Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
---|
YDR187C_d | 11.40 | 3.40E-30 | 1.64 | YDR187C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W |
YIL142W | 10.10 | 3.88E-24 | 1.64 | CCT2 | Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YJL014W | 9.92 | 1.78E-23 | 1.64 | CCT3 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YDR212W | 9.82 | 4.41E-23 | 1.64 | TCP1 | Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein |
YJR064W | 8.19 | 1.32E-16 | 0.68 | CCT5 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YJL008C | 7.50 | 3.08E-14 | 0.20 | CCT8 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo |
YLR163C | 7.31 | 1.38E-13 | 0.95 | MAS1 | Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins |
YFL037W | 6.35 | 1.07E-10 | 0.38 | TUB2 | Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria |
YJL111W | 5.97 | 1.19E-9 | 0.12 | CCT7 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance |
YHR074W | 5.85 | 2.51E-9 | 0.33 | QNS1 | Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide |
YDR188W | 5.52 | 1.73E-8 | 0.41 | CCT6 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif |
YDR243C | 5.11 | 1.63E-7 | 1.39 | PRP28 | RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site |
YLR147C | 3.72 | 1.01E-4 | 0.06 | SMD3 | Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 |
YGL065C | 3.65 | 1.29E-4 | 0.02 | ALG2 | Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol |
YOR056C | 3.63 | 1.40E-4 | 0.01 | NOB1 | Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress |