Deletion Strain | FD score | P-value | Gene | Gene Description |
---|
YDR184C | 8.84 | 4.82E-19 | ATC1 | Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress |
YDL151C_d | 7.09 | 6.91E-13 | BUD30_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay |
YML037C_p | 6.53 | 3.23E-11 | YML037C_p | Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene |
YIL157C | 6.25 | 2.05E-10 | COA1 | Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly |
YML038C | 6.01 | 9.02E-10 | YMD8 | Putative nucleotide sugar transporter, has similarity to Vrg4p |
YGR240C | 5.99 | 1.03E-9 | PFK1 | Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes |
YPR132W | 5.87 | 2.14E-9 | RPS23B | Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal |
YCR007C_p | 5.76 | 4.28E-9 | YCR007C_p | Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene |
YKR077W | 5.68 | 6.75E-9 | MSA2 | Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation |
YDL013W | 5.58 | 1.19E-8 | SLX5 | Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers |
YCR026C | 4.82 | 7.21E-7 | NPP1 | Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication |
YOL116W | 4.81 | 7.59E-7 | MSN1 | Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress |
YPL156C | 4.80 | 7.95E-7 | PRM4 | Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift |
YLR139C | 4.60 | 2.09E-6 | SLS1 | Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery |
YOR270C | 4.60 | 2.12E-6 | VPH1 | Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress |