9061122

3-ethoxynaphthalene-2-carboxamide

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2355
Screen concentration 103.1 μM
Source Chembridge (Fragment library)
PubChem CID 5302957
SMILES CCOC1=CC2=CC=CC=C2C=C1C(=O)N
Standardized SMILES CCOc1cc2ccccc2cc1C(=O)N
Molecular weight 215.2478
ALogP 2.07
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 11.5
% growth inhibition (Hom. pool) 3.82


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5302957
Download HIP data (tab-delimited text)  (excel)
Gene:EXO84(YBR102C)|FD-Score:3.27|P-value:5.36E-4|Clearance:0.07||SGD DESC:Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate Gene:GLC7(YER133W)|FD-Score:-4.56|P-value:2.50E-6|Clearance:0||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:MCD4(YKL165C)|FD-Score:-3.4|P-value:3.31E-4|Clearance:0||SGD DESC:Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Gene:PDS5(YMR076C)|FD-Score:-3.32|P-value:4.55E-4|Clearance:0||SGD DESC:Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis Gene:PUP3(YER094C)|FD-Score:3.33|P-value:4.30E-4|Clearance:0.06||SGD DESC:Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 Gene:SMD2(YLR275W)|FD-Score:3.2|P-value:6.93E-4|Clearance:0.14||SGD DESC:Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 Gene:UBA2(YDR390C)|FD-Score:4.34|P-value:7.04E-6|Clearance:1.01||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Gene:EXO84(YBR102C)|FD-Score:3.27|P-value:5.36E-4|Clearance:0.07||SGD DESC:Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate Gene:GLC7(YER133W)|FD-Score:-4.56|P-value:2.50E-6|Clearance:0||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:MCD4(YKL165C)|FD-Score:-3.4|P-value:3.31E-4|Clearance:0||SGD DESC:Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes Gene:PDS5(YMR076C)|FD-Score:-3.32|P-value:4.55E-4|Clearance:0||SGD DESC:Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis Gene:PUP3(YER094C)|FD-Score:3.33|P-value:4.30E-4|Clearance:0.06||SGD DESC:Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 Gene:SMD2(YLR275W)|FD-Score:3.2|P-value:6.93E-4|Clearance:0.14||SGD DESC:Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 Gene:UBA2(YDR390C)|FD-Score:4.34|P-value:7.04E-6|Clearance:1.01||SGD DESC:Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5302957
Download HOP data (tab-delimited text)  (excel)
Gene:AGE1(YDR524C)|FD-Score:3.11|P-value:9.44E-4||SGD DESC:ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif Gene:ALR2(YFL050C)|FD-Score:-3.37|P-value:3.80E-4||SGD DESC:Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition Gene:ATG27(YJL178C)|FD-Score:4.07|P-value:2.39E-5||SGD DESC:Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site Gene:ATG34(YOL083W)|FD-Score:3.36|P-value:3.92E-4||SGD DESC:Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog Gene:DAL81(YIR023W)|FD-Score:3.38|P-value:3.67E-4||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DSE2(YHR143W)|FD-Score:3.98|P-value:3.48E-5||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:ECM7(YLR443W)|FD-Score:3.17|P-value:7.68E-4||SGD DESC:Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency Gene:ELC1(YPL046C)|FD-Score:3.54|P-value:2.04E-4||SGD DESC:Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair Gene:GCN2(YDR283C)|FD-Score:4.72|P-value:1.17E-6||SGD DESC:Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control Gene:GIN4(YDR507C)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication Gene:HIS5(YIL116W)|FD-Score:6.98|P-value:1.49E-12||SGD DESC:Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:HXT4(YHR092C)|FD-Score:4.09|P-value:2.16E-5||SGD DESC:High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication Gene:IME4(YGL192W)|FD-Score:5.11|P-value:1.62E-7||SGD DESC:Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids Gene:NUR1(YDL089W)|FD-Score:-4.14|P-value:1.76E-5||SGD DESC:Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate Gene:PAC2(YER007W)|FD-Score:4.9|P-value:4.73E-7||SGD DESC:Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl Gene:PDX3(YBR035C)|FD-Score:3.42|P-value:3.17E-4||SGD DESC:Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism Gene:PTC3(YBL056W)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication Gene:RAX1(YOR301W)|FD-Score:4.2|P-value:1.32E-5||SGD DESC:Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily Gene:RNH70(YGR276C)|FD-Score:3.2|P-value:6.98E-4||SGD DESC:3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts Gene:RPL22A(YLR061W)|FD-Score:-3.3|P-value:4.77E-4||SGD DESC:Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication Gene:RPL26A(YLR344W)|FD-Score:3.74|P-value:9.12E-5||SGD DESC:Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication Gene:SAC6(YDR129C)|FD-Score:9.86|P-value:3.26E-23||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SSH1(YBR283C)|FD-Score:-3.4|P-value:3.35E-4||SGD DESC:Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential Gene:SSP1(YHR184W)|FD-Score:3.44|P-value:2.96E-4||SGD DESC:Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis Gene:TGL4(YKR089C)|FD-Score:-4.58|P-value:2.30E-6||SGD DESC:Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p Gene:TIF4631(YGR162W)|FD-Score:-4|P-value:3.14E-5||SGD DESC:Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication Gene:TRP1(YDR007W)|FD-Score:4.04|P-value:2.67E-5||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP3(YKL211C)|FD-Score:4.68|P-value:1.46E-6||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TRP4(YDR354W)|FD-Score:4.64|P-value:1.75E-6||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:VPS70(YJR126C)|FD-Score:3.39|P-value:3.47E-4||SGD DESC:Protein of unknown function involved in vacuolar protein sorting Gene:YBR292C(YBR292C_d)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Gene:YDR008C(YDR008C_d)|FD-Score:5.39|P-value:3.57E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR089W(YDR089W_p)|FD-Score:3.18|P-value:7.39E-4||SGD DESC:Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:YFL015C(YFL015C_d)|FD-Score:3.14|P-value:8.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene Gene:YGL041C-B(YGL041C-B_p)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR035W-A(YGR035W-A_p)|FD-Score:3.67|P-value:1.19E-4||SGD DESC:Putative protein of unknown function Gene:YLR173W(YLR173W_p)|FD-Score:4.28|P-value:9.34E-6||SGD DESC:Putative protein of unknown function Gene:YLR255C(YLR255C_d)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR287C(YLR287C_p)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene Gene:YOL019W-A(YOL019W-A_p)|FD-Score:3.2|P-value:6.97E-4||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YPL073C(YPL073C_d)|FD-Score:3.13|P-value:8.63E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments Gene:AGE1(YDR524C)|FD-Score:3.11|P-value:9.44E-4||SGD DESC:ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif Gene:ALR2(YFL050C)|FD-Score:-3.37|P-value:3.80E-4||SGD DESC:Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition Gene:ATG27(YJL178C)|FD-Score:4.07|P-value:2.39E-5||SGD DESC:Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site Gene:ATG34(YOL083W)|FD-Score:3.36|P-value:3.92E-4||SGD DESC:Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog Gene:DAL81(YIR023W)|FD-Score:3.38|P-value:3.67E-4||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DSE2(YHR143W)|FD-Score:3.98|P-value:3.48E-5||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:ECM7(YLR443W)|FD-Score:3.17|P-value:7.68E-4||SGD DESC:Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency Gene:ELC1(YPL046C)|FD-Score:3.54|P-value:2.04E-4||SGD DESC:Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair Gene:GCN2(YDR283C)|FD-Score:4.72|P-value:1.17E-6||SGD DESC:Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control Gene:GIN4(YDR507C)|FD-Score:3.51|P-value:2.28E-4||SGD DESC:Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication Gene:HIS5(YIL116W)|FD-Score:6.98|P-value:1.49E-12||SGD DESC:Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:HXT4(YHR092C)|FD-Score:4.09|P-value:2.16E-5||SGD DESC:High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication Gene:IME4(YGL192W)|FD-Score:5.11|P-value:1.62E-7||SGD DESC:Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids Gene:NUR1(YDL089W)|FD-Score:-4.14|P-value:1.76E-5||SGD DESC:Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate Gene:PAC2(YER007W)|FD-Score:4.9|P-value:4.73E-7||SGD DESC:Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl Gene:PDX3(YBR035C)|FD-Score:3.42|P-value:3.17E-4||SGD DESC:Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism Gene:PTC3(YBL056W)|FD-Score:3.47|P-value:2.56E-4||SGD DESC:Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication Gene:RAX1(YOR301W)|FD-Score:4.2|P-value:1.32E-5||SGD DESC:Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily Gene:RNH70(YGR276C)|FD-Score:3.2|P-value:6.98E-4||SGD DESC:3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts Gene:RPL22A(YLR061W)|FD-Score:-3.3|P-value:4.77E-4||SGD DESC:Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication Gene:RPL26A(YLR344W)|FD-Score:3.74|P-value:9.12E-5||SGD DESC:Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication Gene:SAC6(YDR129C)|FD-Score:9.86|P-value:3.26E-23||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SSH1(YBR283C)|FD-Score:-3.4|P-value:3.35E-4||SGD DESC:Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential Gene:SSP1(YHR184W)|FD-Score:3.44|P-value:2.96E-4||SGD DESC:Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis Gene:TGL4(YKR089C)|FD-Score:-4.58|P-value:2.30E-6||SGD DESC:Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p Gene:TIF4631(YGR162W)|FD-Score:-4|P-value:3.14E-5||SGD DESC:Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication Gene:TRP1(YDR007W)|FD-Score:4.04|P-value:2.67E-5||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:TRP3(YKL211C)|FD-Score:4.68|P-value:1.46E-6||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:TRP4(YDR354W)|FD-Score:4.64|P-value:1.75E-6||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:VPS70(YJR126C)|FD-Score:3.39|P-value:3.47E-4||SGD DESC:Protein of unknown function involved in vacuolar protein sorting Gene:YBR292C(YBR292C_d)|FD-Score:3.32|P-value:4.51E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Gene:YDR008C(YDR008C_d)|FD-Score:5.39|P-value:3.57E-8||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR089W(YDR089W_p)|FD-Score:3.18|P-value:7.39E-4||SGD DESC:Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress Gene:YFL015C(YFL015C_d)|FD-Score:3.14|P-value:8.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene Gene:YGL041C-B(YGL041C-B_p)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR035W-A(YGR035W-A_p)|FD-Score:3.67|P-value:1.19E-4||SGD DESC:Putative protein of unknown function Gene:YLR173W(YLR173W_p)|FD-Score:4.28|P-value:9.34E-6||SGD DESC:Putative protein of unknown function Gene:YLR255C(YLR255C_d)|FD-Score:3.23|P-value:6.14E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR287C(YLR287C_p)|FD-Score:3.65|P-value:1.33E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene Gene:YOL019W-A(YOL019W-A_p)|FD-Score:3.2|P-value:6.97E-4||SGD DESC:Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching Gene:YPL073C(YPL073C_d)|FD-Score:3.13|P-value:8.63E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR390C4.347.04E-61.01UBA2Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YER094C3.334.30E-40.06PUP3Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YBR102C3.275.36E-40.07EXO84Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
YLR275W3.206.93E-40.14SMD2Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2
YDR413C_d3.060.001120.02YDR413C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing
YOR169C_d3.030.001220.17YOR169C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W
YDR416W2.860.002120.07SYF1Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
YNL256W2.790.002630.07FOL1Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
YKL021C2.720.003250.01MAK11Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats
YHR074W2.710.003400.02QNS1Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
YNL313C2.690.003570.03EMW1Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
YML031W2.660.003940.06NDC1Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
YJL074C2.600.004690.01SMC3Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
YGL074C_d2.580.004880.03YGL074C_dDubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
YCR093W2.560.005280.00CDC39Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR129C9.863.26E-23SAC6Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
YIL116W6.981.49E-12HIS5Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YDR008C_d5.393.57E-8YDR008C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL192W5.111.62E-7IME4Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids
YER007W4.904.73E-7PAC2Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
YDR283C4.721.17E-6GCN2Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
YKL211C4.681.46E-6TRP3Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
YDR354W4.641.75E-6TRP4Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YLR173W_p4.289.34E-6YLR173W_pPutative protein of unknown function
YOR301W4.201.32E-5RAX1Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
YHR092C4.092.16E-5HXT4High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication
YJL178C4.072.39E-5ATG27Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site
YDR007W4.042.67E-5TRP1Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
YHR143W3.983.48E-5DSE2Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YLR344W3.749.12E-5RPL26ARibosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication

GO enrichment analysis for SGTC_2355
biological processes

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.2681.16E-97SGTC_22547938975 95.2 μMChembridge (Fragment library)29692770.0833333
0.2567.31E-89SGTC_21976588183 93.1 μMChembridge (Fragment library)8841360.145161
0.2538.68E-87SGTC_2607solasodine 47.4 μMMicrosource (Natural product library)67106420.0357143
0.2493.89E-84SGTC_10583448-5425 97.3 μMChemDiv (Drug-like library)72797050.127273
0.2417.93E-79SGTC_2642cholecalciferol 100.0 μMMicrosource (Natural product library)98214650.0375
0.2392.52E-77SGTC_1801486-1293 102.8 μMChemDiv (Drug-like library)41405360.130435
0.2246.97E-68SGTC_2650prasterone 100.0 μMMicrosource (Natural product library)167592470.0625
0.2202.32E-65SGTC_511013-0126 23.4 μMChemDiv (Drug-like library)16278500.145161
0.2194.58E-65SGTC_14964469-0713 57.4 μMChemDiv (Drug-like library)7466910.233333
0.2182.45E-64SGTC_24885268135 45.7 μMMiscellaneous12703560.107143
0.2184.40E-64SGTC_14823346-2049 8.5 μMChemDiv (Drug-like library)38268040.176471
0.2171.70E-63SGTC_24865283202 22.4 μMMiscellaneous13777510.111111
0.2152.70E-62SGTC_1824st053723 68.6 μMTimTec (Natural product derivative library)6752250.0847458
0.2148.69E-62SGTC_2618avocadyne 43.4 μMMicrosource (Natural product library)30151890.0185185
0.2096.28E-59SGTC_140354-0009 295.0 μMChemDiv (Drug-like library)17135070.2

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_269exalamide29 μM0.441863316Miscellaneous221.295463.05612ergosterol biosynthesis
SGTC_22037227154166.4 μM0.372093896304Chembridge (Fragment library)202.249062.46612
SGTC_18233-hydroxy-2-naphthoic acid106 μM0.3589747104TimTec (Natural product derivative library)188.179422.12623
SGTC_23027771753200 μM0.3488372203047Chembridge (Fragment library)217.286842.13412
SGTC_1090132-003633.7 μM0.34693967274ChemDiv (Drug-like library)293.31663.26423
SGTC_3250913558349.47 μM0.3469397699353Chembridge (Drug-like library)299.321182.80214
SGTC_14003771-899851.5 μM0.345455670767ChemDiv (Drug-like library)299.321182.72214
SGTC_21945927483104.55 μM0.340909760979Chembridge (Fragment library)201.221241.89112
SGTC_1809st05008157.6 μM0.3333335036894TimTec (Natural product derivative library)347.45014.62713
SGTC_3184910875849.47 μM0.333333902885Chembridge (Drug-like library)241.28512.94712