 3.55 | 1.95E-4 | ACE2 | Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication |
YDR214W | 3.50 | 2.35E-4 | AHA1 | Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress |