Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGR185C | 6.08 | 6.07E-10 | 2.14 | TYS1 | Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress |
YNL260C_p | 6.00 | 9.65E-10 | 2.14 | LTO1_p | Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species |
YML092C | 3.86 | 5.61E-5 | 0.04 | PRE8 | Alpha 2 subunit of the 20S proteasome |
YDR407C | 3.83 | 6.50E-5 | 0.02 | TRS120 | One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic |
YHR118C | 3.81 | 7.04E-5 | 0.13 | ORC6 | Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p |
YKL004W | 3.68 | 1.18E-4 | 0.02 | AUR1 | Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance |
YLR359W | 3.66 | 1.27E-4 | 0.01 | ADE13 | Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency |
YDR473C | 3.65 | 1.33E-4 | 0.04 | PRP3 | Splicing factor, component of the U4/U6-U5 snRNP complex |
YBR123C | 3.60 | 1.57E-4 | 0.05 | TFC1 | One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 |
YFL039C | 3.56 | 1.89E-4 | 0.15 | ACT1 | Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions |
YBR049C | 3.41 | 3.29E-4 | 0.02 | REB1 | RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication |
YKL078W | 3.39 | 3.52E-4 | 0.00 | DHR2 | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis |
YOL146W | 3.38 | 3.56E-4 | 0.10 | PSF3 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YOR256C | 3.28 | 5.14E-4 | 0.05 | TRE2 | Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication |
YGR190C_d | 3.24 | 6.04E-4 | 0.05 | YGR190C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W |