7971645

N-(2-methylphenyl)pyrrolidine-1-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2295
Screen concentration 200.0 μM
Source Chembridge (Fragment library)
PubChem CID 2978226
SMILES CC1=CC=CC=C1NC(=O)N2CCCC2
Standardized SMILES Cc1ccccc1NC(=O)N2CCCC2
Molecular weight 204.2682
ALogP 2.1
H-bond donor count 1
H-bond acceptor count 1
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.81
% growth inhibition (Hom. pool) 2.26


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2978226
Download HIP data (tab-delimited text)  (excel)
Gene:AUR1(YKL004W)|FD-Score:-3.45|P-value:2.77E-4|Clearance:0||SGD DESC:Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance Gene:BET3(YKR068C)|FD-Score:-3.32|P-value:4.45E-4|Clearance:0||SGD DESC:Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex Gene:DAD1(YDR016C)|FD-Score:3.6|P-value:1.61E-4|Clearance:0.48||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Gene:ECO1(YFR027W)|FD-Score:4.39|P-value:5.63E-6|Clearance:0.46||SGD DESC:Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress Gene:KAP95(YLR347C)|FD-Score:3.12|P-value:9.19E-4|Clearance:0.01||SGD DESC:Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p Gene:SMC5(YOL034W)|FD-Score:5.51|P-value:1.84E-8|Clearance:1.11||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair Gene:SPT15(YER148W)|FD-Score:-3.51|P-value:2.25E-4|Clearance:0||SGD DESC:TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability Gene:TRR1(YDR353W)|FD-Score:3.93|P-value:4.21E-5|Clearance:0.34||SGD DESC:Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication Gene:UTP10(YJL109C)|FD-Score:5.58|P-value:1.22E-8|Clearance:0.07||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance Gene:UTP11(YKL099C)|FD-Score:12.6|P-value:6.25E-37|Clearance:7.06||SGD DESC:Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit Gene:YOR146W(YOR146W_d)|FD-Score:3.1|P-value:9.60E-4|Clearance:0.14||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C Gene:AUR1(YKL004W)|FD-Score:-3.45|P-value:2.77E-4|Clearance:0||SGD DESC:Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance Gene:BET3(YKR068C)|FD-Score:-3.32|P-value:4.45E-4|Clearance:0||SGD DESC:Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex Gene:DAD1(YDR016C)|FD-Score:3.6|P-value:1.61E-4|Clearance:0.48||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Gene:ECO1(YFR027W)|FD-Score:4.39|P-value:5.63E-6|Clearance:0.46||SGD DESC:Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress Gene:KAP95(YLR347C)|FD-Score:3.12|P-value:9.19E-4|Clearance:0.01||SGD DESC:Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p Gene:SMC5(YOL034W)|FD-Score:5.51|P-value:1.84E-8|Clearance:1.11||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair Gene:SPT15(YER148W)|FD-Score:-3.51|P-value:2.25E-4|Clearance:0||SGD DESC:TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability Gene:TRR1(YDR353W)|FD-Score:3.93|P-value:4.21E-5|Clearance:0.34||SGD DESC:Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication Gene:UTP10(YJL109C)|FD-Score:5.58|P-value:1.22E-8|Clearance:0.07||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance Gene:UTP11(YKL099C)|FD-Score:12.6|P-value:6.25E-37|Clearance:7.06||SGD DESC:Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit Gene:YOR146W(YOR146W_d)|FD-Score:3.1|P-value:9.60E-4|Clearance:0.14||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2978226
Download HOP data (tab-delimited text)  (excel)
Gene:AAT1(YKL106W)|FD-Score:5.92|P-value:1.63E-9||SGD DESC:Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis Gene:ACM1(YPL267W)|FD-Score:-3.25|P-value:5.86E-4||SGD DESC:Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein Gene:ADD37(YMR184W)|FD-Score:3.55|P-value:1.90E-4||SGD DESC:Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress Gene:ASG7(YJL170C)|FD-Score:-5.3|P-value:5.85E-8||SGD DESC:Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor Gene:AST1(YBL069W)|FD-Score:-4.18|P-value:1.44E-5||SGD DESC:Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication Gene:BUD19(YJL188C_d)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:BUR2(YLR226W)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II Gene:CAF130(YGR134W)|FD-Score:3.42|P-value:3.11E-4||SGD DESC:Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation Gene:CAP2(YIL034C)|FD-Score:3.83|P-value:6.35E-5||SGD DESC:Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress Gene:CCC1(YLR220W)|FD-Score:5.86|P-value:2.34E-9||SGD DESC:Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress Gene:CHL4(YDR254W)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15 Gene:COG6(YNL041C)|FD-Score:8.86|P-value:3.85E-19||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:3.84|P-value:6.14E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COQ8(YGL119W)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication Gene:COX6(YHR051W)|FD-Score:3.25|P-value:5.81E-4||SGD DESC:Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels Gene:CRC1(YOR100C)|FD-Score:-3.45|P-value:2.76E-4||SGD DESC:Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Gene:CSG2(YBR036C)|FD-Score:-3.16|P-value:7.88E-4||SGD DESC:Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress Gene:DCS1(YLR270W)|FD-Score:4.02|P-value:2.86E-5||SGD DESC:Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress Gene:DOA1(YKL213C)|FD-Score:4.75|P-value:1.01E-6||SGD DESC:WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress Gene:DSE2(YHR143W)|FD-Score:3.91|P-value:4.59E-5||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:ERS1(YCR075C)|FD-Score:4.94|P-value:3.84E-7||SGD DESC:Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains Gene:FIT2(YOR382W)|FD-Score:3.43|P-value:2.99E-4||SGD DESC:Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall Gene:FRE4(YNR060W)|FD-Score:-3.73|P-value:9.44E-5||SGD DESC:Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels Gene:GDT1(YBR187W_p)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis Gene:GIT1(YCR098C)|FD-Score:5.05|P-value:2.19E-7||SGD DESC:Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability Gene:GSF2(YML048W)|FD-Score:4.53|P-value:2.99E-6||SGD DESC:ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Gene:GUP1(YGL084C)|FD-Score:-5.11|P-value:1.65E-7||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:HAP2(YGL237C)|FD-Score:4.6|P-value:2.11E-6||SGD DESC:Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding Gene:HHT1(YBR010W)|FD-Score:-3.46|P-value:2.73E-4||SGD DESC:Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation Gene:IMO32(YGR031W)|FD-Score:-3.62|P-value:1.46E-4||SGD DESC:Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 Gene:ISA2(YPR067W)|FD-Score:3.95|P-value:3.91E-5||SGD DESC:Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations Gene:LTV1(YKL143W)|FD-Score:3.27|P-value:5.29E-4||SGD DESC:Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature Gene:MET22(YOL064C)|FD-Score:3.1|P-value:9.74E-4||SGD DESC:Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway Gene:MRP13(YGR084C)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MRPL23(YOR150W)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS5(YBR251W)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSK1(YNL073W)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys) Gene:MXR2(YCL033C)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan Gene:PDE2(YOR360C)|FD-Score:-3.29|P-value:4.98E-4||SGD DESC:High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon Gene:PEP4(YPL154C)|FD-Score:3.59|P-value:1.68E-4||SGD DESC:Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates Gene:RHR2(YIL053W)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication Gene:RPL15B(YMR121C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress Gene:RPL7B(YPL198W)|FD-Score:6.76|P-value:6.98E-12||SGD DESC:Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication Gene:RRM3(YHR031C)|FD-Score:-3.17|P-value:7.59E-4||SGD DESC:DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Gene:SNC1(YAL030W)|FD-Score:6.57|P-value:2.53E-11||SGD DESC:Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication Gene:SPO11(YHL022C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation Gene:SPS2(YDR522C)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component Gene:TDA1(YMR291W)|FD-Score:-3.47|P-value:2.56E-4||SGD DESC:Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:TPO1(YLL028W)|FD-Score:4.18|P-value:1.43E-5||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane Gene:TRM2(YKR056W)|FD-Score:3.88|P-value:5.17E-5||SGD DESC:tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair Gene:VTH1(YIL173W)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting Gene:YAL045C(YAL045C_d)|FD-Score:3.92|P-value:4.49E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A Gene:YCT1(YLL055W)|FD-Score:4.18|P-value:1.44E-5||SGD DESC:High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene Gene:YEL028W(YEL028W_d)|FD-Score:5.73|P-value:5.09E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YER039C-A(YER039C-A_p)|FD-Score:-3.23|P-value:6.23E-4||SGD DESC:Putative protein of unknown function; YER039C-A is not an essential gene Gene:YER077C(YER077C_p)|FD-Score:3.82|P-value:6.73E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport Gene:YER135C(YER135C_d)|FD-Score:3.9|P-value:4.80E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Gene:YFH7(YFR007W)|FD-Score:4.14|P-value:1.73E-5||SGD DESC:Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases Gene:YGL242C(YGL242C_p)|FD-Score:-3.68|P-value:1.16E-4||SGD DESC:Putative protein of unknown function; deletion mutant is viable Gene:YJL027C(YJL027C_p)|FD-Score:5.32|P-value:5.32E-8||SGD DESC:Putative protein of unknown function Gene:YKL033W-A(YKL033W-A_p)|FD-Score:-3.75|P-value:8.73E-5||SGD DESC:Putative protein of unknown function; similar to uncharacterized proteins from other fungi Gene:YLR194C(YLR194C)|FD-Score:3.52|P-value:2.12E-4||SGD DESC:Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress Gene:YLR307C-A(YLR307C-A_p)|FD-Score:3.49|P-value:2.37E-4||SGD DESC:Putative protein of unknown function Gene:YLR434C(YLR434C_d)|FD-Score:-3.32|P-value:4.56E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Gene:YMR084W(YMR084W_p)|FD-Score:-3.38|P-value:3.63E-4||SGD DESC:Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 Gene:YMR166C(YMR166C_p)|FD-Score:-4.08|P-value:2.27E-5||SGD DESC:Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene Gene:YMR193C-A(YMR193C-A_d)|FD-Score:4.35|P-value:6.86E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR310C(YMR310C_p)|FD-Score:-6.19|P-value:2.96E-10||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene Gene:YOR105W(YOR105W_p)|FD-Score:8.33|P-value:4.12E-17||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YOR293C-A(YOR293C-A_p)|FD-Score:3.21|P-value:6.55E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YOR366W(YOR366W_d)|FD-Score:-3.62|P-value:1.48E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C Gene:YPR1(YDR368W)|FD-Score:-4.08|P-value:2.22E-5||SGD DESC:NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication Gene:YSC83(YHR017W)|FD-Score:3.53|P-value:2.04E-4||SGD DESC:Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 Gene:YUR1(YJL139C)|FD-Score:5.42|P-value:3.01E-8||SGD DESC:Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication Gene:AAT1(YKL106W)|FD-Score:5.92|P-value:1.63E-9||SGD DESC:Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis Gene:ACM1(YPL267W)|FD-Score:-3.25|P-value:5.86E-4||SGD DESC:Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein Gene:ADD37(YMR184W)|FD-Score:3.55|P-value:1.90E-4||SGD DESC:Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress Gene:ASG7(YJL170C)|FD-Score:-5.3|P-value:5.85E-8||SGD DESC:Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor Gene:AST1(YBL069W)|FD-Score:-4.18|P-value:1.44E-5||SGD DESC:Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication Gene:BUD19(YJL188C_d)|FD-Score:3.37|P-value:3.77E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:BUR2(YLR226W)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II Gene:CAF130(YGR134W)|FD-Score:3.42|P-value:3.11E-4||SGD DESC:Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation Gene:CAP2(YIL034C)|FD-Score:3.83|P-value:6.35E-5||SGD DESC:Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress Gene:CCC1(YLR220W)|FD-Score:5.86|P-value:2.34E-9||SGD DESC:Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress Gene:CHL4(YDR254W)|FD-Score:-3.69|P-value:1.12E-4||SGD DESC:Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15 Gene:COG6(YNL041C)|FD-Score:8.86|P-value:3.85E-19||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COG8(YML071C)|FD-Score:3.84|P-value:6.14E-5||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:COQ8(YGL119W)|FD-Score:3.58|P-value:1.69E-4||SGD DESC:Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication Gene:COX6(YHR051W)|FD-Score:3.25|P-value:5.81E-4||SGD DESC:Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels Gene:CRC1(YOR100C)|FD-Score:-3.45|P-value:2.76E-4||SGD DESC:Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Gene:CSG2(YBR036C)|FD-Score:-3.16|P-value:7.88E-4||SGD DESC:Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress Gene:DCS1(YLR270W)|FD-Score:4.02|P-value:2.86E-5||SGD DESC:Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress Gene:DOA1(YKL213C)|FD-Score:4.75|P-value:1.01E-6||SGD DESC:WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress Gene:DSE2(YHR143W)|FD-Score:3.91|P-value:4.59E-5||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:ERS1(YCR075C)|FD-Score:4.94|P-value:3.84E-7||SGD DESC:Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains Gene:FIT2(YOR382W)|FD-Score:3.43|P-value:2.99E-4||SGD DESC:Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall Gene:FRE4(YNR060W)|FD-Score:-3.73|P-value:9.44E-5||SGD DESC:Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels Gene:GDT1(YBR187W_p)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis Gene:GIT1(YCR098C)|FD-Score:5.05|P-value:2.19E-7||SGD DESC:Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability Gene:GSF2(YML048W)|FD-Score:4.53|P-value:2.99E-6||SGD DESC:ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Gene:GUP1(YGL084C)|FD-Score:-5.11|P-value:1.65E-7||SGD DESC:Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport Gene:HAP2(YGL237C)|FD-Score:4.6|P-value:2.11E-6||SGD DESC:Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding Gene:HHT1(YBR010W)|FD-Score:-3.46|P-value:2.73E-4||SGD DESC:Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation Gene:IMO32(YGR031W)|FD-Score:-3.62|P-value:1.46E-4||SGD DESC:Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 Gene:ISA2(YPR067W)|FD-Score:3.95|P-value:3.91E-5||SGD DESC:Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations Gene:LTV1(YKL143W)|FD-Score:3.27|P-value:5.29E-4||SGD DESC:Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature Gene:MET22(YOL064C)|FD-Score:3.1|P-value:9.74E-4||SGD DESC:Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway Gene:MRP13(YGR084C)|FD-Score:3.5|P-value:2.29E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MRPL23(YOR150W)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MRPS5(YBR251W)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSK1(YNL073W)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys) Gene:MXR2(YCL033C)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan Gene:PDE2(YOR360C)|FD-Score:-3.29|P-value:4.98E-4||SGD DESC:High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon Gene:PEP4(YPL154C)|FD-Score:3.59|P-value:1.68E-4||SGD DESC:Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates Gene:RHR2(YIL053W)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication Gene:RPL15B(YMR121C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress Gene:RPL7B(YPL198W)|FD-Score:6.76|P-value:6.98E-12||SGD DESC:Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication Gene:RRM3(YHR031C)|FD-Score:-3.17|P-value:7.59E-4||SGD DESC:DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p Gene:SNC1(YAL030W)|FD-Score:6.57|P-value:2.53E-11||SGD DESC:Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication Gene:SPO11(YHL022C)|FD-Score:3.7|P-value:1.08E-4||SGD DESC:Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation Gene:SPS2(YDR522C)|FD-Score:3.45|P-value:2.81E-4||SGD DESC:Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component Gene:TDA1(YMR291W)|FD-Score:-3.47|P-value:2.56E-4||SGD DESC:Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:TPO1(YLL028W)|FD-Score:4.18|P-value:1.43E-5||SGD DESC:Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane Gene:TRM2(YKR056W)|FD-Score:3.88|P-value:5.17E-5||SGD DESC:tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair Gene:VTH1(YIL173W)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting Gene:YAL045C(YAL045C_d)|FD-Score:3.92|P-value:4.49E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A Gene:YCT1(YLL055W)|FD-Score:4.18|P-value:1.44E-5||SGD DESC:High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene Gene:YEL028W(YEL028W_d)|FD-Score:5.73|P-value:5.09E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YER039C-A(YER039C-A_p)|FD-Score:-3.23|P-value:6.23E-4||SGD DESC:Putative protein of unknown function; YER039C-A is not an essential gene Gene:YER077C(YER077C_p)|FD-Score:3.82|P-value:6.73E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport Gene:YER135C(YER135C_d)|FD-Score:3.9|P-value:4.80E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Gene:YFH7(YFR007W)|FD-Score:4.14|P-value:1.73E-5||SGD DESC:Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases Gene:YGL242C(YGL242C_p)|FD-Score:-3.68|P-value:1.16E-4||SGD DESC:Putative protein of unknown function; deletion mutant is viable Gene:YJL027C(YJL027C_p)|FD-Score:5.32|P-value:5.32E-8||SGD DESC:Putative protein of unknown function Gene:YKL033W-A(YKL033W-A_p)|FD-Score:-3.75|P-value:8.73E-5||SGD DESC:Putative protein of unknown function; similar to uncharacterized proteins from other fungi Gene:YLR194C(YLR194C)|FD-Score:3.52|P-value:2.12E-4||SGD DESC:Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress Gene:YLR307C-A(YLR307C-A_p)|FD-Score:3.49|P-value:2.37E-4||SGD DESC:Putative protein of unknown function Gene:YLR434C(YLR434C_d)|FD-Score:-3.32|P-value:4.56E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Gene:YMR084W(YMR084W_p)|FD-Score:-3.38|P-value:3.63E-4||SGD DESC:Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 Gene:YMR166C(YMR166C_p)|FD-Score:-4.08|P-value:2.27E-5||SGD DESC:Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene Gene:YMR193C-A(YMR193C-A_d)|FD-Score:4.35|P-value:6.86E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YMR310C(YMR310C_p)|FD-Score:-6.19|P-value:2.96E-10||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene Gene:YOR105W(YOR105W_p)|FD-Score:8.33|P-value:4.12E-17||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YOR293C-A(YOR293C-A_p)|FD-Score:3.21|P-value:6.55E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YOR366W(YOR366W_d)|FD-Score:-3.62|P-value:1.48E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C Gene:YPR1(YDR368W)|FD-Score:-4.08|P-value:2.22E-5||SGD DESC:NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication Gene:YSC83(YHR017W)|FD-Score:3.53|P-value:2.04E-4||SGD DESC:Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 Gene:YUR1(YJL139C)|FD-Score:5.42|P-value:3.01E-8||SGD DESC:Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKL099C12.606.25E-377.06UTP11Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
YJL109C5.581.22E-80.07UTP10Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance
YOL034W5.511.84E-81.11SMC5Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
YFR027W4.395.63E-60.46ECO1Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
YDR353W3.934.21E-50.34TRR1Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication
YDR016C3.601.61E-40.48DAD1Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YLR347C3.129.19E-40.01KAP95Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p
YOR146W_d3.109.60E-40.14YOR146W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
YPL124W2.960.001530.02SPC29Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication
YDL165W2.940.001650.13CDC36Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
YNL261W2.810.002470.05ORC5Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
YIL083C2.760.002850.03CAB2Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
YKL060C2.730.003160.04FBA1Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YML098W2.690.003540.04TAF13TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
YPR186C2.650.004020.21PZF1Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YNL041C8.863.85E-19COG6Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YOR105W_p8.334.12E-17YOR105W_pProtein of unknown function; expressed at both mRNA and protein levels
YPL198W6.766.98E-12RPL7BRibosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication
YAL030W6.572.53E-11SNC1Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication
YKL106W5.921.63E-9AAT1Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
YLR220W5.862.34E-9CCC1Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress
YEL028W_d5.735.09E-9YEL028W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL139C5.423.01E-8YUR1Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication
YJL027C_p5.325.32E-8YJL027C_pPutative protein of unknown function
YCR098C5.052.19E-7GIT1Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
YCR075C4.943.84E-7ERS1Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
YKL213C4.751.01E-6DOA1WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
YGL237C4.602.11E-6HAP2Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
YML048W4.532.99E-6GSF2ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
YMR193C-A_d4.356.86E-6YMR193C-A_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

GO enrichment analysis for SGTC_2295
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1019.66E-15SGTC_1671st016596 74.5 μMTimTec (Natural product derivative library)28291670.193548
0.0953.21E-13SGTC_624k048-0052 28.0 μMChemDiv (Drug-like library)68355310.126984Golgi
0.0872.44E-11SGTC_40960-0234 25.7 μMChemDiv (Drug-like library)68211120.128571Golgi
0.0863.08E-11SGTC_9791426-2828 121.0 μMChemDiv (Drug-like library)7478720.181818
0.0831.50E-10SGTC_13631636-0063 10.4 μMChemDiv (Drug-like library)60721850.118644Golgi
0.0831.68E-10SGTC_23027771753 200.0 μMChembridge (Fragment library)22030470.163265
0.0765.28E-9SGTC_14813346-2004 36.0 μMChemDiv (Drug-like library)27705220.123288
0.0765.57E-9SGTC_7771315-0167 517.0 μMChemDiv (Drug-like library)42217670.084507Golgi
0.0766.17E-9SGTC_1985st071382 65.5 μMTimTec (Natural product derivative library)61232370.114754
0.0691.14E-7SGTC_30579095946 49.5 μMChembridge (Drug-like library)245400430.183333Golgi
0.0681.93E-7SGTC_6320781-2353 4.7 μMChemDiv (Drug-like library)68115150.0694444Golgi
0.0682.04E-7SGTC_32779138724 49.5 μMChembridge (Drug-like library)159434180.0909091Golgi
0.0672.90E-7SGTC_10603448-7350 82.0 μMChemDiv (Drug-like library)5701780.229167Golgi
0.0672.96E-7SGTC_7461095-0025 46.6 μMChemDiv (Drug-like library)67492860.0655738RSC & ERG11
0.0663.99E-7SGTC_22987976326 193.8 μMChembridge (Fragment library)22358180.111111

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2893904848825.97 μM0.4468096467338Chembridge (Drug-like library)337.458583.46913fatty acid desaturase (OLE1)
SGTC_8500388-014375.9 μM0.40909167273ChemDiv (Drug-like library)277.31723.76722
SGTC_23037774051200 μM0.3877552953184Chembridge (Fragment library)281.30593.01813
SGTC_2159565861173.75 μM0.375793844Chembridge (Fragment library)289.35281.9234
SGTC_3274913829849.47 μM0.3617015756Chembridge (Drug-like library)293.32322.66624
SGTC_2946906550271.43 μM0.35087716489101Chembridge (Drug-like library)324.37372.35613
SGTC_2992907459171.43 μM0.34545517741321Chembridge (Drug-like library)374.453981.91215
SGTC_22016605497169.86 μM0.340909670741Chembridge (Fragment library)232.32142.18102ergosterol biosynthesis
SGTC_2838900268771.43 μM0.3333336457060Chembridge (Drug-like library)357.877063.64713fatty acid desaturase (OLE1)
SGTC_2840900877171.43 μM0.3333332992978Chembridge (Drug-like library)364.437563.54613