| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YEL046C | 4.96 | 3.58E-7 | GLY1 | Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis |
| YER106W | 4.76 | 9.90E-7 | MAM1 | Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle |
| YNL093W | 4.68 | 1.46E-6 | YPT53 | Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication |
| YCL069W | 4.65 | 1.66E-6 | VBA3 | Permease of basic amino acids in the vacuolar membrane |
| YKR034W | 4.14 | 1.73E-5 | DAL80 | Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication |
| YLR295C | 3.95 | 3.97E-5 | ATP14 | Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress |
| YNL127W | 3.93 | 4.26E-5 | FAR11 | Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 |
| YDL133W | 3.92 | 4.45E-5 | SRF1 | Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients |
| YER152C | 3.92 | 4.49E-5 | YER152C | Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene |
| YHL034C | 3.60 | 1.57E-4 | SBP1 | Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 |
| YLR354C | 3.56 | 1.87E-4 | TAL1 | Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate |
| YKL212W | 3.46 | 2.67E-4 | SAC1 | Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism |
| YLR443W | 3.45 | 2.80E-4 | ECM7 | Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency |
| YER001W | 3.38 | 3.57E-4 | MNN1 | Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family |
| YIL047C | 3.36 | 3.95E-4 | SYG1 | Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency |
