Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDL081C | 6.80 | 5.39E-12 | RPP1A | Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component |
YHR010W | 6.52 | 3.50E-11 | RPL27A | Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication |
YKL037W | 6.47 | 4.89E-11 | AIM26 | Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT |
YHR179W | 6.18 | 3.28E-10 | OYE2 | Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress |
YNL298W | 6.11 | 4.95E-10 | CLA4 | Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p |
YKR084C | 5.94 | 1.38E-9 | HBS1 | GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay |
YJL120W_d | 5.94 | 1.45E-9 | YJL120W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO |
YER137C_p | 5.84 | 2.61E-9 | YER137C_p | Putative protein of unknown function |
YBL042C | 5.80 | 3.30E-9 | FUI1 | High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress |
YPL125W | 5.66 | 7.72E-9 | KAP120 | Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p |
YLR014C | 5.36 | 4.15E-8 | PPR1 | Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p |
YHR120W | 5.33 | 5.03E-8 | MSH1 | DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis |
YBL104C | 5.21 | 9.58E-8 | SEA4 | Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites |
YMR245W_d | 5.06 | 2.15E-7 | YMR245W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YPL193W | 5.03 | 2.40E-7 | RSA1 | Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly |