Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YKR063C | 5.28 | 6.34E-8 | 0.72 | LAS1 | Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability |
YGR278W | 4.56 | 2.58E-6 | 0.07 | CWC22 | Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein |
YKR083C | 4.49 | 3.52E-6 | 0.18 | DAD2 | Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis |
YLR127C | 4.31 | 8.03E-6 | 0.19 | APC2 | Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p |
YPL063W | 4.13 | 1.83E-5 | 0.07 | TIM50 | Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel |
YPR180W | 4.05 | 2.53E-5 | 0.33 | AOS1 | Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability |
YMR290W-A_d | 3.73 | 9.71E-5 | 0.21 | YMR290W-A_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase |
YLR033W | 3.52 | 2.17E-4 | 0.06 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YFR050C | 3.46 | 2.72E-4 | 0.37 | PRE4 | Beta 7 subunit of the 20S proteasome |
YGL040C | 3.09 | 0.00101 | 0.18 | HEM2 | Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus |
YIL063C | 2.90 | 0.00184 | 0.02 | YRB2 | Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential |
YGL061C | 2.88 | 0.00197 | 0.02 | DUO1 | Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis |
YHR188C | 2.87 | 0.00207 | 0.01 | GPI16 | Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog |
YDR160W | 2.86 | 0.00211 | 0.01 | SSY1 | Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes |
YJL203W | 2.85 | 0.00221 | 0.12 | PRP21 | Subunit of the SF3a splicing factor complex, required for spliceosome assembly |