9026858

6-amino-1-(2-phenylethyl)pyrimidine-2,4-dione

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2351
Screen concentration 72.3 μM
Source Chembridge (Fragment library)
PubChem CID 1409300
SMILES C1=CC=C(C=C1)CCN2C(=CC(=O)NC2=O)N
Standardized SMILES NC1=CC(=O)NC(=O)N1CCc2ccccc2
Molecular weight 231.2505
ALogP 0.88
H-bond donor count 2
H-bond acceptor count 3
Response signature RNA processing & uracil transport

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.72
% growth inhibition (Hom. pool) 4.91


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 1409300
Download HIP data (tab-delimited text)  (excel)
Gene:CDC19(YAL038W)|FD-Score:5.78|P-value:3.77E-9|Clearance:0.65||SGD DESC:Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication Gene:GLC7(YER133W)|FD-Score:5.44|P-value:2.64E-8|Clearance:0.65||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:GLN4(YOR168W)|FD-Score:3.55|P-value:1.90E-4|Clearance:0.48||SGD DESC:Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions Gene:HRR25(YPL204W)|FD-Score:4.25|P-value:1.09E-5|Clearance:0.2||SGD DESC:Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) Gene:JIP5(YPR169W)|FD-Score:-4.71|P-value:1.24E-6|Clearance:0||SGD DESC:Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein Gene:MEC1(YBR136W)|FD-Score:3.96|P-value:3.78E-5|Clearance:0.1||SGD DESC:Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres Gene:MTR10(YOR160W)|FD-Score:5.25|P-value:7.56E-8|Clearance:0.65||SGD DESC:Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:NOC4(YPR144C)|FD-Score:3.85|P-value:5.84E-5|Clearance:0.3||SGD DESC:Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Gene:NUG1(YER006W)|FD-Score:-3.52|P-value:2.16E-4|Clearance:0||SGD DESC:GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus Gene:PRE4(YFR050C)|FD-Score:5.31|P-value:5.53E-8|Clearance:0.65||SGD DESC:Beta 7 subunit of the 20S proteasome Gene:PUP3(YER094C)|FD-Score:4.05|P-value:2.56E-5|Clearance:0.05||SGD DESC:Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 Gene:RPC82(YPR190C)|FD-Score:4|P-value:3.15E-5|Clearance:0.04||SGD DESC:RNA polymerase III subunit C82 Gene:RPL15A(YLR029C)|FD-Score:4.6|P-value:2.12E-6|Clearance:0.2||SGD DESC:Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication Gene:SMD2(YLR275W)|FD-Score:-3.54|P-value:1.99E-4|Clearance:0||SGD DESC:Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 Gene:SNM1(YDR478W)|FD-Score:4.4|P-value:5.50E-6|Clearance:0.03||SGD DESC:Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP Gene:UTP8(YGR128C)|FD-Score:-4.5|P-value:3.43E-6|Clearance:0||SGD DESC:Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:VRG4(YGL225W)|FD-Score:4.37|P-value:6.33E-6|Clearance:0.12||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:YAL034C-B(YAL034C-B_d)|FD-Score:5.5|P-value:1.90E-8|Clearance:0.65||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR198C(YLR198C_d)|FD-Score:-3.44|P-value:2.94E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W Gene:YPT1(YFL038C)|FD-Score:5.7|P-value:6.04E-9|Clearance:0.65||SGD DESC:Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) Gene:YTH1(YPR107C)|FD-Score:-3.63|P-value:1.39E-4|Clearance:0||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation Gene:CDC19(YAL038W)|FD-Score:5.78|P-value:3.77E-9|Clearance:0.65||SGD DESC:Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication Gene:GLC7(YER133W)|FD-Score:5.44|P-value:2.64E-8|Clearance:0.65||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:GLN4(YOR168W)|FD-Score:3.55|P-value:1.90E-4|Clearance:0.48||SGD DESC:Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions Gene:HRR25(YPL204W)|FD-Score:4.25|P-value:1.09E-5|Clearance:0.2||SGD DESC:Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) Gene:JIP5(YPR169W)|FD-Score:-4.71|P-value:1.24E-6|Clearance:0||SGD DESC:Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein Gene:MEC1(YBR136W)|FD-Score:3.96|P-value:3.78E-5|Clearance:0.1||SGD DESC:Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres Gene:MTR10(YOR160W)|FD-Score:5.25|P-value:7.56E-8|Clearance:0.65||SGD DESC:Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress Gene:NOC4(YPR144C)|FD-Score:3.85|P-value:5.84E-5|Clearance:0.3||SGD DESC:Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Gene:NUG1(YER006W)|FD-Score:-3.52|P-value:2.16E-4|Clearance:0||SGD DESC:GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus Gene:PRE4(YFR050C)|FD-Score:5.31|P-value:5.53E-8|Clearance:0.65||SGD DESC:Beta 7 subunit of the 20S proteasome Gene:PUP3(YER094C)|FD-Score:4.05|P-value:2.56E-5|Clearance:0.05||SGD DESC:Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 Gene:RPC82(YPR190C)|FD-Score:4|P-value:3.15E-5|Clearance:0.04||SGD DESC:RNA polymerase III subunit C82 Gene:RPL15A(YLR029C)|FD-Score:4.6|P-value:2.12E-6|Clearance:0.2||SGD DESC:Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication Gene:SMD2(YLR275W)|FD-Score:-3.54|P-value:1.99E-4|Clearance:0||SGD DESC:Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 Gene:SNM1(YDR478W)|FD-Score:4.4|P-value:5.50E-6|Clearance:0.03||SGD DESC:Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP Gene:UTP8(YGR128C)|FD-Score:-4.5|P-value:3.43E-6|Clearance:0||SGD DESC:Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:VRG4(YGL225W)|FD-Score:4.37|P-value:6.33E-6|Clearance:0.12||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:YAL034C-B(YAL034C-B_d)|FD-Score:5.5|P-value:1.90E-8|Clearance:0.65||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR198C(YLR198C_d)|FD-Score:-3.44|P-value:2.94E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W Gene:YPT1(YFL038C)|FD-Score:5.7|P-value:6.04E-9|Clearance:0.65||SGD DESC:Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) Gene:YTH1(YPR107C)|FD-Score:-3.63|P-value:1.39E-4|Clearance:0||SGD DESC:Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 1409300
Download HOP data (tab-delimited text)  (excel)
Gene:ABF2(YMR072W)|FD-Score:-3.27|P-value:5.44E-4||SGD DESC:Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation Gene:ACH1(YBL015W)|FD-Score:-3.81|P-value:6.91E-5||SGD DESC:Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth Gene:ADK1(YDR226W)|FD-Score:-3.65|P-value:1.31E-4||SGD DESC:Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress Gene:ADY2(YCR010C)|FD-Score:3.3|P-value:4.82E-4||SGD DESC:Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication Gene:AIM23(YJL131C)|FD-Score:-6.08|P-value:5.83E-10||SGD DESC:Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss Gene:AIM29(YKR074W)|FD-Score:3.21|P-value:6.69E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss Gene:API2(YDR525W_d)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology Gene:ATC1(YDR184C)|FD-Score:-3.27|P-value:5.31E-4||SGD DESC:Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress Gene:ATG32(YIL146C)|FD-Score:5.62|P-value:9.32E-9||SGD DESC:Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane Gene:ATX1(YNL259C)|FD-Score:3.94|P-value:4.06E-5||SGD DESC:Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake Gene:BRP1(YGL007W_d)|FD-Score:3.35|P-value:3.98E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:BUD30(YDL151C_d)|FD-Score:7.19|P-value:3.25E-13||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CDC73(YLR418C)|FD-Score:5.12|P-value:1.55E-7||SGD DESC:Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress Gene:CRC1(YOR100C)|FD-Score:3.29|P-value:5.08E-4||SGD DESC:Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Gene:CTR1(YPR124W)|FD-Score:3.72|P-value:1.01E-4||SGD DESC:High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:ECM30(YLR436C)|FD-Score:3.84|P-value:6.12E-5||SGD DESC:Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm Gene:ERG5(YMR015C)|FD-Score:6.96|P-value:1.68E-12||SGD DESC:C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs Gene:ERV29(YGR284C)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress Gene:FRE4(YNR060W)|FD-Score:7.16|P-value:3.96E-13||SGD DESC:Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels Gene:FUR4(YBR021W)|FD-Score:30.7|P-value:2.23E-207||SGD DESC:Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation Gene:GBP2(YCL011C)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication Gene:GCN5(YGR252W)|FD-Score:5.07|P-value:1.95E-7||SGD DESC:Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation Gene:GEP5(YLR091W)|FD-Score:-4.78|P-value:8.80E-7||SGD DESC:Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine Gene:GID7(YCL039W)|FD-Score:-3.3|P-value:4.92E-4||SGD DESC:Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions Gene:GMC1(YDR506C)|FD-Score:3.2|P-value:6.79E-4||SGD DESC:Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein Gene:GRH1(YDR517W)|FD-Score:-3.98|P-value:3.49E-5||SGD DESC:Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress Gene:IRC10(YOL015W)|FD-Score:-5.36|P-value:4.13E-8||SGD DESC:Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci Gene:ISY1(YJR050W)|FD-Score:-5.2|P-value:1.02E-7||SGD DESC:Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles Gene:LEO1(YOR123C)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:LGE1(YPL055C)|FD-Score:3.85|P-value:5.95E-5||SGD DESC:Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division Gene:LIP5(YOR196C)|FD-Score:-3.34|P-value:4.23E-4||SGD DESC:Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase Gene:LSB1(YGR136W)|FD-Score:-3.27|P-value:5.38E-4||SGD DESC:Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress Gene:MCK1(YNL307C)|FD-Score:4.21|P-value:1.27E-5||SGD DESC:Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family Gene:MSC3(YLR219W)|FD-Score:4.68|P-value:1.44E-6||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress Gene:MSH3(YCR092C)|FD-Score:3.85|P-value:5.80E-5||SGD DESC:Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability Gene:MSH5(YDL154W)|FD-Score:5.6|P-value:1.06E-8||SGD DESC:Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans Gene:MSL1(YIR009W)|FD-Score:3.15|P-value:8.03E-4||SGD DESC:U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members Gene:MTF1(YMR228W)|FD-Score:-3.28|P-value:5.28E-4||SGD DESC:Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation Gene:MTM1(YGR257C)|FD-Score:3.29|P-value:5.01E-4||SGD DESC:Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor Gene:NYV1(YLR093C)|FD-Score:-4.09|P-value:2.13E-5||SGD DESC:v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane Gene:ORM1(YGR038W)|FD-Score:3.8|P-value:7.12E-5||SGD DESC:Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control Gene:PAN5(YHR063C)|FD-Score:3.22|P-value:6.46E-4||SGD DESC:2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE Gene:PGC1(YPL206C)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs Gene:PRM1(YNL279W)|FD-Score:3.17|P-value:7.50E-4||SGD DESC:Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p Gene:PTH2(YBL057C)|FD-Score:3.25|P-value:5.85E-4||SGD DESC:One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth Gene:REC104(YHR157W)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination Gene:RGA1(YOR127W)|FD-Score:3.56|P-value:1.87E-4||SGD DESC:GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:RPL26A(YLR344W)|FD-Score:-3.67|P-value:1.23E-4||SGD DESC:Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication Gene:RTF1(YGL244W)|FD-Score:4.17|P-value:1.52E-5||SGD DESC:Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:SAC7(YDR389W)|FD-Score:4.48|P-value:3.65E-6||SGD DESC:GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate Gene:SCD6(YPR129W)|FD-Score:3.17|P-value:7.50E-4||SGD DESC:Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress Gene:SCP160(YJL080C)|FD-Score:4.65|P-value:1.62E-6||SGD DESC:Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins Gene:SDC1(YDR469W)|FD-Score:5.44|P-value:2.59E-8||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 Gene:SIS2(YKR072C)|FD-Score:3.78|P-value:7.90E-5||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:SMF3(YLR034C)|FD-Score:3.26|P-value:5.56E-4||SGD DESC:Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress Gene:SPH1(YLR313C)|FD-Score:3.21|P-value:6.58E-4||SGD DESC:Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p Gene:SSN3(YPL042C)|FD-Score:-3.89|P-value:4.91E-5||SGD DESC:Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression Gene:SUC2(YIL162W)|FD-Score:4.1|P-value:2.06E-5||SGD DESC:Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively Gene:SUL2(YLR092W)|FD-Score:-3.38|P-value:3.60E-4||SGD DESC:High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates Gene:TAN1(YGL232W)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress Gene:TSR2(YLR435W)|FD-Score:-3.99|P-value:3.36E-5||SGD DESC:Protein with a potential role in pre-rRNA processing Gene:UBP13(YBL067C)|FD-Score:5.06|P-value:2.15E-7||SGD DESC:Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication Gene:UBP7(YIL156W)|FD-Score:3.46|P-value:2.75E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin-protein fusions Gene:URA7(YBL039C)|FD-Score:-5.48|P-value:2.11E-8||SGD DESC:Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication Gene:URN1(YPR152C)|FD-Score:-5.83|P-value:2.72E-9||SGD DESC:Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase Gene:VHR2(YER064C_p)|FD-Score:3.85|P-value:5.96E-5||SGD DESC:Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:VMA3(YEL027W)|FD-Score:5.14|P-value:1.34E-7||SGD DESC:Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis Gene:WHI3(YNL197C)|FD-Score:-3.29|P-value:4.95E-4||SGD DESC:RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication Gene:WWM1(YFL010C)|FD-Score:3.56|P-value:1.89E-4||SGD DESC:WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 Gene:XPT1(YJR133W)|FD-Score:-3.71|P-value:1.03E-4||SGD DESC:Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine Gene:YBR296C-A(YBR296C-A_p)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YDL114W(YDL114W_p)|FD-Score:-4.48|P-value:3.82E-6||SGD DESC:Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene Gene:YDL118W(YDL118W_p)|FD-Score:-3.16|P-value:7.89E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein Gene:YEL028W(YEL028W_d)|FD-Score:3.38|P-value:3.58E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YEL045C(YEL045C_d)|FD-Score:-3.66|P-value:1.26E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Gene:YER084W(YER084W_p)|FD-Score:-4.27|P-value:9.80E-6||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YGR045C(YGR045C_d)|FD-Score:-4.62|P-value:1.95E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR093W(YGR093W_p)|FD-Score:4.44|P-value:4.50E-6||SGD DESC:Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:YHR049C-A(YHR049C-A_d)|FD-Score:-5.52|P-value:1.74E-8||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR127W(YHR127W)|FD-Score:-3.22|P-value:6.49E-4||SGD DESC:Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis Gene:YJL182C(YJL182C_d)|FD-Score:3.18|P-value:7.25E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W Gene:YKL018C-A(YKL018C-A_p)|FD-Score:-3.84|P-value:6.16E-5||SGD DESC:Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YLR460C(YLR460C_p)|FD-Score:5.19|P-value:1.06E-7||SGD DESC:Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine Gene:YMR187C(YMR187C_p)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Putative protein of unknown function; YMR187C is not an essential gene Gene:YMR262W(YMR262W_p)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene Gene:YNL057W(YNL057W_d)|FD-Score:-4.28|P-value:9.21E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL122C(YNL122C_p)|FD-Score:5.21|P-value:9.33E-8||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene Gene:YNL162W-A(YNL162W-A_p)|FD-Score:-5.36|P-value:4.10E-8||SGD DESC:Putative protein of unknown function; identified by homology Gene:YNR005C(YNR005C_d)|FD-Score:-3.37|P-value:3.78E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR064C(YNR064C)|FD-Score:3.29|P-value:5.07E-4||SGD DESC:Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides Gene:YOL019W-A(YOL019W-A_p)|FD-Score:-5.21|P-value:9.28E-8||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YOR152C(YOR152C_p)|FD-Score:-4.9|P-value:4.83E-7||SGD DESC:Putative protein of unknown function; YOR152C is not an essential gene Gene:YOR309C(YOR309C_d)|FD-Score:-3.93|P-value:4.22E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58 Gene:YPR089W(YPR089W_p)|FD-Score:4.75|P-value:1.02E-6||SGD DESC:Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p Gene:YPR159C-A(YPR159C-A_p)|FD-Score:-5.27|P-value:6.90E-8||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YSP1(YHR155W)|FD-Score:4.6|P-value:2.15E-6||SGD DESC:Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication Gene:YUR1(YJL139C)|FD-Score:-3.3|P-value:4.92E-4||SGD DESC:Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication Gene:ABF2(YMR072W)|FD-Score:-3.27|P-value:5.44E-4||SGD DESC:Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation Gene:ACH1(YBL015W)|FD-Score:-3.81|P-value:6.91E-5||SGD DESC:Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth Gene:ADK1(YDR226W)|FD-Score:-3.65|P-value:1.31E-4||SGD DESC:Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress Gene:ADY2(YCR010C)|FD-Score:3.3|P-value:4.82E-4||SGD DESC:Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication Gene:AIM23(YJL131C)|FD-Score:-6.08|P-value:5.83E-10||SGD DESC:Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss Gene:AIM29(YKR074W)|FD-Score:3.21|P-value:6.69E-4||SGD DESC:Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss Gene:API2(YDR525W_d)|FD-Score:3.41|P-value:3.20E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology Gene:ATC1(YDR184C)|FD-Score:-3.27|P-value:5.31E-4||SGD DESC:Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress Gene:ATG32(YIL146C)|FD-Score:5.62|P-value:9.32E-9||SGD DESC:Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane Gene:ATX1(YNL259C)|FD-Score:3.94|P-value:4.06E-5||SGD DESC:Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake Gene:BRP1(YGL007W_d)|FD-Score:3.35|P-value:3.98E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:BUD30(YDL151C_d)|FD-Score:7.19|P-value:3.25E-13||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:CDC73(YLR418C)|FD-Score:5.12|P-value:1.55E-7||SGD DESC:Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress Gene:CRC1(YOR100C)|FD-Score:3.29|P-value:5.08E-4||SGD DESC:Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Gene:CTR1(YPR124W)|FD-Score:3.72|P-value:1.01E-4||SGD DESC:High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress Gene:ECM30(YLR436C)|FD-Score:3.84|P-value:6.12E-5||SGD DESC:Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm Gene:ERG5(YMR015C)|FD-Score:6.96|P-value:1.68E-12||SGD DESC:C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs Gene:ERV29(YGR284C)|FD-Score:3.45|P-value:2.84E-4||SGD DESC:Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress Gene:FRE4(YNR060W)|FD-Score:7.16|P-value:3.96E-13||SGD DESC:Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels Gene:FUR4(YBR021W)|FD-Score:30.7|P-value:2.23E-207||SGD DESC:Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation Gene:GBP2(YCL011C)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication Gene:GCN5(YGR252W)|FD-Score:5.07|P-value:1.95E-7||SGD DESC:Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation Gene:GEP5(YLR091W)|FD-Score:-4.78|P-value:8.80E-7||SGD DESC:Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine Gene:GID7(YCL039W)|FD-Score:-3.3|P-value:4.92E-4||SGD DESC:Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions Gene:GMC1(YDR506C)|FD-Score:3.2|P-value:6.79E-4||SGD DESC:Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein Gene:GRH1(YDR517W)|FD-Score:-3.98|P-value:3.49E-5||SGD DESC:Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress Gene:IRC10(YOL015W)|FD-Score:-5.36|P-value:4.13E-8||SGD DESC:Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci Gene:ISY1(YJR050W)|FD-Score:-5.2|P-value:1.02E-7||SGD DESC:Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles Gene:LEO1(YOR123C)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:LGE1(YPL055C)|FD-Score:3.85|P-value:5.95E-5||SGD DESC:Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division Gene:LIP5(YOR196C)|FD-Score:-3.34|P-value:4.23E-4||SGD DESC:Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase Gene:LSB1(YGR136W)|FD-Score:-3.27|P-value:5.38E-4||SGD DESC:Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress Gene:MCK1(YNL307C)|FD-Score:4.21|P-value:1.27E-5||SGD DESC:Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family Gene:MSC3(YLR219W)|FD-Score:4.68|P-value:1.44E-6||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress Gene:MSH3(YCR092C)|FD-Score:3.85|P-value:5.80E-5||SGD DESC:Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability Gene:MSH5(YDL154W)|FD-Score:5.6|P-value:1.06E-8||SGD DESC:Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans Gene:MSL1(YIR009W)|FD-Score:3.15|P-value:8.03E-4||SGD DESC:U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members Gene:MTF1(YMR228W)|FD-Score:-3.28|P-value:5.28E-4||SGD DESC:Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation Gene:MTM1(YGR257C)|FD-Score:3.29|P-value:5.01E-4||SGD DESC:Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor Gene:NYV1(YLR093C)|FD-Score:-4.09|P-value:2.13E-5||SGD DESC:v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane Gene:ORM1(YGR038W)|FD-Score:3.8|P-value:7.12E-5||SGD DESC:Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control Gene:PAN5(YHR063C)|FD-Score:3.22|P-value:6.46E-4||SGD DESC:2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE Gene:PGC1(YPL206C)|FD-Score:3.64|P-value:1.37E-4||SGD DESC:Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs Gene:PRM1(YNL279W)|FD-Score:3.17|P-value:7.50E-4||SGD DESC:Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p Gene:PTH2(YBL057C)|FD-Score:3.25|P-value:5.85E-4||SGD DESC:One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth Gene:REC104(YHR157W)|FD-Score:4.18|P-value:1.46E-5||SGD DESC:Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination Gene:RGA1(YOR127W)|FD-Score:3.56|P-value:1.87E-4||SGD DESC:GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:RPL26A(YLR344W)|FD-Score:-3.67|P-value:1.23E-4||SGD DESC:Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication Gene:RTF1(YGL244W)|FD-Score:4.17|P-value:1.52E-5||SGD DESC:Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:SAC7(YDR389W)|FD-Score:4.48|P-value:3.65E-6||SGD DESC:GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate Gene:SCD6(YPR129W)|FD-Score:3.17|P-value:7.50E-4||SGD DESC:Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress Gene:SCP160(YJL080C)|FD-Score:4.65|P-value:1.62E-6||SGD DESC:Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins Gene:SDC1(YDR469W)|FD-Score:5.44|P-value:2.59E-8||SGD DESC:Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 Gene:SIS2(YKR072C)|FD-Score:3.78|P-value:7.90E-5||SGD DESC:Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis Gene:SMF3(YLR034C)|FD-Score:3.26|P-value:5.56E-4||SGD DESC:Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress Gene:SPH1(YLR313C)|FD-Score:3.21|P-value:6.58E-4||SGD DESC:Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p Gene:SSN3(YPL042C)|FD-Score:-3.89|P-value:4.91E-5||SGD DESC:Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression Gene:SUC2(YIL162W)|FD-Score:4.1|P-value:2.06E-5||SGD DESC:Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively Gene:SUL2(YLR092W)|FD-Score:-3.38|P-value:3.60E-4||SGD DESC:High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates Gene:TAN1(YGL232W)|FD-Score:3.62|P-value:1.49E-4||SGD DESC:Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress Gene:TSR2(YLR435W)|FD-Score:-3.99|P-value:3.36E-5||SGD DESC:Protein with a potential role in pre-rRNA processing Gene:UBP13(YBL067C)|FD-Score:5.06|P-value:2.15E-7||SGD DESC:Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication Gene:UBP7(YIL156W)|FD-Score:3.46|P-value:2.75E-4||SGD DESC:Ubiquitin-specific protease that cleaves ubiquitin-protein fusions Gene:URA7(YBL039C)|FD-Score:-5.48|P-value:2.11E-8||SGD DESC:Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication Gene:URN1(YPR152C)|FD-Score:-5.83|P-value:2.72E-9||SGD DESC:Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase Gene:VHR2(YER064C_p)|FD-Score:3.85|P-value:5.96E-5||SGD DESC:Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:VMA3(YEL027W)|FD-Score:5.14|P-value:1.34E-7||SGD DESC:Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis Gene:WHI3(YNL197C)|FD-Score:-3.29|P-value:4.95E-4||SGD DESC:RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication Gene:WWM1(YFL010C)|FD-Score:3.56|P-value:1.89E-4||SGD DESC:WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 Gene:XPT1(YJR133W)|FD-Score:-3.71|P-value:1.03E-4||SGD DESC:Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine Gene:YBR296C-A(YBR296C-A_p)|FD-Score:3.6|P-value:1.59E-4||SGD DESC:Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YDL114W(YDL114W_p)|FD-Score:-4.48|P-value:3.82E-6||SGD DESC:Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene Gene:YDL118W(YDL118W_p)|FD-Score:-3.16|P-value:7.89E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein Gene:YEL028W(YEL028W_d)|FD-Score:3.38|P-value:3.58E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YEL045C(YEL045C_d)|FD-Score:-3.66|P-value:1.26E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Gene:YER084W(YER084W_p)|FD-Score:-4.27|P-value:9.80E-6||SGD DESC:Protein of unknown function; expressed at both mRNA and protein levels Gene:YGR045C(YGR045C_d)|FD-Score:-4.62|P-value:1.95E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR093W(YGR093W_p)|FD-Score:4.44|P-value:4.50E-6||SGD DESC:Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:YHR049C-A(YHR049C-A_d)|FD-Score:-5.52|P-value:1.74E-8||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHR127W(YHR127W)|FD-Score:-3.22|P-value:6.49E-4||SGD DESC:Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis Gene:YJL182C(YJL182C_d)|FD-Score:3.18|P-value:7.25E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W Gene:YKL018C-A(YKL018C-A_p)|FD-Score:-3.84|P-value:6.16E-5||SGD DESC:Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YLR460C(YLR460C_p)|FD-Score:5.19|P-value:1.06E-7||SGD DESC:Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine Gene:YMR187C(YMR187C_p)|FD-Score:3.12|P-value:8.94E-4||SGD DESC:Putative protein of unknown function; YMR187C is not an essential gene Gene:YMR262W(YMR262W_p)|FD-Score:3.52|P-value:2.19E-4||SGD DESC:Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene Gene:YNL057W(YNL057W_d)|FD-Score:-4.28|P-value:9.21E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YNL122C(YNL122C_p)|FD-Score:5.21|P-value:9.33E-8||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene Gene:YNL162W-A(YNL162W-A_p)|FD-Score:-5.36|P-value:4.10E-8||SGD DESC:Putative protein of unknown function; identified by homology Gene:YNR005C(YNR005C_d)|FD-Score:-3.37|P-value:3.78E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR064C(YNR064C)|FD-Score:3.29|P-value:5.07E-4||SGD DESC:Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides Gene:YOL019W-A(YOL019W-A_p)|FD-Score:-5.21|P-value:9.28E-8||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YOR152C(YOR152C_p)|FD-Score:-4.9|P-value:4.83E-7||SGD DESC:Putative protein of unknown function; YOR152C is not an essential gene Gene:YOR309C(YOR309C_d)|FD-Score:-3.93|P-value:4.22E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58 Gene:YPR089W(YPR089W_p)|FD-Score:4.75|P-value:1.02E-6||SGD DESC:Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p Gene:YPR159C-A(YPR159C-A_p)|FD-Score:-5.27|P-value:6.90E-8||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YSP1(YHR155W)|FD-Score:4.6|P-value:2.15E-6||SGD DESC:Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication Gene:YUR1(YJL139C)|FD-Score:-3.3|P-value:4.92E-4||SGD DESC:Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YAL038W5.783.77E-90.65CDC19Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
YFL038C5.706.04E-90.65YPT1Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
YAL034C-B_d5.501.90E-80.65YAL034C-B_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER133W5.442.64E-80.65GLC7Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
YFR050C5.315.53E-80.65PRE4Beta 7 subunit of the 20S proteasome
YOR160W5.257.56E-80.65MTR10Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
YLR029C4.602.12E-60.20RPL15ARibosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
YDR478W4.405.50E-60.03SNM1Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
YGL225W4.376.33E-60.12VRG4Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YPL204W4.251.09E-50.20HRR25Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
YER094C4.052.56E-50.05PUP3Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YPR190C4.003.15E-50.04RPC82RNA polymerase III subunit C82
YBR136W3.963.78E-50.10MEC1Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres
YPR144C3.855.84E-50.30NOC4Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
YOR168W3.551.90E-40.48GLN4Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YBR021W30.702.23E-207FUR4Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
YDL151C_d7.193.25E-13BUD30_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YNR060W7.163.96E-13FRE4Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YMR015C6.961.68E-12ERG5C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YIL146C5.629.32E-9ATG32Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane
YDL154W5.601.06E-8MSH5Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
YDR469W5.442.59E-8SDC1Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30
YNL122C_p5.219.33E-8YNL122C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene
YLR460C_p5.191.06E-7YLR460C_pMember of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine
YEL027W5.141.34E-7VMA3Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YLR418C5.121.55E-7CDC73Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress
YGR252W5.071.95E-7GCN5Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation
YBL067C5.062.15E-7UBP13Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication
YPR089W_p4.751.02E-6YPR089W_pProtein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p
YLR219W4.681.44E-6MSC3Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_2351
biological processes

protein complexes

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.3241.38E-144SGTC_23939031399 185.9 μMChembridge (Fragment library)15266230.52381RNA processing & uracil transport
0.3095.64E-131SGTC_1814st052110 31.5 μMTimTec (Natural product derivative library)6741630.189655RNA processing & uracil transport
0.2924.68E-116SGTC_22977971671 152.3 μMChembridge (Fragment library)9090160.458333RNA processing & uracil transport
0.2758.94E-103SGTC_20825219693 150.0 μMChembridge (Fragment library)28346490.160714RNA processing & uracil transport
0.2531.29E-86SGTC_1471k673-0312 37.0 μMChemDiv (Drug-like library)240998840.0704225RNA processing & uracil transport
0.2162.30E-63SGTC_1817st052116 64.4 μMTimTec (Natural product derivative library)43613980.285714RNA processing & uracil transport
0.2031.03E-55SGTC_8093998-0021 90.0 μMChemDiv (Drug-like library)7154850.0923077RNA processing & uracil transport
0.2002.90E-54SGTC_3051682-2595 20.8 μMChemDiv (Drug-like library)2260330.103448RNA processing & uracil transport
0.1937.77E-51SGTC_1167k781-0610 148.0 μMChemDiv (Drug-like library)45251690.109375RNA processing & uracil transport
0.1911.92E-49SGTC_33559151058 44.0 μMChembridge (Drug-like library)170157280.119403RNA processing & uracil transport
0.1871.35E-47SGTC_1220236-0016 402.4 μMChemDiv (Drug-like library)68088380.103896RNA processing & uracil transport
0.1862.57E-47SGTC_452diindolylmethane 8.0 μMICCB bioactive library30710.12766RNA processing & uracil transport
0.1764.38E-42SGTC_9231900-2434 73.3 μMChemDiv (Drug-like library)59105700.0833333RNA processing & uracil transport
0.1741.36E-41SGTC_22927671323 168.1 μMChembridge (Fragment library)9375040.277778RNA processing & uracil transport
0.1693.05E-39SGTC_530973-0023 40.0 μMChemDiv (Drug-like library)6747680.172414RNA processing & uracil transport

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_23939031399185.94 μM0.523811526623Chembridge (Fragment library)218.212-0.59324RNA processing & uracil transport
SGTC_22206782180200 μM0.5833803Chembridge (Fragment library)207.18606-0.26124RNA processing & uracil transport
SGTC_22977971671152.32 μM0.458333909016Chembridge (Fragment library)256.259981.39323RNA processing & uracil transport
SGTC_1038k292-0204154 μM0.44454212ChemDiv (Drug-like library)288.38788413
SGTC_23427990637118.86 μM0.3333332033102Chembridge (Fragment library)242.23341.07123RNA processing & uracil transport
SGTC_24305571206200 μM0.3214291731771Miscellaneous315.409924.34704
SGTC_14274048-4900550 nM0.29166724132586ChemDiv (Drug-like library)307.472365.79401
SGTC_23307979373200 μM0.2884621863007Chembridge (Fragment library)247.316122.0241460S ribosome export
SGTC_1817st05211664.4 μM0.2857144361398TimTec (Natural product derivative library)310.73291.85514RNA processing & uracil transport
SGTC_21755807670165.31 μM0.285714241186Chembridge (Fragment library)218.27492.03713