Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YHR062C | 7.94 | 1.02E-15 | 2.03 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YGL172W | 7.88 | 1.69E-15 | 2.03 | NUP49 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) |
YPL128C | 5.85 | 2.51E-9 | 0.56 | TBF1 | Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation |
YDR429C | 5.29 | 6.10E-8 | 0.70 | TIF35 | eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation |
YOR217W | 4.59 | 2.23E-6 | 0.42 | RFC1 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
YIL048W | 4.16 | 1.57E-5 | 0.26 | NEO1 | Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus |
YPL255W | 3.91 | 4.65E-5 | 0.18 | BBP1 | Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p |
YIL004C | 3.73 | 9.68E-5 | 0.10 | BET1 | Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins |
YOR294W | 3.62 | 1.46E-4 | 0.17 | RRS1 | Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice |
YML125C | 3.45 | 2.82E-4 | 0.00 | PGA3 | Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication |
YBL084C | 3.44 | 2.86E-4 | 0.05 | CDC27 | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition |
YKL013C | 3.39 | 3.47E-4 | 0.01 | ARC19 | Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches |
YDR280W | 3.38 | 3.61E-4 | 0.04 | RRP45 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress |
YCR035C | 3.34 | 4.14E-4 | 0.17 | RRP43 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress |
YML092C | 3.18 | 7.48E-4 | 0.00 | PRE8 | Alpha 2 subunit of the 20S proteasome |