Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDL196W_d | 6.61 | 1.90E-11 | 1.41 | YDL196W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |
YDR416W | 6.44 | 5.99E-11 | 1.41 | SYF1 | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans |
YPR165W | 5.03 | 2.46E-7 | 0.08 | RHO1 | GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) |
YDL164C | 4.95 | 3.77E-7 | 0.42 | CDC9 | DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination |
YBL014C | 4.53 | 3.01E-6 | 0.50 | RRN6 | Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p |
YPL094C | 4.03 | 2.79E-5 | 0.32 | SEC62 | Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER |
YBR087W | 3.71 | 1.05E-4 | 0.03 | RFC5 | Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
YGR065C | 3.68 | 1.17E-4 | 0.33 | VHT1 | High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin |
YDR236C | 3.35 | 4.08E-4 | 0.01 | FMN1 | Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane |
YML077W | 3.34 | 4.20E-4 | 0.05 | BET5 | Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi |
YIL021W | 3.29 | 4.95E-4 | 0.06 | RPB3 | RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit |
YBR135W | 3.23 | 6.16E-4 | 0.15 | CKS1 | Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters |
YHR188C | 3.08 | 0.00104 | 0.03 | GPI16 | Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog |
YJL074C | 3.05 | 0.00114 | 0.07 | SMC3 | Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member |
YLR066W | 2.98 | 0.00146 | 0.02 | SPC3 | Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 |