7785178

1-(1-adamantyl)-3-(pyridin-2-ylmethyl)urea

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2280
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 2954328
SMILES C1C2CC3CC1CC(C2)(C3)NC(=O)NCC4=CC=CC=N4
Standardized SMILES O=C(NCc1ccccn1)NC23CC4CC(CC(C4)C2)C3
Molecular weight 285.384
ALogP 2.16
H-bond donor count 2
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 4.5
% growth inhibition (Hom. pool) 3.12


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2954328
Download HIP data (tab-delimited text)  (excel)
Gene:CDC6(YJL194W)|FD-Score:4.76|P-value:9.79E-7|Clearance:0.85||SGD DESC:Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:MTR3(YGR158C)|FD-Score:-3.62|P-value:1.46E-4|Clearance:0||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) Gene:NPA3(YJR072C)|FD-Score:-3.24|P-value:5.96E-4|Clearance:0||SGD DESC:Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress Gene:PRE6(YOL038W)|FD-Score:-3.51|P-value:2.23E-4|Clearance:0||SGD DESC:Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress Gene:RIB3(YDR487C)|FD-Score:-3.34|P-value:4.19E-4|Clearance:0||SGD DESC:3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration Gene:RPL15A(YLR029C)|FD-Score:-7.61|P-value:1.37E-14|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication Gene:RTT105(YER104W)|FD-Score:-3.5|P-value:2.29E-4|Clearance:0||SGD DESC:Protein with a role in regulation of Ty1 transposition Gene:SCC4(YER147C)|FD-Score:3.47|P-value:2.56E-4|Clearance:0.15||SGD DESC:Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX Gene:SLD5(YDR489W)|FD-Score:3.9|P-value:4.73E-5|Clearance:0.41||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:SOG2(YOR353C)|FD-Score:3.5|P-value:2.36E-4|Clearance:0.02||SGD DESC:Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis Gene:THI80(YOR143C)|FD-Score:3.33|P-value:4.41E-4|Clearance:0.25||SGD DESC:Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate) Gene:TSR4(YOL022C)|FD-Score:-6.33|P-value:1.23E-10|Clearance:0||SGD DESC:Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2 Gene:CDC6(YJL194W)|FD-Score:4.76|P-value:9.79E-7|Clearance:0.85||SGD DESC:Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:MTR3(YGR158C)|FD-Score:-3.62|P-value:1.46E-4|Clearance:0||SGD DESC:Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) Gene:NPA3(YJR072C)|FD-Score:-3.24|P-value:5.96E-4|Clearance:0||SGD DESC:Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress Gene:PRE6(YOL038W)|FD-Score:-3.51|P-value:2.23E-4|Clearance:0||SGD DESC:Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress Gene:RIB3(YDR487C)|FD-Score:-3.34|P-value:4.19E-4|Clearance:0||SGD DESC:3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration Gene:RPL15A(YLR029C)|FD-Score:-7.61|P-value:1.37E-14|Clearance:0||SGD DESC:Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication Gene:RTT105(YER104W)|FD-Score:-3.5|P-value:2.29E-4|Clearance:0||SGD DESC:Protein with a role in regulation of Ty1 transposition Gene:SCC4(YER147C)|FD-Score:3.47|P-value:2.56E-4|Clearance:0.15||SGD DESC:Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX Gene:SLD5(YDR489W)|FD-Score:3.9|P-value:4.73E-5|Clearance:0.41||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:SOG2(YOR353C)|FD-Score:3.5|P-value:2.36E-4|Clearance:0.02||SGD DESC:Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis Gene:THI80(YOR143C)|FD-Score:3.33|P-value:4.41E-4|Clearance:0.25||SGD DESC:Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate) Gene:TSR4(YOL022C)|FD-Score:-6.33|P-value:1.23E-10|Clearance:0||SGD DESC:Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2954328
Download HOP data (tab-delimited text)  (excel)
Gene:AAH1(YNL141W)|FD-Score:3.11|P-value:9.22E-4||SGD DESC:Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome Gene:AFT1(YGL071W)|FD-Score:3.49|P-value:2.41E-4||SGD DESC:Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:APL1(YJR005W)|FD-Score:-3.78|P-value:7.82E-5||SGD DESC:Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex Gene:BDF2(YDL070W)|FD-Score:-3.34|P-value:4.17E-4||SGD DESC:Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress Gene:CBP2(YHL038C)|FD-Score:-3.83|P-value:6.48E-5||SGD DESC:Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene Gene:CCR4(YAL021C)|FD-Score:-3.47|P-value:2.58E-4||SGD DESC:Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening Gene:DAN1(YJR150C)|FD-Score:-3.15|P-value:8.03E-4||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:DYN3(YMR299C)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration Gene:ECM8(YBR076W)|FD-Score:3.86|P-value:5.65E-5||SGD DESC:Non-essential protein of unknown function Gene:ELM1(YKL048C)|FD-Score:-4.12|P-value:1.86E-5||SGD DESC:Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring Gene:ERV15(YBR210W)|FD-Score:-4.46|P-value:4.05E-6||SGD DESC:Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication Gene:FUR4(YBR021W)|FD-Score:5.15|P-value:1.28E-7||SGD DESC:Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation Gene:HHF1(YBR009C)|FD-Score:4.56|P-value:2.53E-6||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:HXT3(YDR345C)|FD-Score:-3.29|P-value:5.10E-4||SGD DESC:Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication Gene:ICP55(YER078C)|FD-Score:-4.01|P-value:3.08E-5||SGD DESC:Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family Gene:LIA1(YJR070C)|FD-Score:-5.32|P-value:5.22E-8||SGD DESC:Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress Gene:MBR1(YKL093W)|FD-Score:-3.65|P-value:1.31E-4||SGD DESC:Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants Gene:ODC1(YPL134C)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation Gene:OPT2(YPR194C)|FD-Score:5.58|P-value:1.22E-8||SGD DESC:Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles Gene:PCK1(YKR097W)|FD-Score:3.17|P-value:7.74E-4||SGD DESC:Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol Gene:PEX31(YGR004W)|FD-Score:-3.65|P-value:1.33E-4||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p Gene:PGM2(YMR105C)|FD-Score:-3.4|P-value:3.34E-4||SGD DESC:Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress Gene:PMC1(YGL006W)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a Gene:PPM2(YOL141W)|FD-Score:-3.72|P-value:9.98E-5||SGD DESC:AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p Gene:PPT2(YPL148C)|FD-Score:3.32|P-value:4.47E-4||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:RAI1(YGL246C)|FD-Score:-3.26|P-value:5.59E-4||SGD DESC:Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z Gene:RAX2(YLR084C)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p Gene:RCY1(YJL204C)|FD-Score:-4.02|P-value:2.90E-5||SGD DESC:F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth Gene:RIM4(YHL024W)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Putative RNA-binding protein required for the expression of early and middle sporulation genes Gene:ROG1(YGL144C)|FD-Score:4.1|P-value:2.03E-5||SGD DESC:Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication Gene:RPL22A(YLR061W)|FD-Score:4.63|P-value:1.83E-6||SGD DESC:Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication Gene:RPL24A(YGL031C)|FD-Score:3.22|P-value:6.51E-4||SGD DESC:Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication Gene:RPS18A(YDR450W)|FD-Score:4.52|P-value:3.02E-6||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress Gene:RTT102(YGR275W)|FD-Score:3.43|P-value:2.99E-4||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress Gene:SCW11(YGL028C)|FD-Score:3.52|P-value:2.16E-4||SGD DESC:Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p Gene:SFT2(YBL102W)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 Gene:SLM5(YCR024C)|FD-Score:-3.19|P-value:7.11E-4||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SOL3(YHR163W)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication Gene:SSN3(YPL042C)|FD-Score:3.25|P-value:5.74E-4||SGD DESC:Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression Gene:SWH1(YAR042W)|FD-Score:-3.48|P-value:2.48E-4||SGD DESC:Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction Gene:TIF4631(YGR162W)|FD-Score:3.42|P-value:3.18E-4||SGD DESC:Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication Gene:TMA22(YJR014W)|FD-Score:-3.18|P-value:7.25E-4||SGD DESC:Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress Gene:TOS4(YLR183C)|FD-Score:3.79|P-value:7.64E-5||SGD DESC:Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication Gene:TRM10(YOL093W)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress Gene:URK1(YNR012W)|FD-Score:-3.35|P-value:4.01E-4||SGD DESC:Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP Gene:VPS65(YLR322W_d)|FD-Score:3.21|P-value:6.74E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth Gene:YCR001W(YCR001W_d)|FD-Score:-3.2|P-value:6.87E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene Gene:YCR100C(YCR100C_p)|FD-Score:3.37|P-value:3.82E-4||SGD DESC:Putative protein of unknown function Gene:YDR306C(YDR306C_p)|FD-Score:3.99|P-value:3.24E-5||SGD DESC:F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain Gene:YEA4(YEL004W)|FD-Score:-3.77|P-value:8.01E-5||SGD DESC:Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER Gene:YEN1(YER041W)|FD-Score:3.39|P-value:3.51E-4||SGD DESC:Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p Gene:YER038W-A(YER038W-A_d)|FD-Score:4.01|P-value:3.08E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria Gene:YER087C-A(YER087C-A_d)|FD-Score:-5.3|P-value:5.79E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase Gene:YIP5(YGL161C)|FD-Score:3.71|P-value:1.04E-4||SGD DESC:Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport Gene:YIR020W-A(YIR020W-A_d)|FD-Score:6.14|P-value:4.06E-10||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:YKL071W(YKL071W_p)|FD-Score:-5.69|P-value:6.52E-9||SGD DESC:Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YKL107W(YKL107W_p)|FD-Score:-3.19|P-value:7.20E-4||SGD DESC:Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein Gene:YNL205C(YNL205C_d)|FD-Score:4.48|P-value:3.67E-6||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR072W(YOR072W_d)|FD-Score:-3.15|P-value:8.06E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:YOR376W-A(YOR376W-A_p)|FD-Score:-3.27|P-value:5.43E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:AAH1(YNL141W)|FD-Score:3.11|P-value:9.22E-4||SGD DESC:Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome Gene:AFT1(YGL071W)|FD-Score:3.49|P-value:2.41E-4||SGD DESC:Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:APL1(YJR005W)|FD-Score:-3.78|P-value:7.82E-5||SGD DESC:Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex Gene:BDF2(YDL070W)|FD-Score:-3.34|P-value:4.17E-4||SGD DESC:Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress Gene:CBP2(YHL038C)|FD-Score:-3.83|P-value:6.48E-5||SGD DESC:Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene Gene:CCR4(YAL021C)|FD-Score:-3.47|P-value:2.58E-4||SGD DESC:Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening Gene:DAN1(YJR150C)|FD-Score:-3.15|P-value:8.03E-4||SGD DESC:Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth Gene:DYN3(YMR299C)|FD-Score:-3.55|P-value:1.91E-4||SGD DESC:Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration Gene:ECM8(YBR076W)|FD-Score:3.86|P-value:5.65E-5||SGD DESC:Non-essential protein of unknown function Gene:ELM1(YKL048C)|FD-Score:-4.12|P-value:1.86E-5||SGD DESC:Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring Gene:ERV15(YBR210W)|FD-Score:-4.46|P-value:4.05E-6||SGD DESC:Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication Gene:FUR4(YBR021W)|FD-Score:5.15|P-value:1.28E-7||SGD DESC:Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation Gene:HHF1(YBR009C)|FD-Score:4.56|P-value:2.53E-6||SGD DESC:Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity Gene:HXT3(YDR345C)|FD-Score:-3.29|P-value:5.10E-4||SGD DESC:Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication Gene:ICP55(YER078C)|FD-Score:-4.01|P-value:3.08E-5||SGD DESC:Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family Gene:LIA1(YJR070C)|FD-Score:-5.32|P-value:5.22E-8||SGD DESC:Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress Gene:MBR1(YKL093W)|FD-Score:-3.65|P-value:1.31E-4||SGD DESC:Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants Gene:ODC1(YPL134C)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation Gene:OPT2(YPR194C)|FD-Score:5.58|P-value:1.22E-8||SGD DESC:Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles Gene:PCK1(YKR097W)|FD-Score:3.17|P-value:7.74E-4||SGD DESC:Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol Gene:PEX31(YGR004W)|FD-Score:-3.65|P-value:1.33E-4||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p Gene:PGM2(YMR105C)|FD-Score:-3.4|P-value:3.34E-4||SGD DESC:Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress Gene:PMC1(YGL006W)|FD-Score:3.49|P-value:2.45E-4||SGD DESC:Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a Gene:PPM2(YOL141W)|FD-Score:-3.72|P-value:9.98E-5||SGD DESC:AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p Gene:PPT2(YPL148C)|FD-Score:3.32|P-value:4.47E-4||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:RAI1(YGL246C)|FD-Score:-3.26|P-value:5.59E-4||SGD DESC:Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z Gene:RAX2(YLR084C)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p Gene:RCY1(YJL204C)|FD-Score:-4.02|P-value:2.90E-5||SGD DESC:F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth Gene:RIM4(YHL024W)|FD-Score:3.69|P-value:1.11E-4||SGD DESC:Putative RNA-binding protein required for the expression of early and middle sporulation genes Gene:ROG1(YGL144C)|FD-Score:4.1|P-value:2.03E-5||SGD DESC:Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication Gene:RPL22A(YLR061W)|FD-Score:4.63|P-value:1.83E-6||SGD DESC:Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication Gene:RPL24A(YGL031C)|FD-Score:3.22|P-value:6.51E-4||SGD DESC:Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication Gene:RPS18A(YDR450W)|FD-Score:4.52|P-value:3.02E-6||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress Gene:RTT102(YGR275W)|FD-Score:3.43|P-value:2.99E-4||SGD DESC:Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress Gene:SCW11(YGL028C)|FD-Score:3.52|P-value:2.16E-4||SGD DESC:Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p Gene:SFT2(YBL102W)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 Gene:SLM5(YCR024C)|FD-Score:-3.19|P-value:7.11E-4||SGD DESC:Mitochondrial asparaginyl-tRNA synthetase Gene:SOL3(YHR163W)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication Gene:SSN3(YPL042C)|FD-Score:3.25|P-value:5.74E-4||SGD DESC:Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression Gene:SWH1(YAR042W)|FD-Score:-3.48|P-value:2.48E-4||SGD DESC:Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction Gene:TIF4631(YGR162W)|FD-Score:3.42|P-value:3.18E-4||SGD DESC:Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication Gene:TMA22(YJR014W)|FD-Score:-3.18|P-value:7.25E-4||SGD DESC:Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress Gene:TOS4(YLR183C)|FD-Score:3.79|P-value:7.64E-5||SGD DESC:Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication Gene:TRM10(YOL093W)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress Gene:URK1(YNR012W)|FD-Score:-3.35|P-value:4.01E-4||SGD DESC:Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP Gene:VPS65(YLR322W_d)|FD-Score:3.21|P-value:6.74E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth Gene:YCR001W(YCR001W_d)|FD-Score:-3.2|P-value:6.87E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene Gene:YCR100C(YCR100C_p)|FD-Score:3.37|P-value:3.82E-4||SGD DESC:Putative protein of unknown function Gene:YDR306C(YDR306C_p)|FD-Score:3.99|P-value:3.24E-5||SGD DESC:F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain Gene:YEA4(YEL004W)|FD-Score:-3.77|P-value:8.01E-5||SGD DESC:Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER Gene:YEN1(YER041W)|FD-Score:3.39|P-value:3.51E-4||SGD DESC:Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p Gene:YER038W-A(YER038W-A_d)|FD-Score:4.01|P-value:3.08E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria Gene:YER087C-A(YER087C-A_d)|FD-Score:-5.3|P-value:5.79E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase Gene:YIP5(YGL161C)|FD-Score:3.71|P-value:1.04E-4||SGD DESC:Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport Gene:YIR020W-A(YIR020W-A_d)|FD-Score:6.14|P-value:4.06E-10||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:YKL071W(YKL071W_p)|FD-Score:-5.69|P-value:6.52E-9||SGD DESC:Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YKL107W(YKL107W_p)|FD-Score:-3.19|P-value:7.20E-4||SGD DESC:Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein Gene:YNL205C(YNL205C_d)|FD-Score:4.48|P-value:3.67E-6||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YOR072W(YOR072W_d)|FD-Score:-3.15|P-value:8.06E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Gene:YOR376W-A(YOR376W-A_p)|FD-Score:-3.27|P-value:5.43E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YJL194W4.769.79E-70.85CDC6Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress
YDR489W3.904.73E-50.41SLD5Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YOR353C3.502.36E-40.02SOG2Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis
YER147C3.472.56E-40.15SCC4Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
YOR143C3.334.41E-40.25THI80Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
YKL125W3.070.001060.05RRN3Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo
YMR061W3.020.001260.09RNA14Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping
YPL020C2.930.001700.07ULP1Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions
YMR239C2.860.002100.12RNT1Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes
YJL026W2.740.003040.07RNR2Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YOR319W2.670.003790.01HSH49U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YGL069C_d2.660.003900.04YGL069C_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance
YER036C2.620.004350.04ARB1ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YML093W2.580.004880.03UTP14Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
YER082C2.550.005340.00UTP7Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YIR020W-A_d6.144.06E-10YIR020W-A_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YPR194C5.581.22E-8OPT2Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles
YBR021W5.151.28E-7FUR4Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
YLR061W4.631.83E-6RPL22ARibosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
YBR009C4.562.53E-6HHF1Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YDR450W4.523.02E-6RPS18AProtein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress
YNL205C_d4.483.67E-6YNL205C_dDubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL144C4.102.03E-5ROG1Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
YER038W-A_d4.013.08E-5YER038W-A_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
YDR306C_p3.993.24E-5YDR306C_pF-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
YBR076W3.865.65E-5ECM8Non-essential protein of unknown function
YLR183C3.797.64E-5TOS4Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication
YGL161C3.711.04E-4YIP5Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YHL024W3.691.11E-4RIM4Putative RNA-binding protein required for the expression of early and middle sporulation genes
YLR084C3.611.53E-4RAX2N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p

GO enrichment analysis for SGTC_2280
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1172.13E-19SGTC_22877945887 168.8 μMChembridge (Fragment library)12458530.129032
0.0855.93E-11SGTC_22847945075 39.2 μMChembridge (Fragment library)12454020.166667mitochondrial processes
0.0781.92E-9SGTC_22817943571 200.0 μMChembridge (Fragment library)12440240.119403
0.0648.55E-7SGTC_22977971671 152.3 μMChembridge (Fragment library)9090160.134328RNA processing & uracil transport
0.0594.94E-6SGTC_23519026858 72.3 μMChembridge (Fragment library)14093000.111111RNA processing & uracil transport
0.0587.16E-6SGTC_1657st012939 43.4 μMTimTec (Natural product derivative library)242072570.0517241
0.0588.90E-6SGTC_1817st052116 64.4 μMTimTec (Natural product derivative library)43613980.0684932RNA processing & uracil transport
0.0571.05E-5SGTC_2251lansoprazole 556.0 μMNIH Clinical Collection38830.128205
0.0534.92E-5SGTC_271rotenone 740.0 μMMiscellaneous51020.0823529
0.0525.79E-5SGTC_23939031399 185.9 μMChembridge (Fragment library)15266230.111111RNA processing & uracil transport
0.0518.29E-5SGTC_1951sophoraflavanone G 9.2 μMTimTec (Natural product derivative library)99102340.091954RNA processing & uracil transport
0.0501.10E-4SGTC_1640st009078 66.4 μMTimTec (Natural product derivative library)6906180.162162
0.0501.38E-4SGTC_2151287-0124 461.5 μMChemDiv (Drug-like library)55608630.060241
0.0501.41E-4SGTC_28117967822 32.5 μMChembridge (Drug-like library)22322440.102564
0.0491.68E-4SGTC_2094077-0173 175.6 μMChemDiv (Drug-like library)159934940.114286

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_23659042475200 μM0.486464479Chembridge (Fragment library)255.314982.56622
SGTC_22787948257134.34 μM0.4230771247028Chembridge (Fragment library)297.170962.20713
SGTC_21065357045167.29 μM0.415094668842Chembridge (Fragment library)281.13733.01412
SGTC_23909097792176.6 μM0.4074074497149Chembridge (Fragment library)297.170962.38713
SGTC_9631269-2853151 μM0.3653853668223ChemDiv (Drug-like library)256.34282.57312
SGTC_7420kpi-0133140 μM0.3454552728852ChemDiv (Drug-like library)297.434483.98912ERG2
SGTC_21185526350200 μM0.320755743594Chembridge (Fragment library)212.290243.25912
SGTC_3174495-0002170 μM0.315991618ChemDiv (Drug-like library)351.26143.07613
SGTC_1080509-0257621.13 μM0.283019536624ChemDiv (Drug-like library)269.381323.3611
SGTC_3332914106911.2 μM0.26984117332883Chembridge (Drug-like library)369.67284.71823