| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YJL199C_d | 6.77 | 6.52E-12 | MBB1_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies |
| YEL013W | 5.89 | 1.90E-9 | VAC8 | Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions |
| YPR076W_d | 5.73 | 5.06E-9 | YPR076W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YDR354W | 5.27 | 6.90E-8 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
| YGR291C_d | 4.96 | 3.52E-7 | YGR291C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| YEL022W | 4.90 | 4.85E-7 | GEA2 | Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication |
| YML061C | 4.85 | 6.17E-7 | PIF1 | DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells |
| YJL036W | 4.65 | 1.62E-6 | SNX4 | Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p |
| YKL214C | 4.65 | 1.64E-6 | YRA2 | Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus |
| YMR215W | 4.61 | 1.98E-6 | GAS3 | Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation |
| YKL211C | 4.61 | 2.01E-6 | TRP3 | Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p |
| YNL269W | 4.60 | 2.09E-6 | BSC4 | Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p |
| YPL256C | 4.60 | 2.12E-6 | CLN2 | G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) |
| YDL237W | 4.52 | 3.09E-6 | AIM6 | Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene |
| YAL027W | 4.45 | 4.27E-6 | SAW1 | 5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus |
