7976326

[5-(4-amino-2-methylphenyl)furan-2-yl]methanol

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2298
Screen concentration 193.8 μM
Source Chembridge (Fragment library)
PubChem CID 2235818
SMILES CC1=C(C=CC(=C1)N)C2=CC=C(O2)CO
Standardized SMILES Cc1cc(N)ccc1c2oc(CO)cc2
Molecular weight 203.2371
ALogP 1.96
H-bond donor count 2
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 10.56
% growth inhibition (Hom. pool) 3.36


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2235818
Download HIP data (tab-delimited text)  (excel)
Gene:GAB1(YLR459W)|FD-Score:-4.34|P-value:7.14E-6|Clearance:0||SGD DESC:GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI Gene:MCM6(YGL201C)|FD-Score:-3.38|P-value:3.68E-4|Clearance:0||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p Gene:MVD1(YNR043W)|FD-Score:3.75|P-value:9.00E-5|Clearance:0.83||SGD DESC:Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer Gene:SEC14(YMR079W)|FD-Score:-3.88|P-value:5.24E-5|Clearance:0||SGD DESC:Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs Gene:GAB1(YLR459W)|FD-Score:-4.34|P-value:7.14E-6|Clearance:0||SGD DESC:GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI Gene:MCM6(YGL201C)|FD-Score:-3.38|P-value:3.68E-4|Clearance:0||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p Gene:MVD1(YNR043W)|FD-Score:3.75|P-value:9.00E-5|Clearance:0.83||SGD DESC:Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer Gene:SEC14(YMR079W)|FD-Score:-3.88|P-value:5.24E-5|Clearance:0||SGD DESC:Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2235818
Download HOP data (tab-delimited text)  (excel)
Gene:ADD37(YMR184W)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress Gene:ASG7(YJL170C)|FD-Score:-3.38|P-value:3.66E-4||SGD DESC:Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor Gene:ATG12(YBR217W)|FD-Score:4.05|P-value:2.60E-5||SGD DESC:Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation Gene:CIN5(YOR028C)|FD-Score:3.29|P-value:5.00E-4||SGD DESC:Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication Gene:CKI1(YLR133W)|FD-Score:-3.59|P-value:1.68E-4||SGD DESC:Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication Gene:COS12(YGL263W)|FD-Score:-4.62|P-value:1.92E-6||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:CRG1(YHR209W)|FD-Score:3.74|P-value:9.17E-5||SGD DESC:S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin Gene:CRN1(YLR429W)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly Gene:ERS1(YCR075C)|FD-Score:5.15|P-value:1.33E-7||SGD DESC:Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains Gene:ERV46(YAL042W)|FD-Score:4.01|P-value:3.00E-5||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport Gene:GPM2(YDL021W)|FD-Score:-5.11|P-value:1.61E-7||SGD DESC:Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Gene:GRE2(YOL151W)|FD-Score:3.21|P-value:6.72E-4||SGD DESC:3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress Gene:GYP1(YOR070C)|FD-Score:4.33|P-value:7.56E-6||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HAL5(YJL165C)|FD-Score:3.26|P-value:5.54E-4||SGD DESC:Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication Gene:IMA5(YJL216C)|FD-Score:-3.97|P-value:3.62E-5||SGD DESC:Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose Gene:KGD1(YIL125W)|FD-Score:-3.53|P-value:2.10E-4||SGD DESC:Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA Gene:MCH5(YOR306C)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport Gene:MDM32(YOR147W)|FD-Score:4.05|P-value:2.60E-5||SGD DESC:Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 Gene:MHF1(YOL086W-A)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 Gene:MRF1(YGL143C)|FD-Score:-3.11|P-value:9.22E-4||SGD DESC:Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability Gene:MRP2(YPR166C)|FD-Score:-3.27|P-value:5.43E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NDE2(YDL085W)|FD-Score:-3.64|P-value:1.39E-4||SGD DESC:Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain Gene:NFU1(YKL040C)|FD-Score:3.91|P-value:4.57E-5||SGD DESC:Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria Gene:OSM1(YJR051W)|FD-Score:4.15|P-value:1.66E-5||SGD DESC:Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication Gene:PMT5(YDL093W)|FD-Score:-3.27|P-value:5.45E-4||SGD DESC:Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals Gene:RAD24(YER173W)|FD-Score:-4.94|P-value:3.95E-7||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein Gene:RAD57(YDR004W)|FD-Score:3.87|P-value:5.33E-5||SGD DESC:Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p Gene:RBG2(YGR173W)|FD-Score:3.14|P-value:8.35E-4||SGD DESC:Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein Gene:RPI1(YIL119C)|FD-Score:3.31|P-value:4.69E-4||SGD DESC:Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF Gene:RPL38(YLR325C)|FD-Score:-3.51|P-value:2.27E-4||SGD DESC:Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog Gene:RPS25A(YGR027C)|FD-Score:-3.26|P-value:5.48E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication Gene:RPS28B(YLR264W)|FD-Score:-3.11|P-value:9.41E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication Gene:SCW4(YGR279C)|FD-Score:-3.23|P-value:6.19E-4||SGD DESC:Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating Gene:SKY1(YMR216C)|FD-Score:3.79|P-value:7.62E-5||SGD DESC:SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 Gene:SLG1(YOR008C)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response Gene:SNT309(YPR101W)|FD-Score:3.87|P-value:5.37E-5||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p Gene:SPP1(YPL138C)|FD-Score:4.17|P-value:1.54E-5||SGD DESC:Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein Gene:VID24(YBR105C)|FD-Score:-4.8|P-value:8.04E-7||SGD DESC:GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles Gene:YDL241W(YDL241W_p)|FD-Score:3.21|P-value:6.75E-4||SGD DESC:Putative protein of unknown function; YDL241W is not an essential gene Gene:YDR290W(YDR290W_d)|FD-Score:3.44|P-value:2.90E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103 Gene:YGL242C(YGL242C_p)|FD-Score:-5.41|P-value:3.12E-8||SGD DESC:Putative protein of unknown function; deletion mutant is viable Gene:YGR025W(YGR025W_d)|FD-Score:-3.21|P-value:6.68E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR064W(YGR064W_d)|FD-Score:3.19|P-value:7.07E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C Gene:YGR093W(YGR093W_p)|FD-Score:5.6|P-value:1.06E-8||SGD DESC:Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:YGR153W(YGR153W_p)|FD-Score:3.39|P-value:3.50E-4||SGD DESC:Putative protein of unknown function Gene:YLR311C(YLR311C_d)|FD-Score:-3.42|P-value:3.11E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR316C-B(YMR316C-B_d)|FD-Score:4.46|P-value:4.11E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR066C(YNR066C_p)|FD-Score:-3.47|P-value:2.62E-4||SGD DESC:Putative membrane-localized protein of unknown function Gene:YNR073C(YNR073C_p)|FD-Score:-5.2|P-value:1.02E-7||SGD DESC:Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p Gene:ADD37(YMR184W)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress Gene:ASG7(YJL170C)|FD-Score:-3.38|P-value:3.66E-4||SGD DESC:Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor Gene:ATG12(YBR217W)|FD-Score:4.05|P-value:2.60E-5||SGD DESC:Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation Gene:CIN5(YOR028C)|FD-Score:3.29|P-value:5.00E-4||SGD DESC:Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication Gene:CKI1(YLR133W)|FD-Score:-3.59|P-value:1.68E-4||SGD DESC:Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication Gene:COS12(YGL263W)|FD-Score:-4.62|P-value:1.92E-6||SGD DESC:Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:CRG1(YHR209W)|FD-Score:3.74|P-value:9.17E-5||SGD DESC:S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin Gene:CRN1(YLR429W)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly Gene:ERS1(YCR075C)|FD-Score:5.15|P-value:1.33E-7||SGD DESC:Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains Gene:ERV46(YAL042W)|FD-Score:4.01|P-value:3.00E-5||SGD DESC:Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport Gene:GPM2(YDL021W)|FD-Score:-5.11|P-value:1.61E-7||SGD DESC:Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Gene:GRE2(YOL151W)|FD-Score:3.21|P-value:6.72E-4||SGD DESC:3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress Gene:GYP1(YOR070C)|FD-Score:4.33|P-value:7.56E-6||SGD DESC:Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion Gene:HAL5(YJL165C)|FD-Score:3.26|P-value:5.54E-4||SGD DESC:Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication Gene:IMA5(YJL216C)|FD-Score:-3.97|P-value:3.62E-5||SGD DESC:Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose Gene:KGD1(YIL125W)|FD-Score:-3.53|P-value:2.10E-4||SGD DESC:Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA Gene:MCH5(YOR306C)|FD-Score:3.44|P-value:2.95E-4||SGD DESC:Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport Gene:MDM32(YOR147W)|FD-Score:4.05|P-value:2.60E-5||SGD DESC:Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 Gene:MHF1(YOL086W-A)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 Gene:MRF1(YGL143C)|FD-Score:-3.11|P-value:9.22E-4||SGD DESC:Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability Gene:MRP2(YPR166C)|FD-Score:-3.27|P-value:5.43E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:NDE2(YDL085W)|FD-Score:-3.64|P-value:1.39E-4||SGD DESC:Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain Gene:NFU1(YKL040C)|FD-Score:3.91|P-value:4.57E-5||SGD DESC:Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria Gene:OSM1(YJR051W)|FD-Score:4.15|P-value:1.66E-5||SGD DESC:Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication Gene:PMT5(YDL093W)|FD-Score:-3.27|P-value:5.45E-4||SGD DESC:Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals Gene:RAD24(YER173W)|FD-Score:-4.94|P-value:3.95E-7||SGD DESC:Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein Gene:RAD57(YDR004W)|FD-Score:3.87|P-value:5.33E-5||SGD DESC:Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p Gene:RBG2(YGR173W)|FD-Score:3.14|P-value:8.35E-4||SGD DESC:Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein Gene:RPI1(YIL119C)|FD-Score:3.31|P-value:4.69E-4||SGD DESC:Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF Gene:RPL38(YLR325C)|FD-Score:-3.51|P-value:2.27E-4||SGD DESC:Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog Gene:RPS25A(YGR027C)|FD-Score:-3.26|P-value:5.48E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication Gene:RPS28B(YLR264W)|FD-Score:-3.11|P-value:9.41E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication Gene:SCW4(YGR279C)|FD-Score:-3.23|P-value:6.19E-4||SGD DESC:Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating Gene:SKY1(YMR216C)|FD-Score:3.79|P-value:7.62E-5||SGD DESC:SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 Gene:SLG1(YOR008C)|FD-Score:3.68|P-value:1.16E-4||SGD DESC:Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response Gene:SNT309(YPR101W)|FD-Score:3.87|P-value:5.37E-5||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p Gene:SPP1(YPL138C)|FD-Score:4.17|P-value:1.54E-5||SGD DESC:Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein Gene:VID24(YBR105C)|FD-Score:-4.8|P-value:8.04E-7||SGD DESC:GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles Gene:YDL241W(YDL241W_p)|FD-Score:3.21|P-value:6.75E-4||SGD DESC:Putative protein of unknown function; YDL241W is not an essential gene Gene:YDR290W(YDR290W_d)|FD-Score:3.44|P-value:2.90E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103 Gene:YGL242C(YGL242C_p)|FD-Score:-5.41|P-value:3.12E-8||SGD DESC:Putative protein of unknown function; deletion mutant is viable Gene:YGR025W(YGR025W_d)|FD-Score:-3.21|P-value:6.68E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR064W(YGR064W_d)|FD-Score:3.19|P-value:7.07E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C Gene:YGR093W(YGR093W_p)|FD-Score:5.6|P-value:1.06E-8||SGD DESC:Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:YGR153W(YGR153W_p)|FD-Score:3.39|P-value:3.50E-4||SGD DESC:Putative protein of unknown function Gene:YLR311C(YLR311C_d)|FD-Score:-3.42|P-value:3.11E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR316C-B(YMR316C-B_d)|FD-Score:4.46|P-value:4.11E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR066C(YNR066C_p)|FD-Score:-3.47|P-value:2.62E-4||SGD DESC:Putative membrane-localized protein of unknown function Gene:YNR073C(YNR073C_p)|FD-Score:-5.2|P-value:1.02E-7||SGD DESC:Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YNR043W3.759.00E-50.83MVD1Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer
YHR069C2.910.001790.18RRP4Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
YFR027W2.730.003150.01ECO1Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress
YKL145W2.730.003210.09RPT1One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance
YDR232W2.640.004190.04HEM15-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YJR012C_p2.600.004710.05YJR012C_pEssential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
YNL075W2.550.005410.03IMP4Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
YLR117C2.520.005940.05CLF1Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
YKL014C2.460.006890.07URB1Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
YLR106C2.400.008290.00MDN1Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus
YNL006W2.390.008388.92E-4LST8Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
YKL060C2.390.008400.02FBA1Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YDR327W_d2.370.008790.01YDR327W_dDubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1
YLL050C2.360.009100.02COF1Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
YKL018W2.340.009640.12SWD2Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR093W_p5.601.06E-8YGR093W_pPutative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YCR075C5.151.33E-7ERS1Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
YMR316C-B_d4.464.11E-6YMR316C-B_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR070C4.337.56E-6GYP1Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
YPL138C4.171.54E-5SPP1Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein
YJR051W4.151.66E-5OSM1Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; OSM1 has a paralog, FRD1, that arose from the whole genome duplication
YBR217W4.052.60E-5ATG12Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
YOR147W4.052.60E-5MDM32Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34
YAL042W4.013.00E-5ERV46Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport
YKL040C3.914.57E-5NFU1Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
YDR004W3.875.33E-5RAD57Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
YPR101W3.875.37E-5SNT309Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p
YMR216C3.797.62E-5SKY1SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1
YHR209W3.749.17E-5CRG1S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
YMR184W3.711.02E-4ADD37Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_2298
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0912.80E-12SGTC_2489cantharidin 73.4 μMICCB bioactive library25450.0612245cell wall signaling
0.0773.00E-9SGTC_22927671323 168.1 μMChembridge (Fragment library)9375040.0967742RNA processing & uracil transport
0.0723.05E-8SGTC_22216807166 181.1 μMChembridge (Fragment library)6749250.0634921
0.0673.08E-7SGTC_8034488-1585 147.0 μMChemDiv (Drug-like library)7472040.102941
0.0663.99E-7SGTC_22957971645 200.0 μMChembridge (Fragment library)29782260.111111
0.0657.42E-7SGTC_2415hr heat shock (37°C) + cantharidin 155.4 μMICCB bioactive library25450.0612245cell wall signaling
0.0631.47E-6SGTC_6690108-0021 26.2 μMChemDiv (Drug-like library)172010.186047fatty acid desaturase (OLE1)
0.0603.63E-6SGTC_5931203-0218 61.7 μMChemDiv (Drug-like library)36669560.101695
0.0535.37E-5SGTC_1117retinoic acid 1.1 μMTimTec (Natural product library)4447950.0588235
0.0525.92E-5SGTC_6023130-1533 38.1 μMChemDiv (Drug-like library)7209410.0793651
0.0527.02E-5SGTC_2000st075254 36.4 μMTimTec (Natural product derivative library)172341750.0833333
0.0482.03E-4SGTC_15324',5'-dihydroxyflavone 78.7 μMTimTec (Pure natural product library)1655210.0862069Golgi
0.0482.09E-4SGTC_1240136-0217 7.1 μMChemDiv (Drug-like library)39769050.0540541mitochondrial stress
0.0482.37E-4SGTC_22787948257 134.3 μMChembridge (Fragment library)12470280.0634921
0.0482.39E-4SGTC_1871488-2104 32.7 μMChemDiv (Drug-like library)28528590.0731707calcium & mitochondrial duress

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_22997976368114.88 μM0.6756762979718Chembridge (Fragment library)223.65562.13423
SGTC_23399000433200 μM0.552988954Chembridge (Fragment library)203.237121.95623
SGTC_3003907561271.43 μM0.3571436501993Chembridge (Drug-like library)348.197863.315
SGTC_2938905974627.26 μM0.3508776471769Chembridge (Drug-like library)452.21334.18434fatty acid desaturase (OLE1)
SGTC_21605660466132.93 μM0.3252859134Chembridge (Fragment library)209.672082.5242260S ribosome export
SGTC_3542783-35004.88 μM0.326740761ChemDiv (Drug-like library)254.283862.28624cell wall
SGTC_23599039622200 μM0.2978726463596Chembridge (Fragment library)241.6891232.94623endomembrane recycling
SGTC_3332914106911.2 μM0.25862117332883Chembridge (Drug-like library)369.67284.71823
SGTC_9052-aminofluorene215 μM0.2558141539ChemDiv (Drug-like library)181.233142.74611cell wall signaling
SGTC_3308912833217.57 μM0.25423717332805Chembridge (Drug-like library)369.67284.50223plasma membrane duress