7990716

[4-(5-methyl-1,3-benzoxazol-2-yl)phenyl]methanamine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2343
Screen concentration 14.8 μM
Source Chembridge (Fragment library)
PubChem CID 6456862
SMILES CC1=CC2=C(C=C1)OC(=N2)C3=CC=C(C=C3)CN
Standardized SMILES Cc1ccc2oc(nc2c1)c3ccc(CN)cc3
Molecular weight 238.2845
ALogP 2.87
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.9
% growth inhibition (Hom. pool) 1.14


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6456862
Download HIP data (tab-delimited text)  (excel)
Gene:ASA1(YPR085C)|FD-Score:3.22|P-value:6.31E-4|Clearance:0.27||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 Gene:BRF1(YGR246C)|FD-Score:4.42|P-value:4.97E-6|Clearance:0.46||SGD DESC:TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB Gene:CDC48(YDL126C)|FD-Score:-3.67|P-value:1.19E-4|Clearance:0||SGD DESC:AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP Gene:EXO70(YJL085W)|FD-Score:-4.05|P-value:2.53E-5|Clearance:0||SGD DESC:Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:GPI15(YNL038W)|FD-Score:-4.51|P-value:3.25E-6|Clearance:0||SGD DESC:Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein Gene:KAR1(YNL188W)|FD-Score:5.13|P-value:1.45E-7|Clearance:0.71||SGD DESC:Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Gene:LAS1(YKR063C)|FD-Score:-5.32|P-value:5.07E-8|Clearance:0||SGD DESC:Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability Gene:RIB7(YBR153W)|FD-Score:-3.27|P-value:5.32E-4|Clearance:0||SGD DESC:Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway Gene:RMP1(YLR145W)|FD-Score:3.79|P-value:7.52E-5|Clearance:0.04||SGD DESC:Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P Gene:RSC8(YFR037C)|FD-Score:3.96|P-value:3.76E-5|Clearance:0.17||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SEC18(YBR080C)|FD-Score:-4.92|P-value:4.23E-7|Clearance:0||SGD DESC:ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF Gene:SLD5(YDR489W)|FD-Score:3.24|P-value:6.06E-4|Clearance:0.01||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:TFC3(YAL001C)|FD-Score:3.75|P-value:8.81E-5|Clearance:0.51||SGD DESC:Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding Gene:ASA1(YPR085C)|FD-Score:3.22|P-value:6.31E-4|Clearance:0.27||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 Gene:BRF1(YGR246C)|FD-Score:4.42|P-value:4.97E-6|Clearance:0.46||SGD DESC:TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB Gene:CDC48(YDL126C)|FD-Score:-3.67|P-value:1.19E-4|Clearance:0||SGD DESC:AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP Gene:EXO70(YJL085W)|FD-Score:-4.05|P-value:2.53E-5|Clearance:0||SGD DESC:Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:GPI15(YNL038W)|FD-Score:-4.51|P-value:3.25E-6|Clearance:0||SGD DESC:Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein Gene:KAR1(YNL188W)|FD-Score:5.13|P-value:1.45E-7|Clearance:0.71||SGD DESC:Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p Gene:LAS1(YKR063C)|FD-Score:-5.32|P-value:5.07E-8|Clearance:0||SGD DESC:Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability Gene:RIB7(YBR153W)|FD-Score:-3.27|P-value:5.32E-4|Clearance:0||SGD DESC:Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway Gene:RMP1(YLR145W)|FD-Score:3.79|P-value:7.52E-5|Clearance:0.04||SGD DESC:Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P Gene:RSC8(YFR037C)|FD-Score:3.96|P-value:3.76E-5|Clearance:0.17||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SEC18(YBR080C)|FD-Score:-4.92|P-value:4.23E-7|Clearance:0||SGD DESC:ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF Gene:SLD5(YDR489W)|FD-Score:3.24|P-value:6.06E-4|Clearance:0.01||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:TFC3(YAL001C)|FD-Score:3.75|P-value:8.81E-5|Clearance:0.51||SGD DESC:Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6456862
Download HOP data (tab-delimited text)  (excel)
Gene:ADK1(YDR226W)|FD-Score:4.36|P-value:6.40E-6||SGD DESC:Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress Gene:AIM10(YER087W)|FD-Score:-3.27|P-value:5.41E-4||SGD DESC:Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:AIR1(YIL079C)|FD-Score:3.99|P-value:3.27E-5||SGD DESC:Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication Gene:AKR2(YOR034C)|FD-Score:-5.76|P-value:4.28E-9||SGD DESC:Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication Gene:BRP1(YGL007W_d)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:BUD25(YER014C-A)|FD-Score:-3.69|P-value:1.11E-4||SGD DESC:Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Gene:CDC26(YFR036W)|FD-Score:3.81|P-value:6.87E-5||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:CHO1(YER026C)|FD-Score:-3.8|P-value:7.22E-5||SGD DESC:Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline Gene:CRP1(YHR146W)|FD-Score:3.26|P-value:5.48E-4||SGD DESC:Protein that binds to cruciform DNA structures Gene:CSM4(YPL200W)|FD-Score:3.97|P-value:3.56E-5||SGD DESC:Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements Gene:CTF3(YLR381W)|FD-Score:-3.65|P-value:1.29E-4||SGD DESC:Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6 Gene:CTL1(YMR180C)|FD-Score:5.03|P-value:2.51E-7||SGD DESC:RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm Gene:CUP2(YGL166W)|FD-Score:4.36|P-value:6.63E-6||SGD DESC:Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication Gene:DDC1(YPL194W)|FD-Score:-3.82|P-value:6.55E-5||SGD DESC:DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress Gene:DOT1(YDR440W)|FD-Score:4.4|P-value:5.41E-6||SGD DESC:Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response Gene:ECM33(YBR078W)|FD-Score:3.77|P-value:8.09E-5||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:EMP70(YLR083C)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments Gene:ENT3(YJR125C)|FD-Score:3.18|P-value:7.46E-4||SGD DESC:Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p Gene:GAL11(YOL051W)|FD-Score:3.46|P-value:2.66E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator Gene:GSH2(YOL049W)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock Gene:HOT13(YKL084W)|FD-Score:3.79|P-value:7.52E-5||SGD DESC:Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc Gene:IES5(YER092W)|FD-Score:-3.28|P-value:5.21E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions Gene:IGD1(YFR017C)|FD-Score:4.03|P-value:2.79E-5||SGD DESC:Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication Gene:ILV1(YER086W)|FD-Score:-3.53|P-value:2.06E-4||SGD DESC:Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation Gene:IRC15(YPL017C)|FD-Score:-4.12|P-value:1.92E-5||SGD DESC:Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci Gene:LAA1(YJL207C)|FD-Score:3.21|P-value:6.65E-4||SGD DESC:AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene Gene:LHP1(YDL051W)|FD-Score:-3.91|P-value:4.59E-5||SGD DESC:RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen Gene:LYS14(YDR034C)|FD-Score:3.22|P-value:6.33E-4||SGD DESC:Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer Gene:LYS4(YDR234W)|FD-Score:3.66|P-value:1.26E-4||SGD DESC:Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway Gene:MKC7(YDR144C)|FD-Score:-3.15|P-value:8.14E-4||SGD DESC:GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p Gene:MRI1(YPR118W)|FD-Score:4.12|P-value:1.93E-5||SGD DESC:5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway Gene:MRPL10(YNL284C)|FD-Score:-3.6|P-value:1.62E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels Gene:MUD1(YBR119W)|FD-Score:3.41|P-value:3.29E-4||SGD DESC:U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing Gene:NSG1(YHR133C)|FD-Score:-3.69|P-value:1.13E-4||SGD DESC:Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress Gene:OMS1(YDR316W)|FD-Score:4.5|P-value:3.32E-6||SGD DESC:Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations Gene:PAU4(YLR461W)|FD-Score:-3.09|P-value:9.96E-4||SGD DESC:Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme Gene:PET191(YJR034W)|FD-Score:-3.68|P-value:1.17E-4||SGD DESC:Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery Gene:PFS1(YHR185C)|FD-Score:-3.49|P-value:2.38E-4||SGD DESC:Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation Gene:PKH1(YDR490C)|FD-Score:4.89|P-value:5.07E-7||SGD DESC:Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p Gene:QRI5(YLR204W)|FD-Score:4.33|P-value:7.37E-6||SGD DESC:Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA Gene:RCN1(YKL159C)|FD-Score:-3.15|P-value:8.23E-4||SGD DESC:Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region Gene:RIM4(YHL024W)|FD-Score:5.08|P-value:1.86E-7||SGD DESC:Putative RNA-binding protein required for the expression of early and middle sporulation genes Gene:RKM5(YLR137W)|FD-Score:3.26|P-value:5.63E-4||SGD DESC:Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species Gene:SIZ1(YDR409W)|FD-Score:-4.13|P-value:1.85E-5||SGD DESC:SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring Gene:SNZ1(YMR096W)|FD-Score:3.82|P-value:6.74E-5||SGD DESC:Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins Gene:SSM4(YIL030C)|FD-Score:6.78|P-value:5.98E-12||SGD DESC:Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation Gene:TMA108(YIL137C)|FD-Score:-3.2|P-value:6.93E-4||SGD DESC:Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease Gene:TRM12(YML005W)|FD-Score:3.11|P-value:9.31E-4||SGD DESC:S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA Gene:UIP3(YAR027W)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family Gene:WSC2(YNL283C)|FD-Score:-4.25|P-value:1.05E-5||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response Gene:YBR238C(YBR238C)|FD-Score:-4.5|P-value:3.34E-6||SGD DESC:Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span Gene:YBT1(YLL048C)|FD-Score:-3.57|P-value:1.78E-4||SGD DESC:Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters Gene:YDR132C(YDR132C_p)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication Gene:YDR182W-A(YDR182W-A_p)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YEF1(YEL041W)|FD-Score:3.42|P-value:3.13E-4||SGD DESC:ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication Gene:YER084W(YER084W_p)|FD-Score:4.68|P-value:1.45E-6||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YFR057W(YFR057W_p)|FD-Score:4.94|P-value:3.86E-7||SGD DESC:Putative protein of unknown function Gene:YGL118C(YGL118C_d)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL159W(YGL159W_p)|FD-Score:5.64|P-value:8.36E-9||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YGL185C(YGL185C_p)|FD-Score:4.01|P-value:3.02E-5||SGD DESC:Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YHR022C-A(YHR022C-A_p)|FD-Score:-3.32|P-value:4.53E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YHR049C-A(YHR049C-A_d)|FD-Score:-3.17|P-value:7.72E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJL132W(YJL132W_p)|FD-Score:3.4|P-value:3.34E-4||SGD DESC:Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene Gene:YKL030W(YKL030W_d)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene MAE1 Gene:YKR005C(YKR005C_p)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Putative protein of unknown function Gene:YMR226C(YMR226C)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments Gene:YMR265C(YMR265C_p)|FD-Score:3.1|P-value:9.75E-4||SGD DESC:Putative protein of unknown function Gene:YNL057W(YNL057W_d)|FD-Score:-3.39|P-value:3.56E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL184C(YNL184C_p)|FD-Score:-3.17|P-value:7.73E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YNR073C(YNR073C_p)|FD-Score:5.56|P-value:1.35E-8||SGD DESC:Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p Gene:YOL029C(YOL029C_p)|FD-Score:-3.26|P-value:5.64E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens Gene:YPQ1(YOL092W_p)|FD-Score:3.86|P-value:5.58E-5||SGD DESC:Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter Gene:YPR078C(YPR078C_p)|FD-Score:3.25|P-value:5.69E-4||SGD DESC:Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible Gene:YPR170C(YPR170C_d)|FD-Score:4.94|P-value:3.93E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B Gene:YPT10(YBR264C)|FD-Score:-4.24|P-value:1.12E-5||SGD DESC:Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles Gene:ADK1(YDR226W)|FD-Score:4.36|P-value:6.40E-6||SGD DESC:Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress Gene:AIM10(YER087W)|FD-Score:-3.27|P-value:5.41E-4||SGD DESC:Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:AIR1(YIL079C)|FD-Score:3.99|P-value:3.27E-5||SGD DESC:Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication Gene:AKR2(YOR034C)|FD-Score:-5.76|P-value:4.28E-9||SGD DESC:Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication Gene:BRP1(YGL007W_d)|FD-Score:3.45|P-value:2.77E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:BUD25(YER014C-A)|FD-Score:-3.69|P-value:1.11E-4||SGD DESC:Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Gene:CDC26(YFR036W)|FD-Score:3.81|P-value:6.87E-5||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:CHO1(YER026C)|FD-Score:-3.8|P-value:7.22E-5||SGD DESC:Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline Gene:CRP1(YHR146W)|FD-Score:3.26|P-value:5.48E-4||SGD DESC:Protein that binds to cruciform DNA structures Gene:CSM4(YPL200W)|FD-Score:3.97|P-value:3.56E-5||SGD DESC:Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements Gene:CTF3(YLR381W)|FD-Score:-3.65|P-value:1.29E-4||SGD DESC:Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6 Gene:CTL1(YMR180C)|FD-Score:5.03|P-value:2.51E-7||SGD DESC:RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm Gene:CUP2(YGL166W)|FD-Score:4.36|P-value:6.63E-6||SGD DESC:Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication Gene:DDC1(YPL194W)|FD-Score:-3.82|P-value:6.55E-5||SGD DESC:DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress Gene:DOT1(YDR440W)|FD-Score:4.4|P-value:5.41E-6||SGD DESC:Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response Gene:ECM33(YBR078W)|FD-Score:3.77|P-value:8.09E-5||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:EMP70(YLR083C)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments Gene:ENT3(YJR125C)|FD-Score:3.18|P-value:7.46E-4||SGD DESC:Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p Gene:GAL11(YOL051W)|FD-Score:3.46|P-value:2.66E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator Gene:GSH2(YOL049W)|FD-Score:-3.44|P-value:2.88E-4||SGD DESC:Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock Gene:HOT13(YKL084W)|FD-Score:3.79|P-value:7.52E-5||SGD DESC:Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc Gene:IES5(YER092W)|FD-Score:-3.28|P-value:5.21E-4||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions Gene:IGD1(YFR017C)|FD-Score:4.03|P-value:2.79E-5||SGD DESC:Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication Gene:ILV1(YER086W)|FD-Score:-3.53|P-value:2.06E-4||SGD DESC:Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation Gene:IRC15(YPL017C)|FD-Score:-4.12|P-value:1.92E-5||SGD DESC:Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci Gene:LAA1(YJL207C)|FD-Score:3.21|P-value:6.65E-4||SGD DESC:AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene Gene:LHP1(YDL051W)|FD-Score:-3.91|P-value:4.59E-5||SGD DESC:RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen Gene:LYS14(YDR034C)|FD-Score:3.22|P-value:6.33E-4||SGD DESC:Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer Gene:LYS4(YDR234W)|FD-Score:3.66|P-value:1.26E-4||SGD DESC:Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway Gene:MKC7(YDR144C)|FD-Score:-3.15|P-value:8.14E-4||SGD DESC:GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p Gene:MRI1(YPR118W)|FD-Score:4.12|P-value:1.93E-5||SGD DESC:5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway Gene:MRPL10(YNL284C)|FD-Score:-3.6|P-value:1.62E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels Gene:MUD1(YBR119W)|FD-Score:3.41|P-value:3.29E-4||SGD DESC:U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing Gene:NSG1(YHR133C)|FD-Score:-3.69|P-value:1.13E-4||SGD DESC:Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress Gene:OMS1(YDR316W)|FD-Score:4.5|P-value:3.32E-6||SGD DESC:Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations Gene:PAU4(YLR461W)|FD-Score:-3.09|P-value:9.96E-4||SGD DESC:Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme Gene:PET191(YJR034W)|FD-Score:-3.68|P-value:1.17E-4||SGD DESC:Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery Gene:PFS1(YHR185C)|FD-Score:-3.49|P-value:2.38E-4||SGD DESC:Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation Gene:PKH1(YDR490C)|FD-Score:4.89|P-value:5.07E-7||SGD DESC:Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p Gene:QRI5(YLR204W)|FD-Score:4.33|P-value:7.37E-6||SGD DESC:Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA Gene:RCN1(YKL159C)|FD-Score:-3.15|P-value:8.23E-4||SGD DESC:Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region Gene:RIM4(YHL024W)|FD-Score:5.08|P-value:1.86E-7||SGD DESC:Putative RNA-binding protein required for the expression of early and middle sporulation genes Gene:RKM5(YLR137W)|FD-Score:3.26|P-value:5.63E-4||SGD DESC:Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species Gene:SIZ1(YDR409W)|FD-Score:-4.13|P-value:1.85E-5||SGD DESC:SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring Gene:SNZ1(YMR096W)|FD-Score:3.82|P-value:6.74E-5||SGD DESC:Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins Gene:SSM4(YIL030C)|FD-Score:6.78|P-value:5.98E-12||SGD DESC:Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation Gene:TMA108(YIL137C)|FD-Score:-3.2|P-value:6.93E-4||SGD DESC:Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease Gene:TRM12(YML005W)|FD-Score:3.11|P-value:9.31E-4||SGD DESC:S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA Gene:UIP3(YAR027W)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family Gene:WSC2(YNL283C)|FD-Score:-4.25|P-value:1.05E-5||SGD DESC:Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response Gene:YBR238C(YBR238C)|FD-Score:-4.5|P-value:3.34E-6||SGD DESC:Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span Gene:YBT1(YLL048C)|FD-Score:-3.57|P-value:1.78E-4||SGD DESC:Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters Gene:YDR132C(YDR132C_p)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication Gene:YDR182W-A(YDR182W-A_p)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YEF1(YEL041W)|FD-Score:3.42|P-value:3.13E-4||SGD DESC:ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication Gene:YER084W(YER084W_p)|FD-Score:4.68|P-value:1.45E-6||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YFR057W(YFR057W_p)|FD-Score:4.94|P-value:3.86E-7||SGD DESC:Putative protein of unknown function Gene:YGL118C(YGL118C_d)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGL159W(YGL159W_p)|FD-Score:5.64|P-value:8.36E-9||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YGL185C(YGL185C_p)|FD-Score:4.01|P-value:3.02E-5||SGD DESC:Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YHR022C-A(YHR022C-A_p)|FD-Score:-3.32|P-value:4.53E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YHR049C-A(YHR049C-A_d)|FD-Score:-3.17|P-value:7.72E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJL132W(YJL132W_p)|FD-Score:3.4|P-value:3.34E-4||SGD DESC:Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene Gene:YKL030W(YKL030W_d)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene MAE1 Gene:YKR005C(YKR005C_p)|FD-Score:3.66|P-value:1.24E-4||SGD DESC:Putative protein of unknown function Gene:YMR226C(YMR226C)|FD-Score:3.52|P-value:2.17E-4||SGD DESC:NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments Gene:YMR265C(YMR265C_p)|FD-Score:3.1|P-value:9.75E-4||SGD DESC:Putative protein of unknown function Gene:YNL057W(YNL057W_d)|FD-Score:-3.39|P-value:3.56E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL184C(YNL184C_p)|FD-Score:-3.17|P-value:7.73E-4||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YNR073C(YNR073C_p)|FD-Score:5.56|P-value:1.35E-8||SGD DESC:Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p Gene:YOL029C(YOL029C_p)|FD-Score:-3.26|P-value:5.64E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens Gene:YPQ1(YOL092W_p)|FD-Score:3.86|P-value:5.58E-5||SGD DESC:Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter Gene:YPR078C(YPR078C_p)|FD-Score:3.25|P-value:5.69E-4||SGD DESC:Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible Gene:YPR170C(YPR170C_d)|FD-Score:4.94|P-value:3.93E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B Gene:YPT10(YBR264C)|FD-Score:-4.24|P-value:1.12E-5||SGD DESC:Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles

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Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YNL188W5.131.45E-70.71KAR1Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
YGR246C4.424.97E-60.46BRF1TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
YFR037C3.963.76E-50.17RSC8Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YLR145W3.797.52E-50.04RMP1Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
YAL001C3.758.81E-50.52TFC3Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YDR489W3.246.06E-40.01SLD5Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YPR085C3.226.31E-40.27ASA1Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
YML126C2.950.001570.04ERG133-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
YBR142W2.910.001790.02MAK5Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
YOL040C2.900.001880.10RPS15Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
YGL137W2.800.002560.08SEC27Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
YPL252C2.720.003250.01YAH1Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
YHR143W-A2.720.003310.01RPC10RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress
YGL150C2.710.003410.04INO80ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription
YDR087C2.670.003790.02RRP1Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YIL030C6.785.98E-12SSM4Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
YGL159W_p5.648.36E-9YGL159W_pPutative protein of unknown function; deletion mutant has no detectable phenotype
YNR073C_p5.561.35E-8YNR073C_pPutative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p
YHL024W5.081.86E-7RIM4Putative RNA-binding protein required for the expression of early and middle sporulation genes
YMR180C5.032.51E-7CTL1RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm
YFR057W_p4.943.86E-7YFR057W_pPutative protein of unknown function
YPR170C_d4.943.93E-7YPR170C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YDR490C4.895.07E-7PKH1Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p
YER084W_p4.681.45E-6YER084W_pProtein of unknown function; expressed at both mRNA and protein levels
YDR316W4.503.32E-6OMS1Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations
YDR440W4.405.41E-6DOT1Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response
YDR226W4.366.40E-6ADK1Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress
YGL166W4.366.63E-6CUP2Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication
YLR204W4.337.37E-6QRI5Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
YPR118W4.121.93E-5MRI15'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway

GO enrichment analysis for SGTC_2343
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1133.56E-18SGTC_3730844-0104 25.9 μMChemDiv (Drug-like library)53758040.0833333ERAD & cell cycle
0.1023.88E-15SGTC_23499023730 187.1 μMChembridge (Fragment library)41262870.0847458
0.0814.58E-10SGTC_384k007-0144 5.2 μMChemDiv (Drug-like library)68248860.084507ERAD & cell cycle
0.0809.35E-10SGTC_7334069-0007 56.1 μMChemDiv (Drug-like library)57174250.0909091ERAD & cell cycle
0.0714.04E-8SGTC_30539095903 49.5 μMChembridge (Drug-like library)171740180.101449Golgi
0.0707.27E-8SGTC_1026k007-1105 30.6 μMChemDiv (Drug-like library)70667940.0757576ERAD & cell cycle
0.0681.75E-7SGTC_14143917-0015 5.4 μMChemDiv (Drug-like library)66187020.0882353
0.0631.16E-6SGTC_1161k007-0610 110.0 μMChemDiv (Drug-like library)58438500.0757576ERAD & cell cycle
0.0604.31E-6SGTC_32569138902 49.5 μMChembridge (Drug-like library)172287730.126984PDR1
0.0595.65E-6SGTC_1777st045864 34.8 μMTimTec (Natural product derivative library)46914620.0540541
0.0595.73E-6SGTC_352k048-0007 5.1 μMChemDiv (Drug-like library)68119110.0588235ERAD & cell cycle
0.0586.97E-6SGTC_509pifithrin 175.0 μMICCB bioactive library48170.123077mitochondrial processes
0.0561.79E-5SGTC_1852st056254 31.4 μMTimTec (Natural product derivative library)4425830.109375
0.0552.37E-5SGTC_1651st011928 86.1 μMTimTec (Natural product derivative library)7201980.0952381RSC complex & mRNA processing
0.0526.17E-5SGTC_1065prochlorperazine maleate 2.5 μMNIH Clinical Collection64360570.0857143

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_3252810-4341181 μM0.531915774970ChemDiv (Drug-like library)252.311043.96213amide catabolism
SGTC_21525568786200 μM0.4772735399883Chembridge (Fragment library)226.23071.76424
SGTC_6051315-0399119 μM0.47272724020461ChemDiv (Drug-like library)381.254666.69203Golgi
SGTC_15130337-055919 μM0.431818775073ChemDiv (Drug-like library)211.216063.03813
SGTC_930109-004559.23 μM0.41860588733ChemDiv (Drug-like library)210.23132.53413DNA damage response
SGTC_12131315-0166115 μM0.415094768401ChemDiv (Drug-like library)266.294562.88713
SGTC_21285255449168.49 μM0.387755736008Chembridge (Fragment library)211.219361.38314
SGTC_14524194-0072190 μM0.3870971343545ChemDiv (Drug-like library)408.248064.14914
SGTC_1100850-0284111.64 μM0.3728813906265ChemDiv (Drug-like library)391.26066.11103
SGTC_7771315-0167517 μM0.3666674221767ChemDiv (Drug-like library)381.254666.69203Golgi