Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR008C_d | 8.30 | 5.27E-17 | YDR008C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YBL031W | 7.08 | 6.96E-13 | SHE1 | Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function |
YPR128C | 6.90 | 2.57E-12 | ANT1 | Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation |
YBR214W | 6.45 | 5.42E-11 | SDS24 | Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication |
YLR057W | 5.65 | 7.80E-9 | MNL2 | Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene |
YNL154C | 5.45 | 2.57E-8 | YCK2 | Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication |
YMR282C | 5.26 | 7.30E-8 | AEP2 | Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader |
YBR069C | 5.04 | 2.39E-7 | TAT1 | Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress |
YPL206C | 4.68 | 1.46E-6 | PGC1 | Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs |
YML115C | 4.67 | 1.50E-6 | VAN1 | Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant |
YKR091W | 4.58 | 2.35E-6 | SRL3 | Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate |
YDR035W | 4.54 | 2.78E-6 | ARO3 | 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan |
YKL039W | 4.44 | 4.58E-6 | PTM1 | Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication |
YHR198C | 4.44 | 4.60E-6 | AIM18 | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss |
YHL011C | 4.42 | 4.92E-6 | PRS3 | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes |